Dafne Fernandes Machado, Stela Souza Peña, Mariana Carneiro Alves, Giovana Capecci Siqueira, Leonardo Amarante Pereira, Samantha Sanches de Carvalho, Thais Moura Gascon, Beatriz da Costa Aguiar Alves, Glaucia Luciano da Veiga, Fernando Luiz Affonso Fonseca, Vagner Loduca Lima, Priscilla Ballalai
{"title":"Atypical Presentation of Choroidal Osteoma: Two Case Reports.","authors":"Dafne Fernandes Machado, Stela Souza Peña, Mariana Carneiro Alves, Giovana Capecci Siqueira, Leonardo Amarante Pereira, Samantha Sanches de Carvalho, Thais Moura Gascon, Beatriz da Costa Aguiar Alves, Glaucia Luciano da Veiga, Fernando Luiz Affonso Fonseca, Vagner Loduca Lima, Priscilla Ballalai","doi":"10.2147/IMCRJ.S495500","DOIUrl":"10.2147/IMCRJ.S495500","url":null,"abstract":"<p><p>Choroidal osteoma is a rare, benign, osseous choristoma presenting as an orange-yellow, well-defined fundus mass. It presents unilaterally in most cases, has a predilection for the female sex, and favor a juxtapapillary location, becoming clinically manifest when it involves the macula. Almost 60% of eyes with osteoma may suffer significant visual loss. Choroidal osteomas can easily be mistaken for other conditions with similar presentations. We herein report two rare cases presentation of choroidal osteoma: a 74-year-old male with 2-year blurred vision in the right eye (RE) initially misdiagnosed with age-related macular degeneration received intravitreal injections and after a multimodal evaluation, following cataract surgery in RE, confirmed to be choroidal osteoma and a 19-year-old female with a history of choroidal hemangioma presented with blurred vision in her left eye (LE), with examination revealed an irregular orange-yellow lesion along the superotemporal arcade with serous macular detachment, later diagnosed as choroidal osteoma.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"891-894"},"PeriodicalIF":0.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Community-Acquired Pneumonia with Acute Kidney Injury Complicated by Rhabdomyolysis- A Challenging Case Report in Resource Limit Setting.","authors":"Ibrahim Abdullahi Mohamed, Abdullahi Abdirahman Omar, Mohamed Abdulahi Hassan, Omar Hassan Badawi","doi":"10.2147/IMCRJ.S492874","DOIUrl":"10.2147/IMCRJ.S492874","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired pneumonia (CAP) is a common infectious disease that can lead to complications such as rhabdomyolysis (RM), a rare but potentially life-threatening condition involving muscle breakdown. RM can further complicate the clinical course by causing acute kidney injury (AKI). We present a case of Community-acquired pneumonia with AKI complicated by rhabdomyolysis in a resource-limited setting.</p><p><strong>Case presentation: </strong>A 67-year-old male presented with high fever, cough, and shortness of breath. He had no significant medical history. On examination, he was febrile, tachypneic, and tachycardic, with right-sided lung crackles. Lab tests showed elevated inflammatory markers and impaired kidney function. Chest radiography revealed right upper lobe consolidation, confirming pneumonia and AKI. He was treated with fluids, antibiotics, and supportive care, but his condition worsened, requiring intensive care unit (ICU). In the ICU, dark urine and elevated creatine kinase confirmed rhabdomyolysis. After aggressive fluid therapy and antibiotics the patient improved over six days and was transferred to the ward. By day 10, he fully recovered and was discharged with follow-up.</p><p><strong>Conclusion: </strong>This case underscores the importance of early recognition and prompt management of CAP complicated by AKI and rhabdomyolysis, even in resource-limited settings. Timely intervention can lead to favorable outcomes despite challenges.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"895-901"},"PeriodicalIF":0.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of Placenta Extract Intake on Periodontal Diseases and Oral Environment: A Case Series.","authors":"Hizuru Miyamoto, Kentarou Tahara, Eiichi Hirano","doi":"10.2147/IMCRJ.S487611","DOIUrl":"10.2147/IMCRJ.S487611","url":null,"abstract":"<p><strong>Background: </strong>The placenta extract is used as a dietary supplement. We aimed to investigate the effects of placenta extract on periodontal disease.</p><p><strong>Case presentation: </strong>In this study, placenta extract supplements were found to improve the oral environment of young and middle-aged Japanese women undergoing maintenance; after three months of taking placenta extract, bleeding upon probing was reduced. In addition, two parameters, white blood cells and protein, improved in the SillHa test, suggesting that the placenta extract contributes to the reduction of gingival inflammation through its anti-inflammatory effect. No adverse events were observed with the placenta extract.</p><p><strong>Conclusion: </strong>Placenta extract may lead to better management, including oral rehabilitation and pharmacotherapy. However, its effect on gingival inflammation requires further investigation in a larger number of cases.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"883-890"},"PeriodicalIF":0.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin a Deficiency in an Elderly Patient: A Diagnostic Challenge in the Age of AMD.","authors":"Jakob M Pericak, Eric K Chin, David R P Almeida","doi":"10.2147/IMCRJ.S472944","DOIUrl":"https://doi.org/10.2147/IMCRJ.S472944","url":null,"abstract":"<p><p>The presentation of vitamin A deficiency (VAD)-induced ocular complications can be challenging to diagnose in elderly patients, particularly due to the overlap with age-related macular degeneration (AMD) symptoms. This case report details the presentation, diagnosis, and management of an 88-year-old female with vision loss, highlighting the ocular manifestations of presumed VAD. Despite vitamin A levels being at the lower end of the normal range, the patient's symptoms and spectral domain optical coherence tomography (SD-OCT) findings suggested insufficient levels, leading to thinning of the outer nuclear layer. This case underscores the necessity of considering VAD in differential diagnoses of unexplained vision impairment, particularly in individuals with a history of intestinal malabsorption, while also emphasizing the importance of distinguishing VAD from AMD in elderly patients.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"879-881"},"PeriodicalIF":0.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Improvement of Xerostomia and Reduction of Anxiety Score in a Patient with Generalized Anxiety Disorder and Recalcitrant Geographic Tongue: A Case Report and Literature Review.","authors":"Nadia Tiara Putri, Faiznur Ridho, Indah Suasani Wahyuni","doi":"10.2147/IMCRJ.S480332","DOIUrl":"10.2147/IMCRJ.S480332","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of post-pandemic psychiatric disorders has increased globally in recent decades. Generalized anxiety disorder (GAD) is one of the psychiatric disorders that are partially associated with emotional factors. It can affect the quantity and quality of saliva, present as xerostomia, and trigger the emergence of the geographic tongue (GT).</p><p><strong>Purpose: </strong>This case report aims to discuss the management of xerostomia and geographic tongue in a patient with GAD.</p><p><strong>Case: </strong>A 26-year-old male patient complained of dry and sore mouth for one month after taking medication from the psychiatry department, was diagnosed with GAD, and had already consumed the antidepressant sertraline. Extraoral examination showed dry and exfoliative lips. Intraoral examination showed white plaque with depapilation on the dorsal tongue, frothy saliva, buccal mucosa and dorsal tongue sticking to the dental mirror. The unstimulated salivary flow rate was <0.2 mL/min (sialometry method). The Depression, Anxiety, and Stress Scale-21 (DASS-21) questionnaire was used to estimate the psychological condition and showed an extremely severe level of anxiety (score = 13). The established oral diagnoses were GT with mild xerostomia and exfoliative cheilitis.</p><p><strong>Case management: </strong>For two months, patients received hyaluronic acid gel and mouthwash, as well as a non-pharmacological approach to healthy lifestyle counseling. There was an improvement in xerostomia, and the GT became asymptomatic, with a reduction of DASS score in this patient.</p><p><strong>Conclusion: </strong>Improved psychological conditions will improve xerostomia, but the clinical appearance of the geographic tongue is more difficult to eliminate.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"869-877"},"PeriodicalIF":0.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Bellia, Mariangela Greco, Monia Lunghi, Riccardo Moia, Gianluca Gaidano, Andrea Patriarca
{"title":"A Rare Case of Life-Threatening Jaundice Caused by Epstein-Barr Virus Infection and Secondary Cold Agglutinin Syndrome Successfully Treated with Rituximab.","authors":"Matteo Bellia, Mariangela Greco, Monia Lunghi, Riccardo Moia, Gianluca Gaidano, Andrea Patriarca","doi":"10.2147/IMCRJ.S477296","DOIUrl":"10.2147/IMCRJ.S477296","url":null,"abstract":"<p><strong>Background: </strong>Jaundice and hyperbilirubinemia are common clinical problems characterized by the presence of bile pigments in the blood and their deposition in body tissues. This clinical condition can be associated with a broad spectrum of potential benign and malignant causes, including hepatic inflammation, biliary obstruction, impaired bilirubin conjugation and bilirubin overproduction Therefore, the hyperbilirubinemia diagnostic work-up sometimes can be highly challenging and its therapeutic management can require a multidisciplinary approach.</p><p><strong>Case report: </strong>We report on a unique case of life-threatening jaundice and hepatic failure in a 20-year-old female who presented to the emergency room with complaints of fever, constant left abdominal pain and generalized profuse fatigue. A complete and detailed medical history, multiple tests for various infection, radiologic investigations and histological tests were performed in order to clarify the etiology of that rapidly progressive clinical condition. Based on the results, the patient jaundice was caused by an Epstein-Barr virus (EBV) infection and secondary cold agglutinin syndrome. Given the rare and complex diagnosis, multiple clinical specialists were asked to carry out the best patient management.</p><p><strong>Conclusion: </strong>This rare case highlights how challenging the differential diagnosis and treatment of hyperbilirubinemia can be, presenting a unique case of life-threatening multifactorial hepatic failure treated successfully with rituximab.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"861-867"},"PeriodicalIF":0.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heiler Lozada-Ramos, Jorge Álvarez-Payares, Jorge Enrique Daza-Arana, Luisa María Salas-Marín
{"title":"Cryptococcal Meningitis in an HCV-Positive and IVDU- and HIV-Negative Patient: A Case Report and Literature Review.","authors":"Heiler Lozada-Ramos, Jorge Álvarez-Payares, Jorge Enrique Daza-Arana, Luisa María Salas-Marín","doi":"10.2147/IMCRJ.S486119","DOIUrl":"10.2147/IMCRJ.S486119","url":null,"abstract":"<p><strong>Background: </strong>Cryptococcal meningitis (CM) is a central nervous system (CNS) infection that occurs mainly in immunocompromised individuals such as those with human immunodeficiency virus (HIV) infection. However, the prevalence of CM in immunocompetent patients has increased. Although CM has been reported in patients with hepatitis C virus (HCV) infection, it has not yet been fully established whether there is an association between both conditions. CM has also been reported in patients with intravenous drug use (IVDU), which is related to the immunosuppression caused by these drugs.</p><p><strong>Case presentation: </strong>We report the case of a 24-year-old man who presented with meningitis secondary to <i>Cryptococcus gattii</i> infection. He had a history of IVDU and HCV infection, was HIV-negative and without antiviral treatment. The patient received adequate antifungal treatment during induction, consolidation, and maintenance phases. His condition relapsed, requiring dose adjustment, with an excellent response during clinical follow-up for both meningitis and HCV infection. A brain biopsy was requested during relapse to rule out other co-infection.</p><p><strong>Conclusion: </strong>The case of an individual diagnosed with cryptococcal meningitis, who had a history of IVDU and HCV infection, is presented. The coexistence of such events could shadow the prognosis of this group of subjects, related to immunosuppression that can be caused through different pathways. Having HCV and being a IVDU simultaneously could increase the risk of <i>Cryptococcus</i> infection.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"855-860"},"PeriodicalIF":0.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early SUSVIMO in Neovascular Age-Related Macular Degeneration: Real Word Case Report and Clinical Implications.","authors":"Jakob Pericak, Eric K Chin, David R P Almeida","doi":"10.2147/IMCRJ.S475284","DOIUrl":"10.2147/IMCRJ.S475284","url":null,"abstract":"<p><strong>Purpose: </strong>The current standard of care for neovascular age-related macular degeneration is serial vascular endothelial growth factor (VEGF) inhibitor intravitreal injections at varying treatment intervals. SUSVIMO is a port-delivery system of ranibizumab that serves as an alternative, lower-maintenance treatment.</p><p><strong>Methods: </strong>A case report from a retinal surgery clinic describing the ocular findings, diagnostic workup, and alternative treatment for an 80-year-old man presenting with new-onset neovascular age-related macular degeneration.</p><p><strong>Results: </strong>Resolved foveal thickness, macular volume, and subretinal fluid after SUSVIMO implantation OD. The patient showed a better response to SUSVIMO than to previous anti-VEGF injections. Before the first refill, the patient began to experience subretinal fluid; however, it was resolved after the refill.</p><p><strong>Conclusion: </strong>Although effective, real-world management of neovascular age-related macular degeneration is associated with an extensive treatment burden that can compromise treatment adherence. Herein, we describe how the port delivery system (PDS; SUSVIMO) - a refillable ocular implant that can continuously deliver a novel formulation of ranibizumab with refills possible at six months or longer - is a viable early therapy that mitigates the treatment burden of intravitreal injections.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"849-853"},"PeriodicalIF":0.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spontaneous Focal Hemorrhage of Optic Disc in Peripapillary Hyperreflective Ovoid Mass-Like Structures.","authors":"Fubin Wang","doi":"10.2147/IMCRJ.S473185","DOIUrl":"https://doi.org/10.2147/IMCRJ.S473185","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous focal hemorrhage of optic disc in peripapillary hyperreflective ovoid mass-like structures (PHOMS) is rare. This study reports the image features of two cases of spontaneous hemorrhage of an optic disc in PHOMS.</p><p><strong>Methods: </strong><b>Case 1</b>: A 51-year-old woman complained of visual fatigue for 1 week. Small patchy hemorrhage was observed in the optic disc of the right eye. <b>Case 2</b>: A 17-year-old female presented with complaints of experiencing floaters in the left eye for a duration of 1 day. Small patchy hemorrhage was observed in the left optic disc. The patients underwent the color fundus photograph (CFP), fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA), and Minimum intensity projection (Min-IP) images.</p><p><strong>Results: </strong><b>Case 1</b>: The right eye showed a small patchy hemorrhage of optic disc. PHOMS on SD-OCT of both eyes exhibited an ovoid shape and manifested as peripapillary hyperreflective bright regions on en-face Min-IP image, the active blood flow signal of PHOMS was detected on SD-OCT/OCTA and FAF revealed a hypofluorescent. The optic cup-to-disc (C/D) ratio of both eyes was 0.06, respectively. <b>Case 2</b>: Small patchy hemorrhage was observed in the left optic disc and FAF showed hypofluorescence. PHOMS on SD-OCT of the left eye showed an ovoid shape and manifested as peripapillary hyperreflective bright regions on en-face Min-IP image, the active blood flow signal of PHOMS was detected on SD-OCT/OCTA. C/D in the right eye was 0.4.</p><p><strong>Conclusion: </strong>Spontaneous focal hemorrhage of optic disc may occur in PHOMS. The space-occupying effect of PHOMS may lead to compression of surrounding tissues, resulting in the optic disc congestion and a reduced C/D ratio, thereby involving the microvascular system of the optic disc.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"843-847"},"PeriodicalIF":0.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Lestak, Lenka Prazakova, Martin Fus, Martin Kyncl
{"title":"Optic Nerve Hypoplasia - Case Report.","authors":"Jan Lestak, Lenka Prazakova, Martin Fus, Martin Kyncl","doi":"10.2147/IMCRJ.S479333","DOIUrl":"https://doi.org/10.2147/IMCRJ.S479333","url":null,"abstract":"<p><p>The case report of a young myope (born in 1997) who was diagnosed with bilateral concentric narrowing of the visual field to 15-20 degrees in 2021 is presented. On eye fundus, the findings were normal with central excavation c/d=0.5 and 0.4, respectively. OCT showed loss of retinal nerve fiber layer - in both vertical quadrants, including a reduction in the ganglion cell complex. Electrophysiological examination (PERG) showed normal retinal responses. Visual evoked responses (PVEP) after stimulation squared a 1 degree decrease in amplitudes, with no prolongation of P100 latency. When stimulated with 15-minute squares, responses were normal (see Supplementary Figure). Magnetic resonance imaging of the brain showed a narrowing of the chiasm. In conclusion, optic chiasm hypoplasia may not always have distinct morphological and functional manifestations. In addition to imaging methods, electrophysiological examination of the visual analyser was of great help for its verification.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"835-841"},"PeriodicalIF":0.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}