International Journal of Pharmaceutical Chemistry and Analysis最新文献_第3页

Advancement in the treatment, genetic understanding, and diagnostic approaches for retinoblastoma 视网膜母细胞瘤的治疗、基因理解和诊断方法取得进展

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.006

Manashri Yashwant Mokal, S. Shaikh

{"title":"Advancement in the treatment, genetic understanding, and diagnostic approaches for retinoblastoma","authors":"Manashri Yashwant Mokal, S. Shaikh","doi":"10.18231/j.ijpca.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.006","url":null,"abstract":"The most common intraocular tumor in children is retinoblastoma. In developed countries, there has been an impressive rise in the survival rate and visual outcome of patients with retinoblastoma. This is clarified by developments in retinoblastoma treatment and early detection of tumors. The primary therapy remedy for intraocular retinoblastoma is now chemotherapy along with adjuvant consolidative treatment, instead of external beam radiation. Likewise, prophylactic chemotherapy is now allowed to treat potential micro metastases in enucleated eyes based on the identification of high-risk histopathological factors. Extra ocular retinoblastoma still has a poor future outcome; chances of survival have been reported to be between 50% and 70%. Retinoblastoma patients' overall survival is still struggling in developing countries, mostly because of delayed presentation and greater risk of extra ocular illness while compared to with the developed world, where intraocular disease contributes to majority of cases. To enhance the survival rate for those with retinoblastoma in developing countries, greater priority must be given to early detection of tumors. We provide a summary of the latest clinical management of retinoblastoma in this article.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured dendrimer improves the solubility of carvedilol, furosemide and nimodipine 纳米结构树枝状聚合物可提高卡维地洛、呋塞米和尼莫地平的溶解度

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.008

Jigar V. Patel, V. Patel, Pravinkumar M. Patel

{"title":"Nanostructured dendrimer improves the solubility of carvedilol, furosemide and nimodipine","authors":"Jigar V. Patel, V. Patel, Pravinkumar M. Patel","doi":"10.18231/j.ijpca.2024.008","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.008","url":null,"abstract":"Essential hypertension has been treated for over 30 years using both diuretics and beta-blockers. When it comes to treating heart failure, there are three different generations of beta-blockers that are now in use. Carvedilol is a blocker from the third generation. Nimodipine is a common L-type calcium channel blocker. The hypertension medication furosemide is a loop diuretic. This class of medications' low solubility in water has emerged as a serious obstacle in the pharmaceutical industry's pursuit of better treatments. A novel class of polymers called dendrimers has recently gained a lot of interest due to its impressive solubility-enhancing characteristics. Results from hemolysis studies and cytotoxicity tests using the novel nanostructure dendrimer shown here demonstrate superior performance of synthetic dendritic macromolecules compared to commercially available PAMAM dendrimer. Dendrimers are used to enhance the solubility of nimodipine, furosemide, and carvedilol up to 38.08µg/ml, 70.999µg/ml and 147.065µg/ml respectively. The enhancement of dendrimer-mediated solubility is primarily determined by factors such as dendrimer concentration and generation size. Drugs containing dendrimers may be studied using Fourier-transform infrared spectroscopy. Based on the results of this investigation, nanostructured dendrimer technology may help with hydrophobic medication dispersion.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of aceclofenac fast disintegrating tablets using sida acuta powder 使用西达拉粉配制和评估醋氯芬酸快速崩解片

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.011

T. Anjali, P. Prasanna Kumar, N. Srinivas, K. Shivaji

引用次数: 0

Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets 双氯芬酸钠快速崩解片的设计、配方和体外评价

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.012

P. Prasanna Kumar, T. Anjali, Srinivas Nandyala, K. Sivaji

{"title":"Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets","authors":"P. Prasanna Kumar, T. Anjali, Srinivas Nandyala, K. Sivaji","doi":"10.18231/j.ijpca.2024.012","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.012","url":null,"abstract":"Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been preparedCorn silkpowderwithvarious 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes.The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview: Global burden of liver disease 概述：全球肝病负担

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.001

Krushna Baviskar, Aniket Kshirsagar, Hemant Raut, M.R.N Shaikh

引用次数: 0

Therapeutic landscape of natural products and emulgel in psoriasis 天然产品和润肤露在银屑病中的治疗前景

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.003

Rohit Doke, Ritik R Matade, Swarup Harne, Sakshi Kale, Yashodhan Ponde, Tejas S Naik, Ganesh Lamkhade

{"title":"Therapeutic landscape of natural products and emulgel in psoriasis","authors":"Rohit Doke, Ritik R Matade, Swarup Harne, Sakshi Kale, Yashodhan Ponde, Tejas S Naik, Ganesh Lamkhade","doi":"10.18231/j.ijpca.2024.003","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.003","url":null,"abstract":"Psoriasis, characterized by immune-mediated inflammation triggered by dysfunctions in the immune system, manifests in various skin areas with elevated plaques presenting as common symptoms. Traditional psoriasis treatments often incorporate plant-based remedies, which, although safer, are predominantly hydrophobic, limiting their permeation and absorption into the skin. To address these challenges, researchers have turned to emulgels as drug delivery systems. Emulgels, combining the properties of both emulsions and gels, effectively solubilize hydrophobic drug molecules, enhancing their absorption through the skin. Emulgels shows several advantages including easy application and removal, emollient properties, non-greasiness, cosmetic appeal, and excellent penetration capabilities.This review emphasizes the significance of herbal drugs in psoriasis therapeutics and explores the utilization of emulgels as a delivery system for herbal extracts and constituents in psoriasis treatment. By highlighting the potential of emulgels in enhancing the delivery of herbal remedies for psoriasis management, this review offers insights into novel approaches to address the challenges associated with traditional psoriasis treatments.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, crystal structure studies, characterization and study of novel heterocyclic thiadiazoles as caspase 3 inhibitors for anticancer activity 新型杂环噻二唑作为 Caspase 3 抑制剂的合成、晶体结构研究、表征和抗癌活性研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.045

Bhavini K Gharia, B. Suhagia, Vineet Jain

{"title":"Synthesis, crystal structure studies, characterization and study of novel heterocyclic thiadiazoles as caspase 3 inhibitors for anticancer activity","authors":"Bhavini K Gharia, B. Suhagia, Vineet Jain","doi":"10.18231/j.ijpca.2023.045","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.045","url":null,"abstract":"In the present study we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing cyclopropyl moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Primarily docking studies are carried out with reference structure Pdb code:2DKO. We have reported the new series of 5,6 diaryl substituted with imidazo[2,1- b], , thiadiazoles analogs to target caspase family cysteine proteases. The reaction was monitored by Thin-layer chromatography using suitable mobile phase. The Rf values were compared and determined the melting point of synthesized compounds. Further these derivatives were characterized and confirmed by IR, 1H-NMR, 13C-NMR, and Mass spectral (MS) studies. For anticancer activity, all the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay were evaluated for their anticancer activity. Primary one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compounds and showed good activity against all cancer cell lines. The synthesized drugs were monitored with Caspase 3 inhibitor kit.(CASP3C-1KT)using colorimeteric assay.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"24 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Quality by Design (QBD) approach for the development and validation of RP-HPLC method for the quantification of linagliptin tablets 采用 "质量源于设计"（QBD）方法开发和验证利拉利汀片剂的 RP-HPLC 定量方法

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.047

Abm Mahfuz ul Alam, I. Mamun, Nilufar Nahar, M. Shoeb

{"title":"A Quality by Design (QBD) approach for the development and validation of RP-HPLC method for the quantification of linagliptin tablets","authors":"Abm Mahfuz ul Alam, I. Mamun, Nilufar Nahar, M. Shoeb","doi":"10.18231/j.ijpca.2023.047","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.047","url":null,"abstract":"This study emphasizes the pivotal role of Quality by Design (QbD) in the development of pharmaceutical methods, with a particular focus on risk assessment to ensure consistent quality. The research showcases the creation of a precise and practical HPLC method for Linagliptin Tablets, developed using QbD principles. This optimized method, designed through a systematic Design of Experiment approach, provides a robust and cost-effective solution for pharmaceutical analysis, promoting the consistent quality required within predefined specifications. The method employs C18 column (150 mm x 4.6 mm, 5μM) and employs isocratic elution with a mobile phase composed of Acetonitrile: Sodium Acetate Buffer with a pH of 4.5 in a ratio of 25:75. The flow rate was optimized at 1.0 mL/min, and peak detection was achieved using a UV detector set at 294 nm. The injection volume was standardized at 10 µL, and the Column Oven Temperature was maintained at 25°C. Rigorous validation following ICH Q 2 (R1) and USP <1225> guidelines ensure the method's reliability, with assessments of parameters such as limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and robustness. The method's exceptional sensitivity, selectivity, efficiency, precision, accuracy, and cost-effectiveness make it an optimal choice for pharmaceutical analysis of Linagliptin Tablets.This method is intended for further use in routine analysis for quality control in the pharmaceutical industry and has demonstrated the ability to distinguish marketed products, including comparability with the innovator product.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"33 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on herbal face wash 草本洗面奶回顾

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.038

S. Tiware, Komal Khond Warghane, Priyanka Waghmare, Neha P. Rumale

引用次数: 0

Analytical and bio-analytical methods of rofecoxib: A comprehensive review 罗非昔布的分析和生物分析方法：全面综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.040

Vikas R. Patil, G. Vadnere, K. D. Baviskar, Vinay V. Sarode, Jayesh T. Nimbalkar

引用次数: 0