研究维生素 D3 对新诊断急性髓性白血病的影响

F. Obed, Shatha M. J. Al-Khateeb, Raghada Shams Akram, Mohammad Ali Kareem
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摘要

本研究旨在阐明维生素 D3(VitD3)对新诊断的急性髓性白血病(AML)患者的影响。急性髓性白血病患者共 60 人(男性 30 人,女性 30 人)。患者的平均年龄为(36.44±8.44)岁(25-45 岁)。对照组为 30 名健康受试者(男 15 名,女 15 名),平均年龄为(32.22±5.13)岁。所有受试者均需接受临床检查,以确定是否患有其他疾病,此外还需评估全血细胞计数[血红蛋白(Hb)、血小板(PLT)和白细胞(WBCs)]、铁蛋白、空腹血糖(FBS)、甘油三酯(TG)、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-Ch)、尿素和肌酐。维生素 D3 由 minividase Biomerux/French 检测。急性髓细胞性白血病患者的维生素 D3 明显低于对照组(P=0.001)。男性急性髓细胞性白血病患者的维生素 D3 低于女性,但差异无统计学意义。男性和女性急性髓细胞白血病患者的 VitD3 与血红蛋白、血小板、白细胞、铁蛋白、血脂和总胆固醇之间存在统计学意义上的正相关。这些研究结果表明,血清中维生素 D3 浓度较低可能会被视为早期评估急性髓性白血病的一个潜在因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study the effect of Vitamin D3 in newly diagnosed acute myeloid leukemia
This study is aimed to put light on the effect of vitamin D3 (VitD3) in newly diagnosed acute myeloid leukemia (AML) patients. The AML patients consisted of sixty patients (30 male, 30 female). The average age of patients was (36.44±8.44) years (range 25-45). Thirty healthy subjects were considered as controls (15 male and 15 female), and the average age of control group was (32.22±5.13) years. All subjects had to go through clinical examination to determine existence of other diseases in addition to evaluate some tests as complete blood count [hemoglobin (Hb), platelet (PLT), and white blood cells (WBCs)], ferritin, FBS (fasting blood sugar), TG (triglycerides), TC (total cholesterol), and HDL (high density lipoprotein cholesterol) (HDL-Ch), urea, and creatinine. Vitamin D3 was measured by minividase Biomerux/French. The VitD3 was highly significantly lower in AML patients than in controls (p=0.001). While, VitD3 was lower in male than in female AML patients but the difference was not statistically significant. There were statistically significant positive correlations between VitD3 and Hb, PLT, Wbc, ferritin, FBS, and TG in both male and female AML patients. These findings suggest that lower serum concentrations of vitamin D3 may possibly be considered as a potential factor for early assessment of acute myeloid leukemia.
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