皮内Spesolimab：一种治疗掌跖脓疱病的新颖有效方法- 1例报告。

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

International Medical Case Reports Journal Pub Date : 2025-01-30 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S503807

Si-Ning Wang, Yi-Zhou Lu, Yujuan Zhao, Wei Cao, Rui-Li Zhang

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引用次数: 0

摘要

掌跖脓疱病（PPP）是一种慢性疾病，其特征是手掌和脚底存在无菌脓疱。众所周知，目前还没有治疗这种难治性疾病的黄金标准。目前，以白介素-36受体（IL-36R）为靶点的生物制剂正在成为治疗PPP的有前景的药物。在这里，我们首次报道了一位患有PPP的中国男性接受局部注射spesolimab。我们发现，在这种情况下，少量局内注射斯匹索单抗就能有效抑制PPP。

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Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment - A Case Report.

Palmoplantar pustulosis (PPP) is a chronic condition characterized by the presence of sterile pustules on the palms and soles of the feet. As we all know, there is currently no gold standard for the treatment of this intractable disease. Currently, interleukin-36 receptor (IL-36R)-targeted biologics are emerging as promising treatments for PPP. Here, we were the first to report a Chinese male with PPP who received an intralesional injection of spesolimab. We found that only a small intralesional injection volume of spesolimab could effectively suppress PPP in this case.

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来源期刊

International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

135

审稿时长

16 weeks

期刊介绍： International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.