International Medical Case Reports Journal最新文献

{"title":"Efficacy of Intravenous Tenecteplase Bridge Thrombectomy for Recurrent Ischemic Stroke Within 3 Months: A Case Report.","authors":"Cuicui Liu, Junyan Liu, Huiling Ren, Yuzhu Xu, Wanhu Liu","doi":"10.2147/IMCRJ.S497458","DOIUrl":"10.2147/IMCRJ.S497458","url":null,"abstract":"<p><p>In the previous guideline recommendations, patients who have had a stroke within 3 months are excluded from intravenous thrombolysis (IVT) regimens. Some studies have suggested that IVT with alteplase (rt-PA) may be effective and safe in such patients, but evidence supporting the use of tenecteplase (TNK) is not sufficient. This paper includes an 80-year-old male patient readmitted for recurrence of ischaemic stroke (IS) after 48 days, who received TNK IVT as a bridging therapy prior to thrombectomy, with favourable results at 8-week follow-up. This case highlights that TNK alone or IVT as a bridging therapy prior to thrombectomy can also benefit patients with recurrent stroke within 3 months.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"235-239"},"PeriodicalIF":0.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumed Pediatric Isolated Oculomotor Nerve Schwannoma - A Case Report.","authors":"Shadi Boqaaiya, Aman Raed, Aviv Vidan, Karine Beiruti Wiegler, Yuval Cohen, Otzem Chassid","doi":"10.2147/IMCRJ.S506448","DOIUrl":"10.2147/IMCRJ.S506448","url":null,"abstract":"<p><p>This report presents a healthy 2.5-year-old child exhibiting headache, ptosis, exotropia, and left mydriasis. Initial neuroimaging, including computed tomography (CT), computed tomography angiography (CTA), and standardized magnetic resonance imaging (MRI), failed to identify any lesions; however, high-resolution MRI revealed an ovoid mass adjacent to the left proximal oculomotor nerve within the superior cavernous sinus. This case underscores the necessity for advanced imaging techniques and a thorough diagnostic approach to enhance understanding of this rare pediatric condition. Moreover, it highlights the limited documentation of pediatric oculomotor schwannomas, leading to an inadequate understanding of their diagnosis and management, and emphasizes the need for enhanced awareness and research to establish effective diagnostic protocols, particularly utilizing advanced neuroimaging techniques.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"229-234"},"PeriodicalIF":0.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viable Ileosigmoid Knotting, A Very Phenomenon Finding and Rare Cause of Intestinal Obstruction: A Case Report and Literature Review.","authors":"Sintayehu Asrat Beyene, Nahom Tadesse Bogale, Mahad Mohammed Abdinasir, Addisu Zegeye Desalegne, Megdelawit Ayalew Wossen","doi":"10.2147/IMCRJ.S502430","DOIUrl":"10.2147/IMCRJ.S502430","url":null,"abstract":"<p><strong>Introduction: </strong>Ileosigmoid knotting is the wrapping of an active component of either the ileum or the sigmoid colon over each other. It is an unusual cause of intestinal obstruction, accounting for 1-2% of cases of all mechanical obstruction in the majority published literatures. A viable knot is a unique phenomenon of this seldom cause of bowel obstruction.</p><p><strong>Case presentation: </strong>A sixteen-year-old female patient presents with a complaint of central abdominal distension and obstipation of 12-hour duration. Later, she also developed abdominal cramps and vomiting of ingested matter. Her vital signs were all in the normal range, and the abdominal examination was positive for a grossly distended abdomen with mild upper and central abdominal tenderness. The ileosigmoid knotting was clearly visible on the computed tomography. Emergency exploratory laparotomy was performed, and a viable ileosigmoid knot was identified. Unknotting, derotation, and decompression of the sigmoid colon were performed. The postoperative course was uneventful.</p><p><strong>Discussion: </strong>Ileosigmoid knotting is a rare, life-threatening cause of intestinal obstruction with rapid progression to intestinal vascular compromise and gangrene. It is a hyperactive segment of ileum that winds around the pedicle of the redundant sigmoid colon, resulting in a closed-loop obstruction. There are different classification schemes of ileosigmoid knotting depending on the active component of the knot and based on the viability of the bowel and physiology of the patient. Preoperative diagnosis of this condition is often challenging and usually confirmed intraoperative.</p><p><strong>Conclusion: </strong>A high index of suspicion and prompt surgical exploration are crucial for the best outcome of the patient. Despite being a rare cause of intestinal obstruction, ileosigmoid knotting poses a significant morbidity and mortality to the patient. Management of a patient with viable ileosigmoid knotting is controversial, as some scholars suggest non-resective options and others recommend resective treatment as a recurrence preventive measure.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"223-228"},"PeriodicalIF":0.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin - Induced AGEP: A Case Report.","authors":"Hend M Alotaibi, Sultan AlNasser, Abdulelah Aldossari, Abdulrahman Alluhaybi, Reem Alsergani, Waleed Alrajban","doi":"10.2147/IMCRJ.S488180","DOIUrl":"10.2147/IMCRJ.S488180","url":null,"abstract":"<p><p>Acute Generalized Exanthematous Pustulosis (AGEP) is a relatively rare but severe dermatological adverse reaction characterized by the rapid onset of generalized erythema, coupled with numerous sterile nonfollicular pustules. Agents commonly implicated in triggering AGEP include antibiotics, antifungals, antimalarials, and diltiazem. We present a case of a isotretinoin induced AGEP in a young female patient known to have guttate psoriasis, inverse and scalp psoriasis. She was started on Isotretinoin as she had inflammatory acne as well. Three days later, she developed pruritic, erythematous lesions, some vesicles with a yellowish exudate over the armpits, upper chest, upper arms, and legs. A skin biopsy was performed, which, in conjunction with the clinical presentation, was suggestive of AGEP. In 2010, Filho et al described the first case of isotretinoin-induced AGEP in a female patient diagnosed with Hidradenitis Suppurativa. The EuroSCAR tool was utilized to assess the lesion morphology, clinical course, and histological outcomes, which validated the diagnosis. Using the same criteria, our patient was categorized as \"definite AGEP\", further supporting the isotretinoin-induced AGEP hypothesis. This report highlights isotretinoin as a possible trigger for AGEP, emphasizing the crucial role of a thorough history and vigilant clinical assessment in early identification and management of such reactions.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"211-215"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omadacycline for the Treatment of Severe <i>Legionella</i> Pneumonia Complicated with Multiple Organ Failure: A Case Report.","authors":"Limin Xu, Ying Xiong, Changquan Fang","doi":"10.2147/IMCRJ.S498539","DOIUrl":"10.2147/IMCRJ.S498539","url":null,"abstract":"<p><strong>Background: </strong>Fluoroquinolones and macrolides are the preferred antibiotics for treating Legionnaires' disease. However, the limited utility of these antibiotics in cases of organ dysfunction is a major problem. Omadacycline is a novel tetracycline antibiotic with a good safety profile and in vitro antibacterial activity against <i>Legionella</i>, but it lacks validation by clinical data.</p><p><strong>Case description: </strong>Here, we report a case of severe pneumonia caused by <i>Legionella</i> infection. The patient was empirically treated with antibiotics, after admission but had a poor clinical outcome with severe hepatic and renal insufficiency. After <i>Legionella</i> infection was confirmed by metagenomic next-generation sequencing, the patient was switched to omadacycline antibiotic therapy and eventually discharged after recovery.</p><p><strong>Conclusion: </strong><i>Th</i>e results of this study suggest that metagenomic next-generation sequencing can facilitate early diagnosis of Legionnaires' disease, and omadacycline can be an alternative antibiotic treatment for severe Legionnaires' disease, especially in patients experiencing multiple organ failure.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"217-222"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment - A Case Report.","authors":"Si-Ning Wang, Yi-Zhou Lu, Yujuan Zhao, Wei Cao, Rui-Li Zhang","doi":"10.2147/IMCRJ.S503807","DOIUrl":"10.2147/IMCRJ.S503807","url":null,"abstract":"<p><p>Palmoplantar pustulosis (PPP) is a chronic condition characterized by the presence of sterile pustules on the palms and soles of the feet. As we all know, there is currently no gold standard for the treatment of this intractable disease. Currently, interleukin-36 receptor (IL-36R)-targeted biologics are emerging as promising treatments for PPP. Here, we were the first to report a Chinese male with PPP who received an intralesional injection of spesolimab. We found that only a small intralesional injection volume of spesolimab could effectively suppress PPP in this case.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"205-209"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure Neuritic Leprosy In Children With Grade 2 Disability On Hands And Feet: A Rare Case And Literature Review.","authors":"Hendra Gunawan, Kartika Ruchiatan, Diah Puspitosari, Reti Hindritiani, Hermin Aminah Usman, Stephanie Widjaja","doi":"10.2147/IMCRJ.S497894","DOIUrl":"10.2147/IMCRJ.S497894","url":null,"abstract":"<p><p>Pure neuritic leprosy (PNL) is a rare clinical variant of leprosy, especially in children. This variant of leprosy only involves peripheral nerves without skin involvement or acid-fast bacilli (AFB) found on slit-skin smear examination. The challenging diagnosis and establishment of PNL due to the absence of skin lesions often lead to disability. A case of PNL with grade 2 disability of hands and feet in a 16-year-old boy was reported. The patient has been living in a leprosy-endemic area and has a history of contact with people who have symptoms of leprosy. On physical examination, there were finger contractures on both hands and feet, accompanied by bilateral ulnar, common peroneal, and posterior tibial nerve enlargement without any skin lesions. No AFB was found on the slit-skin smear examination. The diagnosis of PNL was established by the mononeuritis multiplex detected on the nerve conduction examination and the histopathological examine from the biopsy of the left ulnar nerve, which showed lymphocyte infiltration. The patient was treated with multidrug therapy for multibacillary leprosy and consulted with the Department of Physical Medicine and Rehabilitation and the Department of Orthopaedics and Traumatology for contracture management. Clinicians need to be aware of the signs and symptoms of PNL in order to avoid delays in diagnosis and treatment, as the diagnosis and establishment of PNL remain challenging.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"195-203"},"PeriodicalIF":0.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyogenic Granuloma of the Larynx: A Case Report.","authors":"Abdullahi Ali Moallim Hussein, Omar Adam Sheikh, Abdiwahab Abdirahman Mukhtar, Intisar Ahmed Abdi, Nasra Mohamed Ahmed, Shukri Said Mohamed, Mohamed Ali Kahiye, Mohamed Abdikarim Nur, Abdullahi Farah Asseyr","doi":"10.2147/IMCRJ.S494200","DOIUrl":"10.2147/IMCRJ.S494200","url":null,"abstract":"<p><strong>Introduction: </strong>Pyogenic granulomas are benign, painless vascular tumors on the skin and mucosal surfaces. They are commonly found in the head and neck region, although their occurrence in the larynx is rare. The term \"lobular capillary hemangioma\" is now used to describe the histological appearance of these tumors more accurately. Predisposing factors for pyogenic granuloma of the larynx have been linked to prior traumatic injuries, such as intubation, previous surgeries, or laryngopharyngeal reflux.</p><p><strong>Case presentation: </strong>A 33-year-old male visited our clinic with complaints of progressive dysphonia and choking for two months. The patient did not experience dysphagia or dyspnea. There was no history of previous intubation, gastroesophageal reflux disease, or other chronic illnesses. Upon laryngoscopic examination, a polypoid lesion measuring 25×8 mm was found on the posterior commissure of the right vocal cord. No abnormalities were observed during the ear and nose examinations.</p><p><strong>Discussion: </strong>Pyogenic granuloma, or lobular capillary hemangioma, is a hyperplastic lesion that develops on the skin and mucous membranes. It often occurs in response to trauma or hormonal factors. Histologically, pyogenic granulomas differ from granulation tissues due to their lobular arrangement of capillaries in the deeper portions of the lesion. The term \"lobular capillary hemangioma\" has been recently introduced to emphasize this phenomenon. Some of the conditions considered in the differential diagnosis include hemangioma, hemangioendothelioma, angiofibroma, angiosarcoma, Kaposi sarcoma, Wegener's granuloma, Crohn's disease, granulomatous infections such as tuberculosis and histoplasmosis, traumatic granuloma, carcinosarcoma, as well as verrucous and squamous cell carcinoma.</p><p><strong>Conclusion: </strong>We present a case report of lobular capillary hemangioma of the larynx, including its histopathological diagnosis and management course.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"181-186"},"PeriodicalIF":0.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Topography-Guided Trans-Epithelial PRK and PTK for Treatment of Calcific Band Keratopathy Unresponsive to EDTA Chelation Therapy.","authors":"Fedele Passidomo, Giuseppe Addabbo, Francesco Pignatelli, Alfredo Niro, Rosa Buonamassa","doi":"10.2147/IMCRJ.S493245","DOIUrl":"10.2147/IMCRJ.S493245","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of Calcific Band Keratopathy (CBK) treated successfully with transepithelial Phototherapeutic keratectomy (PTK) combined with customized Photorefractive Keratectomy (PRK).</p><p><strong>Methods: </strong>One case report.</p><p><strong>Results: </strong>A 63-year-old man presented to our clinic with decreased visual acuity and ocular discomfort in both eyes. Clinical examination revealed a horizontal gray-whitish band across the central cornea in both eyes, supporting the diagnosis of CBK. Initially, an EDTA chelating procedure was attempted, but it had no effect on the deeper calcium deposits and on the irregular corneal morphology. In both eyes, a topography-guided trans-epithelial PRK with PTK was performed. Following PRK surface ablation, PTK was used to smooth the ablated area using 1% hydroxymethylcellulose as masking agent. The procedure was completed applying 0.02% Mitomycin C. At the 1-month follow-up, both eyes corneal opacities were resolved, and the LE visual acuity had improved to 20/63 and the RE to 20/20, which was maintained at the 3-, 6-, and 12-months follow-up. Furthermore, there was an improvement in spherical equivalent and corneal morphological irregularity index.</p><p><strong>Conclusion: </strong>CBK may be successfully treated using a combined topography-guided trans-epithelial PRK and PTK.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"187-194"},"PeriodicalIF":0.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentations and Characteristics of NSAIDs Hypersensitivity in a Tertiary Care Hospital in Indonesia: A Case Series.","authors":"Adi Nurmesa, Neily Zakiyah, Widya Norma Insani","doi":"10.2147/IMCRJ.S488796","DOIUrl":"10.2147/IMCRJ.S488796","url":null,"abstract":"<p><p>Non-steroidal anti-inflammatory drugs (NSAIDs) are widely administered in all age groups due to their effectiveness in reducing fever, relieving pain, and reducing inflammation. However, they have also been identified as the second most common cause of drug-induced hypersensitivity reactions, after beta-lactam antibiotics. Adverse reactions to NSAIDs can range from expected pharmacological side effects such as gastritis to severe allergies, including anaphylaxis. It is important to distinguish true hypersensitivity reactions from other side effects to ensure proper management and patient safety. Four patients aged 35-60 years were treated with NSAIDs for pain management and subsequently developed hypersensitivity reactions to NSAIDs such as ketorolac, ketoprofen, and diclofenac sodium in the type of allergic reactions such as NSAIDs-induced urticaria/angioedema (NIUA). This case series provides valuable insights into the clinical presentations and potential mechanisms of NSAID hypersensitivity in the documented cases in one of the hospitals in Indonesia. It highlights important areas for future investigation, including the need for larger, controlled studies to better understand incidence, risk factors, and generalizability to broader populations.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"163-171"},"PeriodicalIF":0.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}