Omadacycline for the Treatment of Severe Legionella Pneumonia Complicated with Multiple Organ Failure: A Case Report.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-02-01 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S498539
Limin Xu, Ying Xiong, Changquan Fang
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引用次数: 0

Abstract

Background: Fluoroquinolones and macrolides are the preferred antibiotics for treating Legionnaires' disease. However, the limited utility of these antibiotics in cases of organ dysfunction is a major problem. Omadacycline is a novel tetracycline antibiotic with a good safety profile and in vitro antibacterial activity against Legionella, but it lacks validation by clinical data.

Case description: Here, we report a case of severe pneumonia caused by Legionella infection. The patient was empirically treated with antibiotics, after admission but had a poor clinical outcome with severe hepatic and renal insufficiency. After Legionella infection was confirmed by metagenomic next-generation sequencing, the patient was switched to omadacycline antibiotic therapy and eventually discharged after recovery.

Conclusion: The results of this study suggest that metagenomic next-generation sequencing can facilitate early diagnosis of Legionnaires' disease, and omadacycline can be an alternative antibiotic treatment for severe Legionnaires' disease, especially in patients experiencing multiple organ failure.

奥马达环素治疗重症军团菌肺炎合并多器官功能衰竭1例。
背景:氟喹诺酮类药物和大环内酯类药物是治疗军团病的首选抗生素。然而,这些抗生素在器官功能障碍病例中的有限效用是一个主要问题。奥马达环素是一种新型四环素类抗生素,具有良好的安全性和体外抗菌活性,但缺乏临床数据的验证。病例描述:在这里,我们报告一例由军团菌感染引起的严重肺炎。患者入院后经验性使用抗生素治疗,但临床结果不佳,出现严重肝肾功能不全。经新一代宏基因组测序确认军团菌感染后,患者转入奥马大环素抗生素治疗,最终康复出院。结论:本研究结果提示,新一代宏基因组测序可促进军团病的早期诊断,奥马达环素可作为严重军团病的替代抗生素治疗,尤其是多器官衰竭患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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