International Journal of Medical Sciences最新文献

{"title":"Establishing a Risk Prediction Model for Nasopharyngeal Carcinoma Based on Anti-BNLF2b Serological Biomarkers: A Retrospective Study.","authors":"Hengrong Shao, Mengting Chen, Yufei Xiao, Li Xu, Huaquan Cao, Bo Hong, Yun Qian","doi":"10.7150/ijms.110758","DOIUrl":"https://doi.org/10.7150/ijms.110758","url":null,"abstract":"<p><p><b>Purpose:</b> This study aims to establish a suitable risk prediction model of NPC in regions with relatively low-incidence in southern China. <b>Methods:</b> We retrospectively analysed the data of 198 patients with NPC and 398 healthy individuals admitted to The Second Affiliated Hospital, Zhejiang University School of Medicine, from February 2023 to October 2024. The levels of different serum biomarkers (P85-Ab, VCA-IgA, VCA-IgM, VCA-IgG, Rta-IgG and EA-IgA) were compared between patients with NPC and healthy individuals. Binary logistic regression was used to construct a risk prediction model for NPC, and ROC curves were plotted to evaluate the performance of the model. <b>Results:</b> Compared with healthy individuals, patients with NPC exhibited significantly elevated levels of EA-IgA (P < 0.001), Rta-IgG (P < 0.001), P85-Ab (P < 0.001) and VCA-IgA (χ² = 262.25; P < 0.001). Binary logistic regression showed that P85-Ab (HR = 572.225; P < 0.001), VCA-IgA (HR = 31.877; P < 0.001) and Rta-IgG (HR = 10.670; P = 0.004) were independent risk factors for NPC. The AUC of P85-Ab combined with Rta-IgG and VCA-IgA for predicting the risk of NPC was 0.977 (95% CI: 0.959-0.988), which was greater than the AUC values of Rta-IgG and VCA-IgA (P < 0.01 for all). The combination of P85-Ab with Rta-IgG and VCA-IgA had a sensitivity of 91.36% and a specificity of 99.25%. <b>Conclusion:</b> P85-Ab combined with VCA-IgA and Rta-IgG is an optimal serological biomarker for the diagnosis of NPC in low-incidence regions in southern China.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2165-2173"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Relationship Between <i>NF-κB1</i> and Cytokine Gene Expression in Hematological Malignancy: Leveraging Explained Artificial Intelligence and Machine Learning for Small Dataset Insights.","authors":"Jae-Seung Jeong, Hyunsu Ju, Chi-Hyun Cho","doi":"10.7150/ijms.109493","DOIUrl":"https://doi.org/10.7150/ijms.109493","url":null,"abstract":"<p><p>This study measures expression of <i>nuclear factor kappa B</i> (<i>NF-κB</i>)<i>1</i> and related cytokine genes in bone marrow mononuclear cells in patients with hematological malignancies, analyzing the relationship between them with an integrated framework of statistical analyses, machine learning (ML), and explainable artificial intelligence (XAI). While traditional dimensionality reduction techniques-such as principal component analysis, linear discriminant analysis, and t-distributed stochastic neighbor embedding-showed limited differentiation embedding, ML classifiers (k-Nearest Neighbors, Naïve Bayes Classifier, Random Forest, and XGBoost) successfully identified critical patterns. Notably, normalized caspase-1 counts consistently emerged as the most influential feature associated with NF-κB1 activity across disease groups, as highlighted by SHapley Additive exPlanations analyses. Systematic evaluation of ML performance on small datasets revealed that a minimum sample size of 15-24 is necessary for reliable classification outcomes, particularly in cohorts of acute myeloid leukemia and myelodysplastic syndrome. These findings underscore the pivotal role of caspase-1 to the NF-κB1 gene expression in hematologic malignancy diseases. Furthermore, this study demonstrates the feasibility of leveraging ML and XAI to derive meaningful insights from limited data, offering a robust strategy for biomarker discovery and precision medicine in rare hematological malignancies.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2208-2226"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Hyperbaric Oxygen Therapy Promotes Recovery of Blunt Liver Injury in Rats via Inhibiting Inflammatory Response and Oxidative Stress.","authors":"Houyu Zhao, Tingting Zhang, Yan Wang, Yiqun Fang","doi":"10.7150/ijms.109842","DOIUrl":"https://doi.org/10.7150/ijms.109842","url":null,"abstract":"<p><p><b>Purpose:</b> Blunt Liver Injury (BLI) is a common form of blunt abdominal trauma, with most cases managed non-surgically in current clinical practice. However, the absence of targeted treatments addressing the pathological changes associated with liver injury can result in prolonged recovery and potential long-term complications. Hyperbaric oxygen therapy (HBOT), known for its anti-inflammatory and antioxidant effects, has shown therapeutic potential in various diseases. This prospective randomized controlled experimental animal trial aimed to evaluate the effect of HBOT on BLI in a rat model. <b>Methods:</b> We established a BLI rat model by employing a free-fall weight method. Following injury, one group received no intervention, while the other was treated with HBOT (2.5 ATA, 60 minutes per session, once daily). Liver tissue and serum samples were collected at multiple time points for histological evaluation (HE staining), apoptosis detection (TUNEL staining), proliferation assessment (Ki67 immunohistochemical staining), and measurements of liver transaminase (ALT, AST), inflammatory markers (IL-1β, IL-6, TNF-α), and oxidative stress indicators (SOD, MDA, GSH). <b>Results:</b> The results indicated that HBOT significantly reduced liver transaminase elevation, pathological damage, and hepatocyte apoptosis while promoting hepatocyte proliferation and accelerating liver function recovery. Mechanistically, HBOT alleviated oxidative stress and inflammatory response, highlighting its therapeutic potential. <b>Conclusion:</b> These findings provide further evidence supporting the application of HBOT in the clinical management of BLI. This study helps advance the clinical approach to BLI by shifting the focus from symptom management to mechanism-based treatment.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2174-2185"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Oncolytic Viruses for Targeted Therapy in Triple-Negative Breast Cancer.","authors":"Shasha Tang, Liyun Yong, Yong Cui, Haibin Li, Evelyne Bischof, Fengfeng Cai","doi":"10.7150/ijms.105683","DOIUrl":"https://doi.org/10.7150/ijms.105683","url":null,"abstract":"<p><p>Breast cancer is the most prevalent malignant tumor among women, with triple-negative breast cancer (TNBC) being one of the most aggressive forms due to its high invasiveness and metastatic potential. Traditional treatments such as endocrine therapy and anti-HER2-targeted therapy are largely ineffective for TNBC, and while chemotherapy shows some promise, resistance remains a significant hurdle. Recently, there has been increasing interest in biological therapies, especially oncolytic viruses (OVs). OVs promote anti-tumor effects by selectively killing tumor cells and stimulating immune responses, and have achieved notable breakthroughs in breast cancer treatment. OVs have demonstrated effectiveness comparable to surgery, radiotherapy, or chemotherapy in selected cancers, but data are sparse in the context of TNBC. This review provides an overview of recent progress in the application of OVs as a tool for precision TNBC treatment.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2186-2207"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatable traits identified in Chinese patients hospitalized with AECOPD: A Multicenter Cohort Study.","authors":"Weiwei Meng, Jiankang Wu, Jiayu Wang, Rui Zhao, Sisi Liu, Naishu Xie, Qixuan Huang, Lijun Liu, Yanchao Liang, Huihui Zeng, Yiming Ma, Yan Chen","doi":"10.7150/ijms.111294","DOIUrl":"https://doi.org/10.7150/ijms.111294","url":null,"abstract":"<p><p><b>Background: \"</b>Treatable traits (TTs)\" is a precision medicine strategy for the management of chronic airway diseases. However, data on TTs in hospitalized AECOPD patients are limited. This study aimed to determine the prevalence of TTs in Chinese patients hospitalized with AECOPD and which traits predict future exacerbation risk, and to develop an exacerbation prediction model. <b>Methods:</b> This multicenter, cohort study recruited patients hospitalized with AECOPD from January 2022 to April 2023. Participants underwent a multidimensional assessment to characterize the TTs and were then followed up for one year. Cox regression analyses were used to determine the association between TTs and future exacerbations and develop a prediction model. <b>Results:</b> Finally, 28 TTs, including pulmonary (n=11), extra-pulmonary (n=12) and behavioral/risk factors (n=5) were identified. Five traits were associated with increased risk of future AECOPD readmission, including frequent exacerbations in the past year (adjusted HR: 2.079, 95% CI: 1.246-3.469), O₂ desaturation (adjusted HR: 1.754, 95% CI: 1.001-3.075), eosinophilic airway inflammation (adjusted HR: 1.731, 95% CI: 1.078-2.777), pathogen colonization (adjusted HR: 1.852, 95% CI: 1.147-2.990) and gastroesophageal reflux (adjusted HR: 5.500, 95% CI: 1.923-15.730). Furthermore, one regression model was developed to predict personalized exacerbation risk and showed acceptable performance. <b>Conclusion:</b> TTs can be systematically assessed in Chinese patients hospitalized with AECOPD, some of which are associated with future exacerbation-related readmission.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2227-2236"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variant rs2243115 of the IL-12/IL-35 pathway contributes to the risk of coronary artery disease.","authors":"Qianwen Chen, Wenjuan Zhang, Tian Xie, Jiangtao Dong, Junxia Zhang, Lingfeng Zha","doi":"10.7150/ijms.102562","DOIUrl":"https://doi.org/10.7150/ijms.102562","url":null,"abstract":"<p><p><b>Background:</b> Coronary artery disease (CAD) involves inflammation. IL-12p35, a common subunit of both IL-12 and IL-35, is encoded by the <i>IL12A</i> gene and is a potential therapeutic target in CAD. We probed into the genetic relationships between <i>IL12A</i> and CAD in a Chinese Han population to provide a novel potential target and a theoretical basis for the anti-inflammatory therapies in CAD. <b>Materials and Methods:</b> In total, 768 patients with CADs and 768 controls were recruited for a case-control association analysis of the functional genetic variant rs2243115 of <i>IL12A</i>. Allelic and genotypic associations between rs2243115 and CAD and its subgroup were assessed by Logistic regression analysis. Additionally, multiple linear regression analysis was performed to explore the association between rs2243115, serum lipid levels and CAD severity. Bioinformatic tools were used to predict the potential function of rs2243115. <b>Results:</b> Our results showed no differences in the allele and genotype frequency distribution of rs2243115 between patients with CAD and controls. The subgroup analysis found no association between rs2243115 and CAD in either male or female groups. Furthermore, rs2243115 was not related to early- or late-onset CAD, or CAD severity. However, we did observe that rs2243115 was negatively related to HDL-c level (<i>P</i>=0.016, <i>β</i> <b>=-</b>0.063) and positively related to LDL-c level (<i>P</i>=0.029, <i>β</i>=0.058). Biological function prediction indicated many functional elements in the rs2243115 region, suggesting that rs2243115 may regulate gene expression in the IL-12/IL-35 pathway. <b>Conclusion:</b> The functional genetic variant, rs2243115, of <i>IL12A</i>, may play a role in CAD by regulating the IL-12/IL-35 pathway and affecting lipid levels and inflammatory responses, thereby providing a potential therapeutic target for CAD.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2155-2164"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks of cardiovascular disease and cerebrovascular disease following kidney transplantation: A nationwide, population-based cohort study.","authors":"Tung-Han Tsai, Kuang-Hua Huang, Hsin Chen, Shuo-Yan Gau, Kun-Yu Su, Min-Ling Tsai, Chien-Ying Lee","doi":"10.7150/ijms.108744","DOIUrl":"https://doi.org/10.7150/ijms.108744","url":null,"abstract":"<p><p><b>Background:</b> Kidney transplant recipients (KTRs) have an increased risk for cardiovascular disease (CVD) and cerebrovascular disease (CBD). This study investigated the risks of CVD and CBD following kidney transplantation. <b>Materials and methods:</b> This retrospective cohort study enrolled 3596 KTRs between 2003 and 2017. Propensity Score Matching (PSM) was performed to select patients without a kidney transplant, who were assigned to the control group. Each KTR was matched with five patients without a kidney transplant by sex, age, insured salary, urbanization level, Charlson comorbidity index (CCI), and year of inclusion in the study. A Cox proportional hazards model was employed to investigate the risks of incident CVD and CBD in KTRs after adjusting for relevant variables. Furthermore, we analyzed for CVD and CBD risk 6 months and 1, 3, and 5 years after transplantation. <b>Results:</b> Among KTRs, the CVD incidence rate per 1,000 person-years was 33.98, which was significantly higher than that among patients without a kidney transplant. After adjusting for confounding variables, KTRs had a significantly higher risk of CVD (adjusted hazard ratio [aHR], 1.74; 95% confidence interval [CI], 1.58-1.93) than did patients without a kidney transplant. Regarding cumulative incidence, the risk of CVD increased over time. Among the four follow-up periods we assessed, the 5-year follow-up period had the highest CVD risk (aHR, 1.35; 95% CI, 1.17-1.56), followed by the 3-year follow-up period (aHR, 1.34; 95% CI, 1.13-1.59). KTRs also had a significantly higher risk of CBD (aHR, 1.43; 95% CI, 1.23-1.68) than did patients without a kidney transplant. <b>Conclusion:</b> CVD risk is higher among KTRs than among those without a kidney transplant, and this risk increases over time. CBD risk was also higher among KTRs. Large, randomized controlled prospective studies are needed to thoroughly evaluate the relationship between kidney transplantation and the risks of CVD and CBD.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2237-2246"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Characterization of the Oxidative Stress Profiles in Neonatal Necrotizing Enterocolitis.","authors":"Xiaofeng Xiong, Luyao Wu, Xin Liu, Jing Wang, Jun Xiao, Ke Chen, Didi Zhuansun, Xinyao Meng, Jiexiong Feng, Xuyong Chen","doi":"10.7150/ijms.109008","DOIUrl":"https://doi.org/10.7150/ijms.109008","url":null,"abstract":"<p><p><b>Objective:</b> This study aims to portray the characteristics of oxidative stress (OS) in cases of Necrotizing enterocolitis (NEC), identify the hub genes and associated mechanisms involved, and explore potential drugs for NEC. <b>Methods:</b> We performed a comprehensive analysis integrating bulk-RNA sequencing and single-cell RNA sequencing datasets, coupled with various techniques including differential analysis, gene set enrichment analysis, and immune infiltration analysis. We aimed to systematically elucidate the variations in functions related to OS among distinct cell populations within both NEC and non-NEC tissues. Additionally, we depicted the longitudinal changes in immune cells, with a particular focus on macrophages, throughout the progression of NEC. NEC mice model was established and RT-qPCR was performed to validate the expression of the hub genes. <b>Results:</b> In total, 465 OS related genes were found, and 53 of them were significantly differentially expressed. These genes were mainly involved in several signaling pathways, such as TNF signaling pathway, IL-17 signaling pathway, FOXO signaling pathway, inflammatory bowel disease. The top 10 hub genes were <i>MMP2</i>, <i>IL1A</i>, <i>MMP3</i>, <i>HGF</i>, <i>HP</i>, <i>IL10</i>, <i>PPARGC1A</i>, <i>TLR4</i>, <i>MMP9</i> and <i>HMOX1</i>. Ten kinds of drug were discovered as the potential treatment for NEC. Four specific macrophages subtypes and relative function were identified in NEC. RT-qPCR and immunofluorescence staining confirmed the expression of the hub genes in NEC model. <b>Conclusions:</b> This investigation yielded innovative insights into the immune environment and therapeutic methodologies directed at oxidative stress in the pathogenesis of NEC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2139-2154"},"PeriodicalIF":3.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into the role of ferroptosis in temporomandibular joint osteoarthritis and knee osteoarthritis.","authors":"Yuxin Zhang, Dahe Zhang, Xiaoyu Liao, Qingyu Xu, Lingtong Bu, Jisi Zheng, Pei Shen, Chi Yang","doi":"10.7150/ijms.107057","DOIUrl":"https://doi.org/10.7150/ijms.107057","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by pain, limited movement, and joint stiffness, significantly impacting the quality of life and imposing substantial economic burdens. This review paper delves into the novel insights of ferroptosis, an iron-dependent form of cell death associated with lipid peroxidation, in the context of temporomandibular joint osteoarthritis (TMJ OA) and knee osteoarthritis (KOA). We explore the pathogenic characteristics of OA, including synovitis, chondrocyte death, and extracellular matrix (ECM) degradation, and discuss the limitations of current therapeutic interventions. Emerging evidence suggests a significant relationship between ferroptosis and OA, with iron accumulation and lipid peroxidation observed in osteoarthritic cartilage. This review highlights the role of ferroptosis in chondrocyte malfunction and apoptosis, inflammation, and extracellular matrix breakdown, which are central to OA pathogenesis. We also discuss potential therapeutic targets, such as Transient Receptor Potential Vanilloid 1 (TRPV1), Glutathione Peroxidase 4 (GPX4), and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2), which modulate ferroptosis and OA progression. The paper consolidates studies on ferroptosis in OA, offering a comprehensive understanding of its role and the development of innovative therapies targeting this cell death mechanism to improve treatment outcomes for OA patients.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2119-2131"},"PeriodicalIF":3.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of Renal Endothelial Cells, Interact with Neighboring Cells, and Endothelial Injury in Chronic Kidney Disease: Mechanisms and Therapeutic Implications.","authors":"Meiyu Zhang, Wu Liu, Haoran Dai, Hanxue Jiang, Qihan Zhao, Wenbin Liu, Hongliang Rui, Baoli Liu","doi":"10.7150/ijms.108299","DOIUrl":"https://doi.org/10.7150/ijms.108299","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is closely associated with endothelial dysfunction, leading to symptoms such as albuminuria, edema, and coagulopathy. Recent advancements in single-cell sequencing have deepened our understanding of the heterogeneity of renal endothelial cells, which is significantly influenced by their microenvironment. Understanding the influence of neighboring cells on endothelial heterogeneity is essential for elucidating the mechanisms underlying vascular dysfunction and CKD progression. This review explores the latest research on renal endothelial cell heterogeneity and their interactions with neighboring cells. We further discuss the mechanisms of endothelial injury in CKD, including alterations to the endothelial glycocalyx, inflammation, oxidative stress, and dysfunction of the glomerular filtration barrier. Renal endothelial injury contributes to complications, including cardiovascular disease, diabetic nephropathy, and impaired vascular function. Therapeutic strategies encompass antihypertensive, hypoglycemic, and lipid-lowering treatments, supplemented by emerging approaches such as anti-inflammatory therapies, gene therapy, and lifestyle modifications. Through reviewing the relationship between endothelial injury and CKD progression, we emphasize potential strategies to enhance prognosis and mitigate disease progression.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 9","pages":"2103-2118"},"PeriodicalIF":3.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}