International Medical Case Reports Journal最新文献

{"title":"Congenital Acute Myeloid Leukemia (AML): A Case Report.","authors":"Sondus Alsharidah, Eman Almatar","doi":"10.2147/IMCRJ.S499579","DOIUrl":"10.2147/IMCRJ.S499579","url":null,"abstract":"<p><strong>Background: </strong>Congenital acute myeloid leukemia (AML) is a rare but critical hematologic malignancy diagnosed in neonates and associated with a high mortality rate.</p><p><strong>Case presentation: </strong>This report describes a 3-month-old female diagnosed with congenital AML, characterized by mixed lineage leukemia (MLL) gene rearrangement. The patient presented with severe complications, including typhlitis, abscess, seizures, and pericardial effusion.</p><p><strong>Management and outcomes: </strong>Despite the challenges posed by the patient's age and the severity of her condition, she responded well to initial treatment. However, her long-term prognosis remains uncertain. Hematopoietic stem cell transplantation (HSCT) is being considered as part of her ongoing management.</p><p><strong>Conclusion: </strong>Early diagnosis and tailored treatment strategies for congenital AML are crucial. This case underscores the need for continued research to refine treatment protocols aimed at improving survival rates in this vulnerable population.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"585-590"},"PeriodicalIF":0.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Dysphagia Aortica in a 90-Year-Old Patient: A Case Report.","authors":"Mohamed Omar Hassan, Ahmed Shafie Aden, Osman Farah Dahir, Ahmed Elmi Abdi, Ishak Ahmed Abdi, Said Abdirahman Ahmed, Nasra Mohamud Hilowle, Mohamed Osman Omar Jeele","doi":"10.2147/IMCRJ.S506415","DOIUrl":"10.2147/IMCRJ.S506415","url":null,"abstract":"<p><strong>Background: </strong>Dysphagia aortica is an uncommon condition caused by esophageal compression from vascular malformations, often complicating the clinical course in the elderly. This case explores the management of dysphagia aortica in a 90-year-old Somali woman, emphasizing challenges posed by age-related anatomical changes and comorbidities.</p><p><strong>Case presentation: </strong>The patient presented with chest discomfort, dyspnea, and dysphagia for liquids and solids. Imaging revealed esophageal compression due to ascending aorta dilation. The dysphagia persisted despite pharmacological management, leading to the decision that surgical intervention was too risky. We placed a percutaneous endoscopic gastrostomy (PEG) tube to maintain nutrition, stabilizing her condition and improving her quality of life.</p><p><strong>Conclusion: </strong>This case underscores the importance of individualized, multidisciplinary management in elderly patients with dysphagia aortica. While PEG is a well-established intervention for severe dysphagia, its application in dysphagia aortica, particularly in frail geriatric patients, highlights a crucial, underrecognized approach. This report adds to the limited literature on dysphagia aortica by demonstrating that non-surgical interventions can be effective in maintaining nutrition and quality of life when surgical risks outweigh potential benefits.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"595-599"},"PeriodicalIF":0.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Pustular Psoriasis During Early Pregnancy Successfully Treated with Spesolimab: A Case Report.","authors":"Xinlong Chen, Degui Chang, Chenjian Tang","doi":"10.2147/IMCRJ.S525812","DOIUrl":"10.2147/IMCRJ.S525812","url":null,"abstract":"<p><p>Generalized pustular psoriasis (Gpp) of pregnancy usually occurs in the third trimester of pregnancy. We present a patient with Gpp at 8 weeks of gestation. The patient was finally treated with spesolimab, and her condition improved significantly after 3 days.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"591-594"},"PeriodicalIF":0.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Absorption of a Spontaneous Primary Intraventricular Hemorrhage.","authors":"Xiao-Yong Shi, Yue Lou","doi":"10.2147/IMCRJ.S521860","DOIUrl":"10.2147/IMCRJ.S521860","url":null,"abstract":"<p><p>Spontaneous primary intraventricular hemorrhage (IVH) is a rare type of intracranial hemorrhage that can be concentrated in one or more ventricles. The clinical symptoms after bleeding are diverse, if there is significant bleeding or hydrocephalus, external ventricular drainage (EVD) treatment is often required. Absorption of the hematoma after ventricular hemorrhage usually takes several weeks, and there are very few articles in the literature on hematoma absorption. As far as we know early spontaneous disappearance of spontaneous primary IVH has not previously been reported in the literature. Herein, we describe a rare case of spontaneous primary IVH that rapidly disappeared without surgical intervention. The patient, a 73-year-old male, was admitted to the hospital for \"unclear speech for 16 hours\". An initial head computed tomography (CT) scan showed significant accumulation of blood in both lateral ventricles, the third ventricle, midbrain aqueduct, and fourth ventricle, as well as acute hydrocephalus. The patient was conscious and did not undergo EVD treatment. After 24 hours, head CT re-examination showed that the accumulated blood had been significantly absorbed, and hydrocephalus had improved. Three days later, head CT re-examination showed that the accumulated blood in the ventricles had been absorbed, and the patient did not experience any discomfort. Following observation for a few more days, he was discharged from the hospital.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"573-576"},"PeriodicalIF":0.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive <i>Klebsiella</i> Syndrome with Liver Abscess and Endogenous Endophthalmitis.","authors":"Thang Dinh Nguyen, Huong Tu Lam, Thong Duy Vo","doi":"10.2147/IMCRJ.S407902","DOIUrl":"10.2147/IMCRJ.S407902","url":null,"abstract":"<p><strong>Background: </strong>Invasive Klebsiella syndrome is an emerging infectious condition that frequently involves pyogenic liver abscess (PLA) and metastatic complications such as endogenous endophthalmitis (EE). This condition is often associated with diabetes mellitus and can result in poor visual prognosis despite treatment.</p><p><strong>Case description: </strong>We present the case of a 53-year-old diabetic female who developed EE secondary to a Klebsiella pneumoniae liver abscess. The patient initially presented with fever, fatigue, and abdominal pain, later developing ocular redness and reduced visual acuity. Abdominal ultrasound and computed tomography (CT) confirmed the presence of a multilocular liver abscess. Blood cultures were negative likely due to prior antibiotic use before admission, but Klebsiella pneumoniae was isolated from both the liver abscess and intraocular fluid. She was treated with intravenous (IV) meropenem and metronidazole, along with intravitreal vancomycin and ceftazidime. Despite early percutaneous drainage and antibiotic therapy, the patient's vision did not improve, ultimately requiring evisceration.</p><p><strong>Conclusion: </strong>This case highlights the importance of early recognition of invasive Klebsiella pneumoniae infections and their metastatic potential. Physicians should consider liver abscess as a possible source of infection in patients presenting with EE. Despite aggressive treatment, the prognosis remains poor, particularly in diabetic patients.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"559-565"},"PeriodicalIF":0.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen Planus Pigmentosus as a Cutaneous Extrahepatic Manifestation of Chronic Hepatitis C Virus Infection: A Case Report.","authors":"Erda Avriyanti, Nur Mala Il Ala, Endang Sutedja, Laila Tsaqilah, Chaerani Pratiwi Firdaus, Eva Krishna Sutedja, Hermin Aminah Usman, Risa Miliawati Nurul Hidayah","doi":"10.2147/IMCRJ.S516877","DOIUrl":"10.2147/IMCRJ.S516877","url":null,"abstract":"<p><p>Lichen planus pigmentosus is an uncommon dermatological condition characterized by hyperpigmented and dark-brown macules. It is a rare variant of lichen planus, one of the most common cutaneous extrahepatic manifestations of chronic hepatitis C virus infection. The cutaneous extrahepatic manifestations may indicate an undetected chronic hepatitis C virus infection, showing the need for thorough evaluation in patients presenting with these dermatological conditions. This case report presents a case of lichen planus pigmentosus in a 60-year-old male, initially complained of an itchy dark brown macule on his right temple, which progressively enlarged, covered almost the entire face, and became thicker in several areas. Then, he was diagnosed with chronic hepatitis C virus infection and liver cirrhosis. Dermoscopy examination showed gray-brown dots, globules, and peri-eccrine gray-brown pigmented dots. Laboratory tests revealed low ferritin levels, a positive antinuclear antibody test, but a negative antinuclear antibody profile. The histopathological examination showed basal vacuolar changes on the epidermis and interface dermatitis extending to the area of the hair follicle infundibulum, with melanin pigment deposits between the fibro-collagen connective tissue accompanied by inflammatory and peri-adnexa lymphocytes, and fibrosis around the hair follicles in the dermis, supporting the diagnosis of lichen planus pigmentosus. The patient was treated with sun avoidance and photoprotection, mometasone furoate 0.1% cream twice a day, and direct-acting antiviral agents. Improvement was observed clinically and supported by spectrophotometry examination. This case highlights lichen planus pigmentosus as a potential indicator of previously undetected hepatitis C virus infection, recommending hepatitis C virus testing for patients with lichen planus pigmentosus.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"577-583"},"PeriodicalIF":0.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Cord Stimulation - Device Revision After Weight Loss in a Patient on Chronic Semaglutide - A Case Report.","authors":"Chelsey Hoffmann, Markus A Bendel","doi":"10.2147/IMCRJ.S513630","DOIUrl":"10.2147/IMCRJ.S513630","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord stimulation (SCS) is an effective treatment option for patients suffering from chronic intractable pain of the trunk and/or limbs. One of the potential adverse effects of SCS is discomfort or pain at the site of the implantable pulse generator (IPG). It is a known phenomenon that patient weight loss may exacerbate or increase discomfort or pain at the IPG implantation site.</p><p><strong>Objective: </strong>This case report aims to educate neuromodulation clinicians on the potential impact of glucagon-like peptide-1 receptor agonists (GLP-1RA) medications on patient weight loss and decreased subcutaneous adipose tissue stores post-SCS system implant, necessitating lead anchor or IPG pocket revision.</p><p><strong>Study design: </strong>Case Report.</p><p><strong>Conclusion: </strong>The usage of GLP-1RA medications for diabetes or weight loss therapy continues to increase as does the use of implantable SCS systems for the management of chronically painful conditions. Interventional pain management or neuromodulation clinicians should be well-educated on the indications for use of GLP-1RA medications and their associated mechanisms of action, which may lead to weight loss, decreased subcutaneous adipose tissue stores, and muscle wasting, potentially impacting the comfortability of SCS devices. Pre-screening for the use of GLP-1RA medications should occur prior to SCS implant, and clinicians should plan accordingly to minimize the potential for SCS lead anchor or IPG pocket site discomfort. Further, patient's body habitus and adipose tissue stores should be taken into consideration when planning for IPG pocket site location.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"567-571"},"PeriodicalIF":0.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Wound Infection and Complications Following Traditional Male Circumcision in Rural Somalia: A Case Report of Malpractice in a Resource-Limited Setting.","authors":"Abdullahi Hassan Elmi, Abdullahi Abdirahman Omar, Najib Isse Dirie, Ahmed Omar Abdi, Bashiru Garba","doi":"10.2147/IMCRJ.S522255","DOIUrl":"10.2147/IMCRJ.S522255","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional male circumcision (TMC) is a common cultural and religious practice in Somalia. However, procedures performed by untrained practitioners under non sterile conditions can result in severe complications. This case report describes the delayed presentation and successful management of a 6-year-old boy who experienced wound infection and complications following a traditional circumcision.</p><p><strong>Case presentation: </strong>A 6-year-old boy from Shaan Town, Middle Shabelle region, Somalia, presented with urinary retention, lower abdominal pain, and penile discharge 15 days after traditional circumcision performed using non-sterile equipment. Initially, he experienced painful urinary dribbling progressing to complete urinary retention, accompanied by local infection characterized by swelling, redness, and foul-smelling discharge. Despite oral antibiotics administered at home, his condition deteriorated, prompting hospital admission near Mogadishu, where intravenous antibiotics and catheterization were initiated. Due to worsening symptoms, the patient was referred to our tertiary facility, where surgical debridement and primary closure of necrotic circumcision tissue were successfully performed. Postoperative recovery was uneventful, with complete normalization of urinary function and resolution of infection. Follow-up examinations at two weeks and one month confirmed satisfactory healing without residual complications.</p><p><strong>Conclusion: </strong>This case underscores the significant risks of traditional circumcision performed by untrained practitioners, emphasizing the need for public health interventions. This report highlights the importance of integrating safe medical practices into cultural frameworks to improve outcomes in resource-limited settings.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"553-558"},"PeriodicalIF":0.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracerebral Hemorrhage: A Fatal Complication of Severe Preeclampsia-A Rare Case Report in a Resource-Limited Setting.","authors":"Ibrahim Abdullahi Mohamed, Abdullahi Abdirahman Omar, Mulki Mukhtar Hassan, Mohamed Abdulahi Hassan, Zakaria Mohamed Adan, Zubeir Abdulkadir Mohamed","doi":"10.2147/IMCRJ.S516956","DOIUrl":"https://doi.org/10.2147/IMCRJ.S516956","url":null,"abstract":"<p><strong>Background: </strong>Intracerebral hemorrhage (ICH) is a rare but severe complication of preeclampsia, significantly contributing to maternal morbidity and mortality, particularly in resource-limited settings. The underlying mechanisms include endothelial dysfunction, cerebral autoregulation failure, and breakdown of the blood-brain barrier. This case report aims to highlight a unique presentation of severe preeclampsia complicated by ICH, emphasizing barriers encountered in resource-limited settings and discussing long-term implications and prognosis.</p><p><strong>Case presentation: </strong>A 35-year-old multiparous woman presented two days postpartum with altered mental status, aphasia, and right-sided hemiparesis. Her pregnancy was complicated by severe preeclampsia and intrauterine fetal death. Computed tomography (CT) revealed a left basal ganglia hemorrhage extending into the ventricles. She received conservative management including antihypertensive medications, magnesium sulfate for seizure prophylaxis, and anti-edema therapy. Despite limited diagnostic resources, laboratory evaluations ruled out coagulopathies and vascular anomalies. After 20 days of multidisciplinary care, significant neurological recovery was achieved. Follow-up after four weeks demonstrated complete functional recovery, with resolution confirmed by repeat CT.</p><p><strong>Conclusion: </strong>This case uniquely underscores the critical importance of timely multidisciplinary care and robust antenatal monitoring in mitigating severe complications such as ICH associated with preeclampsia. The patient's full recovery highlights the potential for successful conservative management even in resource-constrained environments. Future clinical practice and research should focus on improving antenatal care accessibility, patient education, and developing context-specific management guidelines to reduce maternal morbidity and mortality in similar settings.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"545-551"},"PeriodicalIF":0.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of a Complicated Forearm Fracture in a Patient with Congenital Insensitivity to Pain: A Case Report.","authors":"Anas Alrusan, Suhaib Bani Essa, Saif Aldin Naif Rawabdeh, Yazan Anaqreh, Modather Hatamleh, Mohammad Alradaideh, Mohammed Baker, Abdelwahab Aleshawi","doi":"10.2147/IMCRJ.S514415","DOIUrl":"https://doi.org/10.2147/IMCRJ.S514415","url":null,"abstract":"<p><strong>Background: </strong>Congenital insensitivity to pain (CIPA) is an extremely rare syndrome that is caused by a mutation in the NTRK gene. CIPA is characterized by recurrent episodes of unexplained fever, infections, skeletal complications, anhidrosis, mental retardation, and ocular injuries due to the absence of reaction to painful stimuli. Several musculoskeletal complications have been reported and included fractures, avascular necrosis, joint dislocations, soft tissue, and bone infections. The severity of these complications presented complex diagnostic and therapeutic dilemmas. The collaboration of medical professionals from different specialties to provide appropriate medical care is needed.</p><p><strong>Case presentation: </strong>We present a case of a 1-year-old girl, diagnosed with CIPA, admitted to our center complaining of wound discharge and fever from a previously repaired left forearm fracture with nail insertion, which was found to be infected after a failed trial of nail removal. A multidisciplinary- management from anesthesia, orthopedics, ophthalmology, and pediatrics was conducted. The patient underwent successful nail removal, wound debridement, and radius bone reduction with the appropriate anesthetic protocol that did not include analgesic medications. The follow-up course was uneventful with proper alignment and virtually stable health status, with no apparent skeletal or ocular complications.</p><p><strong>Conclusion: </strong>This report shows a case of CIPA with complicated forearm fracture. Patients with CIPA should be afforded a multidisciplinary healthcare approach in order to improve their quality of life and decrease the rate of complications. Parents and patients should be educated promptly. Orthopedics complications imply significant morbidity and require prompt surgical intervention with intense follow-up.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"539-543"},"PeriodicalIF":0.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}