Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets

Abstract

Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been preparedCorn silkpowderwithvarious 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes.The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.