Mohammed Alfaifi, Adel Abo Mansour, Bijesh Yadav, Imran Ali Khan
{"title":"诊断为妊娠糖尿病的沙特妇女SIRT1基因的分子变异：一项病例-对照研究","authors":"Mohammed Alfaifi, Adel Abo Mansour, Bijesh Yadav, Imran Ali Khan","doi":"10.2147/IJWH.S510344","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gestational Diabetes Mellitus (GDM) is defined as impaired glucose intolerance resulting in hyperglycemia. SIRT1 deficiency and single nucleotide polymorphisms (SNPs) were also related to diabetes. No documented studies were carried out between GDM and <i>SIRT1</i> SNPs and it is also not confirmed whether <i>SIRT1</i> SNPs had a role in GDM women.</p><p><strong>Objective: </strong>This study was designed to explore the molecular association carried out between GDM women and <i>SIRT1</i> gene SNPs present in the Saudi Arabia. This is a case-control study carried out in Capital city of Saudi Arabia.</p><p><strong>Methods/design: </strong>Serum samples were used for studying biochemical parameters, genotyping and Sanger sequencings for rs4746720 and rs10823112 SNPs. Statistical analysis was carried out between GDM and non-GDM women for anthropometric, biochemical and molecular data.</p><p><strong>Results: </strong>A total of 120 GDM and 120 non-GDM women were recruited based on inclusion and exclusion criteria. Different forms of glucose values have confirmed the statistical association levels between GDM and non-GDM women (p < 0.05). Penalized logistic regression analysis showed the positive association with FBG, OGTT-2hr and HDLc levels (p < 0.05) in GDM women. The rs4746720 SNP was associated with GDM (p = 0.01). ANOVA analysis has confirmed the strong association with FBG (p = 0.002), PPBG (p = 0.0001) and HDLc (p = 0.0003) levels in rs4746720 SNP; while in rs10823112 SNP, both PPBG (p = 0.0001) and HDLc (p = 0.01) were associated. Linkage disequilibrium and GMDR analysis showed significant associations (p < 0.05).</p><p><strong>Conclusion: </strong>This study confirms rs4746720 SNP and glucose levels played a role in this study.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2335-2352"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316047/pdf/","citationCount":"0","resultStr":"{\"title\":\"Molecular Variants in <i>SIRT1</i> Gene Among Saudi Women Diagnosed with Gestational Diabetes Mellitus: A Case-Control Study.\",\"authors\":\"Mohammed Alfaifi, Adel Abo Mansour, Bijesh Yadav, Imran Ali Khan\",\"doi\":\"10.2147/IJWH.S510344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gestational Diabetes Mellitus (GDM) is defined as impaired glucose intolerance resulting in hyperglycemia. SIRT1 deficiency and single nucleotide polymorphisms (SNPs) were also related to diabetes. No documented studies were carried out between GDM and <i>SIRT1</i> SNPs and it is also not confirmed whether <i>SIRT1</i> SNPs had a role in GDM women.</p><p><strong>Objective: </strong>This study was designed to explore the molecular association carried out between GDM women and <i>SIRT1</i> gene SNPs present in the Saudi Arabia. This is a case-control study carried out in Capital city of Saudi Arabia.</p><p><strong>Methods/design: </strong>Serum samples were used for studying biochemical parameters, genotyping and Sanger sequencings for rs4746720 and rs10823112 SNPs. Statistical analysis was carried out between GDM and non-GDM women for anthropometric, biochemical and molecular data.</p><p><strong>Results: </strong>A total of 120 GDM and 120 non-GDM women were recruited based on inclusion and exclusion criteria. Different forms of glucose values have confirmed the statistical association levels between GDM and non-GDM women (p < 0.05). Penalized logistic regression analysis showed the positive association with FBG, OGTT-2hr and HDLc levels (p < 0.05) in GDM women. The rs4746720 SNP was associated with GDM (p = 0.01). ANOVA analysis has confirmed the strong association with FBG (p = 0.002), PPBG (p = 0.0001) and HDLc (p = 0.0003) levels in rs4746720 SNP; while in rs10823112 SNP, both PPBG (p = 0.0001) and HDLc (p = 0.01) were associated. Linkage disequilibrium and GMDR analysis showed significant associations (p < 0.05).</p><p><strong>Conclusion: </strong>This study confirms rs4746720 SNP and glucose levels played a role in this study.</p>\",\"PeriodicalId\":14356,\"journal\":{\"name\":\"International Journal of Women's Health\",\"volume\":\"17 \",\"pages\":\"2335-2352\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316047/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Women's Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJWH.S510344\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S510344","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Molecular Variants in SIRT1 Gene Among Saudi Women Diagnosed with Gestational Diabetes Mellitus: A Case-Control Study.
Background: Gestational Diabetes Mellitus (GDM) is defined as impaired glucose intolerance resulting in hyperglycemia. SIRT1 deficiency and single nucleotide polymorphisms (SNPs) were also related to diabetes. No documented studies were carried out between GDM and SIRT1 SNPs and it is also not confirmed whether SIRT1 SNPs had a role in GDM women.
Objective: This study was designed to explore the molecular association carried out between GDM women and SIRT1 gene SNPs present in the Saudi Arabia. This is a case-control study carried out in Capital city of Saudi Arabia.
Methods/design: Serum samples were used for studying biochemical parameters, genotyping and Sanger sequencings for rs4746720 and rs10823112 SNPs. Statistical analysis was carried out between GDM and non-GDM women for anthropometric, biochemical and molecular data.
Results: A total of 120 GDM and 120 non-GDM women were recruited based on inclusion and exclusion criteria. Different forms of glucose values have confirmed the statistical association levels between GDM and non-GDM women (p < 0.05). Penalized logistic regression analysis showed the positive association with FBG, OGTT-2hr and HDLc levels (p < 0.05) in GDM women. The rs4746720 SNP was associated with GDM (p = 0.01). ANOVA analysis has confirmed the strong association with FBG (p = 0.002), PPBG (p = 0.0001) and HDLc (p = 0.0003) levels in rs4746720 SNP; while in rs10823112 SNP, both PPBG (p = 0.0001) and HDLc (p = 0.01) were associated. Linkage disequilibrium and GMDR analysis showed significant associations (p < 0.05).
Conclusion: This study confirms rs4746720 SNP and glucose levels played a role in this study.
期刊介绍：
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
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