International Journal of Medical Sciences最新文献

{"title":"Knowledge Landscape and Hotspots of Research in Transthyretin Amyloid Cardiomyopathy: A Bibliometric Analysis.","authors":"Yanzhi Liu, Xinqing Li, Anran Xin, Yuhui Zhang, Jian Zhang","doi":"10.7150/ijms.101888","DOIUrl":"https://doi.org/10.7150/ijms.101888","url":null,"abstract":"<p><p><b>Background:</b> Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and frequently underdiagnosed cause of heart failure characterized by the pathological deposition of misfolded transthyretin (TTR) proteins in the cardiac tissue, leading to a poor prognosis and a significant reduction in quality of life. Despite its severity, therapeutic options remain limited, and knowledge gaps persist. This study aims to construct a knowledge map and identify research hotspots within the field of ATTR-CM. <b>Methods:</b> Data were extracted from the Web of Science Core Collection (WoSCC), covering the period from January 1, 2000 to June 1, 2024. Bibliometric analyses were supplemented by qualitative assessments. VOSviewer, CiteSpace, and Bibliometrix were used to visualize academic community clusters, collaboration and citation networks to identify trends and hotspots in ATTR-CM research. <b>Results:</b> A total of 1855 publications were analyzed. Contributions from multiple disciplines fueled a consistent upward trend in publications and citations. Europe and the United States dominated ATTR-CM research, with Mathew S. Maurer as the most prolific author, and the University of London as the leading research institution. The journals publishing these documents and references demonstrated credibility and broad disciplinary coverage. Reference analysis identified 10 main research fields. Keyword analysis unveiled five promising themes for research: early diagnosis and prognosis algorithm, specific medication development, management of comorbidities and complications, epidemiology and genotype-phenotype correlation, and molecular biology and mechanisms. <b>Conclusion:</b> This study is the first comprehensive bibliometric analysis of the ATTR-CM field, supplemented by qualitative assessments. It systematically examines development trends, academic networks, and research themes, while identifying research hotspots and proposing future directions and approaches. These findings provide valuable insights to deepen the understanding of ATTR-CM and may foster advancements in scientific research and clinical applications.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1585-1601"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Fascin-1-Positive Extracellular Vesicles by Nanoflow Cytometry for Early Detection of Hepatocellular Carcinoma in Liquid Biopsy.","authors":"Bodeng Wu, Zhenxun Wang, Guanbo Wang, Quan Zhong, Qiaoting Wu, Jiawei Li, Bo Ma, Xinyi Tan, Jiaming Chen, Yu Wang, Xin Zhang","doi":"10.7150/ijms.102438","DOIUrl":"https://doi.org/10.7150/ijms.102438","url":null,"abstract":"<p><p><b>Background:</b> Hepatocellular carcinoma (HCC) lacks effective early diagnostic biomarkers. Identifying extracellular vesicles (EVs)-associated biomarkers for early HCC detection in HCC progression is precise and critical. <b>Methods:</b> Databases, tissue microarrays (TMA) were used to identify Fascin-1 as a candidate target for HCC, EVs isolated from tumoral and adjacent tissues. The tumor cells were transfected with lentivirus to obtain the engineered EVs. <b>Results:</b> Fascin-1-enriched EVs promoted HCC cell migration and induced cytoskeleton reorganization <i>in vitro</i>. Importantly, quantifying Fascin-1-positive EVs (Fascin-1⁺EVs) in patient plasma by nanoflow cytometry (nFCM) demonstrated high diagnostic performance (AUC=0.8925, 95%CI: 0.7959-0.9891) for discriminating advanced stage from early stage of HCC patients and healthy individuals. <b>Conclusion:</b> Our findings highlight the potential of Fascin-1⁺EVs as a novel non-invasive biomarker for early HCC detection, and quantitative Fascin-1⁺EV analysis by nanoflow cytometry provides a promising approach for HCC diagnosis.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1574-1584"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-epithelial Circulating Tumor Cells Enhance Disease Progression in High-risk Prostate Cancer through EMT and COL1A1 Expression.","authors":"Yiyuan Li, Ruji Wu, Hua Wang, Meinong Zhong, Yunhao Qing, Shuo Lu, Zixiao Zhang, Tan Ma, Jieheng Luo, Hengjun Xiao, Jianguang Qiu, Ke Li","doi":"10.7150/ijms.107703","DOIUrl":"https://doi.org/10.7150/ijms.107703","url":null,"abstract":"<p><p><b>Introduction:</b> Circulating tumor cells (CTCs) are important prognostic indicators for malignancies. However, a reliable positive/negative cutoff value of non-epithelial (NE⁺: hybrid and mesenchymal) CTCs phenotype in prostate cancer (PCa) patients has not been established. Here, we aimed to determine the cutoff value and the prognostic value of NE⁺ CTCs in high-risk prostate cancer (HRPC) patients after radical prostatectomy (RP). <b>Methods:</b> The cutoff value of NE⁺ CTCs was established in spiking experiments, and CTCs were detected in 208 HRPC patients using the CanPatrol^TM platform. The expression and function of COL1A1 in PCa were examined via qRT-PCR, Western blot, wound healing assay, Transwell assay, and immunohistochemistry (IHC). <b>Results:</b> The cutoff value of NE⁺ CTCs was determined to be 45% by spiking experiments. In 208 HRPC patients, the NE⁺ CTCs positive group had higher prostate-specific antigen (PSA) levels, more advanced pathological tumor stage, and lymph node stage (<i>P</i> < 0.001, <i>P</i> = 0.002 and 0.002, respectively). Besides, patients with NE⁺ CTCs ≥ 45% had a shorter median progression-free survival (PFS) than those with NE⁺ CTCs < 45% (44.5 vs. 51.0 months, hazard ratio = 3.31, <i>P</i> < 0.05). Moreover, we identified that COL1A1 was associated with a high proportion of NE⁺ CTCs in HRPC patients via an EMT mechanism. <b>Conclusion:</b> Our findings suggest that NE⁺ CTCs represent a reliable prognostic indicator for HRPC patients and that targeting COL1A1 may prevent the formation of NE⁺ CTCs.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1562-1573"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity.","authors":"Nhi Thi Hong Nguyen, Chyi-Huey Bai, Jung-Su Chang, Yi-Chun Chen, Ya-Li Huang, Fan-Fen Wang, Chien-Yeh Hsu, Arpita Das, Jane C-J Chao","doi":"10.7150/ijms.108760","DOIUrl":"https://doi.org/10.7150/ijms.108760","url":null,"abstract":"<p><p>Pre-pregnancy overweightness or obesity affects nutritional status and micronutrient imbalance such as folate and iron during pregnancy. We studied the relationships between micronutrient intake and dietary patterns with serum folate and iron biomarkers among pregnant population with pre-pregnancy overweightness or obesity. This cross-sectional study utilized data from 2017-2019 Nationwide Nutrition and Health Survey. Participants (<i>n</i> = 436) were Taiwanese pregnant women with pre-pregnancy overweightness or obesity. Dietary evaluation was conducted by food frequency questionnaire and 24-hour dietary recall. Dietary patterns were developed by principal component analysis. Serum folate and iron biomarkers were measured. Logistic and linear regression models were employed to investigate the associations of dietary patterns with serum folate and iron biomarkers. Participants with the highest tertile of serum folate were older, and had less proportion of high parity. After adjusting covariates, the intake of DP-1 (mushrooms, roots, and dairy DP) (β = 0.052; 95% CI = 0.008-0.119; <i>p</i> < 0.05) or DP-3 (vegetables and fruits DP) (β = 0.056; 95% CI = 0.034-0.076; <i>p</i> < 0.05) was associated with increased serum folate. The consumption of DP-4 (animal DP) showed a significant association with elevated serum iron, ferritin, and vitamin B-12. The consumption of DP-1 or DP-3 was linked to a decreased risk of low serum folate. However, the intake of DP-3 was correlated with an increased risk of low serum ferritin. A reduced risk of low serum iron and vitamin B-12 was observed in participants consuming DP-4. The dairy and plant dietary patterns were positively associated with serum folate, and the animal dietary pattern was positively correlated with serum iron and vitamin B-12 in pregnant women with pre-pregnancy overweightness or obesity.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1630-1639"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study.","authors":"Wen-Hung Hsu, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Chao-Hung Kuo, Szu-Chia Chen","doi":"10.7150/ijms.109616","DOIUrl":"https://doi.org/10.7150/ijms.109616","url":null,"abstract":"<p><p>Gastroesophageal reflux disease (GERD) and metabolic syndrome (MetS) have emerged as prominent health issues in past decades. This study aimed to evaluate whether the presence of MetS and its constituent factors was associated with a higher likelihood of GERD in a large cohort of Taiwanese adults. MetS and its components were defined according to the modified National Cholesterol Education Program Expert Panel and Adult Treatment Panel III for Asians, and the presence of GERD was assessed using standardized interviews and questionnaires. Of 121,583 participants from the Taiwan biobank, 16,664 (13.7%) were diagnosed with GERD and 27,441 (22.6%) were diagnosed with MetS. After multivariable analysis, the participants with MetS (odds ratio [OR] = 1.079), abdominal obesity (OR = 1.094), hypertriglyceridemia (OR = 1.085), and low high-density lipoprotein cholesterol (OR = 1.073) (all <i>p</i> < 0.001) were significantly associated with GERD, but high blood pressure and hyperglycemia were not. Furthermore, there was a trend of a stepwise increase in the rate of GERD in accordance with the number of MetS components. Participants with 3 components (<i>vs.</i> 0; OR = 1.093; <i>p</i> = 0.002), 4 components (<i>vs.</i> 0; OR = 1.108; <i>p</i> = 0.005), and 5 components (<i>vs.</i> 0; OR = 1.137; <i>p</i> = 0.029) were significantly associated with GERD. Our results suggest that MetS may be associated with the development of GERD in the Taiwanese population.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1555-1561"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escin Rescues Blood-brain Barrier and Inhibits NLRP3 Inflammasome-mediated Pyroptosis in Rats with Superior Sagital Sinus Thrombosis.","authors":"Min Li, Xinjian Liu, Xinyu Zhou, Ran Meng, Xunming Ji","doi":"10.7150/ijms.102624","DOIUrl":"https://doi.org/10.7150/ijms.102624","url":null,"abstract":"<p><p><b>Objective:</b> The purpose of this study is to investigate the therapeutic value of escin and its potential mechanisms in rats with superior sagittal sinus thrombosis (SSST). <b>Methods:</b> The motor function of rats was assessed using the open field, balance beam, and rotarod tests following one week of escin treatment. Laser Speckle Contrast Imaging (LSCI) was used to evaluate the blood flow in the superior sagittal sinus. Evans blue staining was used to assess the permeability of blood-brain barrier. The protein expression levels of Occludin, ZO-1 and MMP-9 was analyzed by Western blotting to assess blood-brain barrier disruption. Iba1, CD68 and NLRP3 immunofluorescent staining was conducted to evaluate the activation of microglia and NLRP3 inflammasome. The protein expression levels of NLRP3, Caspase-1, IL-1β, IL-18 and GSDMD was analyzed by Western blotting to assess NLRP3 inflammasome activation and pyroptosis. Immunohistochemistry for NeuN was used to evaluate the neuronal pyroptosis. <b>Results:</b> Rats with SSST exhibited decreased movement distance, duration and latency to fall, as well as increased balance latency compared to sham rats, indicating its motor dysfunction. Escin treatment alleviated the motor dysfunction in rats with SSST. LSCI revealed a decrease in the blood flow in the superior sagittal sinus of rats with SSST. There was no discernible change in blood flow between SSST rats treated with escin and those not, suggesting that escin did not promote recanalization of the superior sagittal sinus. By decreasing Evans blue dye content and MMP-9 protein expression and increasing the protein expressions of Occludin and ZO-1, escin treatment improved blood-brain barrier (BBB) disruption and protected tight junction proteins. Escin also reduced the number of microglia-originated macrophage and the number of NLRP3-positive macrophage. Additionally, escin treatment down-regulated the protein expression levels of NLRP3, Caspase-1, IL-1β, IL-18, and GSDMD in the parasagittal cortex of SSST rats, suggesting its ability to inhibit NLRP3 inflammasome activation and therefore reduce pyroptosis. Finally, escin treatment significantly increased the neuronal survival in the parasagittal cortex of rats with SSST. <b>Conclusions:</b> Treatment with escin improved motor function not by recanalizing the SSS. Treatment with escin protected the blood-brain barrier, inhibited the microglia activation and suppressed the NLRP3 inflammasome-mediated pyroptosis in the parasagittal cortex of SSST rats, thereby playing an anti-pyroptosis and neuroprotective effect.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1602-1611"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIM model: a novel model to depict the spatial heterogeneity of the radiation microenvironment.","authors":"Yinan Sun, Ying Bi, Xiaohui Wang, Shunfang Liu, Lu Wang","doi":"10.7150/ijms.104046","DOIUrl":"10.7150/ijms.104046","url":null,"abstract":"<p><p>Radiation-induced disease (RID) is the most important factor limiting the radiotherapy dose for malignant tumors, especially for patients with organ insufficiency or chronic inflammation. In this paper, it studied the changes in the microenvironment after radiation exposure from the perspectives of molecular biology, cell biology and histopathology, and first proposed a novel model of the radiation microenvironment to depict radiation-induced spatial heterogeneity. The radiation microenvironment was divided into the VIM model: vascular microenvironment, inflammatory microenvironment, and metabolic microenvironment according to the special cell functions, molecular expressions and pathological structures after radiation. The structural functions of each microenvironment were explored to provide the new theoretical basis for molecular target prediction, radiation damage assessment, prevention and treatment of radiation-induced disease, and using radiation-induced liver injury as a template to depict the VIM model.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 6","pages":"1477-1484"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Texture Analysis of Multi-parameter MRI Images in Distinguishing Benign and Malignant Lesions of O-RADS MRI 4 Lesions.","authors":"Yan Lei, Hanzhou Tang, Lianlian Liu, Tingting Zheng, Yuan Zhang, Tong Chen, Junkang Shen, Bin Song","doi":"10.7150/ijms.107452","DOIUrl":"10.7150/ijms.107452","url":null,"abstract":"<p><p><b>Objectives:</b> To investigate the diagnostic performance of texture analysis using multi-parameter MRI in distinguishing between benign and malignant lesions with ovarian-adnexal magnetic resonance imaging report and data system (O-RADS MRI) score 4. <b>Methods:</b> A retrospective analysis was conducted of 57 lesions with an O-RADS MRI score of 4, of which 26 were benign and 31 were malignant. Based on the T2WI, ADC, and CE_T1WI, the textural features of the entire lesion were extracted. The minimum redundancy maximum relevance (mRMR) method was used to select features, and the random forest (RF) algorithm was used to construct four prediction models: T2WI, ADC, CE_T1WI, and the combined models. Ten-fold cross-validation was used to verify the model prediction performance, and receiver operating characteristic (ROC) analysis was used to evaluate the model performance, including area under the curve (AUC), accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). <b>Results:</b> 3474 texture features were extracted from the ADC, T2WI, and CE_T1WI images. ADC, T2WI, CE_T1WI, and combined models were constructed. Each model contained ten texture features. The AUC of the ADC, T2WI, CE_T1WI, and combined models were 0.749 (95% CI: 0.621-0.876), 0.671 (95% CI: 0.524-0.818), 0.786 (95% CI: 0.662-0.909), and 0.860 (95% CI: 0.76-0.959), respectively. The AUC of the combined model was significantly higher than those of the other three groups. The accuracy, sensitivity, specificity, PPV, and NPV of the combined model in distinguishing benign and malignant lesions with an O-RADS MRI score of 4 were 75.9%, 77.8%, 74.1%, 72.4%, and 79.3%, respectively. <b>Conclusion:</b> Texture analysis of multi-parameter MRI can improve the diagnostic efficiency of distinguishing benign and malignant lesions with an O-RADS MRI score of 4 and provide some help in clinical decision-making.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 6","pages":"1425-1436"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data Mining of the FDA Adverse Event Reporting System and Animal Experiments for Assessment of Rhabdomyolysis Risk Associated with Lipid-lowering Drugs.","authors":"Shinji Kobuchi, Daisuke Sugiyama, Anna Iima, Ami Obuchi, Ayumi Osaka, Ayana Doi, Hikaru Ueta, Satoshi Yokoyama, Kouichi Hosomi, Mitsutaka Takada, Toshiyuki Sakaeda","doi":"10.7150/ijms.109034","DOIUrl":"https://doi.org/10.7150/ijms.109034","url":null,"abstract":"<p><p>Despite extensive research on pharmacokinetic interactions between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and fibrates, the underlying pharmacodynamic mechanisms contributing to the increased risk of rhabdomyolysis remain unclear. This study aimed to determine the differences among statins or fibrates in terms of their susceptibility to rhabdomyolysis. The data mining of FDA Adverse Event Reporting System (FAERS) suggested the association of both statins and fibrates with rhabdomyolysis and the add-on effect of their combinations. In rats, their administration was associated with outliers in creatine phosphokinase and myoglobin levels and a larger distribution of data than in the control. Additionally, co-administration of cerivastatin increased the gemfibrozil concentration in skin and muscle tissues by more than two-fold without an increase in systemic exposure to gemfibrozil, suggesting that an alteration in the pharmacokinetics of gemfibrozil might contribute to an increased risk of rhabdomyolysis when cerivastatin and gemfibrozil are co-administered. Taken together, caution is uniformly needed in combination therapy with statins and fibrates because of the increased risk of rhabdomyolysis.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1485-1492"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database.","authors":"Manqing Chen, Yuhui Yang, Weiwei Hu, Lingmin Gong, Zhenli Liao, Yifan Fu, Xingyan Li, Hongman Feng, Fangyao Chen","doi":"10.7150/ijms.107976","DOIUrl":"https://doi.org/10.7150/ijms.107976","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to investigate the association between triglyceride-glucose (TyG) index and prognosis in critically ill patients with acute coronary syndrome (ACS), exploring potential heterogeneity of the association among patient subgroups with different characteristics. <b>Methods:</b> Records of patients with ACS were extracted from the MIMIC-IV database. The association between TyG index and mortality was analyzed using Cox proportional-hazard regression model, while potential non-linear associations were assessed using restricted cubic spline (RCS) regression. Meanwhile, linear regression model was used to explore the association between TyG index and length of stay in hospital or ICU. Subpopulation Treatment Effect Pattern Plot (STEPP) was utilized to explore the potential heterogeneous subgroups. Time-dependent Receiver Operating Characteristic (ROC) curve analyses were performed to compare the predictive ability of different Cox proportional-hazard regression models (with or without TyG index). <b>Results:</b> A total of 849 patients were enrolled. Multivariate Cox regression analyses demonstrated that TyG index was significantly associated with 28-day mortality (HR:2.13 [95%CI: 1.23-3.68], <i>P</i><0.01) and 365-day mortality (HR:1.65 [95%CI: 1.11-2.47], <i>P</i><0.01). RCS regression analyses revealed an inverted U-shaped association between TyG index and 28-day mortality (<i>P</i> for non-linearity=0.027) and a linear association between TyG index and 365-day mortality (<i>P</i> for non-linearity =0.086). There were subgroups specified by age for 28-day mortality (<i>P</i> for interaction=0.04) and 365-day mortality (<i>P</i> for interaction<0.01), with a cut-off point of 70 years old obtained by STEPP. TyG index was associated with a higher risk of mortality in subgroups aged ≤ 70 years old. Time-dependent ROC curve suggested that TyG index could slightly improve the prediction of mortality. A higher TyG index was associated with longer time of stay in hospital (<i>β</i>: 1.79 [95%CI: 0.06-3.52], <i>P</i>=0.04). <b>Conclusions:</b> A higher TyG index is associated with both short-term and long-term all-cause mortality in critically ill patients with ACS, especially in short-term all-cause mortality. TyG index is associated with higher mortality risk in patient subgroups aged ≤ 70 years old. A higher TyG index is associated with longer time of stay in hospital. TyG index may serve as a useful prognostic marker for patient management and strategic decision-making in clinical settings.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 7","pages":"1528-1541"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}