International Journal of Women's Health最新文献

{"title":"Causal Effects of Inflammatory Cytokines and Immune Cell Phenotypes on Spontaneous Abortion: Evidence From Mendelian Randomization.","authors":"Shaochong Lin, Xiangming Tian, Sijia Kong, Bolun Zhang, Sidong Wang, Kongfu Zhu, Xiaomin Liu, William S B Yeung, Dandan Cao, Yuanqing Yao","doi":"10.2147/IJWH.S501620","DOIUrl":"10.2147/IJWH.S501620","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the causal relationship between inflammatory cytokines, immune cells and spontaneous abortion (SA).</p><p><strong>Methods: </strong>A bidirectional two-sample Mendelian randomization (MR) analyses was conducted based on the genetic data of 91 inflammatory cytokines (n=14,824), 731 immune traits (n=3757) and SA (18,680 cases and 162,987 controls) cohorts. Five different MR analysis methods and Bayesian-weighted Mendelian randomization (BWMR) analysis were employed to assess the genetic causal connection. In addition, the robustness of this study results was ensured through comprehensive sensitivity analyses assessing heterogeneity, and potential horizontal pleiotropy and reverse causality.</p><p><strong>Results: </strong>These MR results suggest that higher levels of two inflammatory cytokines and ten immune cells are associated with a lower risk of SA (OR < 1.00). In contrast, fifteen immune cell traits exhibit a positive relationship with SA risk (OR > 1.00). Notably, mediation analysis revealed that the causal effect of programmed death ligand 1 (PDL1) on SA was partially mediated by CD45 expression on Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSCs), and Terminally Differentiated CD4⁻CD8⁻ T cells also acted as mediators in the causal effect of tumor necrosis factor-beta (TNF-β) on SA.</p><p><strong>Conclusion: </strong>This study comprehensively assessed the causal relationship between immune-related exposures and SA, identifying several immune factors associated with SA risk. These finding have implications for clinical guidance in pregnancy preparation.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"793-806"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Therapy-Induced Changes in Long Non-Coding RNA Expression Profiles in Umbilical Cord Blood and Placental Tissues of Hepatitis B Virus-Infected Pregnant Women.","authors":"Cuimin Wang, Yuting Huang, Lanfeng Li, Xizhen Huang, Yin Huang, Xiang Fang, Yu Long","doi":"10.2147/IJWH.S511524","DOIUrl":"10.2147/IJWH.S511524","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) is a major global health concern, with maternal-fetal transmission being the primary route of transmission, which can lead to chronic HBV infection in newborns. Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and immune responses, but their involvement in HBV transmission during pregnancy remains unclear. This study aimed to assess the impact of tenofovir disoproxil fumarate (TDF)-based antiviral therapy on lncRNA expression profiles and immune signaling pathways in umbilical cord blood and placental tissues and to identify potential therapeutic targets for preventing intrauterine HBV infection.</p><p><strong>Materials and methods: </strong>Umbilical cord serum and placental tissues were collected from six HBV carriers. Three carriers received TDF-based antiviral therapy, and the remaining carriers who did not receive antiviral therapy served as controls. LncRNA microarray analysis and bioinformatics were used to evaluate the effects of antiviral therapy on lncRNA expression profiles and signaling pathways.</p><p><strong>Results: </strong>Antiviral therapy exerted minimal effects on lncRNA expression profiles in umbilical cord blood. In placental tissues, significant alterations in lncRNA expression profiles were observed, including 249 upregulated and 381 downregulated lncRNAs. Antiviral therapy activated innate immune pathways, such as intracellular DNA sensing, chemokine signaling, type I interferon, Jak-Stat, and interferon-γ-mediated adaptive immunity. Through intersection analysis, CPED1 was found differentially expressed in both cord blood and placental tissues. KEGG pathway analysis suggested that low CPED1 expression may inhibit virus transmission via the JAK-STAT pathway.</p><p><strong>Conclusion: </strong>This study demonstrated that TDF-based antiviral therapy altered lncRNA expression and activated immune signaling pathways in placental tissues, offering insights into the molecular mechanisms of maternal-fetal HBV transmission.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"835-844"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hepatic Steatosis Index and Endometrial Cancer Risk: A Cross-Sectional Study.","authors":"Lili Zheng, Huifang Lei, Xiaoyi Tang, Yuanyin Zheng, Qiuzhen Wu, Peixuan Chen, Yanhong Chen, Liangzhi Cai","doi":"10.2147/IJWH.S497621","DOIUrl":"10.2147/IJWH.S497621","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) and its diagnostic value for EC.</p><p><strong>Patients and methods: </strong>A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as the EC group. A total of 175 patients with pathologically confirmed benign endometrial lesions (endometrial polyps and uterine submucosal fibroids) in the same hospital during the same period were selected as the control group. Non-parametric test were used to compare the differences in HSI and non-alcoholic fatty liver disease (NAFLD) between the two groups, and the diagnostic value of HSI and NAFLD levels on EC was analysed. The cut-off point of continuous variables was determined by receiver operating characteristic (ROC) curve analysis. Logistic regression analysis was used to calculate odds ratios (ORs).</p><p><strong>Results: </strong>The results showed that compared with the control group, serum GGT, CA125, HDL-C and HSI were significantly increased in the EC group (P<0.05). 27.19% of the EC patients (31/114) and 12% of the control group (21/175) had NAFLD, and the difference between the two groups was statistically significant (P<0.05). The results of univariate logistic regression analysis showed that GGT, CA125, HDL-C, HSI and NAFLD were significantly correlated with the occurrence of EC (P<0.05). Further multivariate logistic regression analysis showed that CA125 and HSI elevation were independent risk factors for EC (P<0.05).</p><p><strong>Conclusion: </strong>NAFLD is closely associated with EC, and elevated HSI is an independent risk factor for EC.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"825-833"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Maternal Attitudes and Depression on Bonding During the Postpartum Period.","authors":"Kumru Şenyaşar Meterelliyoz, Kıymet Çağlar Mengi, Menekşe Sıla Yazar, Ayşe Sevim Akbay Kısa","doi":"10.2147/IJWH.S504763","DOIUrl":"10.2147/IJWH.S504763","url":null,"abstract":"<p><strong>Purpose: </strong>Bonding refers to the development of an emotional relationship between a mother and her baby, which forms a strong and continuous bond that provides the baby with a sense of security and plays an important role in its mental well-being throughout life. The objective of this study was to assess the relationship between cognitive distortions, attitudes towards motherhood and postpartum depression, which have not been studied before, as well as to elucidate their impact on the mother-infant bonding process.</p><p><strong>Patients and methods: </strong>The sample of the study was created between November 2018- June 2019 using the non-discriminatory multiplicity snowball sampling technique through social media. Women with infants aged 0-1 year residing in Turkey were asked to participate in the online survey. A sociodemographic data form, the Edinburgh Postpartum Depression Scale, Attitudes Towards Motherhood Scale (AToM), Postpartum Bonding Questionnaire (PBQ), and Cognitive Distortions Scale (CDS) were applied to the sample via social media.</p><p><strong>Results: </strong>The study sample consisted of 387 women with infants aged 0-1 years, and the rate of impairment bonding was found to be 11.4%. CDS, ATOM and depression scores were significantly higher in the impaired attached group (p < 0.05). The findings indicated that an individual with a psychiatric diagnosis was 2.653 times more likely to exhibit impaired bonding (OR: 2.653, 95% CI: [1.08-6.517]; p = 0.033), and those with a higher AToM score were 1.044 times more likely to display impaired bonding (OR: 1.044, 95% CI: [1.013-1.075]; p = 0.004).</p><p><strong>Conclusion: </strong>The cognitive structure of the mother is associated with impaired mother-baby bonding. Eliminating the mentioned cognitive elements with psychotherapy interventions will be protective in terms of impaired bonding related to psychopathologies and/or interpersonal relationship problems.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"773-784"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Mobile Health (mHealth) in Maternal Health Services [Letter].","authors":"Dewi Rashati, Prima Soultoni Akbar","doi":"10.2147/IJWH.S521762","DOIUrl":"10.2147/IJWH.S521762","url":null,"abstract":"","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"771-772"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Waist-Height Ratio and Heart Rate Recovery for Predicting Coronary Heart Disease Risk Among Working Malaysian Women.","authors":"Chizheng Tang, Azmi Mohamed Nahar, Eng Wah Teo, Selina Khoo","doi":"10.2147/IJWH.S497927","DOIUrl":"10.2147/IJWH.S497927","url":null,"abstract":"<p><strong>Purpose: </strong>Coronary heart disease (CHD) is the most common cardiovascular disease leading to global mortality and is a major contributor to disability. As CHD is the main cause of death among women, early prediction of the risk of coronary heart disease would be useful. The Framingham risk score, waist-height ratio, and heart rate recovery have been used to predict CHD risk. The Framingham risk score is used to evaluate 10-year absolute risk of developing CHD. Waist Height Ratio is useful for early detection of the risk of heart disease in Malaysia, where obesity and metabolic syndrome are common across various demographics, because it is a reliable indicator of abdominal fat distribution. Heart Rate Recovery is a useful non-invasive method for early assessment of heart disease risk, featuring simplicity and the ability to represent both cardiovascular fitness and autonomic nervous system function. However, no study has compared waist-height ratio and heart-rate recovery as effective methods for predicting coronary heart disease. There is an increasing trend of CHD in Malaysia, particularly among females. Therefore, this study aimed to compare the effectiveness of waist-height ratio and heart-rate recovery in predicting the risk of coronary heart disease among working Malaysian women.</p><p><strong>Methods: </strong>This is a cross-sectional study. Data on the Framingham risk score, waist-height measurement, and the 6-minute walk test (heart-rate recovery) were collected from 134 working women.</p><p><strong>Results: </strong>The mean age of the participants was 39.13 ± 7.06 years. The results showed that the waist-to-height ratio had a weak but significant correlation with Framingham risk score (r = 0.18). However, heart rate recovery showed a negative correlation (r = -0.029) with the Framingham risk score.</p><p><strong>Conclusion: </strong>The waist-height ratio is considered a more effective risk assessment method than heart-rate recovery for identifying the risk of coronary heart disease in working Malaysian women.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"761-769"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Angiosarcoma with eosinophilia: A Case Report and Literature Review.","authors":"Meiqin Chen, Xiguo Chen, Shun Wang, Dan Lei, Chunxian Peng","doi":"10.2147/IJWH.S505065","DOIUrl":"10.2147/IJWH.S505065","url":null,"abstract":"<p><strong>Background: </strong>Hepatic angiosarcoma is an extremely rare, uncontrollable tumor with strong invasion, high mortality rate, and extremely poor prognosis. There is first report on hepatic angiosarcoma accompanied by eosinophilia.</p><p><strong>Case presentation: </strong>A woman with a chief complaint of poor appetite for about 3 months presented to a local hospital with a liver mass. Laboratory examination revealed a significant increase in eosinophils count was 9.58% in the serum. Abdominal MRI revealed multiple focal high-density lesions in the liver and spleen, and cranial MRI revealed multiple high-density shadows in the skull. Laparoscopic biopsy revealed a hepatic angiosarcoma and targeted treatment with Anlotinib was performed. Two months later, the patient died of splenic rupture and bleeding.</p><p><strong>Conclusion: </strong>Hepatic angiosarcoma often has no specific clinical manifestations, and we found that this case can lead to an increase in eosinophils, which is worth the attention of clinical physicians.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"785-791"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Significance and Co-Expression of Fibroblast Growth Factor Receptor 2 and c-Met in Endometrial Cancer.","authors":"Huiqiao Gao, Qi Lu, Jianxin Zhang","doi":"10.2147/IJWH.S506565","DOIUrl":"10.2147/IJWH.S506565","url":null,"abstract":"<p><strong>Objective: </strong>We sought to study the expression of FGFR2 and c-Met and evaluate the correlation between the two proteins in a series of endometrial cancer patients as well as the prognostic significance of the two markers in endometrium carcinoma.</p><p><strong>Methods: </strong>Patients who were diagnosed with endometrial cancer and had undergone surgical treatment in Beijing Chao-Yang Hospital, Capital Medical University from November 2004 to June 2011 were included in this study. Tissue microarray construction, immunohistochemical staining and scoring were employed to study the expression of FGFR2 and c-Met. SPSS version 22.0 was used to evaluate the correlation between FGFR2 and c-Met expression and the prognosis prediction value of the two markers.</p><p><strong>Results: </strong>In total, 109 patients were included in this study. The median age was 56 years (ranges, 30-79). The most common histologic tumor subtype was adenocarcinoma (86.2%). The five-year survival rate was 87.2%. Significantly different FGFR2 expression was observed among patients with different disease stages (p < 0.001), depths of myometrial invasion (p = 0.001) and lymph node status (p < 0.001). C-Met expression was also increased in tissues from patients with advanced stage disease, deep myometrial invasion and lymph node metastasis (p < 0.001, p = 0.031 and p < 0.001, respectively). The expression of FGFR2 and c-Met was increased in the group with poorer prognosis (overall survival < 5 years) (p = 0.002 and p = 0.023, respectively). Moreover, a strong positive correlation was observed between FGFR2 and c-Met expression (p < 0.01, r = 0.656). FGFR2 was a significant factor that influence the FIGO stage.</p><p><strong>Conclusion: </strong>Higher expression of FGFR2 and c-Met is associated with more advanced stage, deeper myometrial invasion and lymph node metastasis in endometrial cancer and poorer prognosis. In addition, high expression of FGFR2 is correlated with high c-Met expression.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"751-760"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Mobile Health (mHealth) Use by Community Health Workers on the Utilization of Maternity Care in Rural Malawi: A Time Series Analysis [Letter].","authors":"Norlaila Sofia, Tien Zubaidah","doi":"10.2147/IJWH.S522852","DOIUrl":"10.2147/IJWH.S522852","url":null,"abstract":"","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"727-728"},"PeriodicalIF":2.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications.","authors":"Junyou Su, Xiaoting Huang, Shengping Meng, Sumei Wang","doi":"10.2147/IJWH.S512910","DOIUrl":"10.2147/IJWH.S512910","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-1 receptor (IGF-1R) in the serum and placenta of patients with preeclampsia (PE), establish their correlations, and evaluate their diagnostic potential.</p><p><strong>Methods: </strong>22 PE patients and 22 normal pregnant women who underwent cesarean section deliveries at the First Affiliated Hospital of Guangxi Medical University between December 2021 and December 2022 were included in the observation group and the control group. Enzyme-linked immunosorbent assay (ELISA) was utilized to measure the levels of IGF-1 and IGF-1R in serum samples, and immunohistochemical techniques (IHC) were employed to evaluate the levels of IGF-1 and IGF-1R in placental samples. The association between IGF-1, IGF-1R, and PE was analyzed, and the diagnostic accuracy of serum IGF-1 and IGF-1R for PE was assessed by ROC curve analysis.</p><p><strong>Results: </strong>The levels of IGF-1 and IGF-1R in the serum and average optical density (AOD) value of IGF-1 and IGF-1R in placental tissue of the observation group were significantly lower. In the group with PE, there was a reduction in the number of positive cells for IGF-1 and IGF-1R in placental tissue. Positive correlations were noted between IGF-1 and IGF-1R levels in both serum and placental tissue and neonatal birth weight. The ROC curve analysis revealed that serum IGF-1 exhibited an AUC of 0.944 for diagnosing PE, with a sensitivity of 86.00% and specificity of 100.00%. Serum IGF-1R showed an AUC of 0.820 for diagnosing PE, with a sensitivity of 77.00% and specificity of 77.00%.</p><p><strong>Conclusion: </strong>The expression of IGF-1 and IGF-1R in the serum and placental tissues of preeclamptic pregnant women was significantly reduced. This reduction implies that IGF-1 and IGF-1R may potentially be used as biomarkers in the clinical prediction, diagnosis, and prognosis evaluation of PE.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"729-738"},"PeriodicalIF":2.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}