International Journal of Women's Health最新文献

{"title":"Aerobic Vaginitis Caused By <i>Streptococcus Β- Hemolyticus</i> and <i>Staphylococcus Epidermidis</i> in a 26-Year-Old Woman with a History of Frequent Antibiotics Administration.","authors":"Pati Aji Achdiat, Amalia Laksmi Saraswati, Yulisa Handayani, Rasmia Rowawi, Retno Hesty Maharani","doi":"10.2147/IJWH.S516616","DOIUrl":"10.2147/IJWH.S516616","url":null,"abstract":"<p><p>Aerobic vaginitis (AV) is a form of vaginitis caused by the presence of aerobic bacteria, primarily <i>group B Streptococcus, Escherichia coli, Enterococcus faecalis, Streptococcus viridans</i>, and <i>Staphylococcus epidermidis</i>. This condition is characterized by clinical signs of acute inflammation, including vaginal redness, burning, increased vaginal secretions with a pH of 5, sticky vaginal discharge, leukocyte infiltration, and vulvar pruritus, which is defined as itching and irritation, and commonly occurs in individuals between the age of 15-30 years and 31-45 years. The report presents a case of AV caused by <i>Streptococcus β-hemolyticus</i> and <i>Staphylococcus epidermidis</i> in a 26-year-old female patient at Hasan Sadikin Hospital, Bandung. The treatment process includes the administration of amoxicillin 500 mg three times daily for 14 days. The patient was unmarried, routinely performed vaginal douching with betel soap, and frequently used a panty liner. Subsequently, a history of frequent antibiotic use was reported, however, the specific names of previously administered antibiotics remain unknown, except for clindamycin, which is the only agent specifically recalled. The patient also had a history of high exposure to stressors and underwent a bacterial culture examination taken from the vaginal introitus, which showed the presence of <i>Streptococcus β-hemolyticus</i> and <i>Staphylococcus epidermidis</i>. This case highlights the significance of AV in the differential diagnosis of vaginal infections, especially in atypical patient populations, and emphasizes the need for appropriate diagnostic measures such as bacterial culture to guide effective treatment strategies.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1437-1444"},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of MRI for Pelvic Lymph Node Extracapsular Invasion in Early-Stage Endometrial Carcinoma.","authors":"Qiufang Bao, Liping Zheng, Linliang Hong","doi":"10.2147/IJWH.S511642","DOIUrl":"10.2147/IJWH.S511642","url":null,"abstract":"<p><strong>Objective: </strong>Endometrial cancer (EC) is the major female malignant tumor in developed countries. MRI is frequently applied in gynecologic malignancies. We probed the diagnostic value of MRI for pelvic lymph node extracapsular invasion (PLNEI) in early-stage EC patients.</p><p><strong>Methods: </strong>Totally 142 early-stage EC patients were retrospectively enrolled and divided into the PLNEI_negative/PLNEI_positive groups. Differences in MRI parameters [volume index (VI), total tumor volume (TTV), tumor volume ratio (TVR), mean apparent diffusion coefficient (ADC_mean)] were analyzed. Early-stage EC patients with PLNEI were categorized into the high/low VI, TTV, TVR, ADC_mean groups. The relationships of VI, TTV, TVR and ADC_mean with clinicopathological characteristics were analyzed. Independent influencing factors for PLNEI, and the diagnostic value of VI, TTV, TVR and ADC_mean for PLNEI were analyzed by logistic univariate/multivariate regression and receiver operating characteristic curve, with differences in areas under the curves compared by Delong test.</p><p><strong>Results: </strong>There were significant differences in the histological type, histological grade, myometrial invasion depth, LVSI positive detection, LVSI type, cervical involvement, and CA125 level between the two groups. The VI, TTV and TVR values were elevated and ADC_mean value was reduced in patients with PLNEI, which were associated with the clinicopathological characteristics of early-stage EC patients. The CA125 level, VI, TTV, TVR and ADC_mean were independent influencing factors for PLNEI, showing high diagnostic value for PLNEI.</p><p><strong>Conclusion: </strong>VI, TTV, TVR, and ADC_mean had high diagnostic value for PLNEI in early-stage EC patients. MRI was a good method to detect PLNEI in EC patients.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1409-1419"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Coronary Syndrome: Considerations Regarding Pregnancy [Letter].","authors":"Kuilin Fei, Xiaoe Jiang, Jingrui Huang","doi":"10.2147/IJWH.S519669","DOIUrl":"10.2147/IJWH.S519669","url":null,"abstract":"","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1407-1408"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Safety and Efficacy of Intraoperative Cell Salvage in Cesarean Delivery for Placenta Accreta Spectrum: A Propensity Score-Matched Retrospective Study.","authors":"Cheng-Juan Sun, Shaofei Su, Yuanyuan Zheng, Wei Song, Haili Jiang","doi":"10.2147/IJWH.S514994","DOIUrl":"10.2147/IJWH.S514994","url":null,"abstract":"<p><strong>Purpose: </strong>The Placenta Accreta Spectrum (PAS) poses a significant obstetric challenge, often leading to life-threatening hemorrhage during delivery. Intraoperative Cell Salvage (IOCS) is a promising but insufficiently studied blood conservation approach.</p><p><strong>Patients and methods: </strong>This retrospective cohort investigation employed propensity score matching to analyze 102 PAS cases diagnosed through combined preoperative MRI and ultrasound at a tertiary referral center between 2018 and 2022, comparing outcomes between the IOCS (n=53) and non-IOCS (n=49) groups, while utilizing inverse probability weighting to address potential selection bias.</p><p><strong>Results: </strong>The analysis revealed that although the IOCS group experienced significantly greater median blood loss (2500 mL versus 1200 mL, p<0.0001), they required fewer allogeneic red blood cell transfusions (2 units versus 1 unit, p<0.0001) without experiencing severe complications such as amniotic fluid embolism. Weak but statistically significant correlations were observed between autologous blood recovery volume and PAS ultrasound scores (r=0.29, p=0.034), whereas total transfusion requirements showed a strong correlation with bleeding severity (r=0.81, p<0.0001). High-risk patients with ultrasound scores ≥9 yielded greater volumes of salvaged blood (715.0 mL vs.484.5 mL, p=0.093) than lower-risk patients. Multivariate regression analysis identified both elevated PAS scores (adjusted OR 1.44, 95% CI 1.06-1.95, p=0.020) and MRI-detected placental vascular abnormalities (adjusted OR 11.11, 95% CI 3.18-38.78, p=0.0002) as independent predictors of transfusion requirements. Comparative analyses showed equivalent hysterectomy rates (16.98% vs.10.20%, p=0.32) and neonatal outcomes, including birth weight (p=0.81), between the two groups.</p><p><strong>Conclusion: </strong>These findings demonstrate that IOCS safely decreases dependence on allogeneic blood products in PAS management, particularly benefiting high-risk patients with vascular anomalies or severe imaging scores, while integrating effectively within comprehensive perioperative care protocols. This technology is particularly valuable in well-resourced clinical environments; however, multicenter prospective studies are warranted to standardize the implementation protocols and fully evaluate the cost-benefit ratios across diverse healthcare settings.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1393-1406"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden and Trends of UTI in Premenopausal and Postmenopausal Women from 1990 to 2021 and Projections to 2044.","authors":"Ke Tang, Jiayao Feng, Hongshen Lai, Zhongxiang Zhao, Yeson Zou, Qian Lv, Fazhong Dai, Xiaofu Qiu, Wenjie Lai","doi":"10.2147/IJWH.S517387","DOIUrl":"10.2147/IJWH.S517387","url":null,"abstract":"<p><strong>Objective: </strong>Urinary tract infection (UTI) are an important health issue for women, and this study aimed to assess the different disease burdens in premenopausal and postmenopausal women.</p><p><strong>Methods: </strong>In this cross-sectional study, secondary analysis was conducted using Global Burden of Disease (GBD) 2021 data to assess the burden of urinary tract infections in women. Our study applied a joinpoint regression model to assess temporal trends and factors, an age-period-cohort (APC) analysis to evaluate age, period, and cohort effects, and a health inequality analysis to examine regional disparities based on the socio-demographic index (SDI), along with a predictive model for future trend forecasting.</p><p><strong>Results: </strong>From 1990 to 2021, UTI incidence grew faster in premenopausal women (average annual percentage change [AAPC] 0.17 [95% CI 0.15-0.18]) than in postmenopausal women (AAPC 0.04 [95% CI 0.02-0.07]), while mortality increased more for postmenopausal women (AAPC 1.08 [95% CI 0.81-1.36]) than premenopausal women (AAPC 0.45 [95% CI 0.33-0.56]). The COVID-19 pandemic saw a surge in premenopausal UTI incidence (AAPC 0.64 [95% CI 0.62-0.66]). Age, period, and cohort analyses revealed an age-related risk increase in premenopausal women, especially in early birth cohorts. Global health inequalities escalated, with a heavier UTI burden in lower SDI countries. By 2044, projections predict 253.33 million cases in premenopausal and 164.72 million in postmenopausal women, with the biggest increases in the 30-34 and 50-54 age brackets.</p><p><strong>Conclusion: </strong>The study underscores global UTI burden disparities between pre- and postmenopausal women, worsened by COVID-19, urging future policies to enhance healthcare access, antibiotic stewardship, and high-risk group targeting.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1375-1392"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial Thickness Change in Response to Progesterone is Associated with Ongoing Pregnancy Rate in Women with Treated Intrauterine Adhesion - A Prospective Cohort Study.","authors":"Zhaojuan Hou, Bin Xu, Jing Zhao, Qiong Zhang, Tianli Yang, Fen Tian, Baisheng Wang, Yanping Li","doi":"10.2147/IJWH.S521115","DOIUrl":"10.2147/IJWH.S521115","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether endometrial thickness (EmT) change prognosticates the ongoing pregnancy rate (OPR) in hormonally prepared frozen-thawed embryo transfers (FETs) in women with treated intrauterine adhesion (IUA).</p><p><strong>Methods: </strong>We prospectively examined 261 FET cycles in women with IUA. Ultimately, 156 patients were included in the final analysis. The primary outcome was OPR. The association between the EmT change ratio and OPR, as well as the relationship between the EmT change and serum hormone concentration, was analyzed.</p><p><strong>Results: </strong>The intraclass correlation coefficient for repeated EmT measurements was 0.944 (95% CI: 0.933-0.954, P < 0.001). Subdividing by the expansion cutoff from 5% to 15%, the 10% expansion group had the highest OPR with optimal sensitivity and specificity. Regarding the baseline characteristics, there were no statistically significant differences between the two groups. Nevertheless, the OPR increased significantly in cycles with endometrial expansion ≥ 10% compared to those with no expansion (55.3% vs 26.3%, P=0.001). The difference was still significant after adjustment between the two groups (adjusted OR, 3.74; 95% CI 1.68-8.34, P=0.001). No correlation was found between the EmT change and serum hormone concentrations.</p><p><strong>Conclusion: </strong>Endometrial expansion was significantly correlated with higher OPR in women with treated IUA in the hormonal protocol for FET.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1363-1374"},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture and Herbal Medicine for Nausea and Vomiting in Pregnancy: An Overview and Quality Assessment of Systematic Reviews.","authors":"Su-Ji Choi, Seoyoon Choi, Dong-Il Kim","doi":"10.2147/IJWH.S512247","DOIUrl":"10.2147/IJWH.S512247","url":null,"abstract":"<p><strong>Background: </strong>Up to 85% of pregnant women experience nausea and vomiting in pregnancy (NVP), which can impact both the pregnant woman and developing fetus. Traditional East Asian Medicine (TEAM) including acupuncture and herbal medicine has been used to treat NVP; however, its effectiveness remains under debate. This study aimed to systematically review the existing evidence from systematic reviews on the effectiveness of TEAM for NVP and to critically evaluate the quality of these reviews.</p><p><strong>Methods: </strong>Nine databases were searched from their inception until January 2024. Search terms included, \"Hyperemesis gravidarum\", \"Nausea\", \"Vomiting\", \"acupuncture\" and \"herbal medicine\". Systematic reviews (SRs) that evaluated the effect of TEAM treatment for NVP were included. We evaluated methodological quality, reporting quality, and risk of bias using the AMSTAR-2, ROBIS tool, and PRISMA guidelines.</p><p><strong>Results: </strong>In total, 20,121 publications were retrieved from the databases. Twenty-five SRs met the inclusion criteria, indicating that acupuncture and related techniques, and herbal medicines are effective in alleviating NVP. Various methods including traditional acupuncture, acupressure, acupoint injection, electroacupuncture, herbal acupoint patching, and herbal decoctions were used. Herbs like ginger and additional aromatherapies such as lemon and cardamom have also shown beneficial effects. However, there are controversies regarding the consistency of results and the quality of methodologies. Despite low risk of bias across reviews, all were deemed low or critically low in methodological quality, with none fully adhering to PRISMA guidelines.</p><p><strong>Conclusion: </strong>This comprehensive review underscores the potential of TEAM in managing NVP but highlights significant gaps in research quality and reporting. Future studies of higher methodological quality are essential to validate these findings and guide clinical practice.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1343-1361"},"PeriodicalIF":2.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dual-Sequence MRI-Based Radiomics Model for Predicting High-Intensity Focused Ultrasound Ablation Efficacy in Adenomyosis Treatment.","authors":"Mengmeng Sun, Xinyi Deng, Hui Xing, Rui Zhang, Bingbing Fu, Tao Ai, Fang Wang, Xuechun Wang, Lei Chen, Xiaogang Mao, Feng Wu","doi":"10.2147/IJWH.S512216","DOIUrl":"https://doi.org/10.2147/IJWH.S512216","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to develop a predictive model for the therapeutic efficacy of high-intensity focused ultrasound (HIFU) ablation in the treatment of adenomyosis, utilizing dual-sequence MRI radiomics.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 114 patients diagnosed with adenomyosis who underwent ultrasound-guided HIFU ablation under conscious sedation between July 2021 and July 2023. Patients were randomly allocated into a training set and a test set at a ratio of 7:3. The study aimed to evaluate the distribution of clinical characteristics among patients experiencing effective versus ineffective ablation at two distinct classification thresholds (0.7 and 0.5). Multiple models were developed to explore the combination of effective radiomic features derived from dual-sequence MRI and clinical data. Radiomic features were extracted from the MRI images of adenomyosis lesions in the training set. This process included feature extraction, selection, model construction, and evaluation. Logistic regression was used to construct the predictive model, and its performance was assessed on the test set using the receiver operating characteristic (ROC) curve. The Delong test, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare the predictive accuracy of the models.</p><p><strong>Results: </strong>The predictive model showed better alignment with actual ablation outcomes, particularly for predicting ablation success rates exceeding 50%. The combination of radiomic features from the two MRI sequences achieved an AUC of 0.84 in the test set. Decision curve analysis demonstrated that the combined model provided greater net benefit than the single-sequence radiomics model across a broader range of risk thresholds. For the prediction of 70% efficacy, the combined model achieved an AUC of 0.804 in the test set, slightly lower the 50% efficacy prediction task.</p><p><strong>Conclusion: </strong>The model, based on dual-sequence MRI radiomics, emerges as a promising tool for predicting the efficacy of HIFU ablation, potentially aiding clinicians in anticipating the outcomes of HIFU ablation procedures.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1321-1332"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Gonadotropin-Releasing Hormone Agonists on IVF/ICSI-ET Outcomes in Long Protocol: A Retrospective Study.","authors":"Min Xu, Honglin Li, Yiyan Zhao, Huimei Li, Chao Zhao, Xi Zhang, Rong Ni, Jian Liang, Jinhuan Xu","doi":"10.2147/IJWH.S517738","DOIUrl":"https://doi.org/10.2147/IJWH.S517738","url":null,"abstract":"<p><strong>Background: </strong>Triptorelin acetate, leuprorelin and goserelin acetate were three commonly used gonadotropin-releasing hormone agonist (GnRH-a) formulations in IVF/ICSI-ET. However, current knowledge about the real-world effects on clinical outcomes of different GnRH-a formulations is limited. In this study, we aimed to compare the clinical outcomes of IVF/ICSI-ET using different GnRH-a formulations in long protocol during follicle phase.</p><p><strong>Methods: </strong>This is a retrospective study. A total of 154 infertile women undergoing IVF/ICSI-ET in long protocol during follicle phase from September 2019 to December 2023 were assigned to three groups according to different GnRH-a formulations (A: triptorelin acetate; B: leuprorelin; C: goserelin acetate). The baseline information, ovulation induction outcomes and pregnancy outcomes were compared among three groups. Student's <i>t</i>-test, Pearson Chi-Square test or Fisher's exact test was used for statistical analysis appropriately.</p><p><strong>Results: </strong>Groups A, B and C included 94, 36 and 24 patients, respectively. Compared with groups A and B, group C had significantly smaller total amount of gonadotropin (A vs B vs C: 2224.20±700.02 U vs 2266.67±884.01 U vs 1685.94±360.24 U) and shouter days of using gonadotropin (A vs B vs C: 11.61±1.91 days vs 11.83±2.48 days vs 9.50±0.98 days) (<i>P</i><0.05). Among the three groups, group C had the best pregnancy outcomes with the highest implantation rate (A vs B vs C: 40.4% vs 32.7% vs 41.9%), clinical pregnancy rate (A vs B vs C: 41.7% vs 39.4% vs 57.9%), live birth rate (A vs B vs C: 32.5% vs 33.3% vs 52.6%) and the lowest miscarriage rate (A vs B vs C: 22.9% vs 15.4% vs 9.1%).</p><p><strong>Conclusion: </strong>Goserelin acetate was found to have good pregnancy outcomes in IVF/ICSI-ET with small amount and shout using days of gonadotropin, but there is a lack of statistical significance when compared to the pregnancy outcomes of triptorelin acetate and leuprorelin. The findings need future confirmation in larger trials or meta-analyses.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1313-1320"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Interventions Related to the Treatment of Women With Polycystic Ovary Syndrome: A Scoping Review.","authors":"Emily Joy Callander, Yanan Hu, Alayna Carrandi, Chau Thien Tay, Aya Mousa, Helena Teede","doi":"10.2147/IJWH.S514423","DOIUrl":"https://doi.org/10.2147/IJWH.S514423","url":null,"abstract":"<p><strong>Context: </strong>Polycystic ovary syndrome (PCOS) affects up to one-in-five reproductive-aged women and its global healthcare-related economic burden is substantial. The aim of this review was to summarise evidence of the cost-effectiveness of interventions related to the treatment of women with PCOS.</p><p><strong>Evidence acquisition: </strong>Six academic databases were systematically searched for relevant records. Cost data were extracted, and an interpretation statement was provided for each study based upon the cost difference or incremental cost-effectiveness ratio, and its statistical significance.</p><p><strong>Evidence synthesis: </strong>The search yielded 10 relevant studies. Only one study was conducted in a low- and middle-income country (LMIC), China. Nine studies focused on infertility treatment, and one study related to pregnancy care. There remains uncertainty regarding cost-effectiveness of the following infertility treatments: In vitro fertilisation (IVF) cycles compared to ovulation induction (OI) cycles in women with clomiphene citrate (CC) resistant PCOS; and urinary follicle stimulating hormone compared to recombinant follicle stimulating hormone for OI. There are likely cost savings associated with laparoscopic ovarian drilling compared to OI with gonadotropins in women with CC-resistant PCOS, as well as with artificial cycle-frozen embryo transfer (AC-FET) without gonadotropin releasing hormone agonist (GnRH-a) pre-treatment compared to AC-FET with GnRH-a pre-treatment in women with PCOS. Treatment with metformin was lower cost and more effective compared to no treatment for achieving normal glucose regulation without developing gestational diabetes mellitus.</p><p><strong>Conclusion: </strong>The high proportion of fertility-related treatment studies reflects reproductive features often being the best-recognised feature of PCOS. However, limited evidence is available from LMICs. Further economic evidence is needed regarding PCOS treatments, particularly lifestyle interventions treating outcomes other than infertility.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"1333-1341"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}