{"title":"用氯化钾和丙二醇口服治疗奶牛低钾血症","authors":"Bala Krishna Rao Dabbir, Venkata Siva Reddy Santimalla, Srinivasulu Reddy Rajavolu","doi":"10.18231/j.ijpca.2023.033","DOIUrl":null,"url":null,"abstract":"Hypokalemia is a fatal metabolic, pathological and induced disorder of Potassium, manifested by low serum levels generally encountered in lactating animals and during thermal-stress. Currently Potassium is given in normal saline intravenously and very slowly. This method is costly, risky and laborious. To study the effect of oral administration of 12 g of elemental Potassium and 200 ml of Propylene glycol orally in hypokalemic cows. After estimating the serum level of potassium with Serum, analyzer, the effect of Nutri-Pot (A) containing 12 g of Potassium in 50-gram pouch and Nutri-Pot (B) containing 200 ml Propylene Glycol in 28 clinically hypokalemic cows was studied. Both A & B were mixed with 200 ml of drinking water and were slowly drenched and the second dose is repeated after 12 hours. Out of 28 cows, 26 were recovered fully and returned to normal condition and milk production. Combined drenching of Potassium and Propylene glycol was only the safest, most effective and economical method than administration through a balling gun and gelatin boluses or by ororuminal intubation. Or parenteral administration.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"98 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oral treatment of hypokalemia with potassium chloride and propylene glycol in cows\",\"authors\":\"Bala Krishna Rao Dabbir, Venkata Siva Reddy Santimalla, Srinivasulu Reddy Rajavolu\",\"doi\":\"10.18231/j.ijpca.2023.033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hypokalemia is a fatal metabolic, pathological and induced disorder of Potassium, manifested by low serum levels generally encountered in lactating animals and during thermal-stress. Currently Potassium is given in normal saline intravenously and very slowly. This method is costly, risky and laborious. To study the effect of oral administration of 12 g of elemental Potassium and 200 ml of Propylene glycol orally in hypokalemic cows. After estimating the serum level of potassium with Serum, analyzer, the effect of Nutri-Pot (A) containing 12 g of Potassium in 50-gram pouch and Nutri-Pot (B) containing 200 ml Propylene Glycol in 28 clinically hypokalemic cows was studied. Both A & B were mixed with 200 ml of drinking water and were slowly drenched and the second dose is repeated after 12 hours. Out of 28 cows, 26 were recovered fully and returned to normal condition and milk production. Combined drenching of Potassium and Propylene glycol was only the safest, most effective and economical method than administration through a balling gun and gelatin boluses or by ororuminal intubation. Or parenteral administration.\",\"PeriodicalId\":14182,\"journal\":{\"name\":\"International Journal of Pharmaceutical Chemistry and Analysis\",\"volume\":\"98 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharmaceutical Chemistry and Analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18231/j.ijpca.2023.033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Chemistry and Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/j.ijpca.2023.033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
低钾血症是一种致命的钾代谢、病理性和诱发性疾病,表现为低血清水平,通常发生在哺乳期动物和热应激期间。目前钾是通过生理盐水缓慢静脉注射的。这种方法成本高、风险大、费力。研究低钾血症奶牛口服12 g单质钾和200 ml丙二醇的作用。用血清分析仪测定血清钾水平后,研究了28头临床低钾奶牛50克袋中含钾12 g的nutriu - pot (A)和200 ml丙二醇的nutriu - pot (B)的效果。A &B与200 ml饮用水混合,缓慢浸透,12小时后重复第二次给药。28头奶牛中,26头完全康复,恢复正常状态和产奶量。钾和丙二醇联合滴注是唯一最安全、最有效和最经济的方法,而不是通过球枪和明胶丸或经口插管给药。或者静脉注射。
Oral treatment of hypokalemia with potassium chloride and propylene glycol in cows
Hypokalemia is a fatal metabolic, pathological and induced disorder of Potassium, manifested by low serum levels generally encountered in lactating animals and during thermal-stress. Currently Potassium is given in normal saline intravenously and very slowly. This method is costly, risky and laborious. To study the effect of oral administration of 12 g of elemental Potassium and 200 ml of Propylene glycol orally in hypokalemic cows. After estimating the serum level of potassium with Serum, analyzer, the effect of Nutri-Pot (A) containing 12 g of Potassium in 50-gram pouch and Nutri-Pot (B) containing 200 ml Propylene Glycol in 28 clinically hypokalemic cows was studied. Both A & B were mixed with 200 ml of drinking water and were slowly drenched and the second dose is repeated after 12 hours. Out of 28 cows, 26 were recovered fully and returned to normal condition and milk production. Combined drenching of Potassium and Propylene glycol was only the safest, most effective and economical method than administration through a balling gun and gelatin boluses or by ororuminal intubation. Or parenteral administration.