Impact of formulation excipients on skin barrier functions: A review

Abstract

The skin serves as the primary barrier protecting the body from external insults, and its integrity is crucial for overall health. Formulation excipients, including emulsifiers, thickeners, and preservatives, commonly used in skincare products, can significantly influence skin barrier function and permeability. This review evaluates the impact of these Excipients on skin barrier function using biophysical measurements such as Trans-epidermal Water Loss (TEWL), skin hydration, and trans-epidermal water content. Furthermore, it discusses the potential implications of excipient-induced alterations in skin barrier function for skin health and tolerability.