International Journal of Medical Sciences最新文献

{"title":"OCT4 promotes lung cancer progression through upregulation of VEGF-correlated chemokine-1.","authors":"Bing-Hua Su, Chung-Teng Wang, Jia-Ming Chang, Huan-Yun Chen, Tang-Hsiu Huang, Yi-Ting Yen, Yau-Lin Tseng, Meng-Ya Chang, Che-Hsin Lee, Li-Hsin Cheng, Yu-Chih Wu, Chao-Liang Wu, Pin Ling, Ai-Li Shiau","doi":"10.7150/ijms.102505","DOIUrl":"10.7150/ijms.102505","url":null,"abstract":"<p><p>Embryonic development and tumor genesis share numerous similarities, with OCT4 standing out as a pivotal transcription factor in embryonic development. Expression of OCT4 is associated with poor prognosis of lung adenocarcinoma. VEGF-correlated chemokine-1 (VCC-1), also known as C-X-C motif chemokine ligand 17 (CXCL17), has been suggested to play a role in promoting tumor angiogenesis and metastasis. In the present study, we show a positive correlation between OCT4 expression levels and tumor metastatic potential, where an increase in OCT4 expression parallels an upregulation of VCC-1 in lung cancer. This relationship was substantiated through DNA microarray analysis and further confirmed by tissue staining of clinical lung cancer samples, demonstrating a positive correlation between OCT4 and VCC-1 expression. In A549 and H1299 human lung cancer cells, modulations in OCT4 expression directly influenced VCC-1 levels, as evidenced by the reporter assay of the VCC-1 promoter, indicating the regulatory role of OCT4 in transactivating VCC-1 expression. Furthermore, enhanced VCC-1 expression in H1299 cells promoted transforming growth factor-β (TGF-β) secretion, contributing to lung cancer cell aggressiveness. Additionally, VCC-1 secretion by H1299 cells could attract THP-1 macrophages, further implicating its role in tumor progression. NOD/SCID mice inoculated with VCC-1-knockdown A549 lung cancer cells exhibited significantly smaller tumors than those inoculated with control cells. On the basis of these findings, we highlight the importance of the OCT4-VCC-1 axis in lung cancer progression. Our findings also provide therapeutic targets for lung cancer.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"680-695"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory and Gustatory Disturbances as Early Indicators of Lung Cancer in Patients with Sleep Disorders: A Retrospective Cohort Study from the TriNetX US Collaborative Networks.","authors":"Ru-Yin Tsai, Chi-Chung Ho, Jhen-You Hu, Yao Hsiao, Hung-En Huang, James Cheng-Chung Wei","doi":"10.7150/ijms.106014","DOIUrl":"10.7150/ijms.106014","url":null,"abstract":"<p><p><b>Background:</b> Olfactory and gustatory disturbances are commonly overlooked symptoms but may be linked to various health conditions, including cancer. Emerging evidence suggests that these sensory impairments could be early indicators of lung cancer, particularly in individuals with sleep disorders, a group already at elevated cancer risk due to factors like circadian disruption and hormonal changes. <b>Objective:</b> To evaluate whether olfactory and gustatory disturbances can serve as early markers for lung cancer in patients with sleep disorders. <b>Methods:</b> A retrospective cohort study was performed using data from the TriNetX database, spanning January 1, 2016, to June 30, 2024. Propensity score matching (1:1) was used to balance baseline characteristics between patients with olfactory and gustatory disturbances and a control group without these disturbances. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated to assess lung cancer risk, with follow-up lasting up to 60 months. <b>Results:</b> After matching, 13,294 patients with olfactory and gustatory disturbances and 13,294 control patients were included. The analysis revealed a significantly higher risk of lung cancer in the disturbance group (HR = 1.431, 95% CI: 1.014-2.021). Subgroup analysis indicated that the risk was particularly elevated in patients over 50, males, and those with dorsalgia. COVID-19 infection did not have a significant impact on lung cancer risk in this population. <b>Conclusion:</b> Olfactory and gustatory disturbances may serve as early markers for lung cancer, particularly in older patients and males with sleep disorders. These findings suggest the potential for using sensory impairments in early cancer detection strategies.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"723-731"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Pan-Cancer Analysis of RAC1 Decoding the Impact on Cancer Prognosis and B cell immune Regulation.","authors":"Zhibo Shao, Hengyu Ren, Xuliren Wang, Qi Zhang, Jingyan Xue, Yayun Chi, Bingqiu Xiu, Jiong Wu","doi":"10.7150/ijms.104488","DOIUrl":"10.7150/ijms.104488","url":null,"abstract":"<p><p>RAC1, a member of the Rho family GTPases, has been implicated in various cancers, yet its pan-cancer landscape and role in the tumor immune microenvironment remain underexplored. This study presents a comprehensive analysis of RAC1 across 33 cancer types, revealing its high expression in a broad range of cancers and its association with poor prognosis. RAC1 expression correlates with genomic alterations, including CNVs, TMB, and MSI. RAC1 knockdown reduces cell proliferation and metastasis in breast and lung cancer cells, suggesting its oncogenic potential. Notably, RAC1 is negatively correlated with B cell infiltration, indicating its role in regulating the immune microenvironment. Functional enrichment analysis showed that high RAC1 expression is linked to lower enrichment in B cell activation and immune response pathways. Single-cell transcriptome analysis identified RAC1 expression primarily in epithelial cells, associated with tumor progression, and spatial transcriptome analysis showed a mutually exclusive co-localization between B cell infiltration regions and RAC1-expressing epithelial cells. Based on RAC1 expression and B cell interaction, a prognostic signature was established to predict prognosis at the pan-cancer level.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"662-679"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of risk factors and predictive models in acute type-a aortic dissection surgery: OI downregulation and its association with immune disorders.","authors":"Fuyan Ding, Jianyang Liu, Hong Wang, Ying Tan, Zhidong Zhang, Gang Qiao, Taibing Fan","doi":"10.7150/ijms.104622","DOIUrl":"10.7150/ijms.104622","url":null,"abstract":"<p><p><b>Background and Objective:</b> Acute type A aortic dissection (ATAAD) represents a critical and life-threatening condition requiring urgent surgical intervention, which is often life-saving. However, postoperative acute lung injury (ALI) has emerged as a prominent complication that significantly impacts patient outcomes and prognosis. This study aims to systematically analyze the risk factors associated with the development of severe ALI following ATAAD surgery, providing insights to improve postoperative management strategies. <b>Methods:</b> A retrospective analysis was conducted using a comprehensive database comprising 483 patients diagnosed with ATAAD. Patients were stratified into two groups based on the severity of postoperative ALI: severe ALI group (n = 182) and non-severe ALI group (n = 301). Clinical data were systematically collected and compared between the two cohorts. Binary logistic regression analysis was employed to identify independent predictors of severe ALI following ATAAD surgery. The diagnostic accuracy of these risk factors was assessed using receiver operating characteristic (ROC) curve analysis, with the area under the curve (AUC) serving as the metric for prognostic performance. <b>Results:</b> The severe ALI group exhibited a higher prevalence of preoperative oxygenation index (OI) ≤ 200 mmHg, smoking history, and coronary artery disease compared to the non-severe ALI group (P < 0.001, P = 0.032, and P = 0.039, respectively), while the prevalence of Marfan syndrome was lower (P = 0.033). Moreover, significant differences were observed in several clinical and intraoperative parameters, including body mass index (BMI), C-reactive protein (CRP), procalcitonin (PCT), D-dimer, white blood cell count (WBC), aortic cross-clamp time, moderate hypothermic circulatory arrest (MHCA) time, cardiopulmonary bypass (CPB) duration, and ICU length of stay (all P < 0.05). Multivariate logistic regression identified preoperative OI [P = 0.008, OR (95% CI): 0.002 (0.000-0.183)], BMI [P = 0.037, OR (95% CI): 1.569 (1.027-2.397)], CRP [P = 0.022, OR (95% CI): 1.292 (1.037-1.609)], D-dimer [P < 0.001, OR (95% CI): 3.841 (1.820-8.108)], MHCA time [P = 0.001, OR (95% CI): 3.306 (1.670-6.544)], and CPB duration [P = 0.017, OR (95% CI): 1.117 (1.020-1.223)] as independent predictors of severe ALI. ROC curve analysis revealed the diagnostic performance of preoperative OI, BMI, CRP, D-dimer, MHCA time, and CPB duration, with AUC values of 0.715, 0.844, 0.871, 0.955, 0.944, and 0.833, respectively (all P < 0.001). <b>Conclusion:</b> Preoperative oxygenation index, BMI, CRP, D-dimer levels, MHCA time, and CPB duration are independent risk factors for the development of severe ALI following ATAAD surgery. These findings underscore the importance of preoperative risk assessment and perioperative optimization to mitigate the risk of severe ALI and improve patient outcomes.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"745-753"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taming Pancreatic Cancer: <i>Ardisia virens</i> Kurz-Derived 4-Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy.","authors":"Chia-Hung Yen, Chien-Ju Lin, Peng-Yu Chen, Yi-Jin Chen, Ling-Rung Wei, Pei-Hsuan Chen, Yi-Chen Yeh, Lily Hui-Ching Wang, Hsun-Shuo Chang, Wan-Chi Tsai","doi":"10.7150/ijms.104112","DOIUrl":"10.7150/ijms.104112","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is a major global health challenge owing to late diagnosis and inherently metastatic nature. Although surgical intervention offers a potential remedy, only few patients are eligible, and drug resistance further complicates treatment. The therapeutic limitations have catalyzed a search for alternative treatments, particularly natural products. High-throughput screening identified six extracts from the Ardisia genus, with four from Ardisia virens Kurz, and 4-hydroxy-2-methoxy-6-tridecylphenyl acetate (HMTA) as the most potent candidate. Herein, we explored the anti-cancer effects of HMTA on PDAC and found it induced strong cytotoxic effects on BxPC-3 and PANC-1 pancreatic cancer cell lines. HMTA inhibited cell proliferation and induced apoptosis, as evidenced by annexin V/PI labeling and caspase 3 activation. HMTA halted cancer cell proliferation at the G2/M phase and induced multinucleation. Molecular docking analysis revealed that HMTA potentially could interact with tubulin, and <i>in vitro</i> assay confirmed it suppresses tubulin polymerization. HMTA significantly inhibited BxPC-3 xenograft tumor growth in mice. Overall, these findings suggested that HMTA is a promising candidate for PDAC therapy.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"651-661"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Metastasis Pain Surveillance: A Comprehensive Imaging-Based Tool Design for Evaluating Metastatic Burden and Guiding Therapeutic Strategies.","authors":"Shuxin Kong, Aishi Deng, Zeyin Guo, Lijia Ma, Xi Su, Junwei Cui, Yongkang Ou, Jinghua Liu, Tao Qin, Zeng Fang","doi":"10.7150/ijms.103916","DOIUrl":"10.7150/ijms.103916","url":null,"abstract":"<p><p><b>Background:</b> The current research aims to elucidate the interplay between the anatomical distribution of spinal metastases, MRI features, and the intensity of bone pain in patients with breast cancer. <b>Methods:</b> A retrospective analysis was used on a cohort of 45 breast cancer patients with verified spinal metastases, examining the relationship between metastatic locations, MRI-derived metrics, and bone pain scores. The Visual Analogue Scale (VAS) was conducted to measure the severity of bone pain. <b>Results:</b> The results revealed a significant association between lumbar spine metastases and elevated pain scores, outpacing those observed in thoracic and cervical regions. Furthermore, a strong correlation was found between the multiplicity of metastatic sites and the ratio of high-intensity areas on MRI, both of which were predictive of increased pain severity. <b>Conclusions:</b> The study's outcomes indicate that distinct MRI profiles, including the number and location of spinal metastases, can serve as prognostic indicators of bone pain intensity in breast cancer patients. Our data highlighted the need for personalized pain management strategies and targeted interventions tailored to specific imaging characteristics. Ultimately, this research underscores the dual role of MRI in both detecting spinal metastases and informing symptom management, with the potential to augment the overall well-being of breast cancer patients with spinal involvement.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"708-715"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Type 2 Diabetes Mellitus Among Hepatitis B Virus Patients: A Large Retrospective Cohort Study.","authors":"Fadi Abu Baker, Abdel-Rauf Zeina, Randa Taher Natour, Saif Abu Mouch, Yael Kopelman, Oren Shibolet, Ariel Israel","doi":"10.7150/ijms.104839","DOIUrl":"10.7150/ijms.104839","url":null,"abstract":"<p><p><b>Background:</b> Hepatitis B virus (HBV) infection and type 2 diabetes mellitus (T2DM) are both major health burdens worldwide. There is a suspected link between the two conditions, but the nature of the relationship is not well understood. This study aimed to investigate the prevalence of T2DM in patients with HBV, compared to matched non-HBV patients. <b>Methods:</b> A retrospective cohort study was conducted using data from the Leumit-Health-Service (LHS) database, a major health insurance provider in Israel, covering the years 2000-2020. The study included patients with HBV infection and matched controls using propensity score matching. T2DM's prevalence was assessed and compared between both groups. <b>Results:</b> A total of 3,436 HBV carriers and 34,360 matched controls were included. T2DM's prevalence was significantly higher among HBV patients compared to the control group (22.1% vs. 19.5%; P<0.001). Through multivariate analysis, we identified age, obesity, smoking, and specific HBV-related parameters, such as chronic active disease or evidence of advanced fibrosis at presentation, as independent risk factors for T2DM in HBV patients. <b>Conclusions:</b> This study revealed a higher prevalence of T2DM in HBV patients compared to controls, and identified specific risk factors associated with T2DM in HBV patients. Enhanced screening and management of metabolic risk factors should be considered in this population.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"716-722"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of MET channels on aminoglycosides- and cisplatin-induced ototoxicity.","authors":"Lile Ouyang, Lu Ma, Yong Feng","doi":"10.7150/ijms.103270","DOIUrl":"10.7150/ijms.103270","url":null,"abstract":"<p><p>Aminoglycosides and cisplatin drugs are extensively utilized for their high efficacy in treating various conditions in the clinic, however, their ototoxic side effects warrant significant attention. These drugs could penetrate the inner ear via specific channels or transporters, which not only affect the survival of hair cells but also induce the overproduction of reactive oxygen species. Currently, scientific research mainly addresses this issue through the downstream intervention of reactive oxygen species. However, recent studies have revealed that directly reducing the uptake of these drugs by hair cells can effectively avoid initial damage. In particular, the interactions between drugs and hair cells, as well as the specific functions of relevant channels and transporters, can be explored in detail through the use of molecular dynamics simulations. The swift advancement in the field of structural biology has shed light on the structural functions of various channels and transporters closely related to drug absorption, such as electromechanical transduction channels (MET) and organic cation transporter-2, etc., providing theoretical basis and potential targets for novel ear protection strategies. It is, therefore, imperative to investigate the regulatory role of the MET channel in the up-taking of ototoxic drugs, serving as a pivotal point for the development of preventative and therapeutic approaches. This review aims to highlight the mechanism of inhibition of ototoxic substances absorption by auditory hair cells, explore how to develop novel ear protection methods by targeting these channels and transporters, and provide a new perspective and strategy for addressing drug-induced ototoxicity. The approach to protecting hair cells by targeting these channels and transporters not only broadens our understanding of the underlying mechanisms of ototoxicity, but could also spur further research and progress in the field of auditory protection.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"732-744"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Blood Pressure Control in US Adult CKD Patients from 1999 to 2018.","authors":"Anbang Sun, Lin Zhu, Yanmin Xia, Yao Zheng, Bicheng Hu, Fanghua Li, Yanhong Liao","doi":"10.7150/ijms.103107","DOIUrl":"10.7150/ijms.103107","url":null,"abstract":"<p><p><b>Background:</b> Blood pressure (BP) control can slow down the progression of chronic kidney disease (CKD) and protect against cardiovascular diseases, significantly improving patient survival. Herein, we analyzed the changes in BP control in adult CKD patients with hypertension in the United States from 1999-2000 to 2017-2018. <b>Methods:</b> National Health and Nutrition Examination Survey (NHANES) data from 1999-2000 to 2017-2018 were analyzed, including 5,510 adult CKD patients with BP above 140/90 mmHg or those under an antihypertensive regimen. <b>Results:</b> The proportion of adult CKD patients with uncontrolled BP decreased from 72.9% in 1999-2000 to 46.6% in 2013-2014, then increased to 56.9% in 2017-2018. Although adult CKD patients with albumin-creatinine rate (ACR) 30-299 mg/g or ACR ≥300 mg/g were more likely to take antihypertensive medication than those with ACR <30 mg/g (PR: 2.76, 95% CI: 1.63-4.79 and PR: 4.59, 95% CI: 2.37-9.51), they were more likely to have uncontrolled BP than those with ACR <30 mg/g ((multivariable-adjusted prevalence ratio (PR): 2.25, 95% CI: 1.39-3.75 and PR: 3.14, 95% CI: 1.71-6.07). Adult CKD patients (eGFR ≥60 mL/min/1.73m²) being aware of their high BP diagnosis were less likely to take antihypertensive medication than those with eGFR 30-59 mL/min/1.73m² (PR: 0.27, 95% CI: 0.09-0.65). <b>Conclusions:</b> These results show that BP control should be reinforced in adult CKD patients, particularly in those with ACR ≥300 mg/g, while patients with eGFR ≥60 mL/min/1.73m² should enhance awareness of taking antihypertensive medication.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"696-707"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences of the Chest Images Between Coronavirus Disease 2019 (COVID-19) Patients and Influenza Patients: A Systematic Review and Meta-analysis.","authors":"Yingying Han, Zhijia Wang, Xingzhao Li, Zhuan Zhong","doi":"10.7150/ijms.98194","DOIUrl":"10.7150/ijms.98194","url":null,"abstract":"<p><p><b>Background:</b> Coronavirus disease 2019 (COVID-19) and influenza are two infectious diseases that can pose a great threat to human health. We aimed to compare the differences in chest images between patients with COVID-19 and influenza to deepen the understanding of these two diseases. <b>Methods:</b> We searched PubMed, Embase and Web of Science for articles published before December 25, 2023, and performed a meta-analysis using Stata 14.0 with a random-effects model. The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. <b>Results:</b> Twenty-six articles with 2,159 COVID-19 patients and 1,568 influenza patients were included in the meta-analysis. By comparing chest computed tomography (CT) and chest X-ray, we found that COVID-19 patients had more peripheral lung lesions (OR=3.66, 95% CI: 1.84-7.31). Although COVID-19 patients had more bilateral lung involvement (OR=1.74, 95% CI: 0.90-3.38) and less unilateral lung involvement (OR=0.67, 95% CI: 0.44-1.02), these two results were not statistically significant. Patients with COVID-19 showed more ground-glass opacities (OR=2.83, 95% CI: 1.85-4.32), reverse halo signs (OR=3.47, 95% CI: 2.37-5.08), interlobular septal thickening (OR=2.16, 95% CI: 1.55-3.01), vascular enlargement (OR=5.00, 95% CI: 1.80-13.85) and crazy-paving patterns (OR=2.63, 95% CI: 1.57-4.41) on chest images than patients with influenza. We also found that compared with influenza patients, pleural effusion was rare in COVID-19 patients (OR=0.15, 95% CI: 0.07-0.31). <b>Conclusions:</b> There are some differences in the manifestations and distributions of lesions between patients with COVID-19 and influenza on chest images, which is helpful to distinguish these two infectious diseases.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 3","pages":"641-650"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}