International Journal of Medical Sciences最新文献

{"title":"Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer.","authors":"Minghui Zhao, Xiaoke Di, Yucui Zhao","doi":"10.7150/ijms.107109","DOIUrl":"10.7150/ijms.107109","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC), as one of the most commonly diagnosed cancers globally, requires expedited identification of new drug targets. We conducted proteome-wide MR using genetic data for 4,853 plasma proteins. Summary-level data on lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) were extracted from GWAS meta-analyses (11,273 and 7,426 cases, respectively) and FinnGen cohort (1,590 and 1,510 cases, respectively). We genetically identified eight proteins with a causal role in the etiology of NSCLC. Lower levels of five proteins (CDH17, CXADR, FAM3D, POGLUT3, SFTPB) and higher levels of two proteins (CEACAM5, KLK1) were linked to increased LUAD risk, while higher CD14 levels were associated with elevated LUSC risk. Two proteins, POGLUT3 and SFTPB were validated through Bayesian colocalization. One protein SFTPB was identified using SMR and HEIDI tests. Bidirectional MR found no reverse causality. The primary findings were validated through scRNA-seq, GeneMANIA, GO analysis, druggability assessments and PheWAS analysis. These protein-coding genes are primarily expressed in epithelial cells, macrophages, monocytes, and endothelial cells. Furthermore, CEACAM5, KLK1, and CD14 correspond to existing drugs. These proteins may deepen our comprehension of the etiology and could serve as appealing novel biomarkers and drug targets for NSCLC management.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"4036-4048"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells.","authors":"Hongyu Zhou, Hongyan Chen, Kaitao Luo, Lingmei Kong, Yan Li","doi":"10.7150/ijms.114452","DOIUrl":"10.7150/ijms.114452","url":null,"abstract":"<p><p>Hematological malignancies, such as leukemia and multiple myeloma, are heterogeneous blood diseases that affect blood, lymphoid and other related tissues. Ciclopirox olamine (CPX), which is an antifungal agent, was identified as a promising anti-cancer candidate drug recently, especially in hematologic malignancy. However, CPX resistance in hematologic malignancy and the underlying molecular mechanisms are largely unknown. Our present study found that different leukemia cells exhibited different apoptotic responses to CPX. CPX effectively induced mitochondrial-mediated apoptosis in adult acute myeloid leukemia OCI-AML2 cells. However, in human chronic myelogenous leukemia K562 cells, CPX induced little apoptosis. Further study showed that CPX inhibited autophagy in OCI-AML2 cells, but induced autophagy in K562 cells. Notably, compared with CPX alone, the combination of CPX with the autophagy inhibitor chloroquine (CQ) or Bafilomycin A1 (Baf-A1) significantly enhanced pro-apoptotic activity of CPX, suggesting that CPX-induced autophagy is cytoprotective in K562 cells. Mechanism study showed that CPX induced autophagy by activating AMP-activated protein kinase (AMPK)/Unc-51 like autophagy activating kinase 1 (ULK1) signaling. Ectopic expression of dominant negative AMPKα or pharmacological inhibition of AMPK with its inhibitor compound C partially prevented from CPX inducing autophagy and re-sensitized K562 cells to CPX-induced apoptosis. Taken together, our present study demonstrates that AMPK-ULK1-mediated autophagy protects human chronic myelogenous leukemia K562 cells from CPX-induced apoptosis. To improve the clinical therapeutic efficacy of CPX in chronic myelogenous leukemia, the combination therapy of CQ and CPX might be a worthwhile alternative option.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"4013-4025"},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid profile in coronavirus disease 2019, a prospective case series study.","authors":"Huiying Lin, Xiaoli Zhang, Hangfeng Li, Shuangfang Fang, Huapin Huang, Nan Liu, Houwei Du","doi":"10.7150/ijms.111747","DOIUrl":"10.7150/ijms.111747","url":null,"abstract":"<p><p><b>Background:</b> Cerebrospinal fluid (CSF) analysis in patients with Coronavirus disease 2019 (COVID-19) and co-existing acute neurological involvement remains poorly understood. <b>Objective:</b> To investigate the CSF profile in patients with COVID-19 and co-existing acute neurological involvement. <b>Methods:</b> This prospective case series study included patients with confirmed severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and co-existing acute neurological involvement who underwent lumbar puncture in two teaching hospitals between November 2022 and April 2023. Demographics, clinical characteristics, and CSF profile, including leukocyte count, total protein, and glucose levels, oligoclonal band (OCB) patterns, blood-CSF barrier function, SARS-CoV-2 mRNA, and SARS-CoV-2 antibodies were described. <b>Results:</b> A total of 26 participants were analyzed. The median age was 51 (interquartile range [IQR] 39-76) years, and 18 (69.2%) were male. The median open CSF pressure was 140mm (IQR 110-183) water column, and the median CSF total protein was slightly elevated (485 [IQR 350-611] mg/L). The most frequent pathological finding was elevated CSF total protein (12 [46.2%] samples) and blood-CSF barrier dysfunction (12 [46.2%] samples). SARS-CoV-2 was undetectable in all CSF samples using the reverse-transcriptase-polymerase-chain-reaction detection. SARS-CoV-2-IgG-antibody was positive in five CSF samples, while SARS-Cov-2 IgM antibodies were not detected in all participants. <b>Conclusions:</b> This study showed that some patients with COVID-19 and co-existing acute neurological involvement presented non-specific inflammatory CSF abnormalities despite no SARS-CoV-2 being detected in the CSF. Our findings suggest that neurological injury is related to disordered immune responses associated with systemic inflammation rather than direct virus invasion.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3994-4002"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study.","authors":"Christian A Trejo-Jasso, Héctor Isaac Rocha-González, Eduardo Montes-Martínez, Manuel Castillejos-López, Arnoldo Aquino-Galvez, Dora Patricia Rosete-Olvera, Jose S Lopez-Gonzalez, Mario Perez-Medina, Martha Patricia Sierra-Vargas, Angeles Carlos-Reyes, Misael O García-Martin, Jazmín García-Machorro, Angel Camarena, Victor Ruiz","doi":"10.7150/ijms.111022","DOIUrl":"10.7150/ijms.111022","url":null,"abstract":"<p><p><b>Purpose:</b> Microribonucleic acids (miRNAs) play an important role as non-invasive biomarkers and predictors of inflammatory disease activity. This study aimed to determine differences in expression profiles of miRNAs in patients with asthma compared to healthy controls (HC). <b>Study Design and Methods:</b> In this study, we evaluated a panel of 84 miRNAs in plasma from 3 asthmatic patients and three healthy controls (HC), and we observed decreased levels of miR-17-5p, miR-18a-5p, miR-106b-5p, miR-126-3p, miR-223-3p y miR-374a-5p which were validated in an independent group. Real-time PCR was performed to compare the expression level of each miRNA in a group of 27 asthmatic patients and 27 healthy controls. <b>Results:</b> Correlations between miRNAs and body mass index (BMI) and forced expiratory volume during the first second (FEV1) were also determined. Asthmatic patients had lower levels of miR-17-5p(p=0.026), miR-106-5p (p=0.022), miR-126-3p (p=0.041, and miR-223-3p (p=0.13) than healthy controls. miRNAs did not correlate with BMI and FEV₁. <b>Conclusion:</b> Data suggest that circulating miRNAs described in this study could be employed as biomarkers for asthma prediction.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"4003-4012"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Lead Exposure Predicts Lower Bone Mineral Density in a Large Taiwanese Population-Based Study.","authors":"Po-Yin Shen, Fu-Wen Liang, Cheng-Chang Lu, Shu-Pin Huang, Szu-Chia Chen, Jiun-Hung Geng","doi":"10.7150/ijms.117042","DOIUrl":"10.7150/ijms.117042","url":null,"abstract":"<p><p><b>Background:</b> Chronic exposure to environmental lead (Pb) may impair bone metabolism and increase the risk of osteoporosis; however, large-scale epidemiological data remain limited. This study aimed to examine the association between long-term environmental Pb exposure and bone mineral density (BMD) in a nationally representative Taiwanese cohort. <b>Methods:</b> A total of 32,239 participants aged 30-70 years were included after excluding those with missing lead exposure or BMD data. BMD was assessed via calcaneal quantitative ultrasound, and T-scores were calculated. Environmental Pb exposure was estimated using a validated Geo-AI model. Univariable and multivariable linear regression models were used to evaluate associations between Pb exposure and T-scores, adjusting for demographic, lifestyle, comorbidity, and laboratory factors. <b>Results:</b> Among all participants, 7.2% had T-scores < -2.5. These individuals were older, had lower educational attainment, and demonstrated less favorable metabolic and clinical profiles. Multivariable stepwise regression analysis revealed a significant inverse association between lead exposure and baseline T-scores: each 0.001 µg/m³ increase in airborne Pb was independently associated with a -0.013 decrease in baseline T-score (95% CI: -0.017 to -0.009, p < 0.0001). More importantly, in longitudinal analyses, each 0.001 µg/m³ increase in Pb concentration was independently associated with a -0.006 decrease in within-individual T-score change over time (95% CI: -0.010 to -0.003, p = 0.0002). Other significant factors influencing T-scores and T-score changes included age, sex, body mass index, education, exercise, and albumin levels. <b>Conclusions:</b> Chronic environmental Pb exposure is significantly associated with reduced bone mineral density in the general population. These findings underscore the need for environmental risk assessments in osteoporosis screening and public health prevention strategies, particularly in vulnerable populations.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3985-3993"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Interaction of Dasatinib with Thymoquinone: A Pharmacokinetic Study in Rats.","authors":"Ajaz Ahmad, Mohammad Raish, Khalid M Alkharfy, Yousef A Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Muzaffer Iqbal, Ibrahim A Abdelrahman, Naushad Ali, Ali Akhtar, Fahad I Al-Jenoobi","doi":"10.7150/ijms.109707","DOIUrl":"10.7150/ijms.109707","url":null,"abstract":"<p><p>Dasatinib (DAS), a multi-kinase inhibitor targeting Src and BCR-ABL families, is approved for Ph+ acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CML). Its metabolism by CYP3A4 and transported by efflux pump P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) render it susceptible to drug, food, and herbal interactions. This study investigated the potential impact of thymoquinone (TQ) co-administration on dasatinib pharmacokinetics (PK) and the subsequent risk of altered efficacy or toxicity. Wistar rats were pretreated with a daily oral dose of TQ (40 mg/kg) for one week before receiving a single oral dose of DAS (25 mg/kg). Blood samples were collected at different time points, and plasma concentrations of DAS were measured using UPLC-MS/MS. A non-compartmental analysis was applied to calculate the PK parameters of DAS. Additionally, the impact of TQ treatment on hepatic and intestinal protein expressions of CYP3A4, Pgp and BCRP were investigated using Western blot analysis. TQ pretreatment significantly altered the disposition of DAS in animals as compared to untreated animals. More specifically, a substantial increase in DAS Cmax (213.26%), AUC_0-t (166.53%), AUMC_0-∞ (0.34%), K<i>el</i> (93.85%) and Tmax (83.33%) were observed (<i>p<0.05</i>). In addition, a significant reduction in DAS Vd (67.70%) and clearance CL (36.35%) of were evident in the TQ treatment group (<i>p<0.05</i>). Furthermore, TQ pretreatment inhibited CYP3A4 and Pgp and BCRP1 in the liver and lumen tissues. TQ pretreatment significantly alters the disposition of DAS in rats. This is likely due to an increase in DAS bioavailability <i>via</i> a modulation in the protein expressions of CYP3A4 and Pgp and BCRP1 in the liver and lumen tissues. Thus, the concurrent intake of TQ-containing products with DAS can lead to a serious interaction. Further clinical studies are warranted to evaluate the clinical impact of such observations.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3939-3945"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Fine Particulate Matter (PM2.5) and Wet-Bulb Globe Temperature (WBGT) with Osteoporosis Incidence: A Nationwide Prospective Cohort Study.","authors":"En-Che Chang, Fu-Wen Liang, Jiun-Chi Huang, Hao-Han Chang, Shu-Pin Huang, Szu-Chia Chen, Chih-Da Wu, Ya-Chin Huang, Jiun-Hung Geng","doi":"10.7150/ijms.115460","DOIUrl":"10.7150/ijms.115460","url":null,"abstract":"<p><p><b>Background:</b> Fine particulate matter (PM2.5) negatively impacts human health, contributing to cardiovascular, kidney, and lung diseases, as well as cancer. Emerging evidence suggests that PM2.5 exposure may also impair bone density, increasing osteoporosis risk. Ambient temperature and humidity interact with PM2.5, potentially influencing disease onset. However, most studies focus on Western populations or low-pollution environments and lack long-term follow-up data. This study investigated the association between PM2.5 exposure, wet-bulb globe temperature (WBGT), and osteoporosis in a large Taiwanese cohort. <b>Methods:</b> Data from 19,981 participants in the Taiwan Biobank (TWB) were analyzed. PM2.5 exposure and WBGT were estimated using a Geo-AI-based ensemble mixed spatial model. Bone density was assessed using quantitative ultrasound, with osteoporosis defined as a T-score ≤ -2.5. Cox proportional hazards models assessed associations between PM2.5 exposure, WBGT, and osteoporosis risk. <b>Results:</b> Among participants (65% women, mean age 51 years, BMI 24 kg/m²), 1,303 (6.5%) developed osteoporosis during a 43-month follow-up. Incidence rates by PM2.5 quartiles were: 8.4% (1st), 5.7% (2nd), 5.3% (3rd), and 6.6% (4th). High PM2.5 quartile exposure was associated with a 1.66-fold increased osteoporosis risk (HR: 1.66, 95% CI: 1.43-1.92, p < 0.001). Log-transformed PM2.5 exposure also showed significant risk (HR: 1.73, 95% CI: 1.02-2.95, p = 0.043). Higher WBGT (26-27°C) independently increased osteoporosis risk (HR: 1.49, 95% CI: 1.33-1.66, p < 0.001). WBGT further amplified risk among individuals with lower PM2.5 exposure. <b>Conclusions:</b> PM2.5 exposure and elevated WBGT independently and interactively increased osteoporosis risk. Findings underscore the need for preventive strategies addressing environmental factors.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3974-3984"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Epicardium in Heart Failure Treatment: Opportunities and Challenges.","authors":"Chenlei Zhou, Yaping Xu, Zhikun Guo","doi":"10.7150/ijms.118408","DOIUrl":"10.7150/ijms.118408","url":null,"abstract":"<p><p>Heart failure remains one of the leading causes of morbidity and mortality worldwide. Conventional treatment strategies, while beneficial, face numerous limitations. Drug therapies may lead to resistance, while device-based treatments such as LVAD and ICD carry risks of infection, bleeding, device failure, and high costs. For end-stage heart failure, heart transplantation is further constrained by donor shortages and immune rejection. In contrast, cell-based therapies have emerged as a promising alternative. Recent studies have highlighted the critical role of the epicardium and epicardium-derived cells (EPDCs) in cardiac regeneration. These cells contribute to heart repair through multiple mechanisms, including direct cell therapy, the development of epicardium-based biomaterials, and integration with gene therapy approaches. This review outlines the anatomical structure and biological functions of the epicardium, explores the regenerative potential of the epicardium and EPDCs, and evaluates their application in heart failure treatment. Furthermore, it discusses the translational potential and current challenges associated with epicardial-based therapies, offering novel insights and strategies for heart failure management.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3946-3957"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional Factors Related to Engagement in Child-to-Parent Violence among Adolescents with Attention-Deficit/Hyperactivity Disorder.","authors":"Wen-Jiun Chou, Ray C Hsiao, Peng-Wei Wang, Cheng-Fang Yen","doi":"10.7150/ijms.116091","DOIUrl":"10.7150/ijms.116091","url":null,"abstract":"<p><p><b>Background:</b> Child-to-parent violence (CPV) has received increasing attention because of the growing response from parents. This study examined the rates of various CPV types and the reasons underlying why adolescents with attention-deficit/hyperactivity disorder (ADHD) engage in CPV and examined the associations of multidimensional factors with CPV in adolescents with ADHD. <b>Method:</b> In total, 247 adolescents with ADHD and their parents participated in the study. The types (including psychological aggression, physical aggression, financial demand, and control or domination) and instrumental and reactive reasons of CPV, individual factors (demographic characteristics, ADHD symptoms, internalizing and externalizing behavior problems, self-esteem, and social information processing [SIP] during conflict), parent-child interaction factors (parenting styles and parent-to-child violence), and family factors (violence among adult family members) were collected. <b>Results:</b> In total, 78.9% of adolescents with ADHD engaged in CPV in the year preceding their evaluation. Both instrumental and reactive reasons were reported for CPV. Aggression response of SIP (<i>p</i> = .003) and parent-to-child violence (<i>p</i> < .001) were positively associated with psychological aggression. Externalizing behavior problems were positively associated with physical aggression (<i>p</i> < .001) and financial demand (<i>p</i> = .001). Finally, externalizing behavior problems (<i>p</i> = .001), aggression response of SIP (<i>p</i> = .001), and violence among adult family members (<i>p</i> = .006) were positively associated with control or domination. <b>Conclusion:</b> Many adolescents with ADHD had engaged in CPV. Multiple individual, parent-child interaction, and family factors were significantly correlated with CPV.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3965-3973"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential impact of omentin-1 genetic variants with the clinical features and progression of buccal mucosa cancer.","authors":"Ya-Hsin Wu, Chiao-Wen Lin, Hsiao-Chi Tsai, Chun-Wen Su, Ming-Yu Lien, Shun-Fa Yang, Chih-Hsin Tang","doi":"10.7150/ijms.117708","DOIUrl":"10.7150/ijms.117708","url":null,"abstract":"<p><p>Oral cancer is the fourth most prevalent cancer among Taiwanese men and the ninth most general cancer among men globally. Omentin-1, an adipokine, has been shown to play a protective role by reducing proinflammatory cytokine secretion. The relationships between carcinogenic lifestyle factors, <i>OMNT1</i> polymorphisms, and oral squamous cell carcinoma (OSCC) remain unclear. We investigated the impact of clinicopathological features and four <i>OMNT1</i> gene variants on oral cancer risk in 406 Taiwanese male patients with the condition. Compared with the TT genotype, the TA+AA genotypes of SNP rs2274907 were linked with an increased risk of advanced clinical stage (III+IV). In patients with OSCC who consumed betel quid and cigarette smoke, SNP rs2274907 was associated with a higher risk of advanced clinical stage (III+IV) and lymph node metastasis. Interestingly, the wild-type TT homozygous genotype was associated with significantly higher <i>OMNT1</i> expression levels compared to the AA allele of variant rs2274907. Additionally, <i>OMNT1</i> mRNA levels were lower in oral cancer tissues compared to normal tissues, indicating that omentin-1 acts as a negative regulator of oral cancer.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 15","pages":"3958-3964"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}