Endometriosis and Mortality Risk in US Women: Findings From NHANES 1999-2006.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S530529

Lijie Liu, Chuan Shao, Lujia Li, Nan Wu

{"title":"Endometriosis and Mortality Risk in US Women: Findings From NHANES 1999-2006.","authors":"Lijie Liu, Chuan Shao, Lujia Li, Nan Wu","doi":"10.2147/IJWH.S530529","DOIUrl":null,"url":null,"abstract":"Objective: Less is known about the link between mortality and endometriosis, an often chronic, inflammatory gynecologic condition. We assessed the association between endometriosis and all-cause and cause-specific mortality using a retrospective cohort study design based on data from the National Health and Nutrition Examination Survey (NHANES) 1999-2006.Materials and methods: Both crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for endometriosis and age at endometriosis with all-cause mortality were estimated using weighted Cox proportional hazards regression. Moreover, we also performed an exploratory analysis assessing the relationship between endometriosis and mortality from cancer and cardiovascular disease (CVD).Results: Between 1999 and 2006, a cohort of 5552 women aged 20 to 54 years was studied, representing a weighted population of approximately 66.07 million. Over a median follow-up duration of 16.75 years, 290 participants died from various causes, which extrapolates to an estimated 3,411,632 female deaths in the broader population. A non-significant association was identified between endometriosis and all-cause mortality (HR  1.51, 95% CI: 0.97-2.34, P = 0.066), cancer (HR 1.45, 95% CI: 0.76-2.78, P = 0.260), or CVD (HR 1.75, 95% CI: 0.65-4.73, P = 0.271) mortality. When accounting for the age at endometriosis was diagnosed, the association was significant only among women diagnosed at age ≤30 years (HR = 1.87, 95% CI: 1.15-3.03, P = 0.011 for all-cause mortality; HR = 4.37, 95% CI: 1.54-12.36, P = 0.005 for CVD mortality) and was not significant for those diagnosed after age 30 years.Conclusion: In conclusion, women diagnosed with endometriosis at a younger age may be associated with an increased risk of mortality.","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2233-2244"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301427/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S530529","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Less is known about the link between mortality and endometriosis, an often chronic, inflammatory gynecologic condition. We assessed the association between endometriosis and all-cause and cause-specific mortality using a retrospective cohort study design based on data from the National Health and Nutrition Examination Survey (NHANES) 1999-2006.

Materials and methods: Both crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for endometriosis and age at endometriosis with all-cause mortality were estimated using weighted Cox proportional hazards regression. Moreover, we also performed an exploratory analysis assessing the relationship between endometriosis and mortality from cancer and cardiovascular disease (CVD).

Results: Between 1999 and 2006, a cohort of 5552 women aged 20 to 54 years was studied, representing a weighted population of approximately 66.07 million. Over a median follow-up duration of 16.75 years, 290 participants died from various causes, which extrapolates to an estimated 3,411,632 female deaths in the broader population. A non-significant association was identified between endometriosis and all-cause mortality (HR  1.51, 95% CI: 0.97-2.34, P = 0.066), cancer (HR 1.45, 95% CI: 0.76-2.78, P = 0.260), or CVD (HR 1.75, 95% CI: 0.65-4.73, P = 0.271) mortality. When accounting for the age at endometriosis was diagnosed, the association was significant only among women diagnosed at age ≤30 years (HR = 1.87, 95% CI: 1.15-3.03, P = 0.011 for all-cause mortality; HR = 4.37, 95% CI: 1.54-12.36, P = 0.005 for CVD mortality) and was not significant for those diagnosed after age 30 years.

Conclusion: In conclusion, women diagnosed with endometriosis at a younger age may be associated with an increased risk of mortality.

Abstract Image

查看原文本刊更多论文

美国女性子宫内膜异位症和死亡风险：NHANES 1999-2006的研究结果

目的：子宫内膜异位症是一种常见的慢性炎症性妇科疾病，人们对死亡率与子宫内膜异位症之间的联系知之甚少。我们采用基于1999-2006年国家健康与营养调查（NHANES）数据的回顾性队列研究设计，评估子宫内膜异位症与全因和病因特异性死亡率之间的关系。材料和方法：使用加权Cox比例风险回归估计子宫内膜异位症和子宫内膜异位症年龄与全因死亡率的原始和多变量调整风险比（hr）和95%置信区间（CIs）。此外，我们还进行了一项评估子宫内膜异位症与癌症和心血管疾病（CVD）死亡率之间关系的探索性分析。结果：1999年至2006年间，5552名年龄在20岁至54岁之间的女性进行了研究，加权人口约为6607万。在16.75年的中位随访期间，290名参与者死于各种原因，由此推断，在更广泛的人群中，估计有3,411,632名女性死亡。子宫内膜异位症与全因死亡率（HR  1.51,95% CI： 0.97-2.34,P = 0.066）、癌症（HR 1.45, 95% CI: 0.76-2.78, P = 0.260）或心血管疾病（HR 1.75, 95% CI: 0.65-4.73, P = 0.271）死亡率之间无显著关联。当考虑诊断子宫内膜异位症的年龄时，仅在诊断年龄≤30岁的女性中，全因死亡率的相关性显著(HR = 1.87,95% CI: 1.15-3.03, P = 0.011；心血管疾病死亡率HR = 4.37,95% CI: 1.54-12.36, P = 0.005)，对于30岁以后诊断的患者无显著性差异。结论：总之，年轻诊断为子宫内膜异位症的女性可能与死亡风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.