International Journal of Pharmaceutical Chemistry and Analysis最新文献_第5页

Antibacterial efficacy of amla leaves 阿姆叶的抗菌作用

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.034

Vikas Sharma, Arti Heer, Navneet Kour, Shivangi Sharma

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1-Acetyl D-erythritol from the leaves of Cestrum nocturnum 赤藓糖醇的1-乙酰基d -赤藓糖醇

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.036

Manorama Singh

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Insights into molecular docking: A comprehensive view 分子对接:一个全面的视角

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.030

Sushil S. Burle, Krishna R. Gupta, Yogeshri J. Jibhkate, Atul T. Hemke, Milind J Umekar

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Marine plants: Extraction and their medicinal importance 海洋植物:提取及其药用价值

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.031

Krishna R. Gupta, Tejaswini P. Masne, Milind J. Umekar

{"title":"Marine plants: Extraction and their medicinal importance","authors":"Krishna R. Gupta, Tejaswini P. Masne, Milind J. Umekar","doi":"10.18231/j.ijpca.2023.031","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.031","url":null,"abstract":"The marine is the primary source of uniquely structured natural materials, which are primarily found in living things. Marine algae have long been utilised as food and medicine and are crucial to the ecology. Marine creatures have the potential to be abundant sources of highly bioactive secondary metabolites that could serve as valuable starting points for the creation of novel pharmaceuticals. The sea is regarded as the largest remaining pool of natural molecules to be assessed for therapeutic activity and provides a tremendous resource for novel compounds due to the fact that marine animals make up around half of all species in the world. It is a real fact that the importance of marine organisms as a source of new substances is growing. Algae can be divided into two primary categories: macroalgae (seaweeds), which includes green, brown, and red algae, and microalgae, which includes blue-green algae, dinoflagellates, bacillariophyta (diatoms), etc. The natural bioactive compounds found in marine algae have been demonstrated to be a rich source of anti-diabetic, anti-inflammatory, antiviral, antifungal, hypolipidemic, antioxidant, anti-hypercholesterolemia, antibacterial, and antineoplastic activities. They generate fresh secondary metabolites with potential for use as pharmaceuticals because of their biological activity. The potential pharmacological, therapeutic, and research applications of these substances have been covered in this review.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro antileishmanial evaluation of Vernonia Brachycalyx leaf latex extract against two leishmania species 短萼Vernonia叶乳胶提取物对两种利什曼原虫的体外抗利什曼原虫活性评价

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.035

Alemu Tadesse Feroche

{"title":"In vitro antileishmanial evaluation of Vernonia Brachycalyx leaf latex extract against two leishmania species","authors":"Alemu Tadesse Feroche","doi":"10.18231/j.ijpca.2023.035","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.035","url":null,"abstract":": Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products. In the present study, the antileishmanial activity of the methanolic extract of the leaf latex obtained from the Ethiopian plant Vernonia brachycalyx O. H. (family Asteraceae) was evaluated by in vitro testing against Leishmania aethiopica and . : Antileishmanial activity test was carried out using the Alamar Blue assay on promastigotes and axenic cultured amastigotes of and clinical isolates, and cell viability was fluorometrically determined. Amphotericin B was used as a positive control, and 1% dimethyl sulfoxide (DMSO) and the media were employed as a negative control. Moreover, preliminary phytochemical analysis of the extracts was performed. : Results of the study indicated that the latex possesses good activity against both parasites, with IC values of6.82 ± 0.18 and 6.34 ± 0.20μg/ml against promastigotes and 3.53 ± 0.33 and 2.61 ± 0.907μg/ml against axenically cultured amastigotes of and , respectively. The latex demonstrated selectivity indices (SIs) of 15.27 and 16.42 against promastigotes and 29.50 and 39.90 against axenically cultivated amastigotes of and . While, amphotericin B demonstrated SIs of 7.91 and 8.23 against promastigotes and 7.45 and 7.73 against axenically cultured amastigotes of and , respectively. Phytochemical screening demonstrated that the latex contains flavonoids, tannins, cardiac glycosides, terpenoids, saponins, alkaloids, and steroids. : The findings of this investigation attest that the latex of V. brachycalyx possesses promising antileishmanial activity against and , warranting further investigations into the active constituents.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural flavoring agents used in pharmaceutical industry 用于制药工业的天然调味剂

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.027

Firoj A. Tamboli, Apurva A. Salunkhe, Manasi S. Zade, Yash R. Ghadge, Monali D. Kore, Amruta D. More

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Sex differences in kinetic handling of various therapeutic molecules 不同治疗分子动力学处理的性别差异

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.024

Sunil Chaudhry

引用次数: 0

Strategies for improving hydrophobic drugs solubility and bioavailability 提高疏水药物溶解度和生物利用度的策略

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.029

Krishna R. Gupta, Monali R Dakhole, Ketki S Jinnawar, Milind J Umekar

{"title":"Strategies for improving hydrophobic drugs solubility and bioavailability","authors":"Krishna R. Gupta, Monali R Dakhole, Ketki S Jinnawar, Milind J Umekar","doi":"10.18231/j.ijpca.2023.029","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.029","url":null,"abstract":"Nowadays various drugs synthesized by various computational drug designs as well as various drugs have complex structure. Due to their complex structure, higher molecular weight which will increases solubility issues. Solubility is the most important and challenging task for researchers. Bioavailability and absorption of a drug depends on solubility of drug and thus we achieve pharmacological response. But poor aqueous solubility is a rate limiting step in bioavailability which made drug development more difficult. Drugs having low bioavailability require to be administered at a higher dose to achieve desired drug concentration in the systemic circulation and reach the target site. Thus, instead of getting desired effects drug produces side effects in the gastrointestinal tract. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing. New techniques have been developed with a focus on enhancement of the solubility and oral bioavailability of poorly water-soluble drugs. The present review focuses on new technologies which are being used to resolve solubility issue of poorly soluble drugs which is the rate limiting step in bioavailability.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral treatment of hypokalemia with potassium chloride and propylene glycol in cows 用氯化钾和丙二醇口服治疗奶牛低钾血症

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.033

Bala Krishna Rao Dabbir, Venkata Siva Reddy Santimalla, Srinivasulu Reddy Rajavolu

{"title":"Oral treatment of hypokalemia with potassium chloride and propylene glycol in cows","authors":"Bala Krishna Rao Dabbir, Venkata Siva Reddy Santimalla, Srinivasulu Reddy Rajavolu","doi":"10.18231/j.ijpca.2023.033","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.033","url":null,"abstract":"Hypokalemia is a fatal metabolic, pathological and induced disorder of Potassium, manifested by low serum levels generally encountered in lactating animals and during thermal-stress. Currently Potassium is given in normal saline intravenously and very slowly. This method is costly, risky and laborious. To study the effect of oral administration of 12 g of elemental Potassium and 200 ml of Propylene glycol orally in hypokalemic cows. After estimating the serum level of potassium with Serum, analyzer, the effect of Nutri-Pot (A) containing 12 g of Potassium in 50-gram pouch and Nutri-Pot (B) containing 200 ml Propylene Glycol in 28 clinically hypokalemic cows was studied. Both A & B were mixed with 200 ml of drinking water and were slowly drenched and the second dose is repeated after 12 hours. Out of 28 cows, 26 were recovered fully and returned to normal condition and milk production. Combined drenching of Potassium and Propylene glycol was only the safest, most effective and economical method than administration through a balling gun and gelatin boluses or by ororuminal intubation. Or parenteral administration.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of phytochemical constituents and analysis of antioxidant activity in different parts of plant 植物不同部位的化学成分估算及抗氧化活性分析

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-09-15 DOI: 10.18231/j.ijpca.2023.032

Pankaj Singh, Rasna Gupta, Shikha Shukla, Ankit Gupta, Ram Lakhan Singh

{"title":"Estimation of phytochemical constituents and analysis of antioxidant activity in different parts of plant","authors":"Pankaj Singh, Rasna Gupta, Shikha Shukla, Ankit Gupta, Ram Lakhan Singh","doi":"10.18231/j.ijpca.2023.032","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.032","url":null,"abstract":"Oxidative stress is defined as a condition in which the balance between the production of reactive oxygen species (ROS) and the antioxidant defense system gets disturbed and causes free radical induced diseases. The current research was aimed to carrying out quantification of phytochemicals in different parts of and explores the antioxidant activities of ethanolic extracts of leaf (CFL), seed (CFS), and bark (CFB) to show their therapeutic importance. The antioxidant potential of plant parts was assessed by free radical scavenging activity (FRSA), superoxide anion radical scavenging activity (SARSA), reducing power (RP), lipid peroxidation (LPO), hydroxyl radical scavenging activity (HRSA), and ferric thiocyanate activity (FTC). Quercetin was used as a standard to measure the antioxidant activity. Among the tested plant extracts, CFB had the highest total phenolics and protein content than those of CFS and CFL, whereas CFL had the highest ascorbic acid, carotenoids and carbohydrate content than CFB and CFS plant parts. Antioxidant assay showed CFB had the lowest ICvalue for FRSA (35.48 μg/ml), LPO (91.91 μg/ml), HRSA (106.87 μg/ml) and FTC (53.21 μg/ml). CFS showed the lowest IC for SARSA (24.54 μg/ml) and the highest RP (2.14 ASE/ml). Overall, the bark of could be a potential natural antioxidant source for food as well as pharmaceutical applications.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0