International Journal of Medical Sciences最新文献

{"title":"Non-Coding DNA-Derived Mimotopes of Aβ₄₂ as Novel Candidates for Alzheimer's Peptide Vaccine Design.","authors":"Navya Raj, Shidhi P R, Rebai Ben Ammar, Peramaiyan Rajendran, Biju Vadakkemukadyil Chellappan","doi":"10.7150/ijms.127358","DOIUrl":"https://doi.org/10.7150/ijms.127358","url":null,"abstract":"<p><p>Alzheimer's disease (AD), the leading cause of dementia, is a progressive neurodegenerative disorder marked by memory loss, cognitive decline, and characteristic neuropathology involving amyloid-β (Aβ) plaques and tau tangles. Among emerging therapeutic strategies, Aβ-targeted immunotherapy using monoclonal antibodies or peptide vaccines offers the most promising disease-modifying potential. Mimotopes, short peptides that mimic antigenic epitopes of Aβ, have recently gained attention as safe and effective candidates for vaccine development. In this study, we employed a computational immunoinformatics approach to identify novel Aβ₄₂-mimicking peptides derived from non-coding DNA sequences, representing an unconventional yet rich source of bioactive peptides. A virtual peptide library was generated from intergenic regions of the <i>Escherichia coli</i> genome and screened using B-cell epitope prediction, MHC-binding analysis, and structural similarity modeling to identify potential immunogenic mimotopes. Selected candidates were further evaluated through peptide-antibody docking with Aβ₄₂-specific antibody fragments to assess binding affinity and epitope mimicry. Our findings demonstrate a novel computational framework for mining non-coding DNA to identify therapeutic peptide mimotopes. The identified Aβ₄₂-like peptides exhibit strong potential as synthetic vaccine candidates for Alzheimer's disease, supporting a new direction in rational vaccine design against neurodegenerative disorders.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1320-1332"},"PeriodicalIF":3.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efferocytosis-related genes of SLC26A6, TYRO3, and PDK4 have been identified as predictors of prognosis in hepatocellular carcinoma and are associated with the immune status.","authors":"Jiao-Jiao Yang, Qing Ouyang, Xin-Xin Zeng, Wen-Jian Cen, Ling Deng, Gao-Ping Song, Fang Wang, Li-Yue Sun","doi":"10.7150/ijms.120781","DOIUrl":"https://doi.org/10.7150/ijms.120781","url":null,"abstract":"<p><strong>Background: </strong>Efferocytosis plays a critical role in clearing apoptotic tumor cells and suppressing inflammation in hepatocellular carcinoma (HCC). This study aimed to identify efferocytosis-related genes (ERGs) with prognostic value and develop a predictive model for HCC outcomes.</p><p><strong>Methods: </strong>Using public HCC transcriptomic and clinical data, we identified 13 differentially expressed ERGs (DE-ERGs) from 3,866 DEGs and 74 known ERGs. Cox regression analysis selected SLC26A6, TYRO3, and PDK4 as key prognostic genes for risk model construction. The model, combined with pathologic T stage in a nomogram, showed high predictive accuracy for patient survival.</p><p><strong>Results: </strong>Totally 13 DE-ERGs were gained by overlapping 3,866 DEGs and 74 ERGs, and SLC26A6, TYRO3, and PDK4 were identified as prognosis genes for constructing a risk model with highly proficient in assessing the risk of HCC patients. Then, both risk score and pathologic T stage were recognized as independent factors prognosticating the outcome of HCC patients. Afterwards, we constructed a nomogram utilizing risk score and pathologic T stage to achieve high accuracy in predicting the survival outcomes of HCC patients. Groups at low risk demonstrated enrichment in pathways related to biometabolism and immune response, such as \"fatty acid metabolism\" and \"complement and coagulation cascades\". Additionally, the strongest positive and negative correlation were observed from activated CD4⁺T cell and TYRO3 (cor = 0.37), as well as natural killer cell and SLC26A6 (cor = -0.35), respectively. And risk score exhibited strong predictive capacity in response to immunotherapy. Moreover, lncRNA-miRNA-mRNA network included complex interaction pairs, such as TYRO3-hsa-miR-203b-5p-NUTM2A-AS1. There were 61 drugs with significant differences in IC₅₀ between the high and low risk groups, such as BI.2536 and PD-173074. Single-cell analysis identified hepatocytes as the key cell population, exhibiting dynamic prognostic gene expression during differentiation and disease-specific alterations in cell-cell communication through ligand-receptor interactions.</p><p><strong>Conclusion: </strong>We identified three prognostic genes associated with efferocytosis in HCC and integrated them into a risk prognostic model. These genes not only serve as signatures for predicting HCC prognosis but also offer insights into the treatment of HCC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1369-1394"},"PeriodicalIF":3.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell Profiling Reveals Cooperative Participation of <i>SPP1⁺</i> Myeloid and <i>POSTN⁺</i> Fibroblast Subsets in Inflammation and Remodeling in Thoracic Aortic Aneurysm.","authors":"Yingjiao Ju, Jingyi Yao, Song Zhang, Jiangxu Wu, Jiongao Xiang, Li Min, Mingyuan Liu","doi":"10.7150/ijms.124136","DOIUrl":"https://doi.org/10.7150/ijms.124136","url":null,"abstract":"<p><p>Thoracic aortic aneurysm (TAA) is a life-threatening condition characterized by aortic dilation, inflammation, and extracellular matrix degradation. Despite advances in surgical management, effective pharmacological therapies are still lacking, largely due to an incomplete understanding of the cellular mechanisms driving disease progression. Although recent single-cell RNA sequencing (scRNA-seq) studies have revealed diverse cell types in TAA, the intercellular communication driving pathological remodeling is still poorly defined. Here, we performed integrated scRNA-seq analysis of human TAA (n = 8) and healthy aorta (n = 8) to construct a comprehensive cellular landscape. We identified a disease-associated crosstalk between <i>SPP1</i> ⁺ myeloid cells and <i>POSTN</i> ⁺ fibroblasts, mediated by SPP1 and MK signaling. These two cell subsets were enriched in TAA and co-activated TNF-α signaling via NF-κB and epithelial mesenchymal transition (EMT) pathways, thereby promoting inflammation and ECM remodeling. Cell-cell communication analysis further uncovered upregulated interactions involving SPP1-integrin (e.g., ITGAV/ITGA8/ITGA5+ITGB1) and MDK receptors (SDC4/SDC2/NCL/LRP1/ITGA4/ITGA6+ITGB1) in TAA. These computational findings were further supported by multiplex immunofluorescence and spatial transcriptomics analyses. By integrating key genes and signaling pathways, we identified hub genes and their associated transcription factors, whose regulatory activity was further supported by transcription factor regulon analysis. Our findings highlight the crucial role of myeloid-fibroblast interactions in driving TAA pathogenesis and identify potential therapeutic targets.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1333-1355"},"PeriodicalIF":3.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Scar Reduction Using Topical Application of Captopril-containing Silicone Gel in a Rabbit Model of Hypertrophic Scars.","authors":"Jeeyoon Kim, Hyun-Mu Jo, Jongweon Shin, Eun Young Rha","doi":"10.7150/ijms.123608","DOIUrl":"https://doi.org/10.7150/ijms.123608","url":null,"abstract":"<p><p>Antihypertensive medications, including angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers, have been explored for their potential in treating pathological scars. We compared the scar-reducing effects of topical silicone and captopril (an ACE inhibitor) gel used alone and in combination. Eight New Zealand White rabbits with a total of 80 wounds on both ears were used. The animals were assigned to the control, vehicle, silicone, and captopril 50 mg/g and 50 mg/g captopril-containing silicone groups (n = 16 per group). Treatment began on day 28 post-scarring. The scar elevation index (SEI) was measured by histopathology. Scarring was assessed based on fibroblast counts, capillary counts, and epithelial thickness. Ki-67, collagen type I and III, and vascular endothelial growth factor (VEGF) expression was evaluated using immunohistochemistry. SEI, fibroblast and capillary counts, epithelial thickness and collagen type I and III expression were significantly lower in the captopril-containing silicone group than in the other groups (P < 0.001). Ki-67, and VEGF expression also showed significant decreases in the silicone, captopril 50 mg/g, and captopril-containing silicone groups compared with the control and vehicle groups (P < 0.001). Topical application of captopril 50 mg/g alone or in a captopril-containing silicone formulation effectively reduced scar formation, with enhanced effects observed when captopril was combined with silicone. Captopril, therefore, presents a viable alternative to conventional silicone for scar management across various clinical scenarios.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1234-1242"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>MIAT</i> genetic variants and expression with tumor grade in oral tongue cancer.","authors":"Ping-Ju Chen, Chiao-Wen Lin, Chun-Yi Chuang, Shun-Fa Yang, Ying-Erh Chou","doi":"10.7150/ijms.129445","DOIUrl":"https://doi.org/10.7150/ijms.129445","url":null,"abstract":"<p><p>Oral tongue cancer is an aggressive malignancy and represents the most common subsite of head and neck cancer. The long non-coding RNA myocardial infarction associated transcript (MIAT) has been implicated in the development and progression of several cancers. This study aimed to investigate the association between <i>MIAT</i> single-nucleotide polymorphisms (SNPs) and oral cancer susceptibility as well as related clinicopathological characteristics. In this study, <i>MIAT</i> SNPs (rs4274, rs1061540, and rs1894720) were genotyped using real-time polymerase chain reaction in 1,194 controls and 397 male patients with tongue cancer. A significant association was observed between the <i>MIAT</i> rs4274 AA genotype and the occurrence of tongue cancer compared with controls (p = 0.018). Among the patients, carriers of the rs4274 A allele exhibited a higher likelihood of developing moderately or poorly differentiated tumors [OR (95% CI) = 2.246 (1.217-4.147); p = 0.001]. Betel-quid chewers and smokers carrying the A allele showed similarly elevated risks for poor tumor differentiation. Bioinformatic analyses further indicated that the rs4274 A allele is associated with increased MIAT expression, and higher MIAT levels correlated with higher tumor grade. In conclusion, the <i>MIAT</i> rs4274 A allele is linked to poorer tumor differentiation, particularly among betel-quid chewers and smokers, and elevated MIAT expression supports its potential as a biomarker of tumor aggressiveness.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1278-1284"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of ubiquitin carboxyl-terminal hydrolase isozyme L1 and chromogranin A regulated via histone-modification through Rho/ERK/NFκB signaling in oxaliplatin-resistant colorectal cancer cells.","authors":"Ko-Chao Lee, Kung-Chuan Cheng, Cheng-Yi Huang, Meng-Chiao Hsieh, Shui-Yi Tung, Yung-Yu Hsieh, Kam-Fai Lee, Chih-Chuan Teng, Hsing-Chun Kuo","doi":"10.7150/ijms.126460","DOIUrl":"https://doi.org/10.7150/ijms.126460","url":null,"abstract":"<p><p><b>Background/Aims</b>: Globally, colorectal cancer ranks third in causing 900,000 deaths annually. Some patients undergoing chemotherapy develop resistance, leading to metastasis. We investigated CHGA and UCHL1 proteins correlate with lymph node metastasis (J Cell Mol Med. 2023;27:2004-2020). This study aimed to analyze the relationship of CHGA and UCHL1 with the epithelial-mesenchymal transition (EMT) and the Rho/ERK/NFκB signaling pathway in OXA-resistant CRC cells.</p><p><strong>Methods: </strong>Resistant colorectal cancer cells (HCT-116/OxR) were established using progressive exposure to oxaliplatin (OXA). We employed siRNA, western blot, ROS assessment, apoptosis, and cell cycle assays, and animal models, to examine histone modifications regulating CHGA and UCHL1, and their impact on chemoresistance.</p><p><strong>Results: </strong>HCT-116/OxR cells displayed significantly higher OXA tolerance (elevated IC₅₀) and reduced apoptosis compared with parental HCT-116 cells, confirmed by MTT assays and DAPI staining. Silencing CHGA and UCHL1 genes effectively suppressed the mobility and invasiveness of OXA-resistant HCT-116/OxR cells while promoting G1 phase cell cycle arrest and reducing ROS production and intracellular calcium concentrations. Notably, targeted knockdown of CHGA and UCHL1 in HCT-116/OxR cells successfully restored OXA sensitivity and EMT markers and inactivation of Rho/ERK/NFκB pathway. Further <i>in vivo</i> validation demonstrated that the downregulation of CHGA and UCHL1 expression markedly attenuated OXA resistance in CRC cells. Both CHGA and UCHL1-activated transcription were regulated through the Rho/ERK/NF-κB signaling pathways by histone modifications of H3K4 trimethylation.</p><p><strong>Conclusions: </strong>In this study, Rho/ERK/NFκB signaling-mediated CHGA and UCHL1 expression, which is regulated through histone modifications and affects OXA-resistant CRC EMT outcomes, was assessed, and its potential as an early detection biomarker and prognostic indicator was explored with clinical applications.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1264-1277"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP450 Constraints in Infants: A Multidomain Convergence Framework for Investigating Mechanistic Vulnerability.","authors":"Gary S Goldman","doi":"10.7150/ijms.129127","DOIUrl":"https://doi.org/10.7150/ijms.129127","url":null,"abstract":"<p><strong>Aim and background: </strong>Cytochrome P450 (CYP450) enzymes are the primary hepatic Phase I oxidative biotransformation system for many drugs and xenobiotics; variability in CYP capacity is therefore a key determinant of metabolic reserve. Reserve varies with developmental ontogeny, genotype, and acquired suppression (e.g., cytokine-mediated phenoconversion). Early infancy represents a developmental window in which clearance capacity and redox/energetic buffering may be comparatively constrained. We introduce a hypothesis-generating Three-Axis Convergence Framework (TCF) modeling interacting effects of (i) developmental/genetic reserve limits, (ii) immune-cytokine modulation of metabolism, and (iii) exposure/disposition context, and translate this synthesis into a structured postmortem interpretive tool integrated into the primary medicolegal autopsy, using an enhanced analytic panel applied selectively based on case context and specimen validity/QC to support mechanistic characterization of infant deaths remaining unexplained (often SUID/SIDS).</p><p><strong>Methods: </strong>A structured narrative synthesis was conducted spanning developmental pharmacology, pharmacogenetics, immunology, redox biology, neuropathology, and toxicology. Routine medicolegal postmortem practices used in SUID investigations were reviewed to identify measurement gaps that may limit mechanistic resolution in unexplained cases. The synthesis was formalized into five analytic domains: CYP450 capacity, immune/cytokine load, redox balance/energetics, neurochemical integrity, and xenobiotic/metal burden.</p><p><strong>Results: </strong>The Metabolic Vulnerability Index (MVI) operationalizes the TCF as a five-domain ordinal scoring system (0-15). Domain 1 is anchored by hepatic CYP protein abundance (a more postmortem-stable proxy than CYP activity assays, which are generally constrained by rapid functional decay and QC limitations), normalized to adult reference and interpreted against age-matched developmental expectations. Domain-combination lookup tables route users to 14 mechanistically defined archetypes and specify modifier/exposure-context documentation. Appendices define an operational postmortem workflow, specimen validity rules, analytic QC constraints, detection limits, and a worked example. A Cytokine-Metabolic Suppression Profile (CMSP) is presented as an interpretive coherence summary and does not modify MVI scoring or certification.</p><p><strong>Conclusion: </strong>The MVI provides a structured framework for describing multidomain physiologic constraints in unexplained infant deaths alongside standard forensic practice. In this way, the TCF, MVI, and CMSP together offer a disciplined response to long-standing mechanistic uncertainty in early life-by enabling systematic measurement, coherent interpretation, and transparent identification of evidence gaps, rather than asserting new causes.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1285-1319"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior placenta accreta spectrum: unraveling distinctive clinical features and diagnostic challenges.","authors":"Yating Wu, Kuifang Shen, Caihong Hu, Jianling Wei, Jingrui Huang, Chenlin Pei","doi":"10.7150/ijms.127179","DOIUrl":"https://doi.org/10.7150/ijms.127179","url":null,"abstract":"<p><strong>Background: </strong>Posterior placenta accreta spectrum (PAS) represents a diagnostically challenging subtype of PAS, which has long been overlooked in existing literature due to its relatively low incidence and nonspecific clinical manifestations.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed, Web of Science, and other databases, focusing on studies related to the diagnosis and management of posterior PAS. This review systematically analyzes the risk factors, prenatal diagnostic characteristics, and pregnancy outcomes of posterior PAS, with a focus on clarifying the characteristic differences between posterior PAS and PAS involving other uterine locations.</p><p><strong>Results: </strong>Both ultrasound (US) and magnetic resonance imaging (MRI) have limited diagnostic sensitivity for posterior placenta accreta spectrum (PAS): the sensitivity of US ranges from 56.4% to 62%, while the application rate of MRI signs for posterior PAS is 73.5%, and both of which are 20-30% lower than those for anterior PAS. Irregular retroplacental clear zone on US and cervical varices on MRI are prominent diagnostic indicators for the condition. Notably, compared with anterior PAS, posterior PAS is characterized by shallower myometrial invasion and a more favorable prognosis.</p><p><strong>Conclusions: </strong>Posterior PAS has unique diagnostic and clinical features that distinguish it from anterior PAS. Enhanced recognition of its imaging characteristics and targeted management strategies are crucial to improve maternal outcomes. This review fills the literature gap by systematically summarizing the latest evidence on posterior PAS, providing a reference for clinical practice and future research.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1225-1233"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>NUCB2</i> genetic variants with the clinicopathological features of oral cancer.","authors":"Chang-Chiang Yu, Hsueh-Ju Lu, Ming-Yu Lien, Chiao-Wen Lin, Jian-Hong Yu, Shun-Fa Yang, Chih-Hsin Tang","doi":"10.7150/ijms.129479","DOIUrl":"https://doi.org/10.7150/ijms.129479","url":null,"abstract":"<p><p>Oral cancer ranks as the fourth most common cancer among men in Taiwan and the ninth most common cancer among men worldwide. Nesfatin-1, an adipokine derived from the precursor <i>NUCB2</i> gene, was originally discovered in hypothalamic neurons. The connections among lifestyle factors that promote cancer, <i>NUCB2</i> polymorphisms, and oral cancer are still not well understood. We examined the association of four <i>NUCB2</i> gene polymorphisms (rs1330, rs214101, rs757081, and rs10766383) and clinicopathological characteristics with oral cancer in Taiwanese men compared with healthy controls. According to our data, in patients aged ≥60 years, specific <i>NUCB2</i> genotypes were significantly associated with more aggressive disease features. Compared with the wild-type C/C genotype, carriage of at least one polymorphic allele (T allele at rs1330 or G allele at rs757081) was correlated with an elevated risk of progression to stage III/IV disease. Furthermore, the GA/AA genotypes at rs214101 and the TG/GG genotypes at rs10766383 were associated with elevated risks of both advanced-stage (III/IV) disease and lymph node metastasis. Our findings suggest that <i>NUCB2</i> SNPs may play a pivotal role in oral cancer progression and metastatic potential, particularly in older patients.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1257-1263"},"PeriodicalIF":3.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDH1 mutation creates a dependency on fatty acid metabolism that underlies sensitivity to cuproptosis in acute myeloid leukemia cells","authors":"Xuening Zhang, Dayuan Zheng, Tong Chu, Dongfan Yang, Kuanyun Zhang, Shaokui Liang, Lu Yang, Wenzhe Ma","doi":"10.7150/ijms.127886","DOIUrl":"https://doi.org/10.7150/ijms.127886","url":null,"abstract":"","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 4","pages":"1243-1256"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.medsci.org/v23p1243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}