International Journal of Medical Sciences最新文献

{"title":"Expert Consensus on the Diagnosis and Management of Carotid Atherosclerotic Plaque: Pathophysiology, Clinical Management, and Preventive Approaches.","authors":"Xing Chang, Hang Zhu, Zhijiang Guo, Hongshuo Shi, Yingjie Tian, Qianying Hao, Hui Zhang, Rongjun Zou, Xiaoping Fan, Qihui Zhang, Sang-Bing Ong, Qingyong He, Hao Zhou","doi":"10.7150/ijms.107479","DOIUrl":"10.7150/ijms.107479","url":null,"abstract":"<p><p>To standardize and harmonize pharmacist-led cholesterol-lowering medication therapy management (MTM) for patients with carotid atherosclerosis and plaque, the Expert Consensus on Lipid-Lowering Pharmacotherapy Management in Patients with Carotid Atherosclerosis and Plaque was developed under the leadership of the PLA General Hospital. This consensus establishes a systematic framework spanning the full-cycle management process: data collection, analytical evaluation, intervention implementation, and long-term follow-up, supported by standardized protocols, documentation forms, and assessment tools. It prioritizes seven evidence-based evaluation domains: therapeutic efficacy, drug selection, dosing appropriateness, adverse reactions, drug-drug/food interactions, cost-effectiveness, and medication adherence. By integrating practical workflows with clinical decision-support tools, the consensus aims to optimize therapeutic outcomes, mitigate safety risks, and provide actionable guidance for healthcare professionals managing this high-risk population.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2738-2756"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Laser Therapy for Grade C Periodontitis in Young Individuals.","authors":"Sijia Liu, Wanqing Zhao, Yusen Qie, Na Liu, Qing Liu","doi":"10.7150/ijms.107543","DOIUrl":"10.7150/ijms.107543","url":null,"abstract":"<p><p>Grade C periodontitis in young individuals is characterized by its early onset and rapid progression, resulting in swift periodontal tissue destruction in systemically healthy individuals. The application of laser technology in periodontal therapy has gradually increased in recent years. Laser therapy offers several advantages over traditional antibiotics, such as reduced patient discomfort, minimized postoperative edema, and a lower risk of drug-resistant strains. Recent studies suggest that laser-assisted treatments can significantly augment the clinical efficacy in managing grade C periodontitis. However, available evidence has not drawn distinct conclusions. This review aims to present the research progress in laser and antibacterial photodynamic therapy as the adjuvant treatment of grade C periodontitis in young individuals over the past decade, offering references for clinical practice.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2653-2662"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Percentage-to-Albumin Ratio as a Prognostic Marker for Mortality in Ischemic Stroke Patients.","authors":"Yue-Xin Lu, Bao-Jie Mao, Ming Wang, Shu Wan","doi":"10.7150/ijms.108493","DOIUrl":"10.7150/ijms.108493","url":null,"abstract":"<p><p><b>Background:</b> The neutrophil percentage-to-albumin ratio (NPAR) is an emerging inflammatory biomarker that has demonstrated a significant association with poor outcomes in patients with cardiovascular diseases. However, the existing evidence regarding its prognostic value in ischemic stroke (IS) patients remains limited. Our study aimed to investigate the potential of the NPAR as a prognostic indicator for all-cause mortality in patients with IS. <b>Methods:</b> This study screened IS patients from the Medical Information Mart for Intensive Care (MIMIC-IV) database and categorized them into two groups based on NPAR values, employing propensity score matching to mitigate confounding factors. The primary outcome assessed was 90‒day mortality, and the secondary outcomes included in-hospital mortality, ICU mortality, and mortality at 30‒day and 1‒year after admission. Cox proportional hazards regression analysis and restricted cubic splines were used to explore the relationship between the NPAR and all-cause mortality in critically ill IS patients, whereas Kaplan‒Meier analysis was used to estimate survival curves. Subgroup analysis and interaction tests were performed to evaluate the robustness of the results. Receiver operating characteristic curves were computed to assess the diagnostic value of the NPAR in predicting outcomes. <b>Results:</b> A total of 706 patients (53.3% male) were included in the study, with in-hospital and ICU mortality rates of 18.2% and 12.6%, respectively. The mortality rates at 30‒day, 90‒day, and 1‒year were 19.2%, 29.7%, and 37.8%, respectively. Restricted cubic splines indicated a nonlinear increase in all-cause mortality as the NPAR increased. Multivariate Cox regression analysis revealed a significant association between a high NPAR and all-cause mortality at 90‒day (hazard ratio [HR]: 1.99; 95% confidence interval [95% CI]: 1.44-2.76, p < 0.001), 30‒day (HR: 2.09; 95% CI: 1.39-3.13, p < 0.001), and 1‒year (HR: 1.77; 95% CI: 1.32-2.37, p < 0.001). The subgroup analysis indicates that a significant interaction was observed between hypertension and mortality risk in IS patients (p for interaction = 0.012), suggesting that hypertension may be an important predictor of poor prognosis in these patients. Receiver operating characteristic curves demonstrated that the NPAR provides a modestly greater ability to predict the risk of death in patients with IS compared to the individual indices of neutrophil percentage and albumin levels, although the specificity (0.567) and sensitivity (0.684) of NPAR were not outstanding overall. <b>Conclusion:</b> Our study revealed an independent association between a high NPAR and increased all-cause mortality at 30‒day, 90‒day, and 1‒year and during hospitalization in patients with IS, reinforcing its status as an independent determinant of mortality risk.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2663-2675"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Neuroinflammation in Depression from 2004 to 2023: Global Research Hotspots and Prospects.","authors":"Anni Shi, Na Chen, Qin Ma, Yaxuan Wang, Xiaoling Liu, Jun Lu, Jianyou Guo","doi":"10.7150/ijms.100888","DOIUrl":"10.7150/ijms.100888","url":null,"abstract":"<p><p><b>Background:</b> Neuroinflammation lays a prominent impact in the pathophysiology of depression, and numerous studies have been conducted in recent decades. Bibliometric analysis is of important for understanding the hot spots and research trends in a certain subject field. However, no systematic bibliometric study exists in this field to date. The purpose of the study focused on the trends and hotspots in neuroinflammation of depression and provided future researchers with guidance and sights. <b>Methods:</b> Publications (2004-2023) were obtained from the WoSCC, and analyzed by HistCite, VOSviewer, CiteSpace, and Bibliometrix. The impact of publications was assessed by TGCS. <b>Results:</b> We analyzed 1,496 articles published in 409 journals and authored by 46,533 researchers across 72 countries and regions. The most prolific countries were China, the USA, and Brazil, and the most cited countries were the USA, followed with China and the UK, while the most prolific and cited institution was University Toronto (records=34, TGCS=2,137). Brain Behavior and Immunity is the leading journal that regularly published research in this field (records=93, TGCS=6,247). NLRP3 inflammasome, microglia, TNF-α, and brain-derived neurotrophic factor (BDNF) were the basis of neuroinflammation in depression. C-reactive protein, an important marker of inflammation, has been discussed for the longest time in this disease. In recent five years, two most frontier potential areas in studying depression were gut microbiota dysbiosis and BDNF. <b>Conclusions:</b> There remains a strong research basis for neuroinflammation in depression from this bibliometric analysis. Microglial activation, gut microbiota, cytokine signaling, and oxidative stress were research hotspots in recent years. In the future, chronic stress, hippocampal structure, and gut microbiota will continue to be studied in the field of neuroinflammation in depression. This study may benefit scientists in identifying potential directions for future study and providing clinicians with new ideas for treatment.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2700-2720"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establish VO₂max prediction models based on exercise and body parameters from the step test.","authors":"Chia-An Ho, Hung-Chih Yeh, Hei-Tung Lau, En-Yu Chang, Chih-Wen Hsu, Chun-Hao Chang, Chi-Chang Huang, Wen-Sheng Chang Chien, Chin-Shan Ho","doi":"10.7150/ijms.109977","DOIUrl":"10.7150/ijms.109977","url":null,"abstract":"<p><p>This study addresses the challenge of cardiorespiratory fitness (CRF) assessment by proposing predictive models for maximal oxygen uptake (VO₂max) based on step test parameters. Recognizing VO₂max as a gold standard for CRF evaluation, this study aims to develop a VO₂max prediction model based on a step test, providing a simple and practical alternative for primary healthcare and health monitoring. This model enables clinicians and health management professionals to efficiently assess patients' cardiorespiratory fitness. Through the recruitment of 200 healthy Taiwanese adults, the research combined direct VO₂max measurements with step test heart rate (HR) data and variables like age, sex, percentage body fat (PBF), body mass index (BMI), and resting heart rate (RHR) to develop six predictive models. This method is applicable for clinical health monitoring, cardiorespiratory fitness assessment in patients with chronic diseases, and exercise capacity monitoring in cardiac rehabilitation programs. The study identified that PBF-based models consistently outperformed BMI-based ones, with Model^PBF3, which incorporates HR responses during exercise, achieving the highest accuracy (R² = 0.689; SEE = 4.6971 ml·kg⁻¹·min⁻¹). These results indicate that the model can effectively estimate VO₂max and be applied in primary healthcare, remote health monitoring, and cardiac rehabilitation settings, providing a simple and practical tool for cardiorespiratory fitness assessment in clinical practice. Validation via PRESS cross-validation and Bland-Altman plots confirmed the stability and reliability of the models across diverse subgroups. By bridging the gap between laboratory-grade precision and everyday practicality, the study introduces a robust, low-cost, and user-friendly tool for CRF assessment, adaptable for non-athletes and those unable to perform high-intensity exercises. This research advances the feasibility of CRF self-management in varied settings, while future iterations could extend its applicability to broader demographics and integrate additional physiological variables for universal adoption.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2676-2685"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notable influences of estrogen and sex-specific microenvironment in colorectal cancer revealed by single-cell transcriptome analysis.","authors":"Yihui Zheng, Chaoxin Yang, Guozhong Xiao, Mingyuan Lei, Pengfei Qin, Huaxian Chen, Hongcheng Lin","doi":"10.7150/ijms.106133","DOIUrl":"10.7150/ijms.106133","url":null,"abstract":"<p><p><b>Background:</b> Colorectal cancer (CRC), the third most common malignancy worldwide, exhibits notable sex-specific prognostic differences, yet the underlying biological mechanisms remain poorly understood. <b>Methods:</b> In this study, we conducted single-cell sequencing on 32 CRC samples, followed by pathway enrichment analysis, cell-cell interaction analysis, and transcription factor analysis. The co-expression of GZMB and the transcription factor EOMES in CD8+ T cells was detected using multiplex immunohistochemistry. Western blot and TUNEL assays were employed to validate estrogen-induced apoptosis in CRC cell lines. <b>Results:</b> After quality control, we obtained a total of 167,437 cells across 9 cell types from all samples. Specifically, our analysis revealed sex-based variations in cellular composition, functionality, and intercellular interactions within CRC. Notably, female CRC samples exhibited significant positive correlation between estrogen signaling pathway activation and apoptotic activity, with validation through Western blot and TUNEL assays confirming estrogen-mediated apoptosis induction in CRC cell lines. The immune response was notably enhanced in female CRC, with CD8+ T cells showing increased expression of the EOMES gene regulatory network, thereby boosting T cell immunity. Moreover, B cells of female CRC demonstrated improved capabilities in antigen-presenting and MHC-I interactions with T cells. Additionally, Macro_CCL4 cells engaged in sex-specific TNF-TNFRSF1B crosstalk with CD8+ T cells, potentially leading to enhanced antitumor immunity in females. Conversely, CAF_MMP11 cells exhibiting a myofibroblastic CAF phenotype interacted with malignant epithelial cells via signaling pathways such as THBS, MK, and FN1, likely promoting CRC progression. <b>Conclusions:</b> Our research highlights the distinct immunological and hormonal responses in CRC by sex, which may explain the observed prognostic disparities. These findings may offer additional further biological insights for targeted therapies in CRC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2637-2652"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The screening assessment of pro-inflammatory, anti-inflammatory, Th1, Th2 and Th17 cytokines in saliva of patients with ischemic stroke.","authors":"Dominika Forszt, Karolina Gerreth, Jakub Kopczyński, Anna Zalewska, Katarzyna Hojan, Renata Marchewka, Marzena Bielas, Mateusz Maciejczyk","doi":"10.7150/ijms.110452","DOIUrl":"10.7150/ijms.110452","url":null,"abstract":"<p><p><b>Introduction:</b> Ischemic stroke leads to hypoxia of brain structures, causes inflammation and tissue necrosis. Since the blood-brain barrier is damaged, inflammatory mediators can enter the bloodstream and saliva. This case-control study examines pro-inflammatory, anti-inflammatory, Th1, and Th2 cytokines in the unstimulated saliva of stroke patients and explores the association between these biomarkers and clinical status. <b>Patients and methods:</b> The study group included 22 patients with ischemic stroke, while the control group included 22 healthy individuals that were matched for age, sex, dental, periodontal and oral hygiene status to the study group. Unstimulated saliva was collected from each patient. In each sample, the inflammatory profile was determined using the multiplex ELISA method. Due to the lack of normal distribution, the Mann-Whitney U test was used for comparisons. The research was approved by the Bioethics Committee of the Poznan University of Medical Sciences (59/19, 890/19, 504/21). <b>Results:</b> In the unstimulated saliva of stroke patients, significantly higher levels of pro-inflammatory cytokines (IL-1β (p=0.0003), TNF-α (p≤0.0001), TNF-β; (p≤0.0001)), anti-inflammatory cytokines (IL-1ra (p≤0.0001), TRAIL (p=0.0206)), Th1 cytokines (IFN-<b>γ</b> (p≤0.0001), IL-2Rα (p=0.0021) and IL-12 (p40) (p≤0.0001)) and Th2 cytokines (IL-6 (p=0.0023)) were found compared to healthy participants. Interestingly, Addenbrooke's Cognitive Examination Revised (ACE-R) correlated negatively with TNF-α (p=0.01, r=-0.53), TNF-β (p=0.02, r=-0.60) and IFN-γ (p=0.02, r=-0.50). The Functional Independence Measure (FIM) exhibited a positive association with IL-6 (p=0.003, r=0.62) and BI (p=0.001, r=0.66). The positive correlation was found between Sitting Balance Scale (SBS) and IL-6 (p=0.02, r=0.52). <b>Conclusions:</b> Stroke patients exhibit altered salivary composition characterized by increased secretion of inflammatory mediators. The obtained results do not indicate the dominance of any of the branches of the immune response. The concentration of salivary TNF-α, TNF-β, IFN-<b>γ</b> and IL-12 significantly distinguish patients with ischemic stroke from healthy individuals. Although validation of the results in a larger patient population is necessary, salivary cytokines show potential as diagnostic biomarkers.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2686-2699"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Autonomic Nervous System in Acupuncture for Gastrointestinal Dysmotility: From Anatomical Insights to Clinical Medicine.","authors":"Na-Na Yang, Xiao-Xia Xie, Wen-Li Yan, Yi-Duo Liu, He-Xuan Wang, Liu-Xin Yang, Cun-Zhi Liu","doi":"10.7150/ijms.107643","DOIUrl":"10.7150/ijms.107643","url":null,"abstract":"<p><p>The expanding knowledge on the involvement of the autonomic nervous system in regulating digestive tract homeostasis is shedding new light on the therapeutic potential of acupuncture. This review aims to evaluate the effectiveness and autonomic nervous system associated mechanisms of acupuncture in gastrointestinal dysmotility in both laboratory and clinical settings, guiding future studies. Mechanistically, studies with animal models and human subjects demonstrated that acupuncture, as a non-invasive somatosensory stimulation, can help improve gastrointestinal dysmotility via directly modulating the activation of autonomic nervous system. Additionally, acupuncture has been found to suppress inflammatory response and alter the secretion of gastrointestinal hormones via different somatic autonomic reflex pathways. Importantly, the therapeutic effects of acupuncture are affected by, and even rely on, the selected acupoints, the frequency and intensity of stimulation, type of gastrointestinal disorders, and the treatment frequency. Meanwhile, clinical studies indicated that acupuncture shows promise in alleviating gastrointestinal dysmotility from the esophagus to the colon, including conditions like gastroparesis, functional dyspepsia, postoperative ileus, irritable bowel syndrome, and chronic functional constipation. We argued against a narrow classification of abdominal and hindlimb acupoints as solely activating sympathetic or vagal nerve to decrease or increase gastrointestinal motility, respectively. Lastly, incorporating new technologies will assist to reveal central autonomic network changes in response to acupuncture stimulation.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2620-2636"},"PeriodicalIF":3.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction network between intestinal flora and cell death in microecosystem of pan-cancers.","authors":"Yuhan Zhang, Cenzhu Wang, Tingyan Ruan, Shuai Liang, Huning Jiang, Xi Wu, Rui Hou, Hanfang Fan, Huiyu Wang, Junli Ding, Junying Xu","doi":"10.7150/ijms.111723","DOIUrl":"10.7150/ijms.111723","url":null,"abstract":"<p><p>The human intestinal floras play an important role in human microecosystem, accounting for more than 1,500 species and consisting of beneficial, harmful and neutral bacteria, which take part in regulating the progression of various malignant tumors. Meanwhile, the cell death is a physiological process maintaining biological development and internal environmental homeostasis, including cuproptosis, ferroptosis, disulfidptosis, immunogenic cell death, necroptosis, anoikis, autophagy, pyroptosis and so on. A variety of cell deaths and their related genes have been reported to regulate many malignant tumors. In recent years, there has been increasing interest in understanding the interaction network between intestinal flora and cell death in microecosystem of various malignant tumors. However, this interaction network is still not fully understood and requires further investigation. Therefore, the aim of this study is to explore the potential mechanism network between intestinal flora and cell death in pan-cancers, with the hope that this research could bring a novel insight for the prevention and treatment of tumors.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2596-2608"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies.","authors":"Guang Yang, Wenqing Xie, Hengzhen Li, Wenhao Lu, Ying Liang, Yusheng Li, Yaping Wang, Wenfeng Xiao","doi":"10.7150/ijms.111848","DOIUrl":"10.7150/ijms.111848","url":null,"abstract":"<p><p>The causal impact of blood metabolites on OA has yet to be definitively established, further studies are needed to explore the specific roles of metabolites in OA. This is a genetic correlation and two-sample bidirectional mendelian randomization study. GWAS summary data of metabolites and OA were extracted from large-scale GWAS study based on Europeans and Asians. LDSC was conducted to estimate the genetic correlations between 233 circulating metabolites and 11 OA phenotypes, MR was then performed to explore the casual association. 41.20% of the metabolic traits showed genetic correlation with All OA, 15.88% with Knee/Hip OA, 51.50% with Knee OA, and 52.79% with Spine OA. No significant genetic correlations were detected between the metabolic traits and other OA phenotypes. Lactate levels was associated with increased odds of All OA (OR: 1.1558, P<0.001), Hip OA (OR: 1.1446, P=0.004), Knee/Hip OA (OR: 1.1820, P<0.001), Knee OA (OR: 1.1375, P=0.001), Spine OA (OR: 1.3179, P<0.001), THR (OR: 1.5290, P<0.001), and TJR (OR: 1.2827, P<0.001), except for Thumb OA (OR: 0.9429, P<0.001). Ratio of conjugated linoleic acid to total fatty acids was associated 6 OA phenotypes: Hip OA (OR: 0.9522, P=0.035), Knee/Hip OA (OR: 1.0890, P<0.001), Knee OA (OR: 1.1429, P<0.001), THR (OR: 1.3800, P<0.001), TJR (OR: 1.3102, P<0.001), and TKR (OR: 1.2555, P<0.001). Glycerol levels exhibited significant MR associations with four OA phenotypes: Finger OA (OR: 0.6669, P<0.001), Hand OA (OR: 0.8682, P=0.011), Hip OA (OR: 0.9395, P<0.001), and Knee OA (OR: 1.1409, P=0.036). This study underscores genetic and causal connections between specific metabolites and OA. These findings could inform future therapeutic metabolic pathways involved in OA.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 11","pages":"2609-2619"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}