International Medical Case Reports Journal最新文献

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Marcus-Gunn Jaw-Winking Phenomenon: A Case Report on Rare Oculofacial Synkinesis. Marcus-Gunn眨眼现象:罕见眼面联动1例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S520496
Amjad Fiusal H Alharthe, Hagar Mohammad Alghreeb, Hani B ALBalawi, Naif M ALAli
{"title":"Marcus-Gunn Jaw-Winking Phenomenon: A Case Report on Rare Oculofacial Synkinesis.","authors":"Amjad Fiusal H Alharthe, Hagar Mohammad Alghreeb, Hani B ALBalawi, Naif M ALAli","doi":"10.2147/IMCRJ.S520496","DOIUrl":"10.2147/IMCRJ.S520496","url":null,"abstract":"<p><p>The Marcus-Gunn jaw-winking phenomenon (MGJWP) is an uncommon congenital oculofacial synkinesis resulting from abnormal innervation between the fifth cranial nerve (trigeminal, CN V) and the third cranial nerve (oculomotor, CN III). This case report presents a 5-month-old girl with characteristic left eyelid elevation during suckling movements, highlighting the importance of clinical observation in early diagnosis. The condition was confirmed based on clinical findings, with no associated neurological or structural abnormalities. Management involved observation and follow-up to monitor potential complications such as strabismus or anisometropia. MGJWP remains an essential consideration in cases of unusual eyelid movement, emphasizing the role of multidisciplinary consultation for comprehensive care.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1053-1056"},"PeriodicalIF":0.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Henna-Induced Intravascular Hemolysis in a Glucose-6-Phosphate Dehydrogenase-Deficient Ghanaian Female Child with Full Defect. 指甲花诱导的葡萄糖-6-磷酸脱氢酶完全缺陷的加纳女童血管内溶血。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S534544
Nkechi Oluwakemi Dike, Emmanuel S Blankson, Sarah Segnitome
{"title":"Henna-Induced Intravascular Hemolysis in a Glucose-6-Phosphate Dehydrogenase-Deficient Ghanaian Female Child with Full Defect.","authors":"Nkechi Oluwakemi Dike, Emmanuel S Blankson, Sarah Segnitome","doi":"10.2147/IMCRJ.S534544","DOIUrl":"10.2147/IMCRJ.S534544","url":null,"abstract":"<p><p>Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a sex-linked chromosomal disorder, is the most common enzymopathy in humans. This enzyme, which protects red blood cells, when deficient, predisposes individuals to hemolysis under oxidative stress. Several chemicals and drugs have been commonly known to cause hemolysis in G6PD deficiency. However, an uncommon substance, henna, a plant-based dye used in Africa and Asia, has also been described to trigger hemolysis in G6PD-deficient individuals. It shares similarities in the structural ring and properties with other well-described G6PD hemolytic agents. We present a rare case of severe intravascular hemolysis following topical henna application in an 8-year-old girl with G6PD deficiency, successfully managed at the Upper West Regional Hospital in Ghana.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1035-1040"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous Vertebroplasty Using GeneX® in Osteoporotic Vertebral Compression Fractures: A Case Report. GeneX®经皮椎体成形术治疗骨质疏松性椎体压缩性骨折1例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S505160
Taibang Chen, Lei Cui, Di Du
{"title":"Percutaneous Vertebroplasty Using GeneX<sup>®</sup> in Osteoporotic Vertebral Compression Fractures: A Case Report.","authors":"Taibang Chen, Lei Cui, Di Du","doi":"10.2147/IMCRJ.S505160","DOIUrl":"10.2147/IMCRJ.S505160","url":null,"abstract":"<p><strong>Background: </strong>GeneX<sup>®</sup> allows adsorption and aggregation of molecules and proteins to promote bone formation. According to reports in the literature, it is used in bone defect reconstruction and percutaneous vertebroplasty to promote bone formation.</p><p><strong>Case report: </strong>We designed a prospective cohort study to evaluate the outcomes following of percutaneous vertebroplasty using GeneX in patients with osteoporotic vertebral compression fractures. Vertebroplasty was performed at seven vertebrae in the first seven patients. Overall, there were four leaks in four (57%) of the seven patients. Asymptomatic leak of the GeneX material into the intradiscal and paravertebral structures at the treated vertebral level was observed in three patients (43%). However, the material leaked into the intradural and epidural space in the seventh patient (14%), causing severe neurological deficits. Primary diagnosis was bone cement implantation syndrome. The patient's neurological status improved gradually during the month after surgery. She was able to resume her activities of daily living and had regained her urinary function by 3 months after surgery.</p><p><strong>Conclusion: </strong>Owing to its physicochemical characteristics, even with sophisticated surgical techniques, GeneX cannot be recommended for use in percutaneous vertebroplasty for OVCF. The long-term safety and efficacy of GeneX need to be further validated through Phase II clinical trials. Lumbar cistern drainage can significantly improve neurological deficits in patients caused by GeneX implantation syndrome.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1041-1046"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Plasmodium Falciparum Malaria Mimicking Thrombotic Thrombocytopenic Purpura (TTP): A Case Report From China. 模拟血栓性血小板减少性紫癜(TTP)的重症恶性疟原虫疟疾一例中国报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S536982
Cheng Wang, Man Kong, Ming Huang, Ning Tang, Hongmei Mo
{"title":"Severe Plasmodium Falciparum Malaria Mimicking Thrombotic Thrombocytopenic Purpura (TTP): A Case Report From China.","authors":"Cheng Wang, Man Kong, Ming Huang, Ning Tang, Hongmei Mo","doi":"10.2147/IMCRJ.S536982","DOIUrl":"10.2147/IMCRJ.S536982","url":null,"abstract":"<p><strong>Background: </strong>Plasmodium falciparum Malaria and Thrombocytopenic Purpura (TTP) are serious diseases associated with thrombotic microangiopathic anemia (TMA) pathogenesis. Therefore, clinical treatment is usually delayed because of the overlapping clinical manifestations. This case describes Plasmodium falciparus infection causing markedly elevated von Willebrand factor (vWF) levels but normal ADAMTS13 activity, which closely mimics the presentation of TTP.</p><p><strong>Case presentation: </strong>There is overlap in laboratory and clinical presentations, such as fever, thrombocytopenia, severe anemia, and intravascular coagulation between malaria and TTP. We present the case of a 51-year-old Chinese man who initially presented with fever that quickly progressed to a disturbance of consciousness. Laboratory tests showed a decreased platelet count, elevated lactate levels, and elevated indirect bilirubin levels. The patient's PLASMIC score for TTP was 7, suggesting a high possibility of TTP. There was markedly elevated vWF, but normal ADAMTS13 activity. Therefore, TTP was excluded. However, we found a large amount of P. falciparus in the peripheral blood smears. The patient's condition gradually improved after intravenous artesunate treatment.</p><p><strong>Conclusion: </strong>Malaria and TTP have obvious laboratory and clinical resemblances, owing to the presence of TMA. It is important to quickly perform a differential laboratory diagnosis between malaria and TTP, which may lead to the early initiation of lifesaving treatment in some patients.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1029-1034"},"PeriodicalIF":0.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Impact Trajectories of a Psychoeducational Program for Nursing Home Caregivers: Insights from Clinical Case Studies. 疗养院照顾者心理教育计划的主要影响轨迹:来自临床案例研究的见解。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S529778
S Meziane-Damnée, J Cattoni, L Djabelkhir, C Bayle, C Ware, I Cantegreil, H Lenoir, M Pino, A S Rigaud
{"title":"Primary Impact Trajectories of a Psychoeducational Program for Nursing Home Caregivers: Insights from Clinical Case Studies.","authors":"S Meziane-Damnée, J Cattoni, L Djabelkhir, C Bayle, C Ware, I Cantegreil, H Lenoir, M Pino, A S Rigaud","doi":"10.2147/IMCRJ.S529778","DOIUrl":"10.2147/IMCRJ.S529778","url":null,"abstract":"<p><p>The decision to place a loved one with dementia in a specialized facility is often associated with significant psychological distress among family caregivers, which often manifests itself in feelings of guilt, helplessness, and emotional tension. We conducted a pilot implementation of a seven-session psychoeducational group program designed to support family caregivers during the critical transition from home care to nursing home placement. The intervention included weekly modules addressing fundamental topics such as how nursing homes operate, managing behavioral disorders, end-of-life considerations, and sources of stress for caregivers. Among the 12 initial participants enrolled in the program, we present three illustrative cases that reflect distinct impact trajectories depending on caregiver profiles. Two caregivers showed substantial psychological and relational improvement, characterized by greater acceptance of institutional placement and enhanced coping strategies. In contrast, the third case highlighted the program's limitations in addressing more complex emotional and relational dynamics. These results suggest that, while psychoeducational intervention can facilitate emotional adaptation and promote reevaluation of the relationship between the caregiver and the care recipient, its effectiveness may be limited in cases requiring individualized psychological support. Adapting the intervention to include more flexible and personalized components, such as optional individual or family consultations, could enhance its relevance and effectiveness in meeting the diverse needs of caregivers.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1011-1020"},"PeriodicalIF":0.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic Lymphangioma in the Talus Bone: A Case Report. 距骨囊性淋巴管瘤1例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S529233
Ching Hei Liang, K C Wong, Maribel D Lacambra, Winnie C W Chu
{"title":"Cystic Lymphangioma in the Talus Bone: A Case Report.","authors":"Ching Hei Liang, K C Wong, Maribel D Lacambra, Winnie C W Chu","doi":"10.2147/IMCRJ.S529233","DOIUrl":"10.2147/IMCRJ.S529233","url":null,"abstract":"<p><strong>Background: </strong>Lymphangiomas, predominantly observed in pediatric populations, can occasionally be acquired in adulthood. They are rare benign tumors mostly found in the head and neck region, with solitary cystic lymphangioma in bone being very rare.</p><p><strong>Case presentation: </strong>We report an uncommon case of a solitary cystic lymphangioma in the talus bone of a 19-year-old Chinese female presented with a history of enduring ankle swelling, rest pain, and frequent sprains. The patient's T2-weighted Magnetic Resonance Imaging (MRI) revealed a cystic bone lesion with multiple internal fluid levels, which initially suggested a Giant Cell Tumor (GCT) or chondroblastoma with secondary Aneurysmal Bone Cyst (ABC) change. However, histopathological examination of the tissue sample obtained through curettage suggested the diagnosis of intraosseous lymphangioma. The postoperative period was uneventful with no complications. Patients restored near normal ankle range of motion and there have been no signs of recurrence.</p><p><strong>Conclusion: </strong>This case demonstrates the importance of considering a broad differential diagnosis when evaluating bone lesions, and it underlines the need to correlate pathological findings with radiographic images and clinical examination for an accurate diagnosis.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1021-1028"},"PeriodicalIF":0.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Unicystic Ameloblastoma in a Teenager of Azande Tribe: A Clinical Case Report. 阿赞德部落青少年巨大单囊性成釉细胞瘤一例临床报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-10 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S538385
Malisaba Posite Charles, Tatana Museketwa Faustin, Mihret Adane Woldemichael, Elizabeth Vargas Escalante, Mohamed Abdirahman Mohamud Snr, Fazila Malengera Laetitia, Acan Moses, Mirna Batista Santos, Tumwesigire Samuel, Zeinab Ibrahim Ali, Mughanda Mugheni Olive, Alain Bakwanamaha Maha, Jeannot Baanitse, Mahad Said, Henry Wabinga, Yanurkis Duranones Rosales
{"title":"Giant Unicystic Ameloblastoma in a Teenager of Azande Tribe: A Clinical Case Report.","authors":"Malisaba Posite Charles, Tatana Museketwa Faustin, Mihret Adane Woldemichael, Elizabeth Vargas Escalante, Mohamed Abdirahman Mohamud Snr, Fazila Malengera Laetitia, Acan Moses, Mirna Batista Santos, Tumwesigire Samuel, Zeinab Ibrahim Ali, Mughanda Mugheni Olive, Alain Bakwanamaha Maha, Jeannot Baanitse, Mahad Said, Henry Wabinga, Yanurkis Duranones Rosales","doi":"10.2147/IMCRJ.S538385","DOIUrl":"10.2147/IMCRJ.S538385","url":null,"abstract":"<p><p>Ameloblastoma, a locally aggressive benign odontogenic tumor, represents about 1% of jaw tumors. While typically affecting adults aged 30-60, this case highlights its occurrence in a 17-year-old. Incidence varies globally, with lower rates in non-African populations (around 0.5 per million annually) compared to higher prevalence in Nigeria and South Africa, where Black populations show increased susceptibility. Limited epidemiological data from sub-Saharan Africa, including Uganda, likely underestimates the burden due to underreporting in rural areas with poor healthcare access. A 17-year-old female of the Azande tribe, Bantu ethnicity, presented with a four-year history of a massive, painless right mandibular swelling causing significant facial asymmetry. Examination revealed a large mass (13.8 x 11.5 x 11 cm). A CT scan indicated a unilocular cystic lesion. Histopathology confirmed ameloblastoma with follicular and plexiform patterns. The patient underwent a right total hemi-mandibulectomy, and the excised tumor (19 x 16×10 cm) was classified as an intraluminal unicystic ameloblastoma. This case emphasizes the presentation of a giant unicystic ameloblastoma in a young individual from sub-Saharan Africa, a demographic often underreported. The delayed presentation and substantial tumor size underscore diagnostic and management challenges in resource-limited settings. This report highlights the need for enhanced awareness and improved healthcare access for timely intervention in these populations. Vigilant long-term follow-up is essential due to the tumor's recurrence potential.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1003-1010"},"PeriodicalIF":0.7,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischiopagus Conjoint Twins: A Case Report. Ischiopagus连体双胞胎1例报告。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S525402
Abdihakim Elmi Abdi Shakur, Salad Ahmed Halane, Farah Yusuf Farah
{"title":"Ischiopagus Conjoint Twins: A Case Report.","authors":"Abdihakim Elmi Abdi Shakur, Salad Ahmed Halane, Farah Yusuf Farah","doi":"10.2147/IMCRJ.S525402","DOIUrl":"10.2147/IMCRJ.S525402","url":null,"abstract":"<p><strong>Background: </strong>The birth of conjoined twins is an extremely rare neonatal condition, occurring in approximately 1 in 100,000 live births. Ischiopagus, a form of conjoined twinning where the twins are joined at the pelvis, accounts for 6-11% of all conjoined twins. Ischiopagus conjoined twinning is a congenital anomaly. The surgical separation of conjoined twins is challenging due to the intricate anatomy and physiology involved. Thorough preoperative evaluation, meticulous planning, and a skilled surgical team are essential for ensuring a successful outcome. This condition significantly requires separation surgeries due to the unique anatomical challenges it presents. Clinical outcomes can vary depending on the healthcare facility and resources available. The development of conjoined twins consistently draws significant attention from researchers and clinicians. Aside from the rarity of such cases, the manner in which these twins develop remains a topic of ongoing debate. This report describes a case of ischiopagus conjoined twins, characterized by two heads (dicephalus), four upper limbs (tetrabrachius), and a shared pelvis with single umbilical cord. The mother of the twins was referred from a primary hospital Somali Sudanese Specialized Hospital for specialized care during her twin pregnancy, where a cesarean section was performed.</p><p><strong>Case summary: </strong>The twins delivered by 34 years old gravida 9 para 7, no previous congenital anomalies, the mother was diabetic and she was on anti-diabetic drugs. Both parents had no family history of birth defects or exposure to known teratogens. Imaging (MRI) revealed that that the twins had separate hearts, lungs, kidneys with severe hydronephrosis in one of them, stomach, liver, spleen, and anal canals but shared the bowel loops, a single placenta with one umbilical vein and two umbilical arteries with single umbilical cord. Additionally, they have uterus-like structure with the absence of external genitalia. Despite multiple associated cardiovascular anomalies, there were no external craniofacial, limb, or brain abnormalities. The twins admitted for the neonatal ICU and observed with normal meconium and urinary passage from same opening (cloaca).</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"985-989"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated Colorectal Involvement in Klippel-Trenaunay Syndrome: A Case of Extensive Vascular Malformation. Klippel-Trenaunay综合征孤立性结肠受累:一例广泛血管畸形。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S535985
Nurbek Ilyassov, Yerzhan Shayakhmetov, Anuar Abdikarimov, Erlan Nurgaliev, Saken Saberbekov, Rakymzhan Aralbayev, Aiman Tokusheva, Vitaliy Kalina
{"title":"Isolated Colorectal Involvement in Klippel-Trenaunay Syndrome: A Case of Extensive Vascular Malformation.","authors":"Nurbek Ilyassov, Yerzhan Shayakhmetov, Anuar Abdikarimov, Erlan Nurgaliev, Saken Saberbekov, Rakymzhan Aralbayev, Aiman Tokusheva, Vitaliy Kalina","doi":"10.2147/IMCRJ.S535985","DOIUrl":"10.2147/IMCRJ.S535985","url":null,"abstract":"<p><strong>Background: </strong>Rectal vascular malformations associated with Klippel-Trenaunay syndrome are exceedingly rare. While their diagnosis may be straightforward when characteristic features are present, such cases remain of significant educational value due to their unusual presentation and potential for misdiagnosis.</p><p><strong>Case presentation: </strong>Our study aimed to describe a clinical case of a 45-year old female patient. There were complaints of pain in the perianal area and periodic bleeding during/after defecation, prolapse of hemorrhoids, general weakness. Colonoscopy revealed varicose veins of the rectum, hemangioma of the rectal mucosa, and chronic internal hemorrhoids. Multislice computed tomography of the pelvic organs with intravenous bolus contrast was performed. The preliminary clinical diagnosis was hemangioma of the rectal mucosa, and vascular malformation of the rectum was considered operable. In our clinic, the patient underwent several-stage surgery: (1) implantation of a temporary vena cava filter into the inferior vena cava, (2) two weeks later laparoscopic-assisted anterior resection of the rectum with preventive transverse colostomy and demucosation of the rectal mucosa, (3) after 7 months following discharge, the closure of transverse colostomy. Pathological examination of the gross specimen revealed that mucous membrane of the colon in a section extending 12.0 cm up to the distal edge of the resection is compacted, coarsely lumpy, grayish-bluish in color, with multiple blood-filled cavities. The postoperative period proceeded smoothly. Oral nutrition and patient's activity began on the 1st day. Primary healing of postoperative wounds was occurred. The patient was discharged in satisfactory condition on the 6th day post-surgery.</p><p><strong>Conclusion: </strong>This clinical case is a case-of-interest due to its rare localization, asymptomatic course for a long time with a fairly large size of an excessively vascularized abnormal vascular formation. The appropriate approach to this pathology is laparoscopic surgery, which can be useful for both diagnostic and radical treatment of vascular malformations of the rectum.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"997-1002"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Arteritic Anterior Ischemic Optic Neuropathy in an Otherwise Healthy Young Adult Patient Treated with Liraglutide and Semaglutide for Weight Loss: A Cautionary Tale. 非动脉性前缺血性视神经病变在其他健康的年轻成人患者治疗利拉鲁肽和西马鲁肽减肥:一个警示故事。
IF 0.7
International Medical Case Reports Journal Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S531930
Filippo Lixi, Valerio Calabresi, Feyza Cukurova, Giuseppe Giannaccare
{"title":"Non-Arteritic Anterior Ischemic Optic Neuropathy in an Otherwise Healthy Young Adult Patient Treated with Liraglutide and Semaglutide for Weight Loss: A Cautionary Tale.","authors":"Filippo Lixi, Valerio Calabresi, Feyza Cukurova, Giuseppe Giannaccare","doi":"10.2147/IMCRJ.S531930","DOIUrl":"10.2147/IMCRJ.S531930","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of non-arteritic ischemic optic neuropathy (NAION) in an otherwise healthy patient treated with Glucagon-Like Peptide-1 (GLP-1) receptor agonists (RAs) liraglutide and semaglutide.</p><p><strong>Observations: </strong>A 47-year-old Caucasian female with a Body Mass Index (BMI) of 27.92, and no known history of diabetes, hypertension, or ischemic heart disease, developed a progressive decline in visual acuity in the right eye one month after initiating liraglutide therapy for weight loss. Upon symptom presentation, ophthalmic examination performed elsewhere revealed a best-corrected visual acuity (BCVA) of 20/40, optic nerve head (ONH) swelling, and inferior hemifield scotoma on Humphrey Visual Field testing. Oral corticosteroids were prescribed and discontinued because of poor glycemic control. Liraglutide therapy was continued for further three months and then switched to semaglutide owing to poor clinical results. Eight months later, the patient discontinued weight loss therapy because of progressive visual deterioration and presented to our clinic for a second opinion. Upon examination, BCVA was limited to 20/400, ONH edema was evident and confirmed on optical coherence tomography (OCT), and further worsening of the visual field defects was detected. Given the absence of anatomical and/or systemic risk factors, NAION secondary to GLP-1 RAs was diagnosed.</p><p><strong>Conclusion and importance: </strong>In our patient, liraglutide likely served as the initial trigger for the NAION, with semaglutide acting as an additional contributing factor in the progression of the disease. This case adds to the complex puzzle regarding the association between GLP-1 RAs therapy and NAION. Given the increasing use of these drugs for both obesity and diabetes and the close temporal correlations between GLP-1 RAs use and NAION, healthcare providers should be aware of the possible risk of serious ocular complications. Upon onset of visual symptoms, early ophthalmologic diagnosis and treatment interruption are essential to prevent or limit severe visual morbidities.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"991-995"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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