International Journal of Pharmaceutical Chemistry and Analysis最新文献_第4页

Antifungal efficiency of amla leaves against Alternaria alternata and Bipolaris spicifera 阿木拉叶片对交替交替孢霉和双极孢霉的抗真菌功效

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.050

Vikas Sharma, A. Heer, Navneet Kour, Shivangi Sharma

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Review on dietary supplement in domestic market 国内市场膳食补充剂回顾

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.043

S. Shaikh, Vilas Sawale

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Ensuring data integrity in the pharmaceutical sector 确保制药行业的数据完整性

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.037

Krishna R Gupta

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Recent advances in anticancer drug discovery: A review 抗癌药物发现的最新进展：综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.039

Alemu Tadesse, Kuleni Nemomsa, Frehiwot Beyene

{"title":"Recent advances in anticancer drug discovery: A review","authors":"Alemu Tadesse, Kuleni Nemomsa, Frehiwot Beyene","doi":"10.18231/j.ijpca.2023.039","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.039","url":null,"abstract":"Cancer is a process of uncontrolled cell proliferation that leads to the development of an abnormally growing tumor, determining initially a local disease that might spread, impairing other organs or important processes. One of the most fatal diseases in recent times, cancer kills many lives each year. The effective management of this condition has been impacted by the variances in the disease across the globe, the impact of the medical facilities that are available, and other socioeconomic issues. The aim of this study was to summaries previously published articles regarding recent advances in anticancer drug discoveries. In this review, previously published literature regarding recent advances in anticancer drug discovery collected from journals through PubMed Central, Google Scholar, and Science Direct from March 20 to May 12 was identified well, and points that I assumed were important and recent (2017–2023) were included.Based on my searches, numerous discoveries are identified and grouped as anticancer drug targets, plant derived advances, chemical compounds with in vivo or in vitro cytotoxic drug discovery, and repurposing advances. Based on a variety of articles published by scholars, this review summarizes some recent advancements in anticancer drug discovery. Under this broad topic, promising and clinically evidenced drug targets for anticancer drug binding, some drugs repurposed for cancer treatment, plant-derived advances in cancer therapy, and finally advances in novel chemical compounds in the area of cancer therapy are reviewed.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"4 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Development and characterization of topical gel containing deep eutectic mixture of luliconazole for topical drug delivery system 用于局部给药系统的含卢立康唑深共晶混合物局部凝胶的开发和表征

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.049

Asenath Susan Kemunto Ondieki, Kamal Singh Rathore

{"title":"Development and characterization of topical gel containing deep eutectic mixture of luliconazole for topical drug delivery system","authors":"Asenath Susan Kemunto Ondieki, Kamal Singh Rathore","doi":"10.18231/j.ijpca.2023.049","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.049","url":null,"abstract":"Tinea infections are one of the most occurring dermatophyte infection in the world and more so in tropical countries. It majorly infect children which may lead to them being segregated and shunned away from the community thereby affecting their psychological state. To prepare topical gel containing deep eutectic mixture of luliconazole heating and dispersion method were utilised, and it comprised several steps. The main focus was to improve the solubility as well as the permeability of the drug as it comes into contact with the skin. Choline bitartrate was used as a hydrogen bond donor (HBD), Gallic acid which is a carboxylic acid was used as a hydrogen bond acceptor (HBA), Carbopol 984NF a carbomer was used as a gelling agent. A combination of choline bitartrate and gallic acid in the ratio expressed by formulation code N3 was used for the final preparation. The final properties of the gel; viscosity, spreadability and the drug release profile of the prepared gel were investigated. The drug release of the prepared formulation was compared to the marketed formulation. 4 formulations were prepared using different ratios of the excipients and the optimized formulations were subjected to characterization. Viscosity of the tablet was controlled by amount of gelling agent used in the manufacturing process. Following FTIR studies, it was found that there were no interaction between the drug and the excipients and that the drug release depended on the type of the excipients used in the formulation. Dispersion method was found to be a suitable, easy and efficient technique for designing Topical gel containing deep eutectic mixture (DEM) for topical use.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"11 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138970576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Formulation, modification and evaluation of fast dissolving tablet of irbesartan for hypertension management 用于高血压治疗的厄贝沙坦快速溶解片剂的配方、改良和评估

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.044

Ondieki Kemunto Asenath Susan, Kamal Singh Rathore

{"title":"Formulation, modification and evaluation of fast dissolving tablet of irbesartan for hypertension management","authors":"Ondieki Kemunto Asenath Susan, Kamal Singh Rathore","doi":"10.18231/j.ijpca.2023.044","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.044","url":null,"abstract":"To prepare fast dissolving tablet of Irbesartan an Angiotensin Receptor Blocker (ARB), direct compression method was utilised, and it comprised several steps. The main focus was to improve the disintergation time as well as the dissolution rate of the drug as it comes into contact with water. Lactose and Microcrystalline sodium (MCC) were used as diluents and fillers, Aspartame and Magnesium Stearate were used as lubricants, Crospovidone, Croscarmellose sodium (CCS), Sodium Starch Glycolate (SSG) were used as superdisintergrants as they increase the hydraulic pressure when the come into contact with water. The post compression properties of the tablet; disintergration time, wetting time and the drug release profile of the prepared table were investigated. The drug release of the prepared formulation was compared to the marketed formulation. 5 formulations were prepared using different ratios of the excipients and the optimized formulations were subjected to characterization. Hardness of the tablet was controlled by compression during the manufacturing process. Following FTIR studies, it was found that there were no interaction between the drug and the excipients and that the drug release depended on the type of the excipients used in the formulation. Direct compression was found to be a suitable, easy and efficient technique for designing fast dissolving tablet (FDT) for oral use.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"47 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial efficacy of Tejpata Tejpata 的抗菌功效

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.048

Vikas Sharma, A. Heer, Shivangi Sharma, Sonam Sharma

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Review on extraction techniques for medicinal and aromatic plants 药用和芳香植物提取技术综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.042

G. Malini, B. Saranya, A. Parameswari

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Knowledge, attitude and practice of self-administered insulin by diabetes mellitus patients: A cross sectional study 糖尿病患者对自我管理胰岛素的认识、态度和实践：横断面研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.046

Akshay Hasmukhbhai Parmar, A. Sukhlecha, Kajal Jasubhai Katariya

{"title":"Knowledge, attitude and practice of self-administered insulin by diabetes mellitus patients: A cross sectional study","authors":"Akshay Hasmukhbhai Parmar, A. Sukhlecha, Kajal Jasubhai Katariya","doi":"10.18231/j.ijpca.2023.046","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.046","url":null,"abstract":"Diabetes mellitus is a heterogeneous clinical syndrome secondary to defects in insulin secretion, action, or both. India is emerging as the world's diabetic capital. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence. To assess the knowledge, attitude, and practice (KAP) of self-administered insulin by patients of diabetes mellitus. It was a cross-sectional study conducted by the department of pharmacology at a tertiary care teaching hospital over a period of six months at the medicine outpatient department. A prevalidated questionnaire was used to assess the KAP of insulin use. Informed consent was obtained from the patients prior to giving them a questionnaire. Among the 151 responses, 58 were male and 93 were female. Among them, 66% knew about different types of insulin, and 32% knew about different insulin delivery devices. Around 40% of patients were not aware of HbA1c as a monitoring tool. Nearly 48% patients knew the complications of diabetes. Half of the patients were confident about the self-administration of insulin. About 54% patients took insulin for treatment. Among current insulin users, 75% injected insulin at the upper arm, 83% missed insulin doses, 74% had never used a glucometer, and 32% failed to rotate the site. Knowledge and attitude were good in the majority of patients, but practice regarding the use of insulin was poor. Skilled health care providers could educate diabetes mellitus patients on self-care management and insulin self-therapy and bridge this gap.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moringa oleifera: A comprehensive review on pharmacology, phytochemistry, and clinical applications 油杉：药理学、植物化学和临床应用综述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-12-15 DOI: 10.18231/j.ijpca.2023.041

Shital Darekar, Ashwini Patil, Sunita Bathe, Rohit R Doke

{"title":"Moringa oleifera: A comprehensive review on pharmacology, phytochemistry, and clinical applications","authors":"Shital Darekar, Ashwini Patil, Sunita Bathe, Rohit R Doke","doi":"10.18231/j.ijpca.2023.041","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.041","url":null,"abstract":"commonly referred to as the \"tree of life\" or the \"miracle tree,\" holds wide spectrum of medicinal and non-medicinal benefits, and so it is valuable herbal plant. has been traditionally use for treating various disease conditions such as wounds, pain, ulcers, liver disease, heart disease, cancer, and inflammation. Pharmacological studies have substantiated the hepatoprotective, cardioprotective, and anti-inflammatory potential inherent in extracts derived from various parts of the plant. Notably, bioactive constituents have been identified in every part of the plant, with over one hundred compounds characterized to date. The plant is rich in alkaloids, flavonoids, anthraquinones, vitamins, glycosides, and terpenes, among other things. Furthermore, the discovery of novel chemicals in the plant, such as niazimin A&B and muramoside A&B, has revealed potent hepatoprotective, anticancer, antihypertensive, antioxidant, and nutritional qualities.This current review underscores the traditional and remarkable advantages of Moringa, delving into its pharmacological characteristics, phytopharmaceutical formulations, clinical examinations, toxicity profile, and various other applications. Additionally, it aims to shed light on the plant's commercial and phytopharmaceutical applications with the intention of fostering further research. Despite this comprehensive exploration, the review acknowledges that many conventional uses of Moringa still lack scientific investigation. Consequently, the study advocates for further research to unravel the plant's mechanistic pathways, aiming to pinpoint and isolate the active or synergistic compounds accountable for its medicinal properties.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0