Platelet-Rich Plasma Therapy in Premature Ovarian Insufficiency: A Case Series of IVF Outcomes.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

International Medical Case Reports Journal Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S527318

Rina Nulianti, Syahnural Lubis, Tita Husnitawati Madjid, Wiryawan Permadi, Putri Nadhira Adinda Adriansyah, Aisyah Shofiatun Nisa

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引用次数: 0

Abstract

Introduction: Premature ovarian insufficiency (POI) leads to the early loss of ovarian function before age 40, resulting in infertility and hormonal imbalance. Despite the use of assisted reproductive technologies (ART), success rates remain low in this population. Platelet-rich plasma (PRP) therapy is emerging as a potential adjunct to enhance ovarian reserve.

Case illustrationcase 1: A 25-year-old nulliparous woman with a history of ectopic pregnancy and an anti-Müllerian hormone (AMH) level below 1 ng/mL received two PRP injections scheduled between days 7 to 12 of her cycle. After the first injection, her AMH level remained <0.5 ng/mL. Following the second PRP injection, her AMH level increased to >0.5 ng/mL. A frozen embryo transfer resulted in a successful term pregnancy and healthy newborn.

Case 2: A 36-year-old nulliparous woman, married for seven years, also presented POI and AMH levels <1 ng/mL followed the same PRP and IVF protocol. After two PRP sessions, her AMH levels improved similarly to Case 1. Despite an initial pregnancy, the patient experienced pregnancy loss.

Conclusion: These findings suggest that PRP may improve ovarian response in women with POI undergoing IVF. Further studies are warranted.

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富血小板血浆治疗卵巢功能不全：IVF结果的病例系列。

卵巢功能不全（POI）导致卵巢功能在40岁之前早期丧失，导致不孕和激素失衡。尽管使用了辅助生殖技术（ART），但这一人群的成功率仍然很低。富血小板血浆（PRP）治疗正在成为一种潜在的辅助手段，以增强卵巢储备。病例说明病例1：一名25岁的未生育妇女，有异位妊娠史，抗勒氏杆菌激素（AMH）水平低于1ng /mL，在月经周期的第7天至第12天接受两次PRP注射。第一次注射后，AMH水平维持在0.5 ng/mL。冷冻胚胎移植导致成功足月妊娠和健康新生儿。病例2：一名36岁未婚妇女，结婚7年，也出现了POI和AMH水平。结论：这些发现表明PRP可能改善POI妇女接受体外受精的卵巢反应。进一步的研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

135

审稿时长

16 weeks

期刊介绍： International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.