{"title":"Clinical Prognostic Factors for Overall Survival in Patients Undergoing Radical Radiotherapy for Cervical Cancer.","authors":"Fangfang Hao, Nanfeng Xiao, Meng Wang, Houyi Sang, Judong Luo, Jing Song","doi":"10.2147/IJWH.S543995","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Cervical carcinoma (CC) represents the predominant malignancy affecting the female population, with patient outcomes being a critical focus of clinical investigation. This research conducts a comprehensive evaluation of the clinical determinants influencing short-term survival rates in CC patients receiving definitive radiotherapy treatment.</p><p><strong>Methods: </strong>A total of 99 cervical cancer patients who received radical radiotherapy between April 2017 and March 2022 at two medical institutions were retrospectively examined. Clinical outcomes were evaluated using the Kaplan-Meier method and the Cox proportional hazards model.</p><p><strong>Results: </strong>A total of ninety - nine patients with cervical cancer who received radical radiotherapy were included in the study. The overall survival (OS) rate at 2 - year follow - up was 77.8%.COX unifactorial and multifactorial showed that the analysis of prognostic-related factors suggested that the higher the history of miscarriage and FIGO stage, the lower 2-year OS, and that the history of miscarriage and FIGO stage were independent factors affecting the short-term overall survival, and the difference of all of them was statistically significant (P < 0.05).</p><p><strong>Conclusion: </strong>A history of miscarriage and the FIGO classification stage serve as independent predictors of overall survival (OS) during the initial 24-month period for cervical carcinoma patients undergoing definitive radiotherapy. This study conducted a comprehensive analysis of short-term prognostic indicators for cervical squamous cell carcinoma patients undergoing radical chemoradiotherapy.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3347-3359"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493931/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S543995","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Cervical carcinoma (CC) represents the predominant malignancy affecting the female population, with patient outcomes being a critical focus of clinical investigation. This research conducts a comprehensive evaluation of the clinical determinants influencing short-term survival rates in CC patients receiving definitive radiotherapy treatment.
Methods: A total of 99 cervical cancer patients who received radical radiotherapy between April 2017 and March 2022 at two medical institutions were retrospectively examined. Clinical outcomes were evaluated using the Kaplan-Meier method and the Cox proportional hazards model.
Results: A total of ninety - nine patients with cervical cancer who received radical radiotherapy were included in the study. The overall survival (OS) rate at 2 - year follow - up was 77.8%.COX unifactorial and multifactorial showed that the analysis of prognostic-related factors suggested that the higher the history of miscarriage and FIGO stage, the lower 2-year OS, and that the history of miscarriage and FIGO stage were independent factors affecting the short-term overall survival, and the difference of all of them was statistically significant (P < 0.05).
Conclusion: A history of miscarriage and the FIGO classification stage serve as independent predictors of overall survival (OS) during the initial 24-month period for cervical carcinoma patients undergoing definitive radiotherapy. This study conducted a comprehensive analysis of short-term prognostic indicators for cervical squamous cell carcinoma patients undergoing radical chemoradiotherapy.
期刊介绍:
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.