International Medical Case Reports Journal最新文献

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Ex vivo Liver Autotransplantation for Alveolar Echinococcosis with Brain and Lung Metastases: A Case Report. 体外自体肝移植治疗肺泡包虫病伴脑、肺转移1例。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-04-05 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S507833
Anuar Abdikarimov, Yerzhan Shayakhmetov, Vitaliy Kalina, Saken Saberbekov, Nurbek Ilyassov, Erlan Nurgaliev, Yerlan Omarov
{"title":"Ex vivo Liver Autotransplantation for Alveolar Echinococcosis with Brain and Lung Metastases: A Case Report.","authors":"Anuar Abdikarimov, Yerzhan Shayakhmetov, Vitaliy Kalina, Saken Saberbekov, Nurbek Ilyassov, Erlan Nurgaliev, Yerlan Omarov","doi":"10.2147/IMCRJ.S507833","DOIUrl":"https://doi.org/10.2147/IMCRJ.S507833","url":null,"abstract":"<p><p>Ex vivo liver resection and autotransplantation (ELRA) in extensive abdominal alveolar echinococcosis (AE) is a relatively rare treatment. We present the first case, ever reported in Kazakhstan, of successfully performed ELRA of a patient with extensive abdominal AE with invasion into the inferior vena cava (IVC). A 64-year-old woman was diagnosed with AE of the brain, alveococcectomy from the left frontal lobe was performed. At the same time, liver AE metastased to the lungs and brain was diagnosed. The patient was admitted to our center for the following surgical treatments: (1) laparotomy, (2) extended left hemihepatectomy with resection of IVC ex vivo, (3) plastic surgery of IVC with a synthetic prosthesis, (4) orthotopic transplantation of the remnant right lobe of the liver. The postoperative period proceeded smoothly. The patient was mechanically ventilated for 1.5 days and prescribed strict bed rest with in-bed activity for up to 11 days. Empirical antibiotic therapy was initiated as follows: meropenem 1000 mg three times a day for 10 days, omeprazole 40 mg once a day for 14 days, anticoagulant therapy was not administered in the first post-operation day due to high risk of bleeding. Clexane was prescribed subcutaneously once a day: 0.2 mL for 2 days, then 0.4 mL for next 10 days. Daily transfusion of 100 mL of 10% Albumin was performed to prevent hypoalbuminemia. Drainage systems were removed on the 9th day. On the 12th day, the patient was transferred from the intensive care unit to a hospital room, and discharged with improvement on the 20th day. During a 6-month follow-up, no relapse was observed. Radical surgery for widespread AE, in this case - ELRA, is the preferred treatment, since it does not require immunosuppressive therapy and is quite feasible even with invasion of the portal vein bifurcation, IVC and hepatocaval confluence.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"473-478"},"PeriodicalIF":0.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal and Neonatal Deaths Resulting from Chikungunya Virus Infection During Pregnancy: A Case Series. 妊娠期感染基孔肯雅病毒导致的胎儿和新生儿死亡:一个病例系列。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-04-05 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S506873
Ana Cristina Pedrosa Do Monte, Heloisa Ramos Lacerda
{"title":"Fetal and Neonatal Deaths Resulting from Chikungunya Virus Infection During Pregnancy: A Case Series.","authors":"Ana Cristina Pedrosa Do Monte, Heloisa Ramos Lacerda","doi":"10.2147/IMCRJ.S506873","DOIUrl":"https://doi.org/10.2147/IMCRJ.S506873","url":null,"abstract":"<p><strong>Purpose: </strong>We report maternal outcomes, fetal and neonatal deaths resulting from chikungunya virus (CHIKV) infection during pregnancy, addressing clinical manifestations, complications and laboratory changes.</p><p><strong>Patients and methods: </strong>This case series included four pregnant women infected with the chikungunya virus during gestation, three fetal deaths, and two neonatal deaths confirmed as resulting from maternal-fetal transmission, during an epidemic in 2015 and 2016, in the state of Pernambuco, Northeastern Brazil. Laboratory and clinical-epidemiological criteria were applied to confirm the infection.</p><p><strong>Results: </strong>All the pregnant women were symptomatic with an onset of symptoms from the first trimester of pregnancy until 4 days after birth, with the infection confirmed by laboratory and clinical-epidemiological criteria. Among the fetal deaths, changes in the brain were the most prominent (softening and autolysis). In the neonatal deaths, there were signs of acute suffering, and low Apgar, in addition to the manifestation of severe disease with skin hyperpigmentation, limb edema, and encephalitis.</p><p><strong>Conclusion: </strong>We demonstrate the rare, although possible, occurrence of fetal death due to maternal CHIKV infection at any stage of pregnancy, as well as the risk of vertical transmission during birth, resulting in neonatal mortality. We would suggest that during epidemics this diagnosis should be considered in fetal and neonatal deaths of mothers with symptoms suggestive of chikungunya.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"479-485"},"PeriodicalIF":0.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Aflibercept (8 mg) for Diabetic Macular Edema in Vitrectomized Eyes Refractory to the Other Anti-VEGF Drug Therapies: A Report of Three Cases. 阿非利西普(8mg)治疗其他抗vegf药物治疗难治性玻璃体切除眼糖尿病性黄斑水肿3例疗效分析
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-04-05 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S512953
Ikumi Kashiwagi, Ryota Nonaka, Shotaro Sasaki, Takuto Yamamoto, Kanako Yasuda, Masahiko Shimura
{"title":"Efficacy of Aflibercept (8 mg) for Diabetic Macular Edema in Vitrectomized Eyes Refractory to the Other Anti-VEGF Drug Therapies: A Report of Three Cases.","authors":"Ikumi Kashiwagi, Ryota Nonaka, Shotaro Sasaki, Takuto Yamamoto, Kanako Yasuda, Masahiko Shimura","doi":"10.2147/IMCRJ.S512953","DOIUrl":"https://doi.org/10.2147/IMCRJ.S512953","url":null,"abstract":"<p><strong>Introduction: </strong>To report the efficacy of aflibercept (8 mg) for diabetic macular edema (DME) in vitrectomized eyes refractory to other anti-VEGF drug therapies.</p><p><strong>Case presentations: </strong>This was a single-center retrospective case series. Three eyes with DME that developed after vitrectomy for diabetic vitreous hemorrhage were resistant to other anti-vascular endothelial growth factor (VEGF) drugs but improved with aflibercept (8 mg). Prior to treatment with aflibercept (8 mg), 2 eyes received multiple injections of faricimab and brolucizumab, and 1 eye received multiple injections of faricimab, but none of the 3 eyes showed morphological or functional improvement. Subsequently, aflibercept (8 mg) was administered, and a single dose of aflibercept resulted in marked improvement in all cases.</p><p><strong>Conclusion: </strong>The efficacy of anti-VEGF therapy for DME in vitrectomized eyes is thought to be lower than that of DME in non-vitrectomized eyes. In this case, brolucizumab, which has a high anti-VEGF molar concentration, and faricimab, which has a low anti-VEGF molar concentration but anti-angiopoietin (Ang)-2 activity, were not effective, but aflibercept (8 mg), whose VEGF molar concentration was intermediate between the two, was effective. This may be due to the fact that aflibercept (8 mg) is a fusion protein rather than an antibody, has lower clearance than a small molecule like brolucizumab, and has a higher anti-VEGF molar concentration than faricimab. It is suggested that aflibercept (8 mg) may be effective for DME in vitrectomized eyes and may merit preferential administration in such cases.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"465-471"},"PeriodicalIF":0.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
True Double Umbilical Cord Knots with Good Fetal Outcome: An Incidental Finding on Delivery. 具有良好胎儿结局的真双脐带结:分娩时偶然发现。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S502107
Leonard Ssebwami, Koros Aron Kiptoo, Joan Diana Nabirye, Immaculate Ayebare, Simon Byonanuwe
{"title":"True Double Umbilical Cord Knots with Good Fetal Outcome: An Incidental Finding on Delivery.","authors":"Leonard Ssebwami, Koros Aron Kiptoo, Joan Diana Nabirye, Immaculate Ayebare, Simon Byonanuwe","doi":"10.2147/IMCRJ.S502107","DOIUrl":"10.2147/IMCRJ.S502107","url":null,"abstract":"<p><p>Umbilical cord knots are very rare cases. As opposed to single loop knots, double-and more loop knots are extremely rare. When they occur, adverse outcomes become inevitable in most cases. We present this rare case diagnosed coincidentally on cesarean section at term with good fetal outcome.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"461-463"},"PeriodicalIF":0.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Adjunctive Applications of Integra® in Free-Flap Surgery to the Scalp: A Two-Case Experience. Integra®在头皮自由皮瓣手术中的辅助应用:两例经验。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S509768
James C Yuen, Elizabeth N Dawson, Connor S Miller, Madalyn H Bowman, Aimee A Tran
{"title":"The Adjunctive Applications of Integra<sup>®</sup> in Free-Flap Surgery to the Scalp: A Two-Case Experience.","authors":"James C Yuen, Elizabeth N Dawson, Connor S Miller, Madalyn H Bowman, Aimee A Tran","doi":"10.2147/IMCRJ.S509768","DOIUrl":"10.2147/IMCRJ.S509768","url":null,"abstract":"<p><p>Free flaps for scalp reconstruction occasionally traverse the face to reach the recipient vessels in the neck if the superficial temporal vessels are unavailable and vein grafts are circumvented. When using the latissimus flap, the facial skin at the exposure incision is not redundant enough to cover the proximal flap. Integra<sup>®</sup> (Integra LifeScience) can be applied to cover the exposed portion of the flap containing the vascular pedicle, expediting completion of the operation without the need to perform immediate skin grafting. If flap perfusion is marginal, the surgeon is relieved of the concern for autologous skin graft loss if flap perfusion worsens. After flap perfusion is secured, a skin graft is applied over the neodermis regenerated by Integra. We describe two cases utilizing Integra as an adjunctive skin substitute for coverage of the exposed portion of the flap containing the pedicle, thus obviating the need for immediate skin grafting.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"451-460"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravitreal Corticosteroids in the Management of Refractory Macular Edema in Birdshot Chorioretinopathy. 玻璃体内皮质类固醇治疗鸟射型脉络膜视网膜病变难治性黄斑水肿。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-03-30 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S513752
João Alves Ambrósio, Catarina Pestana Aguiar, Pedro Cardoso Teixeira, Vítor Miranda, João Chibante Pedro, Miguel Ruão
{"title":"Intravitreal Corticosteroids in the Management of Refractory Macular Edema in Birdshot Chorioretinopathy.","authors":"João Alves Ambrósio, Catarina Pestana Aguiar, Pedro Cardoso Teixeira, Vítor Miranda, João Chibante Pedro, Miguel Ruão","doi":"10.2147/IMCRJ.S513752","DOIUrl":"10.2147/IMCRJ.S513752","url":null,"abstract":"<p><strong>Introduction: </strong>Birdshot chorioretinopathy (BCR) is a chronic, bilateral posterior uveitis characterized by yellow-white fundus lesions and a strong association with HLA-A29. Visual decline, often due to cystoid macular edema (CME) and retinal atrophy, necessitates early immunomodulatory therapy. This case report describes the clinical course of BCR and highlights the role of intravitreal corticosteroids in managing inflammation and CME.</p><p><strong>Case report: </strong>A 54-year-old previously healthy male diagnosed with BCR based on clinical findings and a positive HLA-A29 test presented with refractory CME. Over 20 months, his best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were monitored. Initial treatment included topical corticosteroids, methotrexate, and oral corticosteroids to address anterior chamber reaction, vitritis, diffuse retinal lesions, and vasculitis. Cyclosporine was added for persistent inflammation but discontinued due to a cutaneous reaction. Despite these efforts, CME persisted, necessitating intravitreal corticosteroids. BCVA in the right eye (OD) fluctuated between 20/20 and 20/30, while the left eye (OS) ranged from 20/20 to 20/40, with changes linked to treatment adjustments. Recurrent CME episodes were more pronounced in the OS, where CFT varied from 328 to 637 µm, while OD values ranged from 304 to 576 µm. Intravitreal dexamethasone and fluocinolone implants reduced CFT in both eyes, achieving stabilization at the final assessment (OD 341 µm, OS 347 µm).</p><p><strong>Conclusion: </strong>This case illustrates the challenges of managing BCR with refractory CME. While systemic immunomodulatory therapy is foundational, intravitreal corticosteroids play a vital role in controlling CME and preserving visual function. Combining systemic and local therapies proved essential for disease control. Long-term monitoring and individualized treatment are critical in managing this chronic condition.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"445-450"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterior Uveitis From Retained Perfluorocarbon Liquid in the Anterior Chamber, A Case Report. 前房残留全氟碳液体致前葡萄膜炎1例报告
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S517908
Gabriel A Gomide, Ryan Zukerman, Royce W S Chen
{"title":"Anterior Uveitis From Retained Perfluorocarbon Liquid in the Anterior Chamber, A Case Report.","authors":"Gabriel A Gomide, Ryan Zukerman, Royce W S Chen","doi":"10.2147/IMCRJ.S517908","DOIUrl":"10.2147/IMCRJ.S517908","url":null,"abstract":"<p><strong>Purpose: </strong>Perfluorocarbon liquids (PFCL) are routinely used in vitreoretinal surgery to flatten the retina and push subretinal fluid. Perfluorocarbon liquid retention is a common complication of vitreoretinal surgery. While retention in the posterior chamber can lead to an inflammatory response, PFCL in the anterior chamber has been shown to be generally well tolerated.</p><p><strong>Patients and methods: </strong>This report summarizes the findings and treatment of a patient with pathologic myopia and a history of retinal detachment in the left eye repaired with pars plana vitrectomy presenting with one week of blurry vision in the left eye. He was found to have an initial intraocular pressure of 54 mmHg in the left eye along with 1+ conjunctival injection, fine and medium-sized keratic precipitates on the cornea, and 30 cells per high power field. Additionally, there was a retained perfluorocarbon liquid bubble in the anterior chamber from his original retinal detachment repair surgery.</p><p><strong>Results: </strong>After being started on topical steroids and pressure lowering medications, the patient had persistent inflammation and elevated intraocular pressures. The patient's anterior uveitis and elevated intraocular pressure resolved with removal of the perfluorocarbon liquid bubble by anterior chamber tap.</p><p><strong>Conclusion: </strong>Retained PFCL in the anterior chamber can cause anterior uveitis and can be promptly treated by removal.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"439-443"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exuberant Granulation Complicating an Episiotomy Wound: Case Report on the Treatment Using Surgical Excision and Estrogen Vaginal Cream. 会阴切口并发大量肉芽肿:手术切除加阴道雌激素乳膏治疗一例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S505949
Nnabuike Chibuoke Ngene
{"title":"Exuberant Granulation Complicating an Episiotomy Wound: Case Report on the Treatment Using Surgical Excision and Estrogen Vaginal Cream.","authors":"Nnabuike Chibuoke Ngene","doi":"10.2147/IMCRJ.S505949","DOIUrl":"10.2147/IMCRJ.S505949","url":null,"abstract":"<p><strong>Background: </strong>Poor wound healing may limit body functionality and is an indication for clinical intervention. Excessive formation of granulation tissue above the edge of the skin surrounding a wound without re-epithelization is termed exuberant granulation, or proud flesh. It is uncommonly reported as a complication of an episiotomy wound.</p><p><strong>Aim: </strong>This study aimed to report exuberant granulation that complicates an episiotomy wound with a friable vaginal epithelium and to describe the successful treatment of the lesion with surgical excision and topical conjugated equine estrogen vaginal cream.</p><p><strong>Case report: </strong>A 24-year-old para 1 had spontaneous vaginal birth of a normal baby at term in a district hospital. Five months later, she presented to a regional hospital with complaints of pain and incomplete wound healing at the episiotomy site. She had used topical povidone-iodine ointment with no success. Following a physical examination, an exuberant granulation at the episiotomy wound was diagnosed. The lesions were located mostly at 5 to 7 o'clock position in the vagina which had a thin and friable mucosa. The patient was treated with surgical excision and postoperative topical conjugated equine estrogen vaginal cream 0.625 mg per 1 g at a dose of 0.5 g per intravaginal application twice weekly for two weeks, and thereafter once weekly for one week. A review after 6 weeks, 12 weeks, and 6 months confirmed complete wound healing and normal function of the genitalia.</p><p><strong>Conclusion: </strong>Exuberant granulation that complicates an episiotomy wound with friable vaginal mucosa is amenable to surgical excision and postoperative intermittent intermediate doses of topical conjugated equine estrogen vaginal cream.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"427-432"},"PeriodicalIF":0.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of HSV Encephalitis Misdiagnosed as Worsening Psychiatric Condition: A Case Report. 一例被误诊为精神状况恶化的 HSV 脑炎病例:病例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S495100
Elham Abdulhakim Mohammed, Medhanet Azene Gebeyehu, Muhudin Arusi Dari, Yodit Alemayehu
{"title":"A Case of HSV Encephalitis Misdiagnosed as Worsening Psychiatric Condition: A Case Report.","authors":"Elham Abdulhakim Mohammed, Medhanet Azene Gebeyehu, Muhudin Arusi Dari, Yodit Alemayehu","doi":"10.2147/IMCRJ.S495100","DOIUrl":"10.2147/IMCRJ.S495100","url":null,"abstract":"<p><p>Herpes simplex virus (HSV) encephalitis is uncommon but serious condition that can lead to significant morbidity and mortality if not promptly diagnosed and treated. Atypical presentations are becoming more common with improved diagnostic methods, but they remain underexplored. We present the case of a 29-year-old known patient with schizophrenia for the past four years on olanzapine 5 mg PO BID who initially presented to psychiatry emergency with difficulty in proper communication, auditory hallucination, blurring of the eyes, and depressive symptoms for which olanzapine was discontinued, trifluoperazine 5 mg PO daily was initiated, and lorazepam 1 mg p. o. nocturnal was added after the diagnosis of schizophrenia relapse. Despite the above management, the patient presented with abnormal body movements characterized by up-rolling of the eyes, drooling of saliva, jaw jerking followed by repetitive flexion and extension of the upper and lower extremities, and postictal loss of consciousness. He also had low-grade fever and headache for 5 days. The patient was started on phenobarbitone 100 mg PO nocturnal and escalated. However, the frequency of seizures increased. Clinical evaluation, MRI, and EEG eventually confirmed HSV encephalitis. The patient was administered acyclovir 500 mg intravenously every 8 hours for 21 days. After antiviral therapy, the patient was discharged with antiepileptic and antipsychotic medications 18 days after the seizure-free period with significant improvement. Here, we illustrate that HSV encephalitis can present in unfamiliar manner and reinforce the need for a low index of suspicion and early empirical use of acyclovir until definitive laboratory test results are available.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"433-437"},"PeriodicalIF":0.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Herpes Zoster-Associated Neurological Complications with High-Dose Intravenous Ascorbic Acid: Two Case Reports. 静脉注射大剂量抗坏血酸治疗带状疱疹相关神经系统并发症2例报告
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S514241
Raushan Auezova, Assem Adirakhan, Kamila Mussabekova, Nurgul Aldiyarova, Serik Akshulakov, Lizette Auezova
{"title":"Treatment of Herpes Zoster-Associated Neurological Complications with High-Dose Intravenous Ascorbic Acid: Two Case Reports.","authors":"Raushan Auezova, Assem Adirakhan, Kamila Mussabekova, Nurgul Aldiyarova, Serik Akshulakov, Lizette Auezova","doi":"10.2147/IMCRJ.S514241","DOIUrl":"10.2147/IMCRJ.S514241","url":null,"abstract":"<p><strong>Background: </strong>Herpes zoster (HZ), caused by reactivation of the varicella zoster virus, can be associated with serious and difficult-to-treat neurological complications, especially in immunocompromised people. Ascorbic acid (Asc) administered intravenously in high doses has been shown to possess immunomodulatory and anti-inflammatory effects. Here, we report two cases of patients: 1) with postherpetic neuralgia (PHN) and 2) with myelitis presumably caused by HZ, who were successfully treated using this approach as adjunctive therapy. Regarding HZ-related myelitis, this is the first reported case to our knowledge.</p><p><strong>Cases presentation: </strong>A 72-year-old male came to the clinic with treatment-resistant postherpetic trigeminal neuralgia and cervical sympathetic ganglionitis. He rated pain intensity as 10 on the visual analogue scale (VAS). The second patient, a 34-old female, was referred with a preliminary diagnosis of cervical myelitis. She suffered from right-sided sensory-motor impairments and urinary retention. Previous treatment did not result in improvement. Neurological and MRI findings were typical of cervico-thoracic myelitis associated with right-sided hemiparesis. Two months before the onset of the first symptoms, she developed a HZ rash in the cervico-occipital region on the right, suggesting an association between HZ and myelitis. Both patients received two courses of Asc (each course consisting of 20 g administered intravenously daily for five days). The male noted a gradual pain relief from the initial 10 to 2 points on the VAS, with only a slight increase at night. In the female's case, hemiparesis regressed and bladder function was restored. Only mild neurological deficits remained.</p><p><strong>Conclusion: </strong>This study supports the use of high-dose intravenous Asc as adjunctive therapy for HZ-associated neuralgia and myelitis, especially in treatment-resistant cases. In order to determine the optimal dosages, it is necessary to perform clinical trials. Furthermore, it would be interesting to study the potential use of Asc therapy for other HZ-related complications.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"421-425"},"PeriodicalIF":0.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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