International Medical Case Reports Journal最新文献

{"title":"Atypical HPV Typing: Detection of Genital-Associated HPV Type 6 in Verruca Vulgaris of the Hands and Feet in an HIV-Positive Patient.","authors":"Pati Aji Achdiat, Ranisa Larasati, Risa Miliawati Nurul Hidayah, Erda Avriyanti, Hermin Aminah Usman, Retno Hesty Maharani","doi":"10.2147/IMCRJ.S494454","DOIUrl":"10.2147/IMCRJ.S494454","url":null,"abstract":"<p><p>Verruca vulgaris is a cutaneous infection predominantly caused by human papillomavirus (HPV) type 1, 2, and 4. In immunocompromised individuals infected with human immunodeficiency virus (HIV) infection, HPV leads to a higher prevalence of infections and also has a greater likelihood of being infected with atypical types such as genital-associated HPV in extragenital sites. This case report describes a 48-year-old male patient who presented with skin-colored verrucous papules on the hands and feet, with no evidence of genital lesions. Polymerase Chain Reaction (PCR) genotyping identified the presence of HPV types 4, 6, and 16 as an etiology of verruca vulgaris, low-risk HPV with genital-associated lesions, and high-risk HPV. This atypical result may suggest a failure of the immune defense system of the body. Therefore, accurately identifying HPV types through PCR testing in immunocompromised patients is essential for appropriate clinical management and monitoring.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"67-74"},"PeriodicalIF":0.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat Liquefaction and Lipo Particles in a CIED Pocket During Generator Change-Not an Infection: A Rare Case Report.","authors":"Aili Guan, Tao He, Xingang Huang, Wei Xia, Yibing Shao","doi":"10.2147/IMCRJ.S505053","DOIUrl":"10.2147/IMCRJ.S505053","url":null,"abstract":"<p><p>A case of fat liquefaction and fat particles in the pacemaker pocket observed in a female patient 12 years after implantation. The patient had no symptoms and no signs of infection or other discomfort of the heart and pacemaker pocket. The biochemical analysis showed a slight increase in cardiac troponin T, 0.026 ng/mL (reference range, <0.016 ng/mL), a high increase in total cholesterol, 8.70 mmol/L (reference range, <5.18 mmol/L), and low density lipoprotein, 5.38 mmol/L (reference range, <3.37 mmol/L). Thick yellow liquid was seen to flow out of the pacemaker pocket when the pocket was opened, and many fat particles were found adhering to the wall of the pacemaker pocket during the pacemaker replacement procedure. Fat and fibrillar connective tissue with a few inflammatory cells, local tissue degeneration and necrosis were shown on immunohistochemical staining and no bacterial growth including anaerobic bacteria was observed. The aseptic necrosis of post-implantation complications is helpful for differential diagnosis in CIED complication. Moreover, the identification of fat liquefaction has important clinical significance for patient management and surgical decision-making.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"53-58"},"PeriodicalIF":0.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Activity of Behcet's Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports.","authors":"Fitrah Utari Bakti, Irna Sufiawati","doi":"10.2147/IMCRJ.S487703","DOIUrl":"10.2147/IMCRJ.S487703","url":null,"abstract":"<p><strong>Introduction: </strong>The Behçet's Disease Current Activity Form (BDCAF) is crucial for monitoring the progression and treatment efficacy of Behçet's Disease (BD), an autoimmune disorder that can be triggered or exacerbated by viral infections. Herpes simplex virus type 1 (HSV-1) has long been recognized as a potential trigger for BD, as it can induce systemic inflammation and exacerbate symptoms. In contrast, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently emerged and may also initiate or worsen BD symptoms. This report examines three BD cases with oral manifestations specifically triggered by HSV-1 and SARS-CoV-2, comparing their clinical activity and treatment responses.</p><p><strong>Case: </strong>Three female patients, aged 29, 24, and 41 years, presented to the Oral Medicine Department with complaints of canker sores, along with genital and skin lesions and red eyes. Intraoral examination showed ulcerative, erosive, and white plaque lesions throughout the oral mucosa. The first patient was confirmed to have COVID-19 by the SARS-CoV-2 RNA test. The second and third patients had a two-year history of recurrent oral ulcerations with reactive IgG anti-HSV-1 tests. All patients were diagnosed with BD according to the International Criteria for Behcet's Disease. The BDCAF measurements were conducted, showing a BD activity index score of 4 for the COVID-19-positive patient, while scores of 6 and 7 were recorded for the other two patients with seropositive HSV-1.</p><p><strong>Case management: </strong>Medications provided include corticosteroid, antimetabolite, analgesic, antiviral, antifungal, antiseptic mouthwash, and multivitamin. All patients showed good clinical improvement after treatment.</p><p><strong>Conclusion: </strong>The BD activity index scores of a BD patient with COVID-19 were lower than those with HSV-1 infection. This difference may be due to the recent SARS-CoV-2 infection in the patient, whereas reactivation of chronic latent HSV-1 in the other patients likely contributed to a longer history of clinical manifestations, resulting in increased disease activity.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"41-52"},"PeriodicalIF":0.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Excision and Radiotherapy for Giant Keloids in Auricula: A Case Report.","authors":"Shinta Fitri Boesoirie, Retno Arun Winastuti, Agung Dinasti Permana, Novan Arya Yudistira, Vesara Ardhe Gatera, Muhammad Thaufiq Boesoirie","doi":"10.2147/IMCRJ.S496531","DOIUrl":"10.2147/IMCRJ.S496531","url":null,"abstract":"<p><p>Keloids are characterized by excessive growth of fibrous tissue resulting from abnormal wound-healing processes. They may lead to functional impairments, aesthetic deformities, pruritus, and a decreased quality of life. Various therapies, including intralesional corticosteroid injections, cryotherapy, laser therapy, surgical excision, and radiotherapy, have been used to manage keloids, but the recurrence rates remain high. Therefore, this study aimed to report combination therapy for patients with giant keloids in auricula. This report presents a 35-year-old man who had lumps in both ears that got bigger over about 10 years. Surgery was done to remove the keloids and to fix both ears. After surgery, the patient got some radiotherapy, specifically a kind called superficial brachytherapy, to try to lower the chances of the keloids coming back. A combined way of doing surgery and giving radiotherapy showed it could work well for handling big ear keloids and keeping them from coming back. The extra radiotherapy after surgery helped a lot in lowering the chances of the keloids showing up again.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"33-40"},"PeriodicalIF":0.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment Optical Coherence Tomography Evaluation of a Dexamethasone Intravitreal Implant in the Crystalline Lens: A Case Report.","authors":"Joana Santos-Oliveira, Rita Teixeira-Martins, Ana Margarida Ferreira, João Paulo Macedo, Cláudia Oliveira-Ferreira","doi":"10.2147/IMCRJ.S486866","DOIUrl":"10.2147/IMCRJ.S486866","url":null,"abstract":"<p><strong>Purpose: </strong>Ozurdex^® is a dexamethasone intravitreal implant approved for the treatment of macular edema secondary to branch or central retinal vein occlusion, non-infectious uveitis affecting the posterior segment of the eye, and diabetic macular edema.</p><p><strong>Patients and methods: </strong>We report a case of an accidental injection of the implant into the crystalline lens, successfully managed by surgery afterwards. The case description is supported by Anterior Segment Optical Coherence Tomography (AS-OCT) images.</p><p><strong>Results: </strong>A 69-year-old male was observed for bilateral diabetic macular edema. He had previously been treated with bevacizumab and aflibercept, with an incomplete anatomical response (<20% reduction in central macular thickness). The patient consented to undergo a bilateral intravitreal dexamethasone injection (dexamethasone intravitreal implant (0.7 mg)). The procedures were uneventful, except for an extensive conjunctival hemorrhage in the right eye. An appointment was scheduled for fifteen days later, however the patient missed it. Four months later, he referred OD vision loss, which occurred a few days after the injection, and the implant was found within the right crystalline lens. An AS-OCT was done to better understand the implant's location and entry point. Due to decreased visual acuity, the patient was scheduled for surgery. A phacoemulsification surgery with a three-piece hydrophobic intraocular lens implantation in the sulcus associated with anterior vitrectomy was done.</p><p><strong>Conclusion: </strong>The injection of a dexamethasone implant is becoming increasingly common. Nonetheless, it must always be carried out carefully, to avoid complications. If the implant is accidentally injected into the crystalline lens, the AS-OCT can help determine its exact location, which is important for preparing the surgical plan and determining the appropriate timing.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"27-32"},"PeriodicalIF":0.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Recurrent Keratitis as a Complication of <i>Androctonus crassicauda</i> Black Scorpion Sting: A Case Report.","authors":"Asem Alqudah, Abdel Rahman Bani Yassin, Said Yaseen, Leen El Taani","doi":"10.2147/IMCRJ.S486917","DOIUrl":"10.2147/IMCRJ.S486917","url":null,"abstract":"<p><p>Scorpions are a group of arthropods known to be highly toxic to humans. We report the case of a previously healthy 61-year-old male who sustained a sting from an Androctonus crassicauda scorpion to his right eye. The patient was admitted to the intensive care unit (ICU) in a comatose state immediately after the sting. A few days later, he suffered from tearing right-eye pain and loss of vision, which persisted despite initial treatment. The patient was subsequently diagnosed with keratitis and admitted to King Abdullah University Hospital (KAUH). He was prescribed various antibiotics, which initially improved his condition. However, the patient experienced subsequent deterioration and recurrent episodes of keratitis. The patient's visual acuity improved after treatment with a combination of antifungal and antibiotic medications, suggesting a polymicrobial infection. Despite the improvement in his condition, the sting left a central corneal scar, necessitating corneal transplant surgery as a definitive treatment. To the best of our knowledge, this scenario has not been previously documented.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"7-13"},"PeriodicalIF":0.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine Adenomyosarcoma Complicated by Uterine Prolapse and Necrosis: A Case Report.","authors":"Jiahao Chang, Yanqing Jin, Chaoxiong Cui, Haiyan Cheng","doi":"10.2147/IMCRJ.S489194","DOIUrl":"10.2147/IMCRJ.S489194","url":null,"abstract":"<p><p>In this case, the patient had uterine adenocarcinoma with a huge necrotic mass prolapsed from the vagina, complicated by necrotic infection and massive bleeding. Based on ultrasound results preoperatively, uterine prolapse with infected necrosis was considered due to significant vaginal bleeding, prompting emergency surgery and blood transfusion. Postoperatively, pathology review indicated a misdiagnosis. This article aims to analyze the reasons for misdiagnosis through case review and literature review.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"15-22"},"PeriodicalIF":0.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural Hydroxyethyl Starch in Treatment of Post Epidural Puncture Headache: A Case Series and Literature Reviews.","authors":"Yucheng Lai, Wanhong Li, Dizhou Zhao, Xiaoyang Liang, Jieyu Fang","doi":"10.2147/IMCRJ.S504282","DOIUrl":"10.2147/IMCRJ.S504282","url":null,"abstract":"<p><strong>Background: </strong>Post-dural puncture headache (PDPH) is a common complication of obstetric anesthesia. There are still no convenient and effective methods to control the PDPH.</p><p><strong>Case presentation: </strong>Three cases of parturients with accidental dural puncture who suffered post-dural puncture headache (PDPH) after labor analgesia or cesarean section. They were treated with epidural hydroxyethyl starch (HES) through an epidural catheter and achieved well therapeutic effect.</p><p><strong>Conclusion: </strong>Treatment of PDPH by epidural HES is a promising method that may benefit the parturient and doctor.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"23-26"},"PeriodicalIF":0.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transthyretin-Related Familial Amyloidosis Polyneuropathy with Spinal Cord Damage: A Case Report.","authors":"Hailin Liu, Chao Huang, Yanjiao Du, Jiacheng Liu, Xiangyang Ren, Huilin Wang, Jingna Ye, Haitao Zhou, Zhihui Duan","doi":"10.2147/IMCRJ.S486387","DOIUrl":"10.2147/IMCRJ.S486387","url":null,"abstract":"<p><strong>Introduction: </strong>Transthyretin protein-related familial amyloidosis polyneuropathy (TTR-FAP) is an autosomal dominant genetic disease caused by mutations in the TTR gene. The disease is characterized primarily by peripheral and autonomic nerve damage. Disease progression is associated with frequent involvement of the heart, lungs, kidneys, eyes, and other organs. The most common TTR mutation is c.148G>A (p.Val50Met), although the FAP resulting from the mutation rarely involves the spinal cord.</p><p><strong>Patient concerns: </strong>A 68-year-old man was diagnosed with the TTR c.148G>A (p.Val50Met) mutation by ultrasound, pathological, and genetic analyses. He presented with a late-onset, complicated spinal cord injury. The diagnostic process was tortuous, and despite the administration of regular treatment (conventional drugs, cardiac pacemaker, and the specific drug clofenadifen), the patient died.</p><p><strong>Interventions: </strong>To confirm TTR-FAP, ultrasound, MRI, pathological, and genetic tests were performed.</p><p><strong>Outcomes: </strong>The patient ultimately died of heart failure 7.5 years after the initial onset of symptoms.</p><p><strong>Conclusion: </strong>The patient presented with unusual symptoms of spinal cord injury, and despite a long and arduous diagnostic process and administration of standard treatment for over seven years, the outcome was poor. It is thus recommended that clinicians pay attention to the identification of rare diseases with timely imaging, pathological, and genetic testing, to avoid poor outcomes.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"1-5"},"PeriodicalIF":0.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Reversible Corneal Edema as a Novel Side-Effect of Levetiracetam - A Case Report.","authors":"Kimberly Caruana, Matthew Ellul, Andre Grixti","doi":"10.2147/IMCRJ.S497262","DOIUrl":"10.2147/IMCRJ.S497262","url":null,"abstract":"<p><strong>Purpose: </strong>We present a case of levetiracetam-induced corneal edema. To the best of our knowledge, this is the first documented case of bilateral reversible corneal edema secondary to levetiracetam use.</p><p><strong>Patients and methods: </strong>A 59-year-old woman was referred to the ophthalmology department with a few weeks' history of bilateral blurring of vision. She is a known case of secondary progressive multiple sclerosis, and she was started on levetiracetam by her neurologist a few weeks prior to referral in view of new seizure activity. Examination revealed bilateral clinically evident corneal edema, which was documented on corneal topography.</p><p><strong>Results: </strong>Upon levetiracetam dose reduction, symptoms started to improve and eventually the medication was stopped altogether. The patient's vision and corneal edema normalized on follow-up.</p><p><strong>Conclusion: </strong>This novel side effect should be kept in mind when a patient who is on levetiracetam presents with corneal edema as this can avoid misdiagnosis and unnecessary interventions.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"1069-1074"},"PeriodicalIF":0.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}