影响宫颈癌根治放疗患者总生存期的临床预后因素。

IF 2.6 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
International Journal of Women's Health Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S543995
Fangfang Hao, Nanfeng Xiao, Meng Wang, Houyi Sang, Judong Luo, Jing Song
{"title":"影响宫颈癌根治放疗患者总生存期的临床预后因素。","authors":"Fangfang Hao, Nanfeng Xiao, Meng Wang, Houyi Sang, Judong Luo, Jing Song","doi":"10.2147/IJWH.S543995","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Cervical carcinoma (CC) represents the predominant malignancy affecting the female population, with patient outcomes being a critical focus of clinical investigation. This research conducts a comprehensive evaluation of the clinical determinants influencing short-term survival rates in CC patients receiving definitive radiotherapy treatment.</p><p><strong>Methods: </strong>A total of 99 cervical cancer patients who received radical radiotherapy between April 2017 and March 2022 at two medical institutions were retrospectively examined. Clinical outcomes were evaluated using the Kaplan-Meier method and the Cox proportional hazards model.</p><p><strong>Results: </strong>A total of ninety - nine patients with cervical cancer who received radical radiotherapy were included in the study. The overall survival (OS) rate at 2 - year follow - up was 77.8%.COX unifactorial and multifactorial showed that the analysis of prognostic-related factors suggested that the higher the history of miscarriage and FIGO stage, the lower 2-year OS, and that the history of miscarriage and FIGO stage were independent factors affecting the short-term overall survival, and the difference of all of them was statistically significant (P < 0.05).</p><p><strong>Conclusion: </strong>A history of miscarriage and the FIGO classification stage serve as independent predictors of overall survival (OS) during the initial 24-month period for cervical carcinoma patients undergoing definitive radiotherapy. This study conducted a comprehensive analysis of short-term prognostic indicators for cervical squamous cell carcinoma patients undergoing radical chemoradiotherapy.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3347-3359"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493931/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical Prognostic Factors for Overall Survival in Patients Undergoing Radical Radiotherapy for Cervical Cancer.\",\"authors\":\"Fangfang Hao, Nanfeng Xiao, Meng Wang, Houyi Sang, Judong Luo, Jing Song\",\"doi\":\"10.2147/IJWH.S543995\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Cervical carcinoma (CC) represents the predominant malignancy affecting the female population, with patient outcomes being a critical focus of clinical investigation. This research conducts a comprehensive evaluation of the clinical determinants influencing short-term survival rates in CC patients receiving definitive radiotherapy treatment.</p><p><strong>Methods: </strong>A total of 99 cervical cancer patients who received radical radiotherapy between April 2017 and March 2022 at two medical institutions were retrospectively examined. Clinical outcomes were evaluated using the Kaplan-Meier method and the Cox proportional hazards model.</p><p><strong>Results: </strong>A total of ninety - nine patients with cervical cancer who received radical radiotherapy were included in the study. The overall survival (OS) rate at 2 - year follow - up was 77.8%.COX unifactorial and multifactorial showed that the analysis of prognostic-related factors suggested that the higher the history of miscarriage and FIGO stage, the lower 2-year OS, and that the history of miscarriage and FIGO stage were independent factors affecting the short-term overall survival, and the difference of all of them was statistically significant (P < 0.05).</p><p><strong>Conclusion: </strong>A history of miscarriage and the FIGO classification stage serve as independent predictors of overall survival (OS) during the initial 24-month period for cervical carcinoma patients undergoing definitive radiotherapy. This study conducted a comprehensive analysis of short-term prognostic indicators for cervical squamous cell carcinoma patients undergoing radical chemoradiotherapy.</p>\",\"PeriodicalId\":14356,\"journal\":{\"name\":\"International Journal of Women's Health\",\"volume\":\"17 \",\"pages\":\"3347-3359\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493931/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Women's Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJWH.S543995\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S543995","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:宫颈癌(CC)是影响女性人群的主要恶性肿瘤,其患者预后是临床研究的关键焦点。本研究对影响接受明确放疗的CC患者短期生存率的临床因素进行了综合评估。方法:回顾性分析2017年4月至2022年3月在两家医疗机构接受根治性放疗的宫颈癌患者99例。临床结果采用Kaplan-Meier法和Cox比例风险模型进行评估。结果:本研究共纳入99例接受根治性放疗的宫颈癌患者。2年随访的总生存率(OS)为77.8%。COX单因素和多因素分析显示,预后相关因素分析提示流产史和FIGO分期越高,2年OS越低,且流产史和FIGO分期是影响短期总生存的独立因素,两者差异有统计学意义(P < 0.05)。结论:流产史和FIGO分期可作为宫颈癌放疗患者最初24个月总生存(OS)的独立预测因子。本研究对宫颈鳞癌患者行根治性放化疗的短期预后指标进行了综合分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Prognostic Factors for Overall Survival in Patients Undergoing Radical Radiotherapy for Cervical Cancer.

Objective: Cervical carcinoma (CC) represents the predominant malignancy affecting the female population, with patient outcomes being a critical focus of clinical investigation. This research conducts a comprehensive evaluation of the clinical determinants influencing short-term survival rates in CC patients receiving definitive radiotherapy treatment.

Methods: A total of 99 cervical cancer patients who received radical radiotherapy between April 2017 and March 2022 at two medical institutions were retrospectively examined. Clinical outcomes were evaluated using the Kaplan-Meier method and the Cox proportional hazards model.

Results: A total of ninety - nine patients with cervical cancer who received radical radiotherapy were included in the study. The overall survival (OS) rate at 2 - year follow - up was 77.8%.COX unifactorial and multifactorial showed that the analysis of prognostic-related factors suggested that the higher the history of miscarriage and FIGO stage, the lower 2-year OS, and that the history of miscarriage and FIGO stage were independent factors affecting the short-term overall survival, and the difference of all of them was statistically significant (P < 0.05).

Conclusion: A history of miscarriage and the FIGO classification stage serve as independent predictors of overall survival (OS) during the initial 24-month period for cervical carcinoma patients undergoing definitive radiotherapy. This study conducted a comprehensive analysis of short-term prognostic indicators for cervical squamous cell carcinoma patients undergoing radical chemoradiotherapy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
International Journal of Women's Health
International Journal of Women's Health OBSTETRICS & GYNECOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
194
审稿时长
16 weeks
期刊介绍: International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信