International Medical Case Reports Journal最新文献

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Solitary Glomus Tumor on the Base of the Right Thumb: A Rare Case Report and a Literature Review from Saudi Arabia 右拇指基部的孤立性结节瘤:沙特阿拉伯罕见病例报告和文献综述
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-04-01 DOI: 10.2147/imcrj.s456808
Amr Arkoubi
{"title":"Solitary Glomus Tumor on the Base of the Right Thumb: A Rare Case Report and a Literature Review from Saudi Arabia","authors":"Amr Arkoubi","doi":"10.2147/imcrj.s456808","DOIUrl":"https://doi.org/10.2147/imcrj.s456808","url":null,"abstract":": A glomus tumor (GT) is a rare and usually benign tumor that originates from the glomus body, which is involved in thermoregulation in the skin. Solitary or multiple, digital or extra-digital, these cutaneous tumors can be benign or malignant. This report describes the diagnosis and surgical management of a solitary glomus tumor at the base of the right thumb in a young Sudanese woman. The diagnosis of glomus tumor was confirmed by medical history, sonographic findings and histopathological report. The lesion was excised via direct complete excision under local anesthesia, resulting in a complete resolution of symptoms. Owing to its high sensitivity level, the use of ultrasound is appropriate to evaluate a lesion suspected to be a glomus tumor. A clinician needs to take into consideration the likelihood of glomus tumors when assessing a patient who has a skin lesion on fingers, toes, or extra-digital area, with pain triggered by temperature changes, pressure, or touch. Additionally, this report includes a review of recent globally reported cases of glomus tumor in the hand to highlight the distinctiveness of this report in context to its atypical location in the area of the thenar eminence and underscoring it as a unique report of its kind from Saudi Arabia.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Intranasal Melanotic Mucosal Melanoma – A Case Report and Literature Review 原发性鼻腔内黏膜黑色素瘤--病例报告和文献综述
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-04-01 DOI: 10.2147/IMCRJ.S458817
Samson Gashaw, Waltengus Birhanu, Fitsum Alemayehu
{"title":"Primary Intranasal Melanotic Mucosal Melanoma – A Case Report and Literature Review","authors":"Samson Gashaw, Waltengus Birhanu, Fitsum Alemayehu","doi":"10.2147/IMCRJ.S458817","DOIUrl":"https://doi.org/10.2147/IMCRJ.S458817","url":null,"abstract":"Background Intranasal mucosal melanoma is a rare form of melanoma. Presenting as the features of occult malignancy and rapid in its progression. Presented with nonspecific symptoms. So far, no specific risk factor has been identified. The histopathological and immunohistochemical examination helps to confirm the diagnosis. Here, we present a case of primary intranasal melanotic mucosal melanoma and literature review. Case Report The authors present a patient with primary right intranasal melanotic mucosal melanoma. Conclusion An endoscopic medial maxillectomy was done, and the patient was linked to the oncology department for radiotherapy.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Treatment of Chest Deformity in a Patient with Poland Syndrome. Clinical Case Report. 波兰综合征患者胸部畸形的手术治疗。临床病例报告。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-27 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S441944
Ablaikhan Kazbekov, Olzhas Bekarisov, Kairat Tazhin
{"title":"Surgical Treatment of Chest Deformity in a Patient with Poland Syndrome. Clinical Case Report.","authors":"Ablaikhan Kazbekov, Olzhas Bekarisov, Kairat Tazhin","doi":"10.2147/IMCRJ.S441944","DOIUrl":"10.2147/IMCRJ.S441944","url":null,"abstract":"<p><strong>Introduction: </strong>Poland syndrome is a rare congenital syndrome that is characterized by partial or complete unilateral absence of the pectoralis major muscle, congenital malformation of the hand and deformation of the chest. Often the patients has abnormalities of the nipple-areolar complex. Here, we present a case of surgical treatment of local chest deformity with patient with Poland syndrome.</p><p><strong>Case presentation: </strong>We observed a patient, an 18-year-old man. The parents noticed the deformation of the chest from birth. The patient did not receive any treatment until adulthood. The patient contacted our clinical research center to correct chest deformity. After clinical and diagnostic procedures, the patient underwent surgical operation: open thoracoplasty with installation of a wire-frame construction. The early postoperative period was uneventful. Early postoperative outcome was assessed 6 months after surgery.</p><p><strong>Conclusion: </strong>Our experience shows that thoracoplasty using a wire-frame construction is a good method for correcting local chest deformities in patients with Poland syndrome.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140338538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary Artery Fistula and Severe Coronary Artery Stenosis: A Case Report and an Insight for Potential Pathogenesis of Coronary Artery Atherosclerosis. 冠状动脉瘘和严重冠状动脉狭窄:病例报告和对冠状动脉粥样硬化潜在发病机制的启示。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-26 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S442878
Jinchun Liu, Zhijun Yu, Guohua Wang
{"title":"Coronary Artery Fistula and Severe Coronary Artery Stenosis: A Case Report and an Insight for Potential Pathogenesis of Coronary Artery Atherosclerosis.","authors":"Jinchun Liu, Zhijun Yu, Guohua Wang","doi":"10.2147/IMCRJ.S442878","DOIUrl":"10.2147/IMCRJ.S442878","url":null,"abstract":"<p><p>Coronary artery fistulae (CAF) are a rare anomaly characterized by abnormal connections between a coronary artery and a cardiac chamber or a great vessel, with most patients remaining asymptomatic. Despite being predisposed to severe complications like heart failure, patients with CAF infrequently experience severe stenosis in the coronary artery. This study delineates a case involving a 46-year-old male presenting with a fistula bridging the right coronary artery (RCA) and right atrium (RA), manifesting a pronounced 99% stenosis at the right extremity of the coronary artery proximal to the fistula. Concurrently, the individual exhibits six conventional risk factors: age over 40, male gender, hypertension, diabetes, smoking, and hypertriglyceridemia. Following pharmaceutical intervention, the patient was discharged and subjected to extended follow-up. This case highlights the dual processes of \"accelerating damage\" and \"retarding renewal\" in the progression of atherosclerosis. Factors such as shear stress, smoking, and hypertension are posited to expedite endothelial cell damage, while aging and diabetes may impede the renewal and repair of these cells. Together with the concept of secondary atherosclerotic plaque healing, this case prompts the introduction of a \"Double Endothelial Healings\" hypothesis, proposing a potential pathogenetic mechanism for coronary artery atherosclerosis.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhino-Orbital Cerebral Mucormycosis in a Healthy Female Child: Case Report. 一名健康女婴的鼻眶脑粘液瘤病:病例报告。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-26 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S454697
Abdisalam Abdullahi Yusuf, Ismail Gedi Ibrahim, Ibrahim Mohamed Hirsi, Ali Adali, Yonis Yusuf Hassan, Mehmet Zeki Yasar, Ismail Mohamoud Abdullahi, Mohamed Sheikh Hassan
{"title":"Rhino-Orbital Cerebral Mucormycosis in a Healthy Female Child: Case Report.","authors":"Abdisalam Abdullahi Yusuf, Ismail Gedi Ibrahim, Ibrahim Mohamed Hirsi, Ali Adali, Yonis Yusuf Hassan, Mehmet Zeki Yasar, Ismail Mohamoud Abdullahi, Mohamed Sheikh Hassan","doi":"10.2147/IMCRJ.S454697","DOIUrl":"10.2147/IMCRJ.S454697","url":null,"abstract":"<p><p>Mucormycosis is a potentially fatal condition with a high mortality rate, particularly when there is extra nasal involvement, and it is rare for patients with fungal brain disease to survive. It mostly affects patients who are metabolically or immunologically compromised, which constitutes one of the three classical stages of the progression of Rhino-Orbito-Cerebral Mucormycosis (ROCM). Stage I: infection of the nasal mucosa and paranasal sinuses; Stage II: orbital involvement; Stage III: cerebral involvement.Here, we report a case of rhino-orbital cerebral mucormycosis in a 14-year-old girl with no known risk factor who presented with periorbital edema, right eye proptosis, fever, and extreme facial pain, which progressively worsened to confusion and left leg weakness in 3 days after admission. The final diagnosis was rhino-orbital-cerebral mucormycosis. The infection was successfully treated using liposomal amphotericin and surgical debridement to remove infected orbital tissue. Mucormycosis is a potentially fatal disease that necessitates prompt diagnosis and treatment. Children are rarely infected with mucormycosis. The majority of studies show that people are typically between 40 and 50 years old. ROCM is typically diagnosed using clinical symptoms and histopathologic evaluation; however, imaging is critical in determining the presence of intracranial lesion<b>s</b>. The standard treatment for ROCM is amphotericin B at a recommended dose of 1.0-1.5 mg/kg/day for weeks or months, depending on the clinical response and severity of adverse drug reactions, particularly nephrotoxicity.Rhino-orbital cerebral mucormycosis in a healthy female child is uncommon; early diagnosis and prompt treatment with Amphotericin B should be necessary. Devastating consequences will result from a delayed diagnosis.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corticosteroid Therapy in Acute and Subacute Arachnoiditis - A Case Series. 急性和亚急性蛛网膜炎的皮质类固醇疗法--病例系列。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-26 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S445705
Yeng F Her, Ryan T McWilliams, Erik A Ovrom, James C Watson
{"title":"Corticosteroid Therapy in Acute and Subacute Arachnoiditis - A Case Series.","authors":"Yeng F Her, Ryan T McWilliams, Erik A Ovrom, James C Watson","doi":"10.2147/IMCRJ.S445705","DOIUrl":"10.2147/IMCRJ.S445705","url":null,"abstract":"<p><p>Arachnoiditis is difficult to treat. Patients are often left frustrated after many failed trials of conservative therapies without symptom resolution. Surgery may provide symptom relief for a short period of time, but their pain often returned. Herein, we present three cases of acute arachnoiditis following three different pain procedures: epidural blood patch, IDDS implant, and epidural steroid injection. The patients were diagnosed and treated with corticosteroids within 10 days of the procedure. Two patients were treated with the same oral steroid regiment, while the third patient was treated with both oral and IV steroid. All three patients had good outcomes at the completion of their steroid therapy. This case series may provide insight into treating acute and subacute arachnoiditis from pain interventions.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tibial Adamantinoma: A Case Report from a Resource-Limited-Setting. 胫骨金刚瘤:来自资源有限地区的病例报告
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-25 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S440401
Yodit Abraham Yaynishet, Shimalis Tadasa Fayisa, Bereket Amare Dencha, Samuel Sisay Hailu
{"title":"Tibial Adamantinoma: A Case Report from a Resource-Limited-Setting.","authors":"Yodit Abraham Yaynishet, Shimalis Tadasa Fayisa, Bereket Amare Dencha, Samuel Sisay Hailu","doi":"10.2147/IMCRJ.S440401","DOIUrl":"10.2147/IMCRJ.S440401","url":null,"abstract":"<p><strong>Introduction: </strong>Adamantinoma is an infrequent, low-grade malignant bone tumor, predominantly affecting the tibia and often presents diagnostic challenges due to its nonspecific radiographic characteristics.</p><p><strong>Case presentation: </strong>A 55-year-old military personnel, with no history of trauma, who presented with a one-year history of right leg swelling and pain. Radiological examination showed right anterior tibial, mid diaphyseal lytic expansile lesion with internal trabeculations and excisional biopsy led to the diagnosis of adamantinoma. Below knee amputation was done as a definitive management.</p><p><strong>Conclusion: </strong>Despite diagnostic challenges adamantinoma presents, the patient was referred to oncology and underwent amputation, underscoring the importance of considering adamantinoma in differential diagnosis for persistent bone lesions.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Second Trimester Spontaneous Fundal Rupture of Unscarred Bicornuate Uterus in Primipara: A Case Report and Literature Review; Jigjiga University Sheik Hassen Yabare Comprehensive Specialized Hospital, Jigjiga, Ethiopia. 初产妇无痕双角子宫第二孕期自发性宫底破裂:病例报告和文献综述;埃塞俄比亚吉吉加,吉吉加大学谢克-哈森-亚巴雷综合专科医院。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-19 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S446718
Hassen Mohammed Areys, Nour Hies Omer, Osman Ali Osman
{"title":"Second Trimester Spontaneous Fundal Rupture of Unscarred Bicornuate Uterus in Primipara: A Case Report and Literature Review; Jigjiga University Sheik Hassen Yabare Comprehensive Specialized Hospital, Jigjiga, Ethiopia.","authors":"Hassen Mohammed Areys, Nour Hies Omer, Osman Ali Osman","doi":"10.2147/IMCRJ.S446718","DOIUrl":"10.2147/IMCRJ.S446718","url":null,"abstract":"<p><strong>Background: </strong>Primary rupture of an unscarred uterus is rare. Spontaneous rupture of an unscarred bicornuate uterus is a life-threatening obstetric emergency with high morbidity and mortality in the mother and fetus; however, it most commonly occurs in the first trimester of pregnancy.</p><p><strong>Case: </strong>A 20-year-old primigravid woman at 22 weeks of gestation, with no prior surgery, presented with severe abdominal pain, anemia, and hemodynamic instability. With a preoperative diagnosis of uterine rupture, she was transfused with three units of cross-matched whole blood and underwent emergency laparotomy. Intraoperative findings showed a ruptured bicornuate uterus and a dead fetus in the abdomen with huge hemoperitoneum. Postoperative recovery was smooth, and the patient was discharged after being counselled on family planning and subsequent pregnancy.</p><p><strong>Conclusion: </strong>A bicornuate uterus may be an independent risk factor for uterine rupture, which can occur in primigravid women at any stage of pregnancy. Each obstetrician should have a high index of suspicion for a rare condition like ruptured bicornuate uterus, especially for a pregnant woman presenting with acute abdominal pain and hemodynamic instability. Early ultrasonography plays a key role in the evaluation, follow-up, and management of these patients.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Bowel Obstruction Due to Transmural Migration of Gossypiboma: A Case Report. 格氏纤维瘤跨壁移位导致的急性肠梗阻:病例报告
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-19 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S458658
Ghulam Yahia Baset, Farukh Seyar, Zaker Hussain Hussain Pour, Qurban Ali Karimi
{"title":"Acute Bowel Obstruction Due to Transmural Migration of Gossypiboma: A Case Report.","authors":"Ghulam Yahia Baset, Farukh Seyar, Zaker Hussain Hussain Pour, Qurban Ali Karimi","doi":"10.2147/IMCRJ.S458658","DOIUrl":"10.2147/IMCRJ.S458658","url":null,"abstract":"<p><p>gossypiboma is used to describe a retained surgical swab in the body after an operation. It remains an unwanted complication of surgical practice that increase morbidity and mortality of the patient and profound medico legal problems. Intra-abdominal gossypiboma can migrate in to the ileum, stomach, colon or bladder without any apparent opening in the wall of these luminal organs. Vigilant sponge counting during procedures and thorough exploration prior to closure of the abdomen, are essential practices to avoid such occurrences. Herein we present a case of gossypiboma in a 26-year old woman that was in the lumen of small bowel and caused acute intestinal obstruction.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Outcome of a Patient with Concomitant Pancreatic and Renal Carcinoma Receiving Secoisolariciresinol Diglucoside Therapy Alone: A Case Report. 一名胰腺癌和肾癌并发患者单独接受 Secoisolariciresinol Diglucoside 治疗获得成功:病例报告。
IF 0.9
International Medical Case Reports Journal Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.2147/IMCRJ.S446184
Hao Wu, Xing-Hua Zhang, Li-Ping Wang, Hong-Da Tian, Gui-Rong Liu, Dong-Hui Yang, Shu-Lin Liu
{"title":"Successful Outcome of a Patient with Concomitant Pancreatic and Renal Carcinoma Receiving Secoisolariciresinol Diglucoside Therapy Alone: A Case Report.","authors":"Hao Wu, Xing-Hua Zhang, Li-Ping Wang, Hong-Da Tian, Gui-Rong Liu, Dong-Hui Yang, Shu-Lin Liu","doi":"10.2147/IMCRJ.S446184","DOIUrl":"https://doi.org/10.2147/IMCRJ.S446184","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreatic cancer (PC) is among the deadliest malignancies. Kidney cancer (KC) is a common malignancy globally. Chemo- or radio-therapies are not very effective to control PC or KC, and overdoses often cause severe site reactions to the patients. As a result, novel treatment strategies with high efficacy but without toxic side effects are urgently desired. Secoisolariciresinol diglucoside (SDG) belongs to plant lignans with potential anticancer activities, but clinical evidence is not available in PC or KC treatment.</p><p><strong>Patient concerns: </strong>We report a rare case of an 83-year-old female patient with pancreatic and kidney occupying lesions that lacked the conditions to receive surgery or chemo- or radiotherapy.</p><p><strong>Diagnosis: </strong>Pancreatic and kidney cancers.</p><p><strong>Interventions: </strong>We gave dietary SDG to the patient as the only therapeutics.</p><p><strong>Outcomes: </strong>SDG effectively halted progression of both PC and KC. All clinical manifestations, including bad insomnia, loss of appetite, stomach symptoms, and skin itching over the whole body, all disappeared. The initial massive macroscopic hematuria became microscopic and infrequent, and other laboratory results also gradually returned to normal. Most of the cancer biomarkers, initially high such as CEA, CA199, CA724, CA125, came down rapidly, among which CA199 changed most radically. This patient has had progression-free survival of one year so far.</p><p><strong>Conclusion: </strong>These results demonstrate the potent inhibitory effects of SDG on PC and KC of this patient and provide promising novel therapeutics for refractory malignant tumors.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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