Isotretinoin - Induced AGEP: A Case Report.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-02-01 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S488180
Hend M Alotaibi, Sultan AlNasser, Abdulelah Aldossari, Abdulrahman Alluhaybi, Reem Alsergani, Waleed Alrajban
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引用次数: 0

Abstract

Acute Generalized Exanthematous Pustulosis (AGEP) is a relatively rare but severe dermatological adverse reaction characterized by the rapid onset of generalized erythema, coupled with numerous sterile nonfollicular pustules. Agents commonly implicated in triggering AGEP include antibiotics, antifungals, antimalarials, and diltiazem. We present a case of a isotretinoin induced AGEP in a young female patient known to have guttate psoriasis, inverse and scalp psoriasis. She was started on Isotretinoin as she had inflammatory acne as well. Three days later, she developed pruritic, erythematous lesions, some vesicles with a yellowish exudate over the armpits, upper chest, upper arms, and legs. A skin biopsy was performed, which, in conjunction with the clinical presentation, was suggestive of AGEP. In 2010, Filho et al described the first case of isotretinoin-induced AGEP in a female patient diagnosed with Hidradenitis Suppurativa. The EuroSCAR tool was utilized to assess the lesion morphology, clinical course, and histological outcomes, which validated the diagnosis. Using the same criteria, our patient was categorized as "definite AGEP", further supporting the isotretinoin-induced AGEP hypothesis. This report highlights isotretinoin as a possible trigger for AGEP, emphasizing the crucial role of a thorough history and vigilant clinical assessment in early identification and management of such reactions.

异维甲酸诱发AGEP 1例。
急性全身性红斑性脓疱病(AGEP)是一种相对罕见但严重的皮肤不良反应,其特征是迅速发作的全身性红斑,并伴有大量无菌非滤泡性脓疱。通常涉及触发AGEP的药物包括抗生素、抗真菌药、抗疟药和地尔硫卓。我们提出了一例异维甲酸诱导AGEP在一个年轻的女性患者已知有点滴状牛皮癣,逆和头皮牛皮癣。她开始服用异维甲酸,因为她也有炎症性痤疮。3天后,患者出现瘙痒、红斑病变,腋窝、上胸、上臂和腿部出现带黄色渗出物的囊泡。进行皮肤活检,结合临床表现,提示AGEP。2010年,Filho等人报道了首例异维a酸诱导的化脓性汗腺炎女性患者AGEP。EuroSCAR工具用于评估病变形态、临床病程和组织学结果,以验证诊断。使用相同的标准,我们的患者被归类为“明确的AGEP”,进一步支持异维甲酸诱导的AGEP假说。本报告强调异维甲酸可能是AGEP的触发因素,并强调在早期识别和管理此类反应时,全面的病史和警惕的临床评估至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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