International Journal of Women's Health最新文献

{"title":"Association Between Short Birth Interval and Immediate Adverse Perinatal Outcomes Among Women Delivering at a Tertiary Hospital in South-Western Uganda.","authors":"Yel Akol Akol Yel, Hamson Kanyesigye, Paul Kalyebara Kato, Leevan Tibaijuka, Gideon Akandwanaho, Stuart Turanzomwe, Rebecca Agness Akello, Joseph Ngonzi, Musa Kayondo, Onesmus Byamukama","doi":"10.2147/IJWH.S531698","DOIUrl":"10.2147/IJWH.S531698","url":null,"abstract":"<p><strong>Purpose: </strong>Immediate adverse perinatal outcomes (IAPO) are more likely to occur in women with short inter-birth birth intervals (SIBI) compared to optimal inter-birth interval (OIBI). This study determined the association between short inter-birth interval and immediate adverse perinatal outcomes among women delivering at Mbarara Regional Referral Hospital (MRRH).</p><p><strong>Patients and methods: </strong>We conducted a cross-sectional study among mother-baby pairs admitted to MRRH postnatal ward within 24 hours after delivery from the period running from March 2023 to June 2023. The primary exposure variable was birth interval and the primary outcome was IAPO. Data was collected using a structured questionnaire. Modified Poisson Regression analysis was used to determine the relationship between birth interval and immediate adverse perinatal outcomes.</p><p><strong>Results: </strong>Of the 688 participants enrolled, the mean age was 28.06 ±5.04 years. Majority were married (97.8%) and referred to in (44.6%). Low birth weight was significantly higher among women with SIBI compared to OIBI ((9.9% versus 5.8%, p=0.047), while other adverse outcomes (preterm birth, stillbirth, and NICU admissions) were more frequent but not statistically significant. A SIBI was significantly associated with IAPO (aPR): 1.46; 95% C. I [1.02, 2.09], p=0.038). Other factors independently associated with adverse perinatal outcomes were maternal age<20 years ([aPR]: 2.66; 95% C.I [1.05,6.73], p=0.039), obstetric complications (aPR: 2.16; 95% C.I [1.34, 3.48], p=0.002), having a diagnosis of fetal distress (aPR: 2.61; 95% C.I [1.80, 3.79], p<0.001), and a history of malaria in pregnancy (aPR: 1.66; 95% C.I [1.12, 2.48], p=0.013).</p><p><strong>Conclusion: </strong>A SIBI significantly increases the risk of IAPO. Additionally, maternal age below 20 years, the presence of obstetric complications, a diagnosis of fetal distress, and a history of malaria in pregnancy independently contribute to these unfavorable outcomes. We recommend health education and advocacy with emphasis for the utilization of family planning services so as to have OIBI.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3167-3177"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Pregnancy in a PCOS Patient with Elevated Basal Luteinizing Hormone and Repeated Ovulation Induction Failures: A Case Report.","authors":"Ying Fang, Xuehan Zhao, Cong Wang, Chang Liu, Yu Liang, Xiaokui Yang","doi":"10.2147/IJWH.S542581","DOIUrl":"10.2147/IJWH.S542581","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, leading to infertility. Elevated basal luteinizing hormone (bLH) levels in PCOS can impede the efficacy of ovulation induction (OI). This case report explores the management of a 26-year-old woman with PCOS and high bLH levels who experienced repeated failure in OI attempts. During in vitro fertilization-embryo transfer (IVF-ET) treatments, she underwent two cycles of controlled ovarian stimulation using long-acting gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols respectively, both of which failed due to inadequate ovarian response despite normal bLH levels on the day of gonadotropin initiation. In the third cycle, a progestin-primed ovarian stimulation (PPOS) protocol combined with letrozole was adopted without bLH pretreatment, resulting in a successful pregnancy and healthy child after frozen-thawed embryo transfer. This case highlights the need for tailored approaches in managing PCOS patients with high bLH levels and indicates that elevated bLH may not always impair IVF outcomes. Further research is needed to establish the optimal bLH threshold and management protocols to enhance reproductive outcomes for these patients.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3145-3154"},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal Lactobacillus Alteration and Vaginal Symptom Relief After Carbon Dioxide Vaginal Laser Therapy in Postmenopausal Women.","authors":"Teerapan Seehanantawong, Pisut Pongchaikul, Rujira Wattanayingcharoenchai, Komkrit Aimjirakul, Orawee Chinthakanan, Pitak Santanirand, Jittima Manonai","doi":"10.2147/IJWH.S537531","DOIUrl":"10.2147/IJWH.S537531","url":null,"abstract":"<p><strong>Objective: </strong>To assess changes in the prevalence and abundance of vaginal Lactobacillus after fractional micro-ablative carbon dioxide (CO₂) therapy in postmenopausal women with vulvovaginal atrophy (VVA).</p><p><strong>Methods: </strong>This prospective, single-arm clinical study was conducted in postmenopausal women who underwent treatment with CO₂ laser therapy. Eligible participants were enrolled before the first session of therapy and evaluated at weeks 0, 8, 20, and 32. Vaginal fluid samples were collected using a standardized protocol and processed for Gram staining and expanded quantitative urine culture (EQUC). The level of Lactobacillus was assessed using the Nugent scoring system. The secondary outcomes included the prevalence of Lactobacillus, VVA symptoms, and vaginal pH. The results were analyzed using multilevel mixed-effects linear regression and paired <i>t</i>-tests.</p><p><strong>Results: </strong>Forty-three postmenopausal women with at least one symptom of VVA, with a mean age of 67.3 ± 8.7 years, were recruited. The mean Nugent scores for Lactobacillus morphotypes gradually decreased from 2.84 (95% CI: 2.38-3.29) at baseline to 2.28 (95% CI: 1.79-2.77) at week 8, 2.09 (95% CI: 1.60-2.58) at week 20, and further to 1.84 (95% CI: 1.31-2.35) at week 32 (p < 0.05). The prevalence of Lactobacillus increased from 27.9% (12/43) at baseline to 48.8% (21/43) at week 8, 55.8% (24/43) at week 20, and 58.1% (25/43) at week 32 (p < 0.05). VVA symptom severity and vaginal pH consistently declined from baseline to week 32 (p < 0.05).</p><p><strong>Conclusion: </strong>Fractional CO₂ laser treatment improved the prevalence and level of Lactobacillus after treatment and sustained improvements were observed at 3- and 6-month follow-ups. These positive effects were correlated with improvements in VVA symptoms.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3133-3144"},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Roundness Index and Risk of Gestational Diabetes Mellitus in Women of Reproductive Age: NHANES 2007-2018.","authors":"Siqi Shi, Chunying Xie, Jingjing Xiao, Yanling Liu, Shu Cai","doi":"10.2147/IJWH.S551553","DOIUrl":"10.2147/IJWH.S551553","url":null,"abstract":"<p><strong>Objective: </strong>Gestational diabetes mellitus (GDM) is closely related to obesity. This study investigated whether Body Roundness Index (BRI) is independently associated with GDM and compared its discriminative performance with BMI.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The study included 3,343 women aged 20-44 years who had available data on BRI and GDM. Weighted logistic regression and restricted cubic spline (RCS) models were used to examine the association between BRI and GDM. Subgroup and receiver operating characteristic (ROC) curve analyses were performed to evaluate discriminative performance.</p><p><strong>Results: </strong>Among the 3,343 women, 377 (11.3%) reported GDM. Adjusted weighted multivariate logistic regression showed a 39% increase in GDM risk per BRI unit rise (OR = 1.39; 95% CI: 1.19-1.62; <i>P</i> < 0.0001). Subgroup analysis confirmed consistent correlation. RCS analysis revealed a nonlinear relationship at BRI = 3.55, significant below and above (<i>P</i> < 0.05). Based on ROC curve analysis, BRI (AUC = 0.608) was more effective in discriminating between women with and without GDM compared to BMI (AUC = 0.573).</p><p><strong>Conclusion: </strong>This study demonstrates that elevated BRI is independently associated with GDM risk among US reproductive-aged women and shows superior discriminative performance to BMI. These findings highlight the potential value of BRI as an anthropometric indicator associated with GDM risk.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3107-3118"},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Surface Electromyography of the Pelvic Floor Muscles in the Early Postpartum Period in Twin Pregnancies of Different Conception Modes: A Single-Centre Retrospective Study in China.","authors":"Shushu Yu, Xiaolei Chi, Xiaohan Su, Xiang Ying, Shuping Lv, Jue Ma, Yanlin Wang","doi":"10.2147/IJWH.S543734","DOIUrl":"10.2147/IJWH.S543734","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the early postpartum pelvic floor function in twin pregnancies of different conception modalities by measuring surface electromyography of the pelvic floor muscles with the Glazer protocol.</p><p><strong>Methods: </strong>This retrospective study analyzed 241 twin pregnancies delivered via cesarean section at the International Peace Maternity and Child Health Hospital (IPMCHH), affiliated with Shanghai Jiao Tong University School of Medicine, between March 2019 and December 2023. Participants underwent pelvic floor function assessments 42-60 days postpartum. Pelvic floor muscle activity was evaluated using surface electromyography (sEMG) following the Glazer protocol. Univariate and multivariable logistic regression analyses were performed to assess the impact of conception modes (natural vs ART) on early postpartum pelvic floor function in twin pregnancies.</p><p><strong>Results: </strong>The mean anterior resting phase amplitude was 4.80 ± 5.23 μV in the ART group versus 6.38 ± 6.30 μV in the naturally conceived group. Similarly, the posterior resting phase amplitude measured 5.15 ± 5.28 μV (ART) and 6.78 ± 7.67 μV (natural conception). The total Glazer score differed significantly between groups, with ART pregnancies scoring 74.80 ± 14.82 and natural conception pregnancies scoring 67.57 ± 21.57 (P < 0.05). Univariate and multivariable logistic regression analyses confirmed that the total Glazer score during the early postpartum period was independently associated with conception mode (P < 0.05).</p><p><strong>Conclusion: </strong>Women with twin pregnancies conceived via ART may exhibit marginally improved pelvic floor function during the early postpartum period (6-8 weeks) compared to naturally conceived counterparts, potentially attributable to elevated estrogen levels associated with ART.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3087-3095"},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammography Based Nomogram Integrating Radiomics and Clinical Features to Predict Benign or Malignant Regression of BI-RADS 4A Lesions at Follow-Up.","authors":"Guoyan Yao, Lijun Chen, Tingfan Wu, Yuanyuan Liu, Yun Wan, Ziqiang Xia, Bo Liu, MinAn Zheng","doi":"10.2147/IJWH.S539131","DOIUrl":"10.2147/IJWH.S539131","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to develop a nomogram based on mammography radiomic and clinical features to predict the benign and malignant progression of BI-RADS 4a lesions under follow-up.</p><p><strong>Materials and methods: </strong>The retrospective study included 104 patients with over six months of follow-up, consisting of 56 malignant and 48 benign cases, totaling 202 images. Patients were randomly divided into training and validation sets at a 7:3 ratio. In total, 1316 radiomic features were extracted using AK3.30 software including morphological, first-order statistics and texture features. Spearman correlation analysis and the least absolute shrinkage and selection operator (LASSO) method were performed for feature selection. Univariate and multivariate logistic regression analyses were used to identify independent risk factors among clinical features and construct a radiomic-clinical fusion nomogram. The performance of radiomics model and radiomic-clinical fusion model were evaluated using the area under the receiver operating characteristic (ROC) curve. DeLong test was employed to compare the efficacy between the two models.</p><p><strong>Results: </strong>Four radiomic features were selected, combined with two clinical features (positive clinical palpation and history of breast surgery). The AUC values for the radiomics model and radiomic-clinical fusion model in the training and testing groups were 0.858 and 0.860, and 0.923 and 0.904, respectively. The DeLong test showed no significant difference between the two models with a <i>P</i> value > 0.05.</p><p><strong>Conclusion: </strong>The nomogram based on mammography radiomics and clinical features demonstrated good performance in predicting the benign and malignant progression of BI-RADS 4a lesions under follow-up, showing potential for risk stratification of BI-RADS 4a lesions.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3097-3106"},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Success: The Optimal Gonadotrophin Starting Point for Luteal-Phase Stimulation in IVF Patients with Normal Responses.","authors":"Xinyu Nie, Qi Wang, Mengmeng Xu, Rulin Dai, Bo Pang, Cong Hu","doi":"10.2147/IJWH.S540342","DOIUrl":"10.2147/IJWH.S540342","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze and discover the optimal gonadotrophin (Gn) starting point for luteal-phase stimulation (LPS) in in vitro fertilization (IVF) Patients with normal ovarian response (NOR).</p><p><strong>Patients and methods: </strong>A total of 199 IVF or intracytoplasmic sperm injection (ICSI) cycles performed at the Reproductive Center of the First Hospital of Jilin University from January 1, 2021, to December 31, 2023, were recruited in the study. Of these, 121 cycles followed the follicular phase ovarian stimulation (FPS) (119 cases of adding antagonists), while 78 cycles adhered to the LPS protocol. The LPS group was divided into three subgroups based on the timing of Gn initiation: early, mid-, and late LPS. Comparisons were made between the LPS and FPS groups, as well as among the three subgroups, regarding Gn duration, total Gn dose, number of oocytes retrieved, number of embryos, rate of good-quality embryos, blastocyst formation rate, clinical pregnancy rate, cumulative pregnancy rate, live birth rate and cumulative live birth rate.</p><p><strong>Results: </strong>The rate of high-quality embryos in the late luteal phase was significantly higher than that in the early luteal group and slightly higher than that in the mid-luteal group. The clinical pregnancy rate and live birth rate of the late luteal group were slightly higher than those of the early and mid-luteal group, and were not significantly different from those of the FPS group.</p><p><strong>Conclusion: </strong>Initiating Gn stimulation during the late luteal-phase appears to be the optimal timing in NOR patients.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3119-3131"},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress and Clinical Implications of Generative Artificial Intelligence in Perinatal Health Care for Advanced Maternal Age Pregnant Women.","authors":"Shasha Tang, Shihong Zhao","doi":"10.2147/IJWH.S542758","DOIUrl":"10.2147/IJWH.S542758","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the current application status, technical characteristics, and challenges of Generative Artificial Intelligence (Generative AI) in perinatal health care for advanced maternal age pregnant women and explore targeted optimization strategies.</p><p><strong>Methods: </strong>A systematic literature review was conducted by searching PubMed, Web of Science, CNKI, and Wanfang Data from January 2020 to April 2025. Studies were included if they focused on Generative AI applications in perinatal care for women aged ≥35 years; 78 eligible studies (42 Chinese, 36 international) were finally included, covering technical applications, clinical validation, and ethical governance. We summarized the applications of Generative AI in risk prediction, personalized management, and remote monitoring, and analyzed issues related to data governance, technical limitations, resource allocation, and ethical supervision.</p><p><strong>Results: </strong>Generative AI improves healthcare efficiency by integrating multiple data sources for model construction, planning dynamic interventions, and facilitating remote monitoring. Specifically, GANs-based models achieve an AUC of 0.80-0.85 in predicting Group B Streptococcus infection, while Transformer models enhance the accuracy of prenatal depression screening by 15-20% compared to traditional methods. However, it faces challenges including data privacy risks (eg, 32% of maternal health institutions lack encrypted data storage), the \"black box\" nature of models (42% of clinicians report low trust in AI decision-making), urban-rural technological gaps (only 18% of county-level hospitals use AI perinatal tools), and ambiguous liability definitions.</p><p><strong>Conclusion: </strong>Generative AI demonstrates significant application potential in perinatal care for advanced maternal age pregnant women. Promoting its implementation through technological innovation (eg, explainable AI), interpretability optimization, resource deployment (eg, lightweight mobile tools), and ethical supervision is crucial to improving maternal and infant health outcomes in China and globally.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3077-3085"},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of Noninvasive Prenatal Testing in Singleton Pregnancy with and without in vitro Fertilization: A 6-year Observational Study at a Single Tertiary Center.","authors":"Qian Zhang, Yuhong Guo, Bin Liang, Meihuan Chen, Xiaoqing Wu, Na Lin, Hailong Huang, Liangpu Xu","doi":"10.2147/IJWH.S547427","DOIUrl":"10.2147/IJWH.S547427","url":null,"abstract":"<p><strong>Background: </strong>Studies on the use of noninvasive prenatal testing (NIPT) in pregnancies conceived by in vitro fertilization (IVF) remain inadequate. This study aimed to evaluate the performance of NIPT in singleton pregnancies conceived by IVF and to compare it with that in naturally conceived (NC) pregnancies.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 86397 pregnancies (IVF=3723, NC=82674). The performance of NIPT was assessed by calculating the sensitivity, specificity, and positive predictive value (PPV).</p><p><strong>Results: </strong>The failure rate in the IVF group was significantly higher than that in the NC group (0.16% vs 0.04%, <i>p</i> < 0.05). Among the 3717 cases successfully tested in the IVF group, the sensitivities of trisomy (T) 21 and sex chromosome aneuploidy (SCA) were both 100%, with specificities of 99.92% and 99.76%, respectively. The PPVs of T21 and SCA were both 50%. Of the 82630 cases successfully tested in the NC group, all corresponding sensitivities and specificities were greater than 98%. The PPVs of T21, T18, T13, SCA and rare autosomal aneuploidies were 70.86%, 41.67%, 20.51%, 39.90%, and 7.65%, respectively. Furthermore, although the median fetal fractions (FFs) in the IVF group were significantly lower than that in the NC group (11.23% vs 12.05%, <i>p</i> < 0.001), the kinetics of FFs during gestation demonstrated a very similar trend between these two groups.</p><p><strong>Conclusion: </strong>Our findings suggest that NIPT is a valid technique for detecting fetal chromosomal aneuploidies in IVF singleton pregnancies.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3067-3076"},"PeriodicalIF":2.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy Reduces Pain and Alters Fatty Acid Biomarkers in Women with Chronic Non-Specific Low Back Pain.","authors":"Zhou Zhang, Xin Li, Wen Tang, Hao Xie, Hong-Jiang Wang, Hao-Yu Xie, Chu-Huai Wang","doi":"10.2147/IJWH.S551117","DOIUrl":"10.2147/IJWH.S551117","url":null,"abstract":"<p><strong>Background: </strong>Chronic nonspecific low back pain (cNLBP) represents the most prevalent musculoskeletal disorder encountered in clinical practice, constituting approximately two-thirds of all chronic low back pain cases. Epidemiological studies have identified significant gender differences in the incidence of cNLBP, with women exhibiting a slightly higher prevalence and reporting greater pain severity compared to men. However, the underlying mechanisms contributing to the increased severity of cNLBP in women remain largely unexplored. Our research is the first to explore fatty acid biomarkers in female patients with cNLBP undergoing physiotherapy from the perspectives of metabolomics and lipidomics.</p><p><strong>Methods: </strong>The study comprised 13 healthy female volunteers and 15 women diagnosed with cNLBP. Metabolomic and lipidomic analyses were employed to identify lipid metabolites closely associated with cNLBP in women. Subsequently, the 15 patients with cNLBP underwent manual therapy and exercise therapy, which incorporated both manual therapy and exercise therapy. Each therapy session lasted 50 minutes and was conducted over six sessions, occurring every two days. The Visual Analog Scale (VAS) scores of the patients were evaluated before and after treatment, and serum samples were collected for lipid determination at both pre- and post-treatment intervals.</p><p><strong>Results: </strong>Our metabolomic and lipidomic analyses revealed significantly elevated levels of three fatty acids (FAs): C14:0 FA (<i>P</i>=0.046), C20:0 FA (<i>P</i>=0.000001), and C20:1 FA (<i>P</i>=0.0007)), alongside significantly reduced levels of C20:5 (<i>P</i>=0.021) FA in women with cNLBP compared to healthy female volunteers. Receiver Operating Characteristic (ROC) curve analyses demonstrated that the Area Under the Curve (AUC) for these FAs exceeded 75%, indicating robust diagnostic performance. Notably, C20:0 FA exhibited an AUC greater than 95%, suggesting its potential as the most effective biomarker for diagnosing female patients with cNLBP. Additionally, physiotherapy significantly reduced pain levels in these women and was associated with a substantial decrease in blood FA levels.</p><p><strong>Conclusion: </strong>The study revealed a significant correlation between FA levels and female patients with cNLBP undergoing physiotherapy, thereby providing valuable insights for the development of personalized treatment approaches.</p><p><strong>Trial registration: </strong>(Chinese Clinical Trial Registry (https://www.chictr.org.cn), No.ChiCTR2300076620, 10/13/2023).</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3055-3065"},"PeriodicalIF":2.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}