International Journal of Women's Health最新文献

{"title":"Critique on \"Investigating the Success Rate of Vaginal Delivery After Cesarean Section and Its Associated Factors in Afghan Women: Insights from a Maternity Hospital in Kabul\" [Letter].","authors":"Ehsanullah Alokozay, Najibullah Alokozay, Eliass Tokhi","doi":"10.2147/IJWH.S550582","DOIUrl":"10.2147/IJWH.S550582","url":null,"abstract":"","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2325-2326"},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors of Pelvic Organ Prolapse and the Quality of Life Among Jordanian Women: A Case-Control Study.","authors":"Ayman Qatawneh, Shrouq Qudah, Dania Alkouz, Abdulla Kadah, Baha'a Abu Salma, Waed Al-Alawneh, Sara Alhabosh, Majed Salahaldeen, Balqees Aref Banihamad, Bara'a Amer Aldmour, Noor Alkouz, Abdulrahman Alqatawneh, Nadia Muhaidat, Fida Thekrallah, Mohammad Abufaraj","doi":"10.2147/IJWH.S519065","DOIUrl":"10.2147/IJWH.S519065","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse (POP) is a common gynecological problem. Several risk factors have been identified to contribute to the main pathophysiological mechanism of prolapse development. However, the POP data in the Eastern Mediterranean region, including Jordan, are limited, and the risk factors associated with POP were mainly obesity and high number of vaginal deliveries. Since Jordan has a high prevalence of obesity, parity, and type 2 diabetes, the present study aimed primarily to identify the modifiable and non-modifiable factors associated with POP in Jordanian women, and secondly, to evaluate the impact of POP stages on their quality of life.</p><p><strong>Methods: </strong>This study was an age-matched case-control study conducted at the gynecology outpatient clinics at Jordan University Hospital from March 1, 2022, to December 15, 2022. The POP quantification system was used as a standardized method to identify the cases and controls. Sociodemographic, obstetrics, and gynecological characteristics were obtained and correlated with POP. Multivariable logistic regression was performed to determine the independent predictive factors of prolapse occurrence. The Prolapse Quality of Life questionnaire was employed to assess the impact of prolapse across the stages of prolapse.</p><p><strong>Results: </strong>One hundred fifty cases and 150 controls were enrolled in this study, with a median age of 44.5 years. Cystocele and rectocele were the most identified types of prolapse. Nearly 65% of women reported that they had an episiotomy during their deliveries, and 14% reported that there was a family history of prolapse. Multivariable logistic regression revealed that obesity (AOR = 2.31, 95% CI 1.07-5.84, p = 0.03), episiotomy (AOR = 2.88, 95% CI 1.41-5.89, p = 0.004) and family history of prolapse (AOR = 3.45, 95% CI 1.3-9.2, p = 0.013) were associated with POP. Impairment in the quality of life was significantly higher across prolapse severity stages.</p><p><strong>Conclusion: </strong>In Jordan, obesity, episiotomy, and a family history were associated with POP. Quality of life for women with POP was notably impaired as the severity of the prolapse increased.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2299-2311"},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of the KELIM Index for Progression-Free Survival in Ovarian Cancer Under Current Treatment Modalities.","authors":"Jiajin Lv, Yunyi Xu, Chunyan Zeng, Fengyan Huang, Suping Tao","doi":"10.2147/IJWH.S533323","DOIUrl":"10.2147/IJWH.S533323","url":null,"abstract":"<p><strong>Background: </strong>The KELIM index, a dynamic biomarker derived from CA125 kinetics, has shown prognostic value in ovarian cancer. However, its predictive role under contemporary treatment paradigms incorporating bevacizumab and PARP inhibitors remains underexplored.</p><p><strong>Objective: </strong>To evaluate the predictive value of the KELIM index for progression-free survival (PFS) in ovarian cancer patients treated with current therapeutic modalities.</p><p><strong>Methods: </strong>A total of 52 patients with ovarian cancer who underwent surgical treatment in the Affiliated Hospital of Jiaxing University from January 1, 2020 to September 30, 2023 were retrospectively analyzed. Clinicopathological data, treatment details (including bevacizumab/PARPi use), and serial CA125 values were collected. The KELIM index was calculated using the online biomarker kinetics tool (https://www.biomarker-kinetics.org/CA125). Cox regression and Kaplan-Meier analyses assessed prognostic factors.</p><p><strong>Results: </strong>The mean age of the 52 patients was 55.17±13.57 years, and the mean body mass index (BMI) was 22.95±3.62kg/m². There were 35 cases (67.3%) in the KELIM index ≥1 group and 17 cases (32.7%) in the KELIM index < 1 group. Multivariate analysis identified KELIM index (HR=0.25, 95% CI 0.077-0.818, P<0.05) and treatment approach (direct surgery vs NACT+IDS) as independent PFS predictors. Patients with KELIM<1 had a median PFS of 38.3 months, while those with KELIM≥1 did not reach median PFS (P<0.05).</p><p><strong>Conclusion: </strong>The KELIM index is expected to be another high quality index for predicting OC under the current treatment model, potentially guiding personalized treatment intensification.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2291-2297"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incarceration of the Gravid Uterus in Women with Previous Cesarean Section: Case Series and Literature Review.","authors":"Feng Yun, Leyi Fu, Jie Wen, Danqing Chen, Fangfang Wang","doi":"10.2147/IJWH.S524618","DOIUrl":"10.2147/IJWH.S524618","url":null,"abstract":"<p><p>Incarceration of the gravid uterus (IGU) is a rare and serious condition associated with significant maternal and fetal morbidities. Its occurrence in women with a history of cesarean section (CS) poses a great challenge to obstetricians. We report two cases: Case 1 presented with acute urinary retention at 11 weeks of gestation, with IGU diagnosis ultimately established at 15 weeks following persistent symptoms. Initial manual reduction attempts failed, but resolution occurred later. Case 2 developed severe urinary retention at 16 weeks, and the uterus was repositioned after Foley catheter placement. Both patients underwent uncomplicated cesarean deliveries at term. To delineate the clinical characteristics and optimal management of this condition, we conducted a comprehensive literature review and identified 29 additional cases reported over the past 40 years. Analysis revealed a median gestational age of 17 weeks at presentation and 37 weeks at delivery or pregnancy termination. Among them, 16 had one or more risk factors in addition to previous CS. Clinical presentation and treatment methods paralleled those described in non-CS patients. Successful resolution with favorable outcomes was achieved in 19 cases, with interventions initiated before 20 weeks demonstrating a higher resolution rate. Severe maternal complications occurred in 30% of cases, predominantly in unresolved ones, including two uterine ruptures. Early diagnosis and active management are crucial for optimizing obstetric outcomes and reducing maternal complications in these patients.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2255-2263"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Anemia Education Media on Increasing Self-Awareness and Compliance in Consuming Iron Supplements in Adolescent Girls: A Systematic Review.","authors":"Krisna Siska Septiana, Qorinah Estiningtyas Sakilah Adnani, Hadi Susiarno, Vita Murniati Tarawan, Insi Farisa Desy Arya, Ruswana Anwar","doi":"10.2147/IJWH.S532950","DOIUrl":"10.2147/IJWH.S532950","url":null,"abstract":"<p><p>Anemia is a significant global health issue affecting adolescent females. Since 2011, the World Health Organization (WHO) has advocated for iron supplementation as the preferred intervention to prevent and mitigate adolescent anemia. Adherence to the consumption of iron supplement tablets remains inadequate, primarily due to adolescents' insufficient knowledge and self-awareness. Education is essential for enhancing self-awareness and adherence to iron supplement pills. This literature review examines the influence of health education media on anemia prevention, particularly in improving self-awareness and adherence to Iron Supplement Tablet (IST) use among adolescent females. Studies were chosen according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A thorough search across various databases generated 2129 papers: Google Scholar= 2260, PubMed= 130, ScienceDirect= 236, and Scopus= 100. Of these, 597 were discarded for irrelevance, two were inaccessible, and 14 articles were included in the study following the eligibility assessment. The review findings indicate that health education media using Print Media (brochures, flip charts), Media Technology (audiovisual, animated videos), Telephone calls and text messages, Social Media (WhatsApp, TikTok), Game Media (Monopoly), and peer groups substantially increase self-awareness and adherence to iron supplement consumption in preventing anemia among adolescent girls.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2277-2289"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis and Mortality Risk in US Women: Findings From NHANES 1999-2006.","authors":"Lijie Liu, Chuan Shao, Lujia Li, Nan Wu","doi":"10.2147/IJWH.S530529","DOIUrl":"10.2147/IJWH.S530529","url":null,"abstract":"<p><strong>Objective: </strong>Less is known about the link between mortality and endometriosis, an often chronic, inflammatory gynecologic condition. We assessed the association between endometriosis and all-cause and cause-specific mortality using a retrospective cohort study design based on data from the National Health and Nutrition Examination Survey (NHANES) 1999-2006.</p><p><strong>Materials and methods: </strong>Both crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for endometriosis and age at endometriosis with all-cause mortality were estimated using weighted Cox proportional hazards regression. Moreover, we also performed an exploratory analysis assessing the relationship between endometriosis and mortality from cancer and cardiovascular disease (CVD).</p><p><strong>Results: </strong>Between 1999 and 2006, a cohort of 5552 women aged 20 to 54 years was studied, representing a weighted population of approximately 66.07 million. Over a median follow-up duration of 16.75 years, 290 participants died from various causes, which extrapolates to an estimated 3,411,632 female deaths in the broader population. A non-significant association was identified between endometriosis and all-cause mortality (HR  1.51, 95% CI: 0.97-2.34, <i>P</i> = 0.066), cancer (HR 1.45, 95% CI: 0.76-2.78, <i>P </i>= 0.260), or CVD (HR 1.75, 95% CI: 0.65-4.73, <i>P </i>= 0.271) mortality. When accounting for the age at endometriosis was diagnosed, the association was significant only among women diagnosed at age ≤30 years (HR = 1.87, 95% CI: 1.15-3.03, <i>P </i>= 0.011 for all-cause mortality; HR = 4.37, 95% CI: 1.54-12.36, <i>P</i> = 0.005 for CVD mortality) and was not significant for those diagnosed after age 30 years.</p><p><strong>Conclusion: </strong>In conclusion, women diagnosed with endometriosis at a younger age may be associated with an increased risk of mortality.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2233-2244"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Practices Towards Hormone Replacement Therapy Among Women with Perimenopausal Syndrome: A Cross-Sectional Analysis in Quzhou, Zhejiang Province, China.","authors":"Jing Wang, Xinglu Xia, Xi Lin, Xiaomin Xu","doi":"10.2147/IJWH.S513067","DOIUrl":"10.2147/IJWH.S513067","url":null,"abstract":"<p><strong>Background: </strong>Hormone replacement therapy (HRT) plays a critical role in managing perimenopausal syndrome, yet patients' knowledge, attitudes, and practices (KAP) toward HRT remain insufficiently understood. This study aimed to assess KAP toward HRT among patients with perimenopausal syndrome.</p><p><strong>Patients and methods: </strong>This cross-sectional study conducted in Quzhou, Zhejiang Province, China, in February 2024 used a validated self-designed questionnaire to assess demographic characteristics and knowledge, attitudes, and practices (KAP) toward hormone replacement therapy (HRT). Structural equation modeling (SEM) was applied to examine the pathways among KAP dimensions.</p><p><strong>Results: </strong>Among the 520 participants analyzed, 73.3% resided in urban areas, and 37.9% had used HRT for less than one year. The knowledge, attitude, and practice scores were 18.01±6.05 (possible range: 0-26), 37.56±5.07 (possible range: 10-50), and 6.07±1.70 (possible range: 0-8), respectively. There were significant positive correlations among knowledge, attitudes, and practices (all P < 0.001). SEM results showed that knowledge directly influenced attitudes (β = 0.499, P < 0.001) and practices (β = 0.125, P = 0.007), and that attitudes also directly influenced practices (β = 0.175, P = 0.005).</p><p><strong>Conclusion: </strong>Patients exhibited moderate knowledge and relatively positive practices, though their attitudes toward HRT were suboptimal. The findings highlight the interrelationships among knowledge, attitudes, and practices regarding HRT, suggesting that educational efforts may play a key role in improving patient understanding and engagement.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2265-2276"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-Associated Giant Abdominal Desmoid Tumor: A Case Report of Active Surveillance and Surgical Management.","authors":"Xiao Hong Song, Ying Hu, Yongmiao Pan","doi":"10.2147/IJWH.S532226","DOIUrl":"10.2147/IJWH.S532226","url":null,"abstract":"<p><strong>Objective: </strong>There is not much data on pregnancy-related desmoplastic fibroma (DF), and the effectiveness of active surveillance as a primary treatment strategy remains uncertain. Thus, our case illustrates that DF tumors can persist into late pregnancy. Termination of pregnancy in conjunction with surgical removal of the tumor may reduce trauma and complications, ultimately resulting in a healthy infant.</p><p><strong>Case presentation: </strong>This case describes a pregnant woman with a suspected desmoid fibromatosis tumor who refused termination of pregnancy, opting for close monitoring until late gestation and successfully delivering a healthy baby.</p><p><strong>Conclusion: </strong>This case reveals the feasibility and potential safety of individualized, multidisciplinary management approaches - such as active surveillance followed by timely surgical intervention - for DF in pregnancy. It highlights the importance of balancing maternal and fetal risks and presents insights that may assist the clinical-decision making process in similarly complex scenarios involving pregnancy-related DF.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2227-2232"},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-499a-5p Promotes the Proliferation and Migration of Uterine Leiomyoma Cells by Activating the Wnt/β-Catenin Signaling Pathway.","authors":"Jingjing Ni, Yan Ma, Jianping Qiu","doi":"10.2147/IJWH.S533729","DOIUrl":"10.2147/IJWH.S533729","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the functional role and underlying mechanism of miR-499a-5p in the progression of uterine leiomyoma (ULM).</p><p><strong>Methods: </strong>Expression levels of miR-499a-5p were analyzed in ULM tissues and cells. Functional assays were conducted to evaluate the effects of miR-499a-5p knockdown or overexpression on cellular proliferation, migration, apoptosis, and cell cycle progression. The involvement of the Wnt/β-catenin signaling pathway was assessed using pathway-specific protein markers and lithium chloride (LiCl) as a chemical activator.</p><p><strong>Results: </strong>miR-499a-5p was significantly upregulated in ULM tissues and cells. Its knockdown inhibited proliferation and migration, induced apoptosis, and caused cell cycle arrest at the G0/G1 phase. Additionally, downregulation of miR-499a-5p suppressed the activation of the Wnt/β-catenin pathway, an effect that was reversed by LiCl treatment.</p><p><strong>Conclusion: </strong>miR-499a-5p facilitates the development of uterine leiomyoma by activating the Wnt/β-catenin signaling pathway. These findings suggest that miR-499a-5p may serve as a promising molecular biomarker and a potential therapeutic target for ULM management.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2245-2253"},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopy Combined with Transvaginal Approach for Repairing Genital Tract Penetrating Injury: A Case Report.","authors":"Miao Liang, Yu Wen, Yongkang Li, Xiaofan Zhu, Cheng Chen","doi":"10.2147/IJWH.S532755","DOIUrl":"10.2147/IJWH.S532755","url":null,"abstract":"<p><p>Female external genital injuries mainly include sexual-related injuries and accidental injuries. Severe cases may experience rapid and massive bleeding, with possible foreign body retention in the body or concurrent injuries to adjacent organs such as the rectum and bladder. Most of these cases require surgical treatment, and the intraoperative situation is complex and changeable. We report a patient with a penetrating injury of the genital tract and foreign body retention in the body, who was successfully treated using the laparoscopic combined with transvaginal full-layer suture technique. Compared with the traditional transvaginal approach, this method can comprehensively explore the lacerations and surrounding organs of the cavity, and thoroughly clean up residual foreign bodies in the body. This paper explores the safety, feasibility, related surgical techniques, and perioperative precautions of this technique in the treatment of genital tract penetrating injuries.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2217-2225"},"PeriodicalIF":2.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}