International Journal of Women's Health最新文献

{"title":"Docosahexaenoic acid (DHA) Supplementation During Pregnancy Reduces the Risk of Preterm Birth in Threatened Preterm Labor. The Multicenter Randomized Controlled Trial.","authors":"Wiphawi Phattharachindanuwong, Sukanya Chaiyarach, Ratana Komwilaisak, Piyamas Saksiriwuttho, Chatuporn Duangkum, Kiattisak Kongwattanakul, Pilaiwan Kleebkaow, Termtem Waidee, Manasicha Pongsamakthai, Sathida Chantanavilai, Tunyatorn Srisataporn","doi":"10.2147/IJWH.S518312","DOIUrl":"10.2147/IJWH.S518312","url":null,"abstract":"<p><strong>Background: </strong>Threatened preterm labor is a common reason for hospital admission, and DHA supplementation may lower the risk of preterm labor.</p><p><strong>Objective: </strong>To compare the rates of premature birth between individuals with threatened preterm labor who received DHA and those who did not.</p><p><strong>Methods: </strong>In this multi-center randomized controlled trial, the sample size was calculated to be 60 participants. Pregnant individuals who experienced threatened preterm labor at 24 to 34 weeks gestation were given either 1000 milligrams of DHA daily or no DHA supplement. The criteria for inclusion consisted of singleton pregnancies that had been diagnosed with threatened preterm labor, with no cervical change present. DHA supplementation was initiated when threatened preterm labor was diagnosed and continued until 37 weeks of gestation or until delivery, whichever occurred first. The main outcome was to compare the rates of premature births between the two groups. Moreover, we intended to evaluate the side effects of the DHA supplement along with the outcomes for neonates.</p><p><strong>Results: </strong>Sixty-one pregnant individuals were enrolled and randomly assigned to two groups. Group 1 consisted of 30 participants, each receiving a daily intake of 1,000 milligrams of DHA supplement. Group 2, comprising 31 individuals, did not receive any supplemental DHA. The rate of preterm birth was 23.33% (7/30) and 25.81% (8/31) for the participant group receiving DHA and not receiving DHA, respectively, with a p-value of 0.82. The rate of low-birth-weight neonates was 13.33% (4/30) and 19.35% (6/31) for the participant group receiving DHA and not receiving DHA, respectively, with a p-value of 0.73. The overall results did not show any statistically significant differences. In addition, the rates of cesarean sections, peripartum infections, early postpartum hemorrhage, and NICU admissions did not show significant differences between the two groups.</p><p><strong>Conclusion: </strong>Taking DHA supplements after a diagnosis of threatened preterm pregnancy does not decrease the actual rates of early or late preterm births. To reduce the risk of premature birth, DHA should be taken from the beginning of pregnancy, with a recommendation to start in the first trimester. This should ideally start in the second trimester, no later than around 20 weeks of gestation, and should continue until childbirth or approximately 37 weeks of gestation.</p><p><strong>Clinical trial registration: </strong>https://register.clinicaltrials.gov/.</p><p><strong>Clinical trials: </strong>gov; ID: NCT06302023.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"937-945"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis Severity and Risk of Preeclampsia: A Combined Mendelian Randomization and Observational Study.","authors":"Yizheng Zu, Yi Xie, Huale Zhang, Lichun Chen, Shihan Yan, Zhenna Wang, Zhuanji Fang, Shunhe Lin, Jianying Yan","doi":"10.2147/IJWH.S508174","DOIUrl":"10.2147/IJWH.S508174","url":null,"abstract":"<p><strong>Purpose: </strong>Endometriosis has been hypothesized to increase the risk of preeclampsia (PE) and eclampsia, although the exact mechanism of this relationship is not clear. This study aimed to further explore the potential association between endometriosis and PE/eclampsia through Mendelian randomization (MR) and confirm these findings in a retrospective cohort study.</p><p><strong>Methods: </strong>A two-sample MR study was performed using genetic variants associated with endometriosis from the Finnish database, with outcome data for PE and eclampsia from the UK Biobank. Subgroup analyses were conducted based on endometriosis severity (American society of reproductive Medicine (ASRM) stages I-II and III-IV) and anatomical location (uterus, ovary, deep infiltrating endometriosis). Additionally, a retrospective cohort study was conducted to further assess the association, adjusting for confounding factors such as age, Body Mass Index (BMI), dysmenorrhea, history of uterine surgery, and adenomyosis. Multivariate logistic regression was used to analyze the risk of PE/eclampsia based on endometriosis severity.</p><p><strong>Results: </strong>MR using the Inverse Variance Weighted method found a meaningful association between advanced endometriosis (ASRM stages III-IV) and PE/eclampsia (p = 0.008), while no significant associations were observed for lower stages or endometriosis in the uterus and ovary. In the retrospective cohort, the initial association between the revised American Fertility Society (r-AFS) score and PE/eclampsia (OR: 1.02, 95% CI: 1.01-1.03, p < 0.001) weakened after adjusting for confounders. Significant risk factors identified included age (OR: 1.20, 95% CI: 1.10-1.30, p < 0.001), dysmenorrhea (OR: 2.72, 95% CI: 1.31-5.76, p = 0.008) and adenomyosis showing the strongest association (OR: 9.96, 95% CI: 5.00-20.06, p < 0.001).</p><p><strong>Conclusion: </strong>The findings suggest a potential relationship between advanced endometriosis and the risk of PE/eclampsia. However, other clinical factors such as age, dysmenorrhea, and adenomyosis appear to contribute more significantly to the risk. Further studies are needed to confirm these findings and clarify the underlying mechanisms.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"923-935"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Nutritional Beliefs and Practices Among Mothers in Riyadh During the Puerperal Period: a Cross-Sectional Study.","authors":"Anwar M Alhashem, Fay A Alrasheed, Latifa K Alwallan, Maram F Almutairi, Yara M Bin Khathran, Yasmeen A Alenzi, Rehab A Aldahash","doi":"10.2147/IJWH.S484271","DOIUrl":"10.2147/IJWH.S484271","url":null,"abstract":"<p><strong>Purpose: </strong>During the postpartum period, women undergo physical, social, and emotional changes, with misconceptions regarding postpartum nutrition resulting in high neonatal mortality rates. Traditional nutritional beliefs and practices during pregnancy, childbirth, and postnatal care differ among cultures. We assessed nutritional beliefs and practices among mothers during the puerperal period.</p><p><strong>Patients and methods: </strong>This descriptive cross-sectional study was conducted from October 2021 to April 2022 using an online survey questionnaire regarding beliefs and practices on nutrition during the puerperal period with a sample of 381 mothers. Descriptive statistics were used to report sociodemographic characteristics and nutritional beliefs and practices. ANOVA and two-sample independent <i>t</i>-test were used to analyze nutritional practices by sociodemographic factors. Simple linear regression was used to predict age-based nutritional beliefs and practices. Pearson correlation was used to compare nutritional beliefs and practices.</p><p><strong>Results: </strong>Mothers did not avoid food and water after normal delivery. Many preferred Arabic coffee and peel. Age predicted the total scores of nutritional beliefs and practices, with a positive correlation between nutritional beliefs and practices. New mothers followed certain nutritional customs, such as consuming herbs postpartum. Mothers who had only completed high school or less obtained higher scores on nutritional belief evaluations, and those with ≥5 children displayed a greater number of nutritional beliefs. Those who delivered their first and second children naturally prioritized their dietary habits more than those who had a cesarean delivery.</p><p><strong>Conclusion: </strong>The findings suggest complex relationships among various factors and postpartum dietary choices.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"913-922"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Factors Associated With Antepartum Depression Among Pregnant Women in Latent Labor: A Multi-Facility Cross-Sectional Study in Rural Southwestern Uganda.","authors":"Catherine Atuhaire, Kabanda Taseera, Daniel Atwine, Samuel Maling, Vikram Patel","doi":"10.2147/IJWH.S508301","DOIUrl":"10.2147/IJWH.S508301","url":null,"abstract":"<p><strong>Background: </strong>Despite limited studies on antepartum depression (APD) in Sub-Saharan Africa (SSA), it is suggested that the prevalence on the continent may be higher than the global average. This study aimed at determining the prevalence of APD and identifying its associated factors among pregnant women in latent labor in rural south western Uganda.</p><p><strong>Methods: </strong>The findings in this manuscript were part of a prospective cohort that aimed at investigating Social Support and Perinatal Depression among women in latent labor through six weeks postpartum. We conducted a multi-facility study enrolling women in latent labor to assess for APD and its associated factors from November 2023 to March 2024. The study was carried out in three health facilities in Mbarara District, rural southwestern Uganda. The prevalence of APD based on the Mini International Psychiatric Interview (M.I.N.I 7.0.2) using the depression module. Factors associated with APD were analyzed using bivariate and multivariate logistic regression. Variables with a p-value <0.2 in bivariate analysis were included in the multivariable model, with statistical significance set at p<0.05. Odds ratios (OR) and 95% confidence intervals (CI) were reported. Data were analyzed using STATA software version 14.0.</p><p><strong>Results: </strong>Of the 448 enrolled participants, 37 had APD giving a prevalence of 8.2% (95% CI: 6.0-11.2%). Factors that were significantly associated with APD were Maternal age 30-49 years, bad health status before pregnancy, not happy about being pregnant, having had complications during pregnancy and having a history of stressful life events during pregnancy.</p><p><strong>Conclusion: </strong>This study reveals a very significant yet comparatively lower prevalence of antepartum depression among pregnant women in latent labor in rural southwestern Uganda. These insights highlight the persistent need for comprehensive mental health strategies especially the non-pharmacological approaches within antenatal care to enhance maternal and child health outcomes.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"903-912"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and Perspectives of Women Undergoing Oocyte Cryopreservation in Riyadh, Saudi Arabia: A Mixed-Methods Study.","authors":"Fatimah A Alzahrani, Dania Al-Jaroudi, Hamad Ali Alsufyan, Ali A Alzahrani, Saad Abdullah Alshehri, Sultana S K Jalwi, Elhadi Miskeen","doi":"10.2147/IJWH.S496633","DOIUrl":"10.2147/IJWH.S496633","url":null,"abstract":"<p><strong>Objective: </strong>Women increasingly desire fertility at later ages, yet fertility rates decline with age. Oocyte cryopreservation, offer support for women seeking pregnancy at advanced maternal ages. This mixed-methods study explored the experiences and perspectives of 100 women aged 18-47 in Riyadh, Saudi Arabia who underwent oocyte cryopreservation for social and medical reasons. The research aims to understand the motivations, challenges, and satisfaction levels associated with oocyte cryopreservation within the context of Saudi Arabian society and culture.</p><p><strong>Methods: </strong>Using mixed methods, 100 subjects were enrolled in ten months. Self-administered questionnaires were dispersed to 100 women who underwent oocyte cryopreservation at a private clinic. Fifteen women willing to undergo recorded interviews were interviewed for 11-to 25-minute sessions. The interviews were transcribed entirely and subjected to thematic content analysis. Quantitative data was analyzed on STATA BE Version 18.</p><p><strong>Results: </strong>77 women (77%) froze their oocytes for social reasons, and the women understood the medical/non-medical rationale for freezing. Interestingly, women's reasons for oocyte cryopreservation were highly associated with satisfaction (p=0.050), with women stating social reasons being most satisfied. It can also be seen that factors such as the presence of complications during the oocyte cryopreservation process were tied to low satisfaction (p=0.040). Six thematic areas around oocyte cryopreservation are presented, including freezing concepts and aims, patient experience, challenges in service quality, communication and confidentiality, and -proposals.</p><p><strong>Conclusion: </strong>This research has highlighted how the medical and socio-cultural of women impacted the oocyte cryopreservation intersect. There is a need for improved culturally sensitive healthcare and educational services for better access and awareness. This is better to show that the public policy advocacy that contributes to the unique impacts of oocyte cryopreservation on a woman's reproductive health and why is particularly concerning.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"879-895"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Septic Shock and Fetal Demise Due to <i>Bacillus cereus</i> Infection Following Mid-Trimester Genetic Amniocentesis.","authors":"Yasong Xu, Yizhen Ji, Liangkai Zheng, Ling Chen, Li Sun, Qichang Wu","doi":"10.2147/IJWH.S511595","DOIUrl":"10.2147/IJWH.S511595","url":null,"abstract":"<p><strong>Background: </strong>The ubiquitous <i>Bacillus cereus</i> bacterium can cause numerous clinical diseases, from transient bacteremia to life-threatening systemic infections. Studies have indicated that non-anthracis <i>Bacillus</i> species, such as <i>Bacillus cereus</i>, may be clinically significant concerning placental infection, and the resulting outcomes for the fetus.</p><p><strong>Case presentation: </strong>We report a woman who developed an acute intrauterine infection following mid-trimester genetic amniocentesis. Twenty-seven hours after the procedure, the mother experienced septic shock, disseminated intravascular coagulation (DIC), and fetal death. Microbiology cultures of placental and fetal swab samples taken during hysterotomy and maternal blood samples taken upon admission revealed the growth of <i>Bacillus cereus</i>. The placental pathological examination revealed a large number of microorganisms in the fetal vessels of the chorionic villi, along with signs of acute villitis and chorioamnionitis.</p><p><strong>Conclusion: </strong>This case study highlights the significance of placental intravascular organisms in acute intrauterine infection caused by <i>Bacillus cereus</i>. It also emphasizes the importance of histological analysis, which offers crucial details about the time of onset of the infection and the causative agents and informs present and future obstetric care of these patients, and the significance of placental intravascular organisms in acute intrauterine infection caused by <i>Bacillus cereus</i>.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"897-902"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Analysis of Maternal Cardiac Autonomic Function in Kazakh Pregnant Women with Gestational Diabetes.","authors":"Aigul Sartayeva, Khatima Kudabayeva, Nurgul Abenova, Yerlan Bazargaliyev, Laura Danyarova, Gulnaz Adilova, Aliya Zhylkybekova, Amin Tamadon","doi":"10.2147/IJWH.S486267","DOIUrl":"10.2147/IJWH.S486267","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational diabetes mellitus (GDM) is a common complication during pregnancy that poses considerable risks to both maternal and fetal health. However, its effect on cardiac autonomic function, measured by heart rate variability (HRV), remains uncertain. This study aims to investigate potential alterations in cardiac autonomic function in women diagnosed with GDM.</p><p><strong>Methods: </strong>In this cross-sectional study, 80 Kazakh pregnant women in their third trimester with GDM were enrolled from the endocrinology department of Aktobe Medical Center between January and April 2023. A control group of 30 third-trimester pregnant women without GDM was also selected from outpatient clinics in Aktobe City. HRV was measured with participants in a seated position. A nomogram was developed to predict GDM risk, integrating relevant parameters associated with the condition.</p><p><strong>Results: </strong>Women with GDM were found to be older than those in the control group (p=0.005), though there were no significant differences in education level, employment status, or parity between the two groups. GDM was associated with larger fetal size (p=0.035) and a higher incidence of miscarriages and abortions (p<0.05) compared to the control group. Additionally, obesity was more prevalent among women with GDM (p<0.05). HRV parameters showed no significant differences between the GDM group and healthy pregnant women. The nomogram demonstrated good predictive accuracy, with an area under the curve of 0.7847 in the training cohort.</p><p><strong>Conclusion: </strong>The nomogram developed in this study may prove useful for clinicians and patients in making informed clinical decisions and assessing outcomes. Notably, no significant differences in HRV were observed between women with uncomplicated pregnancies and those with GDM.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"865-877"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Potential Blood Markers for Endometriosis Through the Integration and Experimental Validation of Immune Cell Traits Genome and Genome-Wide Associated Data.","authors":"Jie Mei, Xi-Ya Jiang, Bin Zhang, Li Wang, Ai-Xi Zhang, Jie-Jie Li, Shun-Xia Chen, Xiao Xu, Jing-Jing Hu, Shu-Guang Zhou","doi":"10.2147/IJWH.S509722","DOIUrl":"10.2147/IJWH.S509722","url":null,"abstract":"<p><strong>Background: </strong>While endometriosis (EM) has been previously associated with multiple immune factors, the causal relationship underlying these associations remains unclear.</p><p><strong>Objective: </strong>In this study, Two-sample Mendelian randomization (MR) method was employed to investigate the causal relationship between 731 immune cell traits and EM based on tabulated data from genome-wide association studies (GWAS).</p><p><strong>Methods: </strong>MR method includes inverse variance weighting (IVW), the weighted median (WM), MR-Egger, the weighted model, and the simple model. IVW is used as the primary method for judging causal effects. Peripheral blood was obtained from EM patients, and the positive immune cell phenotype was confirmed using flow cytometry.</p><p><strong>Results: </strong>After <i>P-value</i> correction, our two-sample MR showed that <i>CD28 on CD28+ DN (CD4-CD8-)</i> had a suggestive causal relationship with EM (β =0.040, 95% CI =1.02-1.06, <i>P</i> =0.00029, <i>P_FDR</i> = 0.1984). The results of the other two main methods were similar: Weighted median (OR =1.031, 95% CI =1.00-1.07, <i>P</i> =0.082); MR-Egger (OR =1.032, 95% CI =1.10-1.06, <i>P</i> =0.044). The flow cytometry results indicated that the expression level of <i>CD28 on CD28+ DN (CD4-CD-8)</i> was significantly increased in the ectopic intima of EM patients.</p><p><strong>Conclusion: </strong>Our study demonstrated a causal relationship between immune traits and EM, and the results were verified by clinical samples. The study may provide new biomarkers for the early diagnosis and immunotherapy of EM.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"845-853"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Subchorionic Hematoma on Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome.","authors":"Rong Cang, Xuelei Ding, Zan Tian, Zijie Fu, Meijuan He, Ying Liang","doi":"10.2147/IJWH.S496848","DOIUrl":"10.2147/IJWH.S496848","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of subchorionic hematoma (SCH) in patients with obstetric antiphospholipid syndrome (OAPS) on pregnancy outcomes, as well as the clinical value of anticoagulant therapy.</p><p><strong>Methods: </strong>This retrospective study included 109 OAPS patients treated at the Fourth Hospital of Shijiazhuang from December 2019 to December 2021. Patients were divided into two groups: SCH group (n=40) and non-SCH group (n=69). Baseline data, laboratory indicators (anti-β2GP I, lupus anticoagulant, ACL, D-D, AA, ADP, ATIII, PS, and PC), complications, and pregnancy outcomes were compared between the groups.</p><p><strong>Results: </strong>There were no significant differences between the two groups concerning the abortion rate, live birth rate (all P>0.05). However, we reported a significantly higher rate of preterm delivery occurring between 34-37 in the SCH group (13.7% vs 1.7%, P=0.027). The proportion of patients with triple-positive antiphospholipid antibodies (aPLs) was significantly higher in the SCH group compared to the non-SCH group (7.5% vs 0.0%, P=0.047). During pregnancy but before routine first-trimester therapy was initiated, the levels of β2GP I, LA, ACL, D-D, AA, and ADP in the SCH group were higher than those in the non-SCH group, while ATIII, PS, and PC levels were lower (all P < 0.05). After treatment, the levels of β2GP I, LA, ACL, D-D, AA, and ADP decreased in both groups compared to their pre-treatment levels (all P < 0.05); however, the levels of D-D and PS in the SCH group remained higher than those in the non-SCH group (all P < 0.05).</p><p><strong>Conclusion: </strong>In patients with OAPS who present with SCH during pregnancy, laboratory indicators suggest more severe immune disorders and coagulopathy, as well as an increased risk of preterm delivery.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"855-863"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis.","authors":"Xia-Li Wang, Yi-Fang He, Shi-Kun Chen, Jing Cheng, Xiu-Ming Wu","doi":"10.2147/IJWH.S508352","DOIUrl":"10.2147/IJWH.S508352","url":null,"abstract":"<p><strong>Background: </strong>The relationship between Polycystic ovary syndrome (PCOS) and immune dysregulation, along with metabolic disturbances, remains unclear. This study used Mendelian Randomization (MR) to investigate causal relationships between immune cells, PCOS, and possible metabolite mediators.</p><p><strong>Methods: </strong>We explored the genetic-level relationship between immune cells and PCOS, focusing on metabolites as potential mediators. Data from genome-wide association studies (GWAS) included 731 immune cell types (n=3757), 1400 plasma metabolites (n=8299), and PCOS cases (n=797) versus controls (n=140,558). Bidirectional MR analysis examined immune-PCOS relationships, while two-step MR and mediation analysis identified metabolites as potential mediators. The inverse variance-weighted (IVW) method was used for primary causal assessment, with sensitivity analysis validating results.</p><p><strong>Results: </strong>We identified a total of 33 immune cells that were associated with increased or decreased risk of PCOS (<i>P</i> < 0.05), and these immune cells were also associated with alterations in certain metabolite levels (<i>P</i> < 0.05). Among them, 12 immune cells were found to influence the occurrence of PCOS through the mediation of 17 metabolites. Notably, the effects of Myeloid DC %DC, NKT AC, CD20 on CD20- CD38-, CD25 on memory B cell, and HLA DR on CD33dim HLA DR+ CD11b+ were mediated by multiple metabolites on PCOS development. Similarly, histidine betaine (hercynine) levels and alpha-ketoglutarate to ornithine ratio mediated the association of more than one immune cell with PCOS.</p><p><strong>Conclusion: </strong>This study highlights 12 immune cells impacting PCOS through 17 metabolites, advancing the understanding of immune mechanisms in PCOS risk and suggesting potential therapeutic approaches targeting immune modulation.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"807-823"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}