Formulation and evaluation of aceclofenac fast disintegrating tablets using sida acuta powder

Abstract

Aceclofenac is a NSAID with anti-inflammatory, analgesic activity. The aim is to develop the Aceclofenac tablets with sida acuta powder that exhibit rapid disintegration, dissolution and showing maximum pharmacological activity in less time. This is desirable for improving patient compliance. The present study was to formulate and evaluate the fast-disintegrating tablets of Aceclofenac using Sida acuta powder by direct compression technique with varying concentrations. Each formulation was evaluated for pre and post evaluation tests such as Flow property, Bulk density, tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 06 formulations, F6 formulation Aceclofenac with 6%w/w of Sida acuta showed the in-vitro dissolution (99.75%) release of drug within 20 minutes and release of drug mechanism as first order kinetics. It was concluded that the fast-disintegrating tablets are prepared by Natural polymer Sida acuta acts as a disintegrant and showed excellent disintegration time,enhance the dissolution rate.