International Journal of Women's Health最新文献

{"title":"Effectiveness and Safety of Korean Medicine in Treating Female Infertility: A Prospective Multicenter Observational Study.","authors":"Hyo-Jeong Jung, Dong-Il Kim, Su-Ji Choi, Jang-Kyung Park, Jin-Moo Lee","doi":"10.2147/IJWH.S520044","DOIUrl":"10.2147/IJWH.S520044","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective multicenter observational study aimed to systematically collect and analyze data on the characteristics, treatments, and clinical outcomes of patients receiving infertility care at Korean Medicine (KM) hospitals and clinics. The goal was to assess the current status, safety, and effectiveness of KM-based infertility treatments.</p><p><strong>Patients and methods: </strong>A total of 106 patients undergoing infertility treatment were recruited from six university-affiliated KM hospitals and 42 KM clinics. Treatment decisions were made independently by KM physicians without additional study-specific interventions. Data from 96 patients were analyzed after excluding those who did not meet the screening criteria or withdrew consent.</p><p><strong>Results: </strong>The average age of participants was 36.9 years, while their spouses had an average age of 39.3 years. Among the participants, 65.6% received only KM treatments, while 34.4% combined KM with conventional medical treatments. The most common cause of infertility was unexplained infertility (59.4%), and the most frequent pattern identification was Kidney Deficiency type (67.7%). Acupuncture (94.8%) and herbal medicine (93.8%), particularly <i>Jogyeongjongok-tang</i> decoction, were the most commonly used KM interventions. Among the analyzed participants, the clinical pregnancy rate, ongoing pregnancy rate, and live birth rate were 20.8% (95% CI, 13.9-30.0%), 70.0% (95% CI, 48.1-85.5%), and 13.5% (95% CI, 8.1-21.8%), respectively. No congenital anomalies or multiple births were reported, and no serious adverse events occurred during the study.</p><p><strong>Conclusion: </strong>This study provides insights into the characteristics, treatment patterns, clinical outcomes, and safety of KM infertility treatments. Although the small sample size limits definitive conclusions regarding treatment effectiveness and pregnancy outcomes, these findings may serve as a foundation for future research and policy development in KM-based infertility care.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1771-1787"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Hormone Levels and Pain Thresholds in the Luteal Phase of Healthy Women.","authors":"Luyao Zhang, Mingyang Sun, Weiwei Ding, Nan Zhao, Wei Zhang","doi":"10.2147/IJWH.S499942","DOIUrl":"10.2147/IJWH.S499942","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between the level of endogenous sex hormones in the luteal phase and the pain threshold of healthy subjects, and to find the influencing factors of the change in female pain threshold.</p><p><strong>Methods: </strong>Sixty-eight unmarried and nulliparous women, aged 22-28 years old, had regular menstruation with a cycle of 26-30 days, did not smoke, had no pain, no drug abuse, no gynecological problems, and had not participated in other clinical trials in the past 3 months. Blood was collected for analysis of sex hormone concentrations including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and four different pain thresholds were measured after abdominal ultrasound confirmed that the menstrual cycle was in the luteal phase.</p><p><strong>Results: </strong>During the luteal phase, a greater cold pain threshold was correlated with lower FSH (β=-0.743, <i>P</i>=0.012). A greater ischemic pain threshold was correlated with higher LH concentrations (β=1.397, <i>P</i>=0.011). A lower needle pain threshold was associated with higher FSH concentrations (β=0.32, <i>P</i>=0.006), which could explain 19.8% of the total variance of pain from a needle used to draw blood pain threshold.</p><p><strong>Conclusion: </strong>The needle pain threshold, cold pain threshold, ischemic pain threshold in the luteal phase of female healthy volunteers was, respectively, correlated with the concentrations of FSH or LH. These findings suggest that when formulating pain management strategies for women, the level of sex hormone concentrations should be considered, especially during the luteal phase, which may help provide more precise pain interventions for female patients and improve their pain experience.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1745-1754"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Feet Edema in Turner Syndrome by Prenatal Ultrasonography - Case Report and Literature Review.","authors":"Jing Ma, Li Liang, Shanshan Liu, Kailin Yan, Li Zhang","doi":"10.2147/IJWH.S526423","DOIUrl":"10.2147/IJWH.S526423","url":null,"abstract":"<p><strong>Purpose: </strong>Turner syndrome (TS), also known as congenital ovarian hypoplasia syndrome, is a sex chromosome abnormality caused by a complete/partial absence of the second sex chromosome with complete X chromosome. The most common findings by prenatal ultrasonography of TS include thickened nuchal translucency, cystic hygroma, cardiovascular system abnormalities, urinary system diseases, and growth retardation.</p><p><strong>Case presentation: </strong>We present a unique case of TS with the ultrasonographic features of dorsal skin edema on both feet and a progressive slow growth of humerus length (HL) and femur length (FL) at the second trimester of spontaneous pregnancy. We performed an extensive review of prenatal ultrasound features of TS cases from MEDLINE (PUBMED) published in English between 2000 and 2024 to prove this case's uniqueness. A 29-year-old pregnant woman with her second pregnancy after a previous missed abortion presented as the prenatal ultrasound exam for fetal structural anomalies at 24⁺³ weeks gestation revealed an edema of the dorsal skin on both feet and a short long bone of both femur and humerus for gestational age. Nuchal translucency (NT) measurement at week 13⁺⁶ was 1.3mm, and fetal echocardiography at week 24⁺² showed normal. There were no markedly abnormal findings in the results of non-invasive prenatal test (NIPT) cell-free fetal DNA (cff-DNA) at 14⁺⁶ weeks. Then, amniocentesis was performed and the results confirmed Turner syndrome with a 45,X karyotype. The final review included 11 with a total number of 884 cases identified, among which central lymphedema such as increased nuchal translucency or cystic hygroma is the typical finding with TS by ultrasonographic examination. Peripheral lymphedema resulting in fetal substantial swelling in feet was reported in 3 cases. Fetal feet edema accompanied with growth retardation are extremely rare.</p><p><strong>Conclusion: </strong>Peripheral lymphedema such as feet edema accompanied with long bone-involved growth retardation is rare but recognized features by prenatal ultrasonography, which should be considered as an index of chromosomal abnormalities in fetus with TS.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1755-1761"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Gut Microbiota and Metabolomic Profiles in Pregnant Women: Association with Cesarean Section Risk.","authors":"Jing Yuan, Yabing Wang, Lijuan Liu","doi":"10.2147/IJWH.S526040","DOIUrl":"10.2147/IJWH.S526040","url":null,"abstract":"<p><strong>Background: </strong>The gut microbiota and metabolic profiles of pregnant women undergo dynamic changes throughout gestation, potentially influencing the mode of delivery. Emerging evidence suggests that dysbiosis of gut microbiota and metabolic perturbations may contribute to the rising cesarean section (CS) rates. This study aimed to investigate gestation-specific alterations in gut microbiota and serum metabolomes and evaluate their association with CS risk.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 80 healthy pregnant women with singleton pregnancies who delivered at our hospital between January 2022 and December 2023. Participants were stratified into CS (n=40) and vaginal delivery (VD, n=40) groups based on delivery mode, matched for maternal age, pre-pregnancy BMI, and gestational age. Fecal samples were collected one month prior to delivery for gut microbiota analysis using 16S rRNA gene sequencing. Serum samples were subjected to targeted metabolomics via UHPLC-QTOF-MS, focusing on markers of energy metabolism. Peripheral blood was analyzed for T cell subsets and regulatory T cells (Tregs) by flow cytometry. Spearman correlation analysis was performed to assess associations between gut microbial taxa and serum metabolites.</p><p><strong>Results: </strong>The CS group exhibited significantly lower gut microbial α-diversity (Shannon index: 3.22 vs 4.10, P<0.001), reduced Bacteroidetes (15.3% vs 20.1%, P=0.021), and increased Firmicutes (50.2% vs 46.4%, P=0.015), resulting in an elevated Firmicutes/Bacteroidetes ratio (P=0.008). Metabolomic analysis showed higher levels of pyruvic acid and lactate and lower levels of phenylalanine in the CS group (all P<0.05). Immune analysis revealed increased CD4⁺ T cells, CD8⁺ T cells, and Tregs in the CS group (P=0.042, 0.029, 0.015, respectively). Correlation analysis indicated that Bacteroidetes abundance positively correlated with lactate (r=0.45, P<0.001), Firmicutes with phenylalanine (r=0.37, P=0.012), and Lactobacillus negatively with pyruvic acid (r=-0.28, P=0.045).</p><p><strong>Conclusion: </strong>Gestational gut microbiota dysbiosis and metabolic dysregulation are significantly associated with increased CS risk. These findings highlight potential biomarkers for early risk stratification and suggest that personalized microbiota-directed interventions during pregnancy might help optimize delivery outcomes. Further mechanistic studies are warranted to validate causality.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1763-1770"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Female Urethral Cancer Based on Multimodal Ultrasound: A Case Report.","authors":"Minfang Wang, Wanjun Chen, Ying He, Ji Xu, Shasha Zheng, Meng Wu","doi":"10.2147/IJWH.S517310","DOIUrl":"10.2147/IJWH.S517310","url":null,"abstract":"<p><p>While histopathology remains the diagnostic gold standard for urothelial carcinoma, this case highlights the emerging role of advanced ultrasonographic techniques in characterizing urethral malignancies. We present a 51-year-old female with a one-month history of refractory lower urinary tract symptoms (urinary frequency, urgency, dysuria, and nocturia) unresponsive to conventional anti-inflammatory therapy. Multimodal ultrasonographic evaluation, incorporating conventional sonography, transrectal ultrasound, elastography, and contrast-enhanced ultrasonography (CEUS), revealed a complex proximal urethral mass with malignant features. Subsequent cystoscopic and histopathological examinations confirmed the diagnosis of primary urethral adenocarcinoma. This case underscores the diagnostic value of comprehensive ultrasound protocols in evaluating female urethral neoplasms.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1739-1744"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study.","authors":"Xuwen Song, Yikang Wang, Pengsheng Li, Yafei Wang, Xinghui Wen, Qingwen Nie, Wanlu An, Huan Wang, Fang He","doi":"10.2147/IJWH.S517371","DOIUrl":"10.2147/IJWH.S517371","url":null,"abstract":"<p><strong>Background: </strong>Observational epidemiologic investigations into the link between diabetes mellitus and preeclampsia (PE) have been conducted, but genetic evidence is still lacking. We utilized a two-sample Mendelian randomization (MR) analysis to shed light on the potential influence of type 2 diabetes mellitus (T2DM) on PE at the genetic prediction level.</p><p><strong>Methods: </strong>We carried out a two-sample bidirectional MR analysis, utilizing genetic variants associated with T2DM (N=461,920) and PE (N=219,817) from the largest available genome-wide association studies. Using inverse variance weighting (IVW) and five validated approaches-MR-Egger, MR-RAPS, ConMix, weighted median, and weighted mode-we derived a potential causal association between T2DM and PE. The relationship between PE and T2DM was explored using reverse MR analysis.</p><p><strong>Results: </strong>The two-sample MR analysis indicated a causal link between T2DM and PE, with an odds ratio of 1.10 (95% CI, 1.02-1.18; P=0.01). The weighted mode method yielded an odds ratio of 1.22 (95% CI, 1.06-1.40; P=0.019), and the weighted median method produced an odds ratio of 1.19 (95% CI, 1.04-1.36; P=0.022). However, no significant association was detected in the MR-Egger analysis. Heterogeneity was noted in the analysis of T2DM and PE, but no significant horizontal pleiotropy was observed. The results of the reverse MR analysis indicated no significant causal association between PE and T2DM.</p><p><strong>Conclusion: </strong>For the first time, MR analysis showed a positive causal link from T2DM to PE, but not vice versa. The limited number of SNPs in reverse analysis may affect reliability. Future studies should use more instrumental variables to strengthen findings. Further experiments are also needed to explore underlying mechanisms.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1725-1737"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Experiences of Women with Gestational Diabetes in Singapore: A Qualitative Study.","authors":"Monica Ashwini Lazarus, V Vien Lee, Desmond Luan Seng Ong, Tong Wei Yew, Shefaly Shorey, Doris Young, Johan Gunnar Eriksson","doi":"10.2147/IJWH.S517739","DOIUrl":"10.2147/IJWH.S517739","url":null,"abstract":"<p><strong>Purpose: </strong>Gestational Diabetes Mellitus (GDM) is common in Southeast Asian countries. In Singapore, GDM affects approximately one in five pregnancies. Women diagnosed with GDM are at greater risk of developing type 2 Diabetes Mellitus. Little is known about how women with GDM manage the complex interactions between provider demands, personal responsibility, and family relationships. Accordingly, this study aimed to explore how women and their spouses experience GDM, from diagnosis to long-term management.</p><p><strong>Patients and methods: </strong>Individual semi-structured interviews were conducted with 19 women who had GDM in the past five years (2019-2023). Five spouses were interviewed for this study. The interviews were audio-recorded, transcribed, and analyzed using Braun and Clarke's reflexive thematic analysis.</p><p><strong>Results: </strong>We report three themes: diagnosis, management, and long-term experience. During the GDM diagnosis, women described feeling blindsided and emotionally overwhelmed. In GDM management, women struggle to find information and healthcare support. Some women's families were sources of support whereas other women must navigate family attitudes toward GDM that may be counterproductive. Postdelivery, women are unclear about follow-up procedures, feel neglected by the healthcare system in terms of their history of GDM, and struggle to make sustained changes to their individual and family health.</p><p><strong>Conclusion: </strong>Women with GDM face emotional and informational challenges that begin at diagnosis and persist after delivery. Better GDM education and follow-up care encouraging family-centered support will improve long-term outcomes.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1711-1724"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Success Rate of Vaginal Delivery After Cesarean Section and Its Associated Factors in Afghan Women: Insights from a Maternity Hospital in Kabul.","authors":"Parvin Golzareh, Halima Baha, Fahima Aram, Muhammad Haroon Stanikzai, Razia Rabizada, Massoma Jafari","doi":"10.2147/IJWH.S517179","DOIUrl":"10.2147/IJWH.S517179","url":null,"abstract":"<p><strong>Background: </strong>Vaginal Birth After Cesarean delivery (VBAC) is widely regarded as one of the most effective methods to reduce unnecessary Cesarean section and their complications. Despite its proven benefits, data on the success rate of VBAC and the associated factors remain scarce in Afghanistan. This study aimed to address this gap by determining the VBAC success rate and identifying its associated factors in a maternity hospital in Kabul, Afghanistan.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at Malalai Obstetrics and Gynecology Hospital in Kabul, Afghanistan. The study sample included women with a history of previous cesarean section who visited the hospital between March 21 and September 22, 2023. Demographic and clinical information were collected from client files. Descriptive statistics were used to summarize the demographic and clinical characteristics of the study sample. The association between VBAC and various categorical variables were examined using chi-square tests, with a significance level set at <i>p</i> < 0.05. Logistic regression analysis was performed to identify independent predictors of VBAC, with VBAC as the outcome variable and multiple predictors included in the model.</p><p><strong>Results: </strong>Among the 567 women included in the study, 449 (79.2%) had a successful VBAC. Factors associated with successful VBAC and their adjusted odds ratio (95% CI) were lower gestational age: 1.25 (1.05-1.48), absence of gestational hypertension: 2.71 (1.26-5.85), cervical dilation of > 4 cm on admission: 2.77 (1.38-5.55), effacement of ≥ 50% on admission: 2.13 (1.04-4.35), and absence of fetal distress: 7.35 (4.29-12.6).</p><p><strong>Conclusion: </strong>The rate of successful VBAC observed in this study is at a high level (79.2%). This study is the first study to determine the VBAC success rate and its associated factors in Afghanistan. Further research is needed to validate these findings and explore additional factors influencing VBAC success.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1701-1710"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of High-Risk HPV Infection in Community Women at Ho Chi Minh City in 2024: A Cross-Sectional Study with Self-Collect Sampling.","authors":"Ai H T Pham, Thao H Ha, Thanh Q Le, Dat Q Nguyen, Tuan M Vo","doi":"10.2147/IJWH.S519586","DOIUrl":"10.2147/IJWH.S519586","url":null,"abstract":"<p><strong>Objective: </strong>HPV infection is a major contributor to cervical cancer, a common type of cancer affecting Vietnamese women. To develop effective prevention strategies for cervical cancer, it is crucial to understand the prevalence of high-risk HPV infection in communities. The objectives of this study were to determine the prevalence and distribution of HPV types among female residents in Ho Chi Minh City.</p><p><strong>Methods: </strong>This cross-sectional study employed a self-collection method, involving 775 participants selected using a Probability Proportional to Size technique (PPS) between January and December 2024.</p><p><strong>Results: </strong>The study found that 7.5% [95% CI: 5.6-9.3] of the 775 specimens tested positive for high-risk HPV infection, with HPV-16 accounting for 9.7%, HPV-18 for 3.2%, and other high-risk types for 87.1% (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 và 68). Compared to similar studies many years ago in Vietnam, the prevalence of high-risk HPV infection has not changed much. However, among high-risk HPV infections, the ratio of types 16 and 18 has decreased dramatically.</p><p><strong>Conclusion: </strong>Findings from this investigation reveal that the high-risk HPV infection prevalence in Ho Chi Minh City communities is consistent with earlier research. Nevertheless, a significant change has been observed in the distribution of high-risk HPV genotypes. Specifically, the proportional representation of HPV types 16 and 18 within the high-risk HPV infection group has substantially diminished, now representing only approximately 30% of their prevalence a decade prior.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1673-1679"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter Retrospective Cohort Study of Pregnancy Outcomes in Idiopathic Oligohydramnios at Term.","authors":"Hui Gao, Hui Tao, Li Zou, Qing-Qing Luo, Wei-Yuan Zhang","doi":"10.2147/IJWH.S508609","DOIUrl":"10.2147/IJWH.S508609","url":null,"abstract":"<p><strong>Objective: </strong>The effect of idiopathic oligohydramnios or isolated oligohydramnios on perinatal outcomes at term pregnancies is understudied. This study aimed to show the current epidemiological status of idiopathic oligohydramnios in mainland China, evaluate the pregnancy outcomes, and discuss the optimal delivery opportunity and mode.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 106,225 term pregnancies from 37 hospitals in mainland China. All cases that delivered a non-anomalous singleton fetus between 37⁺⁰ and 41⁺⁶ weeks were collected. Perinatal outcomes of different gestational weeks and different delivery modes were compared between the idiopathic oligohydramnios group and the control group.</p><p><strong>Results: </strong>The incidence of idiopathic oligohydramnios in singleton pregnancies at term was 2.6%. Compared with control pregnancies, the idiopathic oligohydramnios group was characterized by lower birth weights and higher cesarean section rates (P <0.01, respectively). From early-term and full-term to late-term, a pregnancy with idiopathic oligohydramnios exhibited the trend of lower risk of cesarean delivery and neonatal intensive care unit (NICU) admission but a higher risk of meconium-stained amniotic fluid, non-reassuring fetal heart rate status (NRFHRS), and emergency cesarean delivery (P <0.01, respectively). Notably, the rate of Apgar score <7 at 5 min and cesarean section was the lowest when delivery occurred during the 39⁺⁰ to 40⁺⁶ weeks. There was a higher incidence of NRFHRS in the idiopathic oligohydramnios vaginal delivery group when compared to the selective cesarean section group (2.6% vs 1.2%, P=0.05), but with no significant differences in postpartum hemorrhage, low Apgar score, or NICU admission.</p><p><strong>Conclusion: </strong>The incidence of adverse pregnancy outcomes is higher in the idiopathic oligohydramnios group than in the control group. Adverse outcomes seem lowest in the group of vaginal delivery during the 39⁺⁰ to 40⁺⁶ weeks, but close intrapartum surveillance and active intervention still need to be applied.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1665-1672"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}