International Journal of Pharmaceutical Chemistry and Analysis最新文献_第2页

Extracellular vesicles the delivery of drugs through genetic engineering 细胞外囊泡通过基因工程输送药物

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.017

Joshi Ankur, S. Priyanka, Malviya Neelesh, Malviya Sapna, Kharia Anil

{"title":"Extracellular vesicles the delivery of drugs through genetic engineering","authors":"Joshi Ankur, S. Priyanka, Malviya Neelesh, Malviya Sapna, Kharia Anil","doi":"10.18231/j.ijpca.2024.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.017","url":null,"abstract":"Researchers from a variety of disciplines are investigating the use of extracellular vesicles (EVs) as delivery vehicles for pharmaceutical solutions. In order to make the most of the therapeutic potential of EVs, various loading strategies have been devised. Despite the widespread application of exogenous methods, endogenous approaches are becoming increasingly preferred instead. Medicinal macro molecules such as proteins and nucleic acids can be loaded with relative ease using this technology that manipulates parental cells through genetic engineering. We examine the most effective ways for EV loading and demonstrate why endogenous is superior. Extracellular vesicles (EVs), which are able to transport pharmaceuticals, have the potential to tackle the problems of biologic therapeutic stability and off-target undesirable effects. In addition, we investigate the most recent findings and applications of this innovative method in order to shed light on the numerous potential therapeutic possibilities in the field of EV-based treatments. The possibility of endogenous loading of EVs with big biological medicines has been brought to light by recent research. In order to optimize the loading of biologic drugs in extracellular vesicles (EVs), researchers have been able to apply cargo selection and loading pathway molecules thanks to advancements in EV biogenesis. It has been established that endogenous EV loading is successful in preclinical in vivo trials, which demonstrates its promise in a variety of therapeutic situations.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fundamental overview and applicability of thaumatin 泰妙菌素的基本概况和适用性

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.021

Madhuri Dalavi, Sakshi Handge, Vaishnavi Pate, Hemant Raut, Amit V. Kakad, M.R.N Shaikh

引用次数: 0

A meta analysis study on plants used by tribes of various districts of Odisha for treatment of liver disease 关于奥迪沙各地区部落用于治疗肝病的植物的元分析研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.014

T. Basuri, Ranjit Mohapatra, N. Dhal, S. N. Kharat

{"title":"A meta analysis study on plants used by tribes of various districts of Odisha for treatment of liver disease","authors":"T. Basuri, Ranjit Mohapatra, N. Dhal, S. N. Kharat","doi":"10.18231/j.ijpca.2024.014","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.014","url":null,"abstract":"This review article include study on plants used by different tribes of different districts of Odisha for the treatment of Liver disease. A Field work was carried out the months of June – July 2016. The ethano-medicinal survey was conducted particularly with Odisha tribes in different districts having forest pockets with the help of local medicine men, locally known as Ayurveda. Data were collected through structure questionnaires and observing during the field visits. In the present study the local population used a total of 20 plant species belonging to 10 families to cure a variety of diseases. Out of the 20 plants,12 was herb, followed by trees and shrubs. The present study concluded that, the Odisha tribes of the study area possess rich knowledge on the medicinal plants and their utilization. Thus, the present study focuses on the documentation of the traditional knowledge of these valuable plants, which could enhance the potential of these medicinal plants to other communities as well and by understanding the importance, other communities can also helpful for conservation of these resources for further use.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of 3- D printing technologies 3- D 印刷技术的作用

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-07-15 DOI: 10.18231/j.ijpca.2024.016

Shilpi Arora, Anubhav Dubey, Mamta Kumari

引用次数: 0

Study the effect of Vitamin D3 in newly diagnosed acute myeloid leukemia 研究维生素 D3 对新诊断急性髓性白血病的影响

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.010

F. Obed, Shatha M. J. Al-Khateeb, Raghada Shams Akram, Mohammad Ali Kareem

{"title":"Study the effect of Vitamin D3 in newly diagnosed acute myeloid leukemia","authors":"F. Obed, Shatha M. J. Al-Khateeb, Raghada Shams Akram, Mohammad Ali Kareem","doi":"10.18231/j.ijpca.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.010","url":null,"abstract":"This study is aimed to put light on the effect of vitamin D3 (VitD3) in newly diagnosed acute myeloid leukemia (AML) patients. The AML patients consisted of sixty patients (30 male, 30 female). The average age of patients was (36.44±8.44) years (range 25-45). Thirty healthy subjects were considered as controls (15 male and 15 female), and the average age of control group was (32.22±5.13) years. All subjects had to go through clinical examination to determine existence of other diseases in addition to evaluate some tests as complete blood count [hemoglobin (Hb), platelet (PLT), and white blood cells (WBCs)], ferritin, FBS (fasting blood sugar), TG (triglycerides), TC (total cholesterol), and HDL (high density lipoprotein cholesterol) (HDL-Ch), urea, and creatinine. Vitamin D3 was measured by minividase Biomerux/French. The VitD3 was highly significantly lower in AML patients than in controls (p=0.001). While, VitD3 was lower in male than in female AML patients but the difference was not statistically significant. There were statistically significant positive correlations between VitD3 and Hb, PLT, Wbc, ferritin, FBS, and TG in both male and female AML patients. These findings suggest that lower serum concentrations of vitamin D3 may possibly be considered as a potential factor for early assessment of acute myeloid leukemia.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 72","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of betulin for hair growth promoting activity in rats 评估白桦脂对大鼠毛发生长的促进作用

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.009

Vinay V. Sarode, Sadhana P. Gautam

{"title":"Evaluation of betulin for hair growth promoting activity in rats","authors":"Vinay V. Sarode, Sadhana P. Gautam","doi":"10.18231/j.ijpca.2024.009","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.009","url":null,"abstract":"Hair has historically been associated with beauty and a person's unique personality. Numerous elements, including metabolism, hormones, inheritance, and the adverse effects of immunosuppressive and anti-neoplastic medications, can adversely impact hair health and lead to hair loss, or alopecia. It is typical everywhere in the world.The current study examined the effect of betulin for hair growth promoting activity in rats.The study used 48 albino wistar rats, weighing 200 ± 30 grams and aged between 12 and 16 months. Testosterone was given at a dose of 0.5 mg/kg to induce hair loss. During 28 days, a once-daily topical application of minoxidil solution was made. On a daily basis for 28 days, betulin was administered orally at concentrations of 10 mg/kg, 20 mg/kg, and 40 mg/kg. A combination of Betulin (10 mg/kg p.o.) and 3% Minoxidil was administered to one group, while the other was treated with Topical Betulin Solution (3 mg/ml once daily for 28 days). ANOVA analysis was used to ascertain the data's statistic.The results showed that effect of Betulin on Alopecia as evidenced by decreased levels of cholesterol, testosterone and increased levels of Hair length.According to the current study, albino wistar rats with Testosterone induced Alopecia can benefit from treatment with an Betulin.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of formulation excipients on skin barrier functions: A review 配方辅料对皮肤屏障功能的影响：综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.005

A. Panwar, Priyanka Rathore

引用次数: 0

Prospective role of Donanemab and amyloid beta therapies in early Alzheimer’s disease: A systematic review 多奈单抗和淀粉样蛋白β疗法在早期阿尔茨海默病中的前瞻性作用：系统综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.004

R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath

{"title":"Prospective role of Donanemab and amyloid beta therapies in early Alzheimer’s disease: A systematic review","authors":"R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath","doi":"10.18231/j.ijpca.2024.004","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.004","url":null,"abstract":"Amyloid-β (Aβ) peptide accumulation in the brain, leading to amyloid plaques, is considered to be the starting point of Alzheimer's disease. It is believed that these plaques impair cognitive and functional capacities and induce neurodegeneration. Research on uncommon genetic variants that either increase or decrease the quantity of Aβ deposited offers proof that amyloid plaques are involved in the disease's progression. Early-stage amyloid plaque buildup increases the likelihood that moderate cognitive impairment may progress to dementia.Donanemab, a humanized IgG1 antibody, targets an N-terminal pyroglutamate Aβ epitope that is unique to plaques that have already begun to develop. It is specific to this epitope and has no known clinical effect. Furthermore, it doesn't show any off-target binding to neurotransmitters, their receptors, or other Aβ species. In this systematic review, we first collect the necessary information after carefully reviewing four different study articles. After the data is collected, we evaluate it and create a graph to compare those study articles.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beetroot powder loaded medicated lip balm 含甜菜根粉的药用润唇膏

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.013

S. Shaikh

引用次数: 0

Molecular docking studies for NPACT ligands for the treatment of melanoma skin cancer 用于治疗黑色素瘤皮肤癌的 NPACT 配体的分子对接研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2024-03-15 DOI: 10.18231/j.ijpca.2024.007

B. Premkumar, Samson Raj Yesuraj, Santhosh Mohan, Savitha Chandran

{"title":"Molecular docking studies for NPACT ligands for the treatment of melanoma skin cancer","authors":"B. Premkumar, Samson Raj Yesuraj, Santhosh Mohan, Savitha Chandran","doi":"10.18231/j.ijpca.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.007","url":null,"abstract":"Approximately 80% of deaths attributable to skin cancer are attributed to melanoma. The main reason for its life-threatening nature is its high tendency to metastasis. The outlook for melanoma patients with distal metastases is grim, as they have a median survival of only six months, despite the utilization of the most advanced treatments now available. The Extracellular signal-regulated kinase (ERK) pathway is the most frequently altered oncogene in melanoma. Phytochemicals are receiving significant recognition due to their minimal toxicity, affordable price, and widespread acceptance as dietary supplements. Preclinical investigations have revealed many cellular and molecular processes via which phytochemicals function in the prevention and treatment of metastatic melanoma.: In this study, we performed virtual screening of 464 phytoconstituents were obtained from the Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify novel ERK inhibitors.: Virtual screening carried out prediction of drug-likeness and molecular docking studies with 2OJG, protein target related to ERK pathway.: Nine compounds achieved better docking score as compared to co-crystallized ligand. The accuracy of the docking method was checked using re-docking. Picetannol and sulfurentin were identified as potential inhibitors with docking score of -9.2 and -8.2, respectively. These two phytoconstituents also found to be non-carcinogenic which was predicted using a free webtool, Swiss ADME.: Our finding suggests that Piceatannol has promising potential to be further explored as ERK-pathway inhibitor in treatment of melanoma","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0