International Journal of Pharmaceutical Chemistry and Analysis最新文献

Formulation and evaluation of natural lip balm 天然润唇膏的配制与评估

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.027

X. Fatima Grace, K. Himana Begam, A. Janani, M. Jayaram

{"title":"Formulation and evaluation of natural lip balm","authors":"X. Fatima Grace, K. Himana Begam, A. Janani, M. Jayaram","doi":"10.18231/j.ijpca.2024.027","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.027","url":null,"abstract":"The formulation and evaluation of a natural lip balm with beetroot juice as the main ingredient are the main subjects of this study. Due to its natural pigments and moisturising qualities, beetroot known for its rich colour and possible health benefits is a promising ingredient in cosmetics. The research begins with the development of a formulation incorporating beetroot juice alongside other natural ingredients to create a lip balm product.Subsequently, the physical, chemical, and sensory aspects of the lip balm formulation are evaluated. The overall quality and consumer attractiveness of the product are assessed by analysing various parameters, including colour, pH, texture, fragrance, and moisturising efficacy. Furthermore, stability checks are carried out to ensure the durability and shelf-life of the lip balm under different storage conditions.The findings of this study aim to contribute to the growing demand for natural and sustainable cosmetics while providing insights into the potential benefits of utilising beetroot juice in lip care products. Ultimately, the research seeks to offer a viable alternative to conventional lip balms, promoting both health-conscious and eco-friendly beauty solutions.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on Alzheimer’s disease 阿尔茨海默病回顾

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.019

Rimjhim Arora, Kamal Singh Rathore, S. S. Saurabh

引用次数: 0

Steps in discovery of alogliptin 发现阿格列汀的步骤

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.018

S. Chaudhry, Abhijit Tailokya, Gopal Wawde, Yogesh Bhide, Kavita Inamdar

引用次数: 0

Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation 氢溴酸替尼列汀水合物口腔溶解条：配方与评估

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.023

S.M. Attar, S. Ghurghure, Sumit

{"title":"Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation","authors":"S.M. Attar, S. Ghurghure, Sumit","doi":"10.18231/j.ijpca.2024.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.023","url":null,"abstract":"Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 81","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and development of antiperspirant formulation from natural extract: An overview 利用天然提取物设计和开发止汗剂配方：概述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.015

Naseef PP, Femina K P, Navaneeth Krishnan, Shifana, Shijiya Sherin KP, Vighnesh S

引用次数: 0

A review on macrocyclic kinase inhibitors in clinical trials 大环激酶抑制剂临床试验综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.020

Alemu Tadesse Feroche, Frehiwot Beyene Woselassie

引用次数: 0

Quantitative estimation of fenticonazole nitrate by zero-order derivative area under curve spectrophotometric methods in bulk and in-capsule dosage form 用零阶导数曲线下面积分光光度法定量估算硝酸芬替康唑散剂和胶囊剂中的含量

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.025

Ashish Gorle, Pritam Jain, Pankaj Nerkar, Nitin Haswani, Saurabh Chordiya, Saipudeen H. Kommakayam

{"title":"Quantitative estimation of fenticonazole nitrate by zero-order derivative area under curve spectrophotometric methods in bulk and in-capsule dosage form","authors":"Ashish Gorle, Pritam Jain, Pankaj Nerkar, Nitin Haswani, Saurabh Chordiya, Saipudeen H. Kommakayam","doi":"10.18231/j.ijpca.2024.025","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.025","url":null,"abstract":"The purpose of this study is to establish Zero-order UV-Spectrophotometric - absorbance and Zero Order- Area under curve (AUC) methods for estimation of Fenticonazole Nitrate in bulk and vaginal capsules. Fenticonazole Nitrate is an antifungal drug and it is completely insoluble in water. Methanol was used as solvent for solubilization of Fenticonazole Nitrate. Maximum absorption for Fenticonazole Nitrate was found to be at wavelength 253 nm when dissolved in Methanol. The methods are based upon measurement of absorbance at 253nm and integration of area under curve for analysis of Fenticonazole Nitrate in the wavelength range of 242-262 nm. The drug followed linearity in the concentration range of 5 - 30µg/mL with correlation coefficient value r> 0.99 for both methods. The proposed methods were validated for accuracy (% recovery), precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Fenticonazole Nitrate in vaginal capsules and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Fenticonazole Nitrate in bulk and Vaginal Capsules.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of the synthesised jelly by UV method development and validation of ramipril 用紫外法测定合成果冻并验证雷米普利

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.024

SK Umeraazmi, B. Krishna Reddy, K. Raja Sekhar Reddy, R. Ramesh, S. Jayasree, S. Sandeep, B. Thangabalan

引用次数: 0

Getting prepared for the fresh COVID19 wave: 为迎接 COVID19 的新一轮浪潮做好准备：

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.026

Anurag Garg, Ravi Singhal, Shyamli Varshney

{"title":"Getting prepared for the fresh COVID19 wave:","authors":"Anurag Garg, Ravi Singhal, Shyamli Varshney","doi":"10.18231/j.ijpca.2024.026","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.026","url":null,"abstract":"Regular supply of pure oxygen is the need of the hour to be prepared for the fresh waves of COVID-19. The cost of such oxygen supplies should be economical to reach out to the masses & avoid unwelcome burden on the national economy. A requirement has always been felt to identify an alternate source of oxygen generation with readily available raw materials which can ensure its cost effectiveness and last mile oxygen availability through independent generation capabilities.Chemical generation of oxygen has been the go-to technology for portable oxygen generation. However, the cost of production and controlling the reaction has generally been uneconomical for commercial applications. The authors undertook a task to build up a prototype of chemical oxygen generator which did not require compressed gas. It on the principle of dissociation of Sodium per carbonate (SPC) into sodium carbonate and hydrogen peroxide. Hydrogen peroxide so produced interacts with catalyst MnO which further decomposes to produce oxygen. A cast iron tank with a reaction chamber at the bottom is fabricated where upper tank consists of water and space for storing gases. The flow of the water is regulated to control the speed of the reaction.The chemical mixture of sodium percarbonate and manganese dioxide is tightly packed in a cloth bag.Oxygen release valve is kept at the top of the tank which is connected via a pipe to the standard to check the quantity of oxygen as well as the oxygen mask for the patient.This equipment, has a to be the in the fight against COVID especially in remote and difficult to access areas as well as areas without electricity.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation of mouth rinse from natural plant's leaf extract and evaluation of antibacterial activity 用天然植物叶提取物配制漱口水并评估其抗菌活性

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.022

Kavita Shukla Pandey, Vinay Gajanan Polpelliwar, T. M. Shirbhate, Zohra Firdous, Pravin Krishnarao Gaidhane, M. Gaidhane

{"title":"Formulation of mouth rinse from natural plant's leaf extract and evaluation of antibacterial activity","authors":"Kavita Shukla Pandey, Vinay Gajanan Polpelliwar, T. M. Shirbhate, Zohra Firdous, Pravin Krishnarao Gaidhane, M. Gaidhane","doi":"10.18231/j.ijpca.2024.022","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.022","url":null,"abstract":"Herbal liquid formulations are the preparation for oral health related issues like toothache, swelling, redness, bacterial or fungal infection in mouth, tooth decay, bleeding gums, weakened gums, etc. Such preparation also improves gums strength, removing bad breath and give fresh feel during good start of the day. Dentists generally use such preparations as antimicrobials before or after oral surgery to sanitize the surface of affected gums and teeth to avoid further contamination. Herbs like Tulsi, Clove, Mint, Ginger etc., are generally used either alone or in combination in herbal mouth-wash preparations which also render antibacterial activities. The other herbs like Eucalyptus and Liquorices have been reported to possess antibacterial, anti-oxidant, aromatic, anti- inflammatory and sweetening properties. In the present work, the research continues with formulation and evaluation of a herbal mouth rinse by using a combination of selected herbal extracts of Tulsi, Bael, Eucalyptus leaves and Liquorices rhizome for their antimicrobial activity against S. aureus using agar well diffusion plate technique. It was found that the formulated herbal mouth rinse or preparations gave satisfactory results in controlling the microorganism. Different physicochemical tests of prepared preparations were performed to figure out their pH, phase separation, homogeneity and scent.,","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0