International Journal of Medical Sciences最新文献

{"title":"CEP55 as a prognostic indicator and a predictive marker in oral squamous cell carcinoma.","authors":"Ying Han, Xin Hu, Haofeng Xiong, Liujun Zeng, Ying Peng, Tong Su","doi":"10.7150/ijms.107996","DOIUrl":"10.7150/ijms.107996","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of CEP55 in the occurrence and development of oral squamous cell carcinoma (OSCC). <b>Materials and Methods:</b> Through the utilization of the online OSCC database and bioinformatic analysis, we examine CEP55 expression and its correlation with prognosis, pathways, and immune infiltration. CEP55 and other biomarkers were stained using immunohistochemical methods in 57 cases of OSCC and 44 cases of adjacent paired tissues, demonstrating the clear involvement of CEP55. <b>Results:</b> The expression levels of CEP55 were significantly higher in OSCC tissues compared to normal tissues. Additionally, higher levels of CEP55 were associated with a worse prognosis. CEP55 expression levels were significantly higher in OSCC tissues compared to normal tissues. Additionally, higher levels of CEP55 were associated with a worse prognosis. GSEA results indicated a correlation between CEP55 and the cell cycle. Immunohistochemical staining revealed a significant positive correlation between CEP55 and cell cycle-related protein markers (PCNA, P16, P21, and P53). Furthermore, CEP55 was found to significantly inhibit tumor immune infiltration. As a result, CEP55 expression decreased infiltration of 9 types of immune cells (iDC, mast cells, pDC, DC, Th17 cells, TFH, Treg, T cells, and neutrophils), while increasing infiltration of only 3 types of immune cells (Tcm, T Helper cells, and Th2 cells). <b>Conclusion:</b> The results suggest that CEP55 plays a crucial role in the progression of OSCC promoting cell cycle progression and suppressing immune infiltration.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2446-2459"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and identification of versican as a sensitive biomarker and potential therapeutic target in basal cell carcinoma.","authors":"Wenlin Li, Yang Wang, Qiang Hu, Sainan Li, Dachuan Guo, Lin Liu, Xiuqing Huang, Lin Dou, Qi Zhou, Tao Shen, Jianmin Chang","doi":"10.7150/ijms.105650","DOIUrl":"10.7150/ijms.105650","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer (NMSC). However, few biomarkers have been developed for the diagnosis of BCC. This study aimed to uncover novel BCC biomarkers for diagnosis and treatment via transcriptome and pathogenesis investigations. Microarray datasets of BCC tissues were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. A total of 558 DEGs were identified between BCC and normal samples from the GSE125285 and GSE42109 datasets. 69 DEGs were expressed in a tissue/organ-specific manner, of which three tissue-specific key genes were finally identified. The three genes showed high performance for BCC diagnosis with AUCs of ≥0.8, indicating that they have high diagnostic significance. CIBERSORT analysis revealed an increase in resting NK cells, M1 macrophages and a decrease in dendritic cells in the immune microenvironment of BCC patients. In addition, versican (VCAN) may be involved in the polarization of M1 macrophages in skin cancer. When VCAN was knocked down, the skin cancer cell line A431 was weakened in terms of proliferation, migration and invasion. Meanwhile, the expression of the key oncogenic factors DDX5 was also reduced and apoptosis was promoted through the BAX/BCL-2/c-Caspase3 pathway. The cell-derived xenograft model study in nude mice showed that knockdown of VCAN in tumour cells significantly suppressed tumour size compared to control tumour cells, suggesting that VCAN is one of the important genes for tumourigenesis. Meanwhile, we examined the level of macrophage M1 polarization in tumour samples from a cell-derived xenograft mouse model, and VCAN knockdown significantly reduced macrophage M1 polarization compared to controls. We also detected the expression of VCAN in tumour samples from BCC patients and verified that VCAN expression was significantly higher in BCC than in normal skin tissue. Thus, VCAN could be a potential clinical target for the diagnosis and treatment of BCC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2488-2501"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old.","authors":"Dizhi Liu, Sihang Fang, Danni Gao, Zhaoping Wang, Tenger Wang, Lei Tang, Mingjun Jiang, Juan Jiao, Hongye Zhao, Huabin Su, Rongqiao Li, Bin Huang, Yuan Lv, Guofang Pang, Caiyou Hu, Ze Yang, Huiping Yuan","doi":"10.7150/ijms.109606","DOIUrl":"10.7150/ijms.109606","url":null,"abstract":"<p><p><b>Background:</b> Thyroid function differs between the oldest-old and younger adults, however, there is a lack of appropriate RIs for the serum FT4, T4, FT3, T3, and TSH concentrations for the oldest-old. <b>Methods:</b> A total of 349 people was selected from the natural longevity cohort of Guangxi residents over 90 years old. The distributions of serum FT4, T4, FT3, T3, and TSH concentrations and the FT3/FT4 ratio were also analyzed. Regression curves and centile curves were constructed. Correlations between body indices and blood pressure and serum thyroid-related hormone levels were analyzed. The RIs were determined using a nonparametric approach (2.5th-97.5th percentiles) following the CLSI guidelines. <b>Results:</b> The RIs for Chinese oldest-old are different from the current standard RIs for younger adults. A notable correlation was found between FT4 levels and age. BMI and WHtR were positively correlated with FT4, FT3, T3 and the FT3/FT4 ratio. The T3 level is correlated with SBP and DBP, and the FT3/FT4 ratio is correlated with SBP. The RIs established for the healthy oldest-old were as follows: T4, 81-193 nmol/L; FT4, 10.39-20.46 pmol/L; T3, 0.94-2.05 nmol/L; FT3, 3.56-6.43 pmol/L; TSH, 0.29-5.28 μIU/ml; and FT3/FT4, 0.197-0.496. <b>Conclusions:</b> In this study, we established RIs of thyroid-related hormone levels for the oldest-old in China and evaluated the associations between thyroid hormone levels and body indices. These findings may provide evidence for the diagnosis and treatment of thyroid-related diseases in the oldest-old.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2408-2418"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-thrombectomy cerebral edema affects outcomes in acute stroke patients treated with thrombectomy.","authors":"Lu Yang, Yuan Kan, Changhong Ren, Sijie Li, Chuanhui Li, Longfei Wu, Jiali Xu, Wenting Guo, Haiqing Song, Qingfeng Ma, Wenbo Zhao, Xunming Ji","doi":"10.7150/ijms.105692","DOIUrl":"10.7150/ijms.105692","url":null,"abstract":"<p><p><b>Objective</b>: Cerebral edema significantly impacts the functional outcomes in patients with acute stroke treated with thrombectomy, especially those with an extended time window (6-24 hours). This study was to investigate whether pre-thrombectomy cerebral edema predicts functional prognosis in ischemic stroke patients within an extended onset time window. <b>Methods:</b> All patients from Xuanwu Hospital of Capital Medical University underwent computed tomography (CT) examination and endovascular treatment between December 2021 and December 2023. Quantitative Net Water Uptake (NWU) was assessed according to baseline CT. The ability to predict onset time and outcomes was assessed by univariate receiver operating characteristic curves and logistic regression analyses. The primary endpoint was an unfunctional outcome at 90 days, defined as a modified Rankin Scale Score of 3-6. <b>Results:</b> We reviewed a total of 247 patients, and the last 134 were included in the study, of whom 41.8% had stroke onset within 6 hours. NWU was significantly lower in patients with stroke onset within 6 hours (6.57±3.43) compared to 6-24 hours (11.69±3.01). Of patients with onset times of 6-24h, the area under the curve (AUC) for distinguishing patient groups according to NWU% was 0.863, with a cut-off value of 9.3 (sensitivity, 80.8%; specificity, 82.1%). A multivariable predictive model including NWU% and age yielded the highest diagnostic ability, with an AUC of 0.857 (sensitivity, 66.7%; specificity, 92.9%). <b>Conclusion:</b> NWU as an imaging biomarker of brain edema predicts functional prognosis after endovascular recanalization therapy in ischemic stroke patients within an extended onset time window.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2354-2361"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Easy-to-Use Risk Stratification System for NSTE-ACS Patients Combining Autonomic Nervous System and Coronary Physiology.","authors":"Xiaomeng Yang, Zeyan Li, Xinyu Liu, Tianyou Xu, Fu Yu, Shoupeng Duan, Qiang Deng, Lang Wang, Zhuo Wang, Hong Jiang, Lilei Yu","doi":"10.7150/ijms.111214","DOIUrl":"10.7150/ijms.111214","url":null,"abstract":"<p><p><b>Background:</b> The evaluation of autonomic nervous system (ANS) function and coronary physiology through quantitative flow ratio (QFR) analysis provides a precise method for assessing the severity and prognosis of acute coronary syndrome (ACS). <b>Aims:</b> This study aimed to develop and validate a risk score model for predicting the long-term prognosis of non-ST-elevation ACS (NSTE-ACS) patients who underwent complete and successful percutaneous coronary intervention (PCI). <b>Methods:</b> NSTE-ACS patients who underwent complete and successful PCI with preoperative and postoperative QFR measurements between January 2018 and December 2020 in our medical center were included. 24-hour Holter monitoring was performed to assess deceleration capacity (DC) and heart rate variability (HRV) parameters. The primary endpoint was the occurrence of major adverse cardiac events (MACEs). <b>Results:</b> The training cohort consisted of 271 patients, while the testing cohort consisted of 119 patients. The nomogram considered diabetes, normalized low-frequency (nLF) power/normalized high-frequency (nHF) power, DC, cardiac troponin I (cTnI), post-PCI QFR of the target vessel. The model demonstrated excellent discriminative ability, with area under the curve (AUC) values of 0.874 (95% CI: 0.809-0.939) for 1-year MACE prediction in the training cohort and 0.893 (95% CI: 0.808-0.978) in the testing cohort. For 2-year MACE prediction, the AUC values were 0.882 (95% CI: 0.822-0.942) and 0.842 (95% CI: 0.724-0.960) in the training and testing cohorts. <b>Conclusions:</b> We successfully developed and validated a risk stratification system that integrates baseline clinical characteristics (diabetes, cTnI levels), ANS parameters (nLF/nHF ratio, DC), and coronary physiological assessment (post-PCI QFR). This model effectively predicts MACEs in NSTE-ACS patients following PCI, providing valuable prognostic information for clinical decision-making.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2342-2353"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Pharmacokinetic-pharmacodynamic Model Analysis of Dapagliflozin for HbA1c-lowering Effects in Japanese Patients with Type 2 Diabetes Mellitus using Long-term Real-world Data.","authors":"Shinji Kobuchi, Shuhei Sakai, Ryosuke Terada, Ken-Ichiro Kato, Tetsuo Hayakawa, Toshiyuki Sakaeda","doi":"10.7150/ijms.111519","DOIUrl":"10.7150/ijms.111519","url":null,"abstract":"<p><p><b>Objectives:</b> Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, has demonstrated population-level benefits in patients with various metabolic, cardiovascular, and renal comorbidities. However, significant inter-individual differences exist in plasma exposure and response to dapagliflozin. This study aimed to identify factors influencing the HbA1c-lowering effects of dapagliflozin using long-term real-world data and a population pharmacokinetic-pharmacodynamic (PK-PD) modeling approach. <b>Methods:</b> A PK-PD model was applied to analyze 415 plasma dapagliflozin concentrations and 508 HbA1c measurements from 85 patients with type 2 diabetes mellitus (T2DM) treated with dapagliflozin for one year. The long-term real-world data enabled the evaluation of treatment variability over time. Inter-individual variability in PK-PD parameters was assessed, and covariate analysis was performed to identify patient-specific factors affecting drug response. <b>Results:</b> HbA1c time profiles were well described using the PK-PD turnover model with an E_max function. Body weight significantly influenced the apparent clearance of dapagliflozin, though its clinical impact on systemic exposure was minimal. Long-term real-world data analysis revealed substantial inter-individual variability in HbA1c response. <b>Conclusion:</b> By integrating pharmacometric modeling with long-term real-world data, this study provided unique insights into the determinants of dapagliflozin efficacy in routine clinical practice. These findings highlight factors that may not be captured in short-term clinical trials. These findings emphasize the importance of individualized treatment strategies and suggest that future research should incorporate additional covariates, such as variations in glycemic response dynamics, to further refine dose optimization and personalized diabetes management.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2333-2341"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cracking Chordoma's Conundrum: Immune Checkpoints Provide a Potential Modality.","authors":"Weihai Liu, Moksada Regmi, Xiaodong Chen, Shikun Liu, Ying Xiong, Yuwei Dai, Yingjie Wang, Jun Yang, Chenlong Yang","doi":"10.7150/ijms.109721","DOIUrl":"10.7150/ijms.109721","url":null,"abstract":"<p><p><b>Objectives:</b> Chordoma, a rare malignant tumor, is notably resistant to conventional treatments including chemotherapy, radiotherapy, and targeted approaches. Immunotherapy, successful in treating other cancer types, presents a promising avenue. However, the immune microenvironment of chordoma is poorly understood, highlighting the need to investigate immune checkpoints and their potential as therapeutic targets in this context. <b>Methods:</b> We performed an integrated analysis of chordoma using public datasets (GSE224776, GSE56183, GSE239531) and our RNA-seq data (11 samples). Differential expression analysis (limma), gene set enrichment analysis (GSEA, clusterProfiler), immune cell infiltration assessment (ESTIMATE, immunedeconv), weighted gene co-expression network analysis (WGCNA), consensus clustering, and machine learning were employed to identify key immune-related gene modules, immunogenic subtypes, and central immune regulators. <b>Results:</b> Hierarchical clustering and principal component analysis segregated chordoma from control samples post quality control. Differential expression analysis identified 2825 upregulated and 1693 downregulated genes, with significant upregulation of immune checkpoints, including PD-1 and CTLA-4. GSEA highlighted enhanced immune-related processes, particularly inflammatory responses, antigen presentation, and immune cell activation. Immune cell deconvolution demonstrated selective enrichment of memory T cells and macrophages, alongside downregulation of neutrophils and decreased effector cell scores. Consensus clustering identified a highly immunogenic chordoma subtype (Cluster 1), and WGCNA and machine learning converged on CCR7 as a central immune regulator, with core T cell-associated genes correlating with immune cell distribution patterns. <b>Conclusion:</b> This study characterizes the chordoma immune landscape, highlighting elevated immune checkpoints, distinct immunogenic subtypes, and a T cell-centered regulatory network. These findings support immune checkpoint inhibitors and other immunotherapies as promising treatments.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2318-2332"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Load Distribution in Subperiosteal Implants and Mini Plates in Orthognathic Surgery.","authors":"Metin Berk Kasapoglu, Zeynep Afra Akbiyik Az","doi":"10.7150/ijms.111111","DOIUrl":"10.7150/ijms.111111","url":null,"abstract":"<p><p><b>Background:</b> Orthognathic surgery is important for correcting craniofacial deformities and restoring occlusion. However, in edentulous patients with severe maxillary atrophy, traditional fixation methods, such as mini plates, may not provide sufficient stability and support for prosthetic rehabilitation. Advances in additive manufacturing have enabled the development of patient-specific subperiosteal implants, offering improved biomechanical performance and more favourable load distribution. <b>Methods:</b> This study utilized finite element analysis to compare the biomechanical performance of traditional mini plates and customized subperiosteal implants in maxillary orthognathic surgery. Computed tomography data were used to construct patient-specific models, and a Le Fort I osteotomy with a 9-mm maxillary advancement was simulated. Displacement and stress distribution were analysed under vertical and oblique loading conditions, focusing on critical regions such as osteotomy sites and screw interfaces. <b>Results:</b> Subperiosteal implants exhibited superior biomechanical performance, with significantly lower displacement (0.58 mm) compared to mini plates (4.50 mm). Stress levels in mini plates frequently exceeded the yield strength of grade IV titanium, whereas subperiosteal implants remained within the elastic limit of Ti6Al4V. Additionally, screw stresses were reduced by 38-42% in the subperiosteal implant group, thereby reducing the risk of mechanical failure. <b>Conclusions:</b> Customized subperiosteal implants provided enhanced stability, reduced stress concentrations, and improved load distribution compared to traditional mini plates. These findings highlight their potential as a transformative solution in orthognathic surgery, particularly for edentulous patients with severe maxillary atrophy. Future research should focus on long-term clinical outcomes and cost-effectiveness to further establish their role in maxillofacial reconstruction.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2257-2268"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating short chain fatty acid levels and body composition in type 2 diabetes mellitus.","authors":"Ching-Hua Hsu, Yi-Chun Tsai, Ping-Shaou Yu, Wei-Wen Hung, Wei-Chun Hung, Shang-Jyh Hwang, Hui-Ju Tsai","doi":"10.7150/ijms.111920","DOIUrl":"10.7150/ijms.111920","url":null,"abstract":"<p><p><b>Background:</b> Short-chain fatty acids (SCFAs) may play key functional roles in the pathophysiology of type 2 diabetes (T2D) through regulating energy intake and substrate metabolism. Body composition, including fat tissue, muscle tissue and the pattern of their distribution in the body, can represent health status and be the cause or consequence of T2D complications. The aim of this study was to explore the relationship between serum SCFA levels and body composition distribution in patients with T2D. <b>Methods:</b> This observational cross-sectional study enrolled 430 patients with T2D from October 2016 to June 2020. The levels of nine kinds of SCFAs in serum were measured using liquid chromatography mass spectrometry. Body composition, including lean tissue and fat tissue, was measured once using bioimpedance spectroscopy at enrollment. <b>Results:</b> The mean age of the patients was 61.7 ± 12.3 years and 54.0% were male. Multivariate linear analysis revealed that the patients with the highest tertile of serum methylbutyrate level (β = -0.81, 95% CI = -1.56, -0.06, p = 0.03) and valerate/isovalerate ratio (β = -1.15, 95% CI = -1.86, -0.44, p = 0.002) had a lower fat tissue index (FTI). In subgroup analysis, the negative association of FTI with serum methylbutyrate level and valerate/isovalerate ratio was only found in the patients who were older, female, and had glycated hemoglobin ≤ 7%, urinary albumin-creatinine ratio < 30 mg/g, homeostatic model assessment for insulin resistance ≤ median value, and body mass index < 30 kg/m². Conversely, none of the nine SCFAs were associated with lean tissue index. <b>Conclusions:</b> This study found that T2D patients with a higher circulating methylbutyrate level and serum valerate/isovalerate ratio had lower FTI. The relationship was consistent in older, female patients with well-controlled glucose. Further research is needed to analyze the interactions between SCFAs and body composition with clinical metabolic outcomes in T2D patients.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2289-2297"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term BPV is an Independent Risk Factor for Renal Prognosis in Hypertensive Patients - a Post-hoc Analysis of the SPRINT Study.","authors":"Yuyi Ruan, Yutong Chen, Naya Huang, Dan Wang, Yuzhu Xu, Jinjin Fan, Wei Chen, Xin Wang","doi":"10.7150/ijms.111843","DOIUrl":"10.7150/ijms.111843","url":null,"abstract":"<p><p><b>Background:</b> Long-term blood pressure variability (BPV) reflects fluctuations in BP over time, which may indicate instability in precise blood pressure control. We conducted a post hoc analysis of the data from the SPRINT (Systolic Blood Pressure Intervention Trial) to assess the effect and associated variables of BPV on the renal prognosis of patients with hypertension. <b>Methods:</b> Excluding patients with CKD, the systolic blood pressure (SBP) at the 1^st, 6^th, and 12^th follow-up months were employed to calculate the SBP coefficient of variation (CV) which represented BPV. Patients were divided into four groups based on the quartiles of BPV, namely Q1 to Q4. <b>Results:</b> Group Q4 patients had higher baseline SBP. Multiple regression identified age, sex, treatment, current smoker, SBP, diastolic blood pressure (DBP), renin-angiotensin-system inhibitors (RASi), β-receptor antagonists, calcium channel blockers (CCBs), and other medications use were factors associated with BPV. The survival analysis showed that group Q4 had significantly more renal outcome events, and BPV was independently associated with the risk of renal outcome events (HR = 1.38, 95% CI: 1.23 - 1.54, <i>P</i> < 0.001). There was a direct correlation between the BPV and risk of renal outcomes when BPV exceeded 0.037. In addition, the RASi preference group reported a significantly higher incidence of renal outcome events compared to the non-preference group (log-rank test χ² = 6.218, <i>P</i> = 0.013) and exhibited a tendency towards higher BPV. <b>Conclusions:</b> High BPV is an independent risk factor for renal outcome events in hypertensive aging patients. The preference of RASi use can increase renal outcome events, but is not related to the rise in BPV. These findings suggest that in elderly hypertensive patients with elevated BPV, the potential risks of RASi-associated renal outcomes may outweigh its established benefits, necessitating cautious consideration of alternative antihypertensive strategies.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2298-2307"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}