International Journal of Women's Health最新文献

{"title":"Research Trends and Hotspots in Minimally Invasive Gynecologic Surgery: A Bibliometric and Visualization Analysis.","authors":"Tong Wu, Kebing Nie, Yueyue Gao, Ying Chen, Jinfeng Yan, Shixuan Wang, Jinjin Zhang","doi":"10.2147/IJWH.S522821","DOIUrl":"10.2147/IJWH.S522821","url":null,"abstract":"<p><p>Minimally invasive gynecologic surgery (MIGS) has changed gynecologic care over the past thirty years by introducing techniques like multiport laparoscopy, robotic-assisted laparoscopy, and single-site surgery. MIGS offers advantages like reduced blood loss, shorter recovery times, and comparable oncological outcomes to open surgery. However, existing literature lacks a systematic synthesis of global research trends and academic performance of researchers. This cross-sectional bibliometric analysis examined 5,379 MIGS-related publications indexed in the Web of Science Core Collection database spanning 2014 to 2023, utilizing tools like VOSviewer and CiteSpace to map academic trends. The study revealed global contributions from 1,888 institutions across 97 countries, with the United States (1,156 publications) and China (1,090 publications) emerging as leading contributors. High-income countries dominated research output, though metrics varied regionally. Key institutions driving innovation included Mayo Clinic (n = 97), Harvard Medical School (n = 87), and Brigham & Women's Hospital (n = 83). Journal performance showed disparities influenced by impact factors, accessibility, and editorial focus, while research hotspots centered on endometriosis, laparoscopy, and hysteroscopy. The findings highlight a dynamic, collaborative global landscape in MIGS research, with disease prevalence and journal specialization shaping academic priorities. This analysis underscores the field's evolution and anticipates future directions, emphasizing the role of multidisciplinary collaboration and technological advancements in advancing clinical practice.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3331-3345"},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Mapping and Visualization Analysis of Almost Five Decades of Egg Freezing Research: Trends, Hotspots and Prospects.","authors":"Xiandong Peng, Hongxia Sun, Jiazhou Chen","doi":"10.2147/IJWH.S529541","DOIUrl":"10.2147/IJWH.S529541","url":null,"abstract":"<p><strong>Background: </strong>Egg freezing, also known as oocyte cryopreservation, has become an increasingly significant topic in reproductive medicine. A large number of articles have been published on egg freezing; however, there is still a lack of studies that use visualization methods for bibliometric analysis of relevant literature. This study aimed to explore the publication landscape and identify key trends, influential authors, institutions, and emerging topics in egg freezing research using bibliometric analysis.</p><p><strong>Methods: </strong>Publications related to egg freezing from 1979 to 2024 were retrieved from the Web of Science Core Collection. A bibliometric analysis was conducted using Excel 365, VOSviewer (version 1.6.20), CiteSpace (version 6.3.R1), and R 4.3.3 to map co-authorship networks, institutional collaborations, and keyword co-occurrence patterns.</p><p><strong>Results: </strong>A total of 1072 publications were identified, with an annual growth rate of 9.68%. The research was contributed by 4392 authors and originated from 1380 institutions in 59 countries. The United States leads with 337 publications accounting for 31.4%, followed by Italy and China. The Royal Women's Hospital in Australia was prominent institutional contributors. Oktay Kutluk. ranks first with 18 articles published and a 18 H-index. The leading journals included <i>Fertility and Sterility, Reproductive Biomedicine Online</i>, and <i>Human Reproduction</i>. Keywords analysis identified three clusters, including egg freezing technology, fertility preservation for young women scheduled for chemotherapy, and social recognition on egg freezing. The most recent occurring keywords were \"outcome\", \"infertility\", and \"knowledge\", indicating core areas of research focus in the future.</p><p><strong>Conclusion: </strong>This bibliometric analysis provides valuable insights into the global trends and research hotspots in egg freezing. The research highlights a growing focus on the technological aspects of egg freezing. Moving forward, researchers should focus on the social aspects of egg freezing, such as public education and awareness regarding egg freezing options.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3241-3257"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining a Treatment Threshold Value for Endometrial Thickness in Women with Breast Cancer Receiving Tamoxifen.","authors":"Lurong Huang, Ye Lu, Yanhui Chen, Hongli Liu, Jian An","doi":"10.2147/IJWH.S531872","DOIUrl":"10.2147/IJWH.S531872","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a prevalent malignancy in women that often requires endocrine treatment, such as tamoxifen, which is known to affect endometrial thickness and pose risks of endometrial pathologies.</p><p><strong>Objective: </strong>This study aimed to determine a clinically relevant threshold for transvaginal ultrasound-measured endometrial thickness in breast cancer patients receiving tamoxifen therapy and assess its predictive value for endometrial pathologies.</p><p><strong>Methods: </strong>We analyzed a total of 205 endometrial biopsies from women dichotomized into premenopausal and postmenopausal groups. We assessed the clinical and pathological characteristics in relation to the presence of endometrial pathologies, employing receiver operating characteristic (ROC) curves to evaluate the predictive value of endometrial thickness as a diagnostic marker.</p><p><strong>Results: </strong>Among the study cohort, 11.71% of patients were diagnosed with endometrial hyperplasia, and 3.90% had endometrial cancer. Our findings indicate that women with endometrial pathologies exhibited significantly greater endometrial thickness (P<0.001) in both premenopausal and postmenopausal cohorts. Notably, demographic and clinical factors including age, body mass index, gravidity, parity, comorbidities, duration of tamoxifen use, and abnormal vaginal bleeding did not differ significantly between groups with or without pathology. The ROC analysis yielded an area under the curve (AUC) of 0.845 for premenopausal and 0.759 for postmenopausal patients, establishing cutoff values of 0.95 cm and 0.55 cm, respectively.</p><p><strong>Conclusion: </strong>Our research confirms that endometrial thickness serves as a significant clinical indicator for diagnosing endometrial pathologies in breast cancer patients receiving tamoxifen therapy, underscoring the necessity for risk-based strategies to monitor patients with thickened endometria and advocating for timely hysteroscopic intervention when warranted.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3189-3199"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Brain Adenocarcinoma and Pelvic Squamous Carcinoma Originating From Cervical Adenosquamous Carcinoma: A Case Report and Literature Review.","authors":"Panbo Liu, Xinyu Miao, Qiqi Xu, Zhuoyao Li, Weiwei Lu, Jiajia Li","doi":"10.2147/IJWH.S526108","DOIUrl":"10.2147/IJWH.S526108","url":null,"abstract":"<p><strong>Background: </strong>Cervical adenosquamous carcinoma (ASC) has a poor prognosis, and brain metastasis (BM) is extremely rare. Patients with BM have a poor prognosis. At present, there is no satisfactory treatment and no standard effective treatment. In recent years, immune checkpoint inhibitors (ICIs) and surgical treatment have emerged as a promising treatment for recurrent and metastatic cervical cancer (CC).</p><p><strong>Case: </strong>We report a 39-year-old CC patient whose cervical biopsy pathology showed adenocarcinoma with stage IIIC1r, and so underwent radical radiotherapy and chemotherapy 7 years ago. She was under a palliative enterostomy 4 years ago after intestinal perforation due to multiple recurrence of pelvic tumor. To our surprise, postoperative histopathology was squamous cell carcinoma and adenocarcinoma, ASC was confirmed. The postoperative efficacy of intravenous chemotherapy combined with immunotherapy was partial response (PR), and the efficacy of immunomaintenance therapy was progressive disease (PD). While she had gone through the recurrence of intestinal leakage 3 years ago, Pelvic exenteration (PE) was performed (postoperative histopathology squamous cell carcinoma), the postoperative effect was complete response (CR), and the patient selected regular reexamination. Isolated BM focus was developed in August 2024, and radiotherapy, chemotherapy and immunotherapy were refused after surgical treatment (postoperative histopathology adenocarcinoma). The progression-free survival (PFS) after BM is nearly one year. At present, the patient's reexamination showed no obvious abnormality.</p><p><strong>Conclusion: </strong>We report a case of ASC, whose at the initial treatment, the cervical lesions were mainly adenocarcinoma. However, pelvic metastatic lesion was mainly squamous carcinoma and underwent chemotherapy combined with immunotherapy combined with PE. The histopathology form of BM is adenocarcinoma. The surgical treatment has achieved remarkable curative effect and survival benefit.The choice of treatment is often based on the number of metastases in the patient's clinical state, tumor size, and metastases in other organs.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3259-3270"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond BMI: A Mendelian Randomization Study of the Causal Effects and Mediating Pathways of Regional Adipose Tissue Depots on Polycystic Ovary Syndrome.","authors":"Jing Yang, Xihui Zhang, Hui Zhang, Xiaolu Guo, Fengjuan Ren, Cui Dong","doi":"10.2147/IJWH.S552619","DOIUrl":"10.2147/IJWH.S552619","url":null,"abstract":"<p><strong>Background: </strong>Previous studies suggest that increased body fat is associated with polycystic ovary syndrome (PCOS) risk. Recent evidence highlights that the distribution of adipose tissue may play a more critical role in predicting PCOS risk compared to total fat mass; however, causal relationships remain unclear. This Mendelian randomization (MR) study aimed to investigate the causal associations between body mass index (BMI)-independent regional adipose tissue distribution and PCOS risk.</p><p><strong>Methods: </strong>Female-specific data on regional adipose tissue depots (n <i>= 19,273</i>), independent of BMI and height, including gluteofemoral adipose tissue (GFAT), abdominal subcutaneous adipose tissue (ASAT), visceral adipose tissue (VAT), and related adipose tissue ratios, were derived from large-scale genome-wide association studies. Independent genetic instruments were selected based on genome-wide significance (<i>P</i> < 5 × 10^-8), and the Steiger test confirmed causal direction. Causal associations were validated through meta-analysis combining discovery and replication PCOS datasets. Additionally, two-step mediation analysis was performed to investigate five potential mediators: sex hormones, lipid metabolism, glucose metabolism, adipose-specific factors, and inflammatory markers.</p><p><strong>Results: </strong>Genetically predicted higher GFAT volume demonstrated a significant causal protective effect on PCOS risk (OR = 0.845, 95% CI: 0.735-0.971). This protective effect was predominantly mediated through reductions in fasting insulin (58.37%, 95% CI: 27.66-89.08%) and leptin (51.75%, 95% CI: 33.54-75.41%). Other mediators included the homeostasis model assessment of insulin resistance (HOMA-IR; 37.20%), sex hormone-binding globulin (SHBG; 24.74%), bioavailable testosterone (BT; 11.99%), and triglycerides (TG; 9.52%). Additionally, suggestive evidence driven by a single genetic instrument linked higher VAT/ASAT, VAT/GFAT, and ASAT/GFAT ratios to increased PCOS risk (OR > 1). Sensitivity analyses and supplementary methods confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>This study provides causal evidence supporting the protective role of GFAT against PCOS and identifies critical metabolic and hormonal pathways as mediators. These results highlight the significance of adipose tissue distribution patterns in the pathogenesis of female endocrine disorders.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3279-3291"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study on the Effects of Modified Hupo San on Reproductive Hormone Levels and Microcirculation in Patients with Menstrual Disorders of Cold Congelation and Blood Stasis Pattern.","authors":"Ran Ma, Na Zhang, Juan Xing, Yan Wang, Xi Zhen","doi":"10.2147/IJWH.S539135","DOIUrl":"10.2147/IJWH.S539135","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.</p><p><strong>Methods: </strong>A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P<0.05 considered statistically significant.</p><p><strong>Results: </strong>The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P<0.05). Progesterone showed no significant difference.</p><p><strong>Conclusion: </strong>Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3271-3278"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of Outcomes, Comorbidities, and Alternative Behavioral Interventions in Adolescent and Adult Women with ADHD.","authors":"Miranda Baby, Vijayan Priya, Janardhan Pallavi, Basude Karthik Chand, Laxmikarthika V Srinivasan, Sandeep Singh Rana, Samah Tawil, Shafiul Haque, Payel Ghosh, Pratik Bhattacharya, Mohd Owais Khan, Syed Khalid Perwez, Faraz Ahmad","doi":"10.2147/IJWH.S511297","DOIUrl":"10.2147/IJWH.S511297","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that persists into late adolescence and even adulthood. While a lot of research has addressed the issues of childhood ADHD, manifestation of the condition in adults, particularly females, remains largely obscure. The aim of the present narrative review is to address the sex-specific subtleties of ADHD in adolescent and adult female populations and critically analyze the various intricately complex facets of the associated comorbidities and outcomes, based upon data extracted from scholarly works indexed in online databases (eg, PubMed, Google Scholar, etc). We provide evidences refuting the presumption that ADHD primarily affects men, highlighting the complexity of clinical outcomes and comorbidities, and the consequent misdiagnosis of women as a possible reason. Comprehensive critical assessment of the multiple aspects of psycho-socio-behavioral, cognitive, and other clinical outcomes and comorbidities associated with ADHD in women indicated widespread dysfunctions and atypical characteristics. Furthermore, we also propose the probable utilities of art-based and other unconventional behavioral therapeutic regimens as alternatives and/or additives for the therapy of female ADHD cases to address case- and gender-specific needs and induce an overall improvement in their functioning. While this is not an exhaustive review of the literature, we hope that our points of discussion will generate further interest among scientists, clinicians, and caregivers to address the age and gender specificity of the condition to advance our perspectives of the condition and eventually establish novel therapeutic measures for the same.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3201-3228"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D in the Treatment of Recalcitrant Oral Lichen Planus: A Case Series.","authors":"Eris Nurul Rahmadhini, Wahyu Hidayat, Dewi Zakiawati","doi":"10.2147/IJWH.S527877","DOIUrl":"10.2147/IJWH.S527877","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP) is a chronic mucocutaneous inflammation. Although the aetiology of OLP was unknown, dysregulation of T lymphocyte function (CD8 T lymphocytes) in autoimmune disease was considered a contributing factor. Vitamin D deficiency was found to exacerbate the condition by increasing oral keratinocyte apoptosis, which led to worsened clinical manifestations and delayed healing in OLP patients. Moreover, OLP management was challenging due to its frequent recurrences. Vitamin D receptor (VDR) has anti-inflammatory and immunomodulatory properties, along with a regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP.</p><p><strong>Purpose: </strong>This case report analyzed recalcitrant OLP lasting over one year and highlighted the significant role of vitamin D in enhancing wound healing.</p><p><strong>Case presentation: </strong>Two female patients, aged 50 and 58 years, complained of pain in the left and right cheeks for one and three years ago. Both patients had received previous therapies but had shown no improvement. Intraoral examination revealed erosive lesions with Wickham striae on the left and right buccal mucosa. We diagnosed both patients with erosive and reticular OLP.</p><p><strong>Case management: </strong>The first-line treatment for both patients was corticosteroid mouthwash and anti-inflammatory therapy. An examination of vitamin D 25 (OH) levels was carried out as a risk factor screening due to the clinical manifestations being quite severe and persistent. The examination results indicated a vitamin D deficiency; both patients received vitamin D replacement therapy. The last control showed that patients' subjective and objective complaints experienced significant changes.</p><p><strong>Conclusion: </strong>Vitamin D deficiency could increase the risk of OLP. Vitamin D examination and administration were important considerations in therapeutic decisions for OLP patients because they could accelerate the healing process.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3229-3239"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a Nomogram Prediction Model for Intraoperative Shivering During Caesarean Section.","authors":"Jinghui Liu, Shan Huang, Luwen Zhang, Libaihe Du, Wenqi Xu, Qingmi Tian, Xiaoping Luo, Mingyang Zhang","doi":"10.2147/IJWH.S531119","DOIUrl":"10.2147/IJWH.S531119","url":null,"abstract":"<p><strong>Objective: </strong>To explore the risk factors of intraoperative shivering in cesarean section patients, construct a prediction model and evaluate its performance.</p><p><strong>Methods: </strong>Clinical data of 260 patients undergoing cesarean section from March 2024 to January 2025 were collected, with intraoperative shivering as the primary outcome. Univariate and multivariable logistic regression analyses were performed to identify statistically significant independent risk factors. A risk prediction model was subsequently developed and visualized as a nomogram. The model's discriminative ability, calibration, and clinical utility were evaluated.</p><p><strong>Results: </strong>The incidence of intraoperative shivering was 32.69%. Multivariable logistic regression analysis revealed that body mass index (BMI), baseline body temperature, American Society of Anesthesiologists (ASA) classification, intraoperative fluid infusion volume, and intraoperative blood loss were independent risk factors for intraoperative shivering (<i>P</i> < 0.05). The area under the curve (AUC) was 0.914, with a sensitivity of 0.894, specificity of 0.823, and Youden index of 0.717, indicating good discriminative ability. The Hosmer-Lemeshow test demonstrated good calibration (χ² = 3.061, <i>P</i> = 0.930). Decision Curve Analysis (DCA) indicated favorable clinical applicability.</p><p><strong>Conclusion: </strong>The nomogram model demonstrates good predictive performance, assisting clinicians in identifying high-risk parturients prone to intraoperative shivering during cesarean section. Early identification based on risk factors enables implementation of targeted interventions, thereby potentially reducing the incidence and adverse impacts of shivering. This improves maternal intraoperative comfort and perioperative outcomes.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3179-3188"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of <i>TP53</i> Mutations in the Malignant Progression of Mucinous Borderline Ovarian Tumors: A Case Report and Literature Review.","authors":"Meirong Liang, Sijun Xie, Katherine Jane Chung Chua, Anais Saunders, Xuqing Deng, Caili Tong, Jinping Lai, Jeremy Chien, Siyuan Zeng","doi":"10.2147/IJWH.S523782","DOIUrl":"10.2147/IJWH.S523782","url":null,"abstract":"<p><strong>Background: </strong>Mucinous ovarian carcinoma (MOC) is characterized by aggressive behavior and limited responsiveness to standard chemotherapeutic regimens. The infrequent occurrence of MOC arising from mucinous borderline ovarian tumors (MBOTs) and the lack of readily identifiable diagnostic markers pose significant challenges to the development of effective treatment strategies. This report presents a case of a 26-year-old woman with MBOT progression to metastatic MOC despite aggressive surgical intervention and adjuvant chemotherapy, aiming to identify potential diagnostic and therapeutic improvements.</p><p><strong>Results: </strong>A review of the literature revealed fewer than 30 comparable cases, underscoring the absence of established guidelines for diagnosing and treating the progression of MBOT to invasive MOC, particularly with respect to the role of <i>TP53</i> mutations. In our patient's case, we observed some changes in immunohistochemical marker expression between the MBOT and the subsequent invasive MOC, including altered p53 expression. Although these changes, considered in the context of existing literature, hint at a complex transformation process potentially involving genetic and epigenetic alterations, including <i>TP53</i> mutations, further detailed genomic or transcriptomic analyses would be required to confirm this in our specific case. The diagnostic process was further complicated by clinical and pathological similarities with gastrointestinal malignancies. Ultimately, disease progression necessitated adjustments to the treatment plan, despite the use of a multi-agent chemotherapy regimen consisting of paclitaxel, carboplatin, and bevacizumab.</p><p><strong>Conclusion: </strong>The transition from MBOT to MOC is characterized by intricate genetic and epigenetic alterations, especially involving <i>TP53</i> mutations. This progression presents considerable diagnostic challenges due to similarities with gastrointestinal cancers. Therefore, given the strong correlation between <i>TP53</i> mutations and chemoresistance, there is a pressing need to develop targeted therapies and enhance diagnostic strategies.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3155-3165"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}