International Journal of Medical Sciences最新文献

{"title":"Cardiovascular System is Influenced by Skeletal Muscle-derived Extracellular Vesicles, Myokines and MicroRNAs Based on Interorgan Communication: A Systematic Review.","authors":"Jiaxin Chen, Jingxin Zong, Sha Su, Xiang Ji, Lei Wang, Xiaowan Han, Mingjing Zhao","doi":"10.7150/ijms.111775","DOIUrl":"10.7150/ijms.111775","url":null,"abstract":"<p><p><b>Background/Aims:</b> To illustrate the types and roles of skeletal muscle-derived bioactive molecules in mediating the communication from skeletal muscle to the heart and blood vessels. <b>Methods:</b> A systematic literature search was performed in four different databases. Eligible articles were screened using the inclusion and exclusion criteria. Two researchers independently performed literature screening and selection, data extraction and literature quality analysis. <b>Results:</b> This study included 29 articles (2 clinical studies and 27 basic studies). Data analysis of the included studies revealed that skeletal muscle synthesizes and releases abundant extracellular vesicles (EVs), myokines (FSTL1, FNDC5/irisin and others) and microRNAs (miRNA-126 and others) to mediate the communication from skeletal muscle to the heart and blood vessels. Certain skeletal muscle-derived EVs, myokines and miRNAs were found to enhance cardiac function, reduce cardiac fibrosis and inhibit cardiac injury, and improve apoptosis and inflammation. In the blood vessels, these bioactive molecules stimulated angiogenesis, improved endothelial cell function, protected against vascular stiffness, and attenuated atherosclerosis and neointimal hyperplasia. Notably, IL-10, FSTL1, b-FGF, VEGF, irisin, musclin, myonectin, exo-miRNA26a, and miRNA-126 definitely played protective roles in the heart and blood vessels through interorgan communication. <b>Conclusion:</b> Skeletal muscle synthesizes and releases EVs, myokines and miRNAs, which mediate the communication from skeletal muscle to the heart and blood vessels. The majority of these bioactive molecules are associated with cardiovascular protective effects. And they may provide new targets for more in-depth mechanism and clinical researches of communication from skeletal muscle to the heart and blood vessels.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2382-2397"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immature Infant Liver: Cytochrome P450 Enzymes and their Relevance to Vaccine Safety and SIDS Research.","authors":"Gary S Goldman, Richard Z Cheng","doi":"10.7150/ijms.114402","DOIUrl":"10.7150/ijms.114402","url":null,"abstract":"<p><p><b>Aim and background:</b> Vaccines are a cornerstone of modern medicine, significantly reducing morbidity and mortality worldwide. Their administration in infants requires consideration of physiological maturity. Cytochrome P450 (CYP450) enzymes, crucial for drug metabolism, are underdeveloped at birth and mature over the first two to three years of life. While vaccines are not directly metabolized by CYP450 enzymes, emerging evidence suggests that certain excipients-such as polysorbate 80 and gelatin-could interact with CYP450 pathways, particularly in genetically susceptible infants. This study integrates pharmacogenetics and epidemiology to examine how CYP450 immaturity and variability may influence vaccine excipient metabolism, immune activation, and infant health outcomes. <b>Methods:</b> A systematic review of peer-reviewed literature, pharmacogenetic data, and epidemiological studies was conducted to assess CYP450 enzyme activity in infants, potential metabolic interactions with vaccine excipients, and temporal associations between vaccination and sudden infant death syndrome (SIDS). Gaps in postmortem investigations were also evaluated for their impact to identify metabolic vulnerabilities. <b>Results:</b> CYP450 enzymes exhibit developmental immaturity in infants and genetic polymorphisms-particularly in CYP2D6 and CYP3A5-may affect vaccine excipient clearance. While epidemiological evidence shows temporal clustering of some SIDS cases post-vaccination, causality remains unproven. Inflammation-induced suppression of CYP450 enzymes raise questions about potential metabolic vulnerabilities, which current postmortem protocols often fail to capture. <b>Conclusion:</b> This study highlights the need for further research into the influence of CYP450 variability on vaccine-related outcomes. Incorporating genetic and metabolic profiling into postmortem protocols may improve our understanding of metabolic contributions to SIDS and refine vaccine safety assessments. <b>Clinical significance:</b> Developmental immaturity and genetic variability in CYP450 enzymes may affect vaccine excipient metabolism and interact with immune activation. This interplay could influence metabolic vulnerabilities in infants, particularly with inflammation-induced CYP450 suppression. Genetic and metabolic profiling before vaccination could identify at-risk infants, while postmortem analysis may enhance SIDS understanding and vaccine safety assessments.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2434-2445"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxyamidotriazole Regulates the Function of Salivary Gland Epithelial Cells and B Cells to Alleviate Experimental Sjögren's Disease in Mice.","authors":"Xiaojuan Zhang, Jingwen Liu, Mei Yang, Juan Li, Lei Zhu","doi":"10.7150/ijms.111897","DOIUrl":"10.7150/ijms.111897","url":null,"abstract":"<p><p>Sjögren's disease (SjD), a systemic autoimmune disease, suffers from restricted treatment choices. The activation of salivary gland epithelial cells and abnormal auto-reactive B cells, triggering cytokine and autoantibody generation, is key to its immunopathogenesis. Carboxyamidotriazole (CAI) was reported to have anti-inflammatory properties by reducing cytokines, yet its role in SjD was unknown. In this research, we targeted to probe CAI's potential treatment effect on SjD-like NOD/Ltj mice and its mechanism. Utilizing the salivary glands of these mice, we employed HE staining, ELISA, immunohistochemistry and flow cytometry. Findings revealed that CAI augmented salivary secretion, decreased water intake and serum autoantibody levels, suppressed histological alterations and lymphocyte foci, and diminished inflammatory factors such as IL-1β and IL-6. It also blocked IκBα degradation and p65 nuclear translocation. <i>In vitro</i>, CAI restrained IL-6 secretion from stimulated SGECs and halted Raji B cells' proliferation at G0/G1 stage. Overall, CAI shows an anti-SjD effect in NOD/Ltj mice, probably by regulating relevant cells and deactivating the NF-κB pathway.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2362-2372"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis.","authors":"Ming-Shan Chen, Shin-Kuang Jiang, Zhi-Yong Chong, Jou-Wei Chiang, Yan-Min Chen, Hsin-Yu Huang, Jui-Chieh Chen","doi":"10.7150/ijms.109340","DOIUrl":"10.7150/ijms.109340","url":null,"abstract":"<p><p>Hypertension (HTN) is a significant risk factor for cardiovascular and cerebrovascular diseases. Accumulating evidence suggests a close relationship between HTN and alterations in the gut microbiota composition and abundance. We recruited 23 HTN patients and 17 controls matched for demographic characteristics. DNA extracted from fecal samples of patients was subjected to Illumina MiSeq sequencing, targeting the V3-V4 region of the bacterial 16S rRNA gene for analysis. We compared the diversity and composition of gut microbiota between the two groups. The α-diversity of gut microbiota in HTN patients was similar to that in the control group. β-diversity analysis showed slight differences in microbial composition between the HTN and control groups. We used Welch's <i>t</i>-test to evaluate the significant difference in the bacterial composition of the top 20 ASVs between the HTN group and the control group, and the results showed that <i>Tyzzerella</i> was significantly increased, while <i>Faecalibacterium</i> was significantly decreased in the HTN group. We performed PCR using <i>Faecalibacterium</i>-specific primers and analyzed their levels through agarose gel electrophoresis, confirming the reduced abundance of <i>Faecalibacterium</i> in the HTN group. In addition, Tax4Fun2 analysis was employed to examine differences in microbial functionality between the HTN group and the control group. In conclusion, we studied the fecal microbiota of HTN population in Taiwan through 16S rRNA gene sequencing, and found that <i>Faecalibacterium</i> has a lower abundance in HTN patients. This unique alteration in gut microbiota may provide insights into the pathogenesis of HTN and aid in the development of novel biomarkers and therapeutic targets.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2460-2469"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Renin-angiotensin System Genes as Novel Prognostic Biomarkers for Oral Squamous Cell Carcinoma.","authors":"Zhengzheng Wu, Can Wang, Jiusong Han, Xiaobing Chen, Jie Wu, Bin Cheng, Juan Wang","doi":"10.7150/ijms.112735","DOIUrl":"10.7150/ijms.112735","url":null,"abstract":"<p><p><b>Purpose:</b> Recent evidence suggests that the renin-angiotensin system (RAS) is involved in OSCC development. This study aimed to identify RAS-related gene (RASRG) biomarkers associated with OSCC prognosis through integrated bioinformatics analysis. <b>Methods:</b> First, we identified module genes by intersecting differentially expressed genes (DEGs) from the TCGA-OSCC dataset with RASRGs using weighted gene co-expression network analysis (WGCNA). Next, Cox and least absolute shrinkage and selection operator (LASSO) regression analyses were utilized to construct an OSCC risk model. We also created a nomogram incorporating risk scores and relevant clinical variables. Subsequently, receiver operating characteristic (ROC) analysis, Kaplan-Meier (KM) curve analysis, Cox regression analysis, and in vitro experiments were performed to assess the accuracy of the prognostic risk model and nomogram. Furthermore, protein-protein interaction (PPI) network, immune infiltration analysis and functional enrichment analyses were employed to reveal OSCC-related pathogenic genes and underlying mechanisms. <b>Results:</b> A novel OSCC risk model was established consisting of six key genes: <i>CMA1</i>, <i>CTSG</i>, <i>OLR1</i>, <i>SPP1</i>, <i>AQP1</i>, and <i>PTX3</i>. This six-gene signature effectively predicted the prognosis of patients with OSCC and served as a reliable independent prognostic parameter. Protein-protein interaction network analysis identified 5 hub genes and 13 miRNAs. Immune infiltration analysis indicated a possible association of the prognostic features of RASRGs with immunomodulation. <b>Conclusion:</b> In this study, we successfully constructed a risk model based on the six identified RAS-related DEGs as potential predictive biomarkers for OSCC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2470-2487"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantage of Tolerability following Arsenic Trioxide-VTD vs VRD in newly diagnosed multiple myeloma patients: a prospective, open-label study.","authors":"Xinyu Zuo, Apeng Yang, Pingping Chen, Yanhui Xie, Zhiyong Zeng, Jiexian Ma","doi":"10.7150/ijms.110231","DOIUrl":"10.7150/ijms.110231","url":null,"abstract":"<p><p>Multiple myeloma is the second most common hematologic malignancy in older patients. The standard front-line VRD regimen (bortezomib/lenalidomide/dexamethasone) achieves high efficacy but is associated with significant toxicity, leading to infections, bone marrow suppression, and treatment discontinuation in approximately 20% of patients. Alternative regimens with reduced toxicity are needed for this demographic. Prior studies suggest adding arsenic trioxide to bortezomib/dexamethasone (BD) enhances remission depth with acceptable safety, while bortezomib/thalidomide/dexamethasone (VTD) offers reduced toxicity, but lower efficacy compared to VRD. This study evaluates the efficacy, safety, and cost-effectiveness of an arsenic trioxide-VTD regimen (AVTD) versus VRD in newly diagnosed multiple myeloma (NDMM) patients. Among 116 participants, AVTD demonstrated comparable efficacy to VRD but significantly reduced infection rates (14.0% vs. 40.7%, P < 0.001) and severe bone marrow suppression (0% vs. 11.9%, P = 0.013). Subgroup analysis of patients >60 years yielded consistent results. Additionally, AVTD was associated with lower treatment costs. In conclusion, the AVTD regimen offers a safer, more cost-effective alternative to VRD for NDMM, particularly in older adult patients, without compromising treatment efficacy.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2373-2381"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CEP55 as a prognostic indicator and a predictive marker in oral squamous cell carcinoma.","authors":"Ying Han, Xin Hu, Haofeng Xiong, Liujun Zeng, Ying Peng, Tong Su","doi":"10.7150/ijms.107996","DOIUrl":"10.7150/ijms.107996","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of CEP55 in the occurrence and development of oral squamous cell carcinoma (OSCC). <b>Materials and Methods:</b> Through the utilization of the online OSCC database and bioinformatic analysis, we examine CEP55 expression and its correlation with prognosis, pathways, and immune infiltration. CEP55 and other biomarkers were stained using immunohistochemical methods in 57 cases of OSCC and 44 cases of adjacent paired tissues, demonstrating the clear involvement of CEP55. <b>Results:</b> The expression levels of CEP55 were significantly higher in OSCC tissues compared to normal tissues. Additionally, higher levels of CEP55 were associated with a worse prognosis. CEP55 expression levels were significantly higher in OSCC tissues compared to normal tissues. Additionally, higher levels of CEP55 were associated with a worse prognosis. GSEA results indicated a correlation between CEP55 and the cell cycle. Immunohistochemical staining revealed a significant positive correlation between CEP55 and cell cycle-related protein markers (PCNA, P16, P21, and P53). Furthermore, CEP55 was found to significantly inhibit tumor immune infiltration. As a result, CEP55 expression decreased infiltration of 9 types of immune cells (iDC, mast cells, pDC, DC, Th17 cells, TFH, Treg, T cells, and neutrophils), while increasing infiltration of only 3 types of immune cells (Tcm, T Helper cells, and Th2 cells). <b>Conclusion:</b> The results suggest that CEP55 plays a crucial role in the progression of OSCC promoting cell cycle progression and suppressing immune infiltration.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2446-2459"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and identification of versican as a sensitive biomarker and potential therapeutic target in basal cell carcinoma.","authors":"Wenlin Li, Yang Wang, Qiang Hu, Sainan Li, Dachuan Guo, Lin Liu, Xiuqing Huang, Lin Dou, Qi Zhou, Tao Shen, Jianmin Chang","doi":"10.7150/ijms.105650","DOIUrl":"10.7150/ijms.105650","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer (NMSC). However, few biomarkers have been developed for the diagnosis of BCC. This study aimed to uncover novel BCC biomarkers for diagnosis and treatment via transcriptome and pathogenesis investigations. Microarray datasets of BCC tissues were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. A total of 558 DEGs were identified between BCC and normal samples from the GSE125285 and GSE42109 datasets. 69 DEGs were expressed in a tissue/organ-specific manner, of which three tissue-specific key genes were finally identified. The three genes showed high performance for BCC diagnosis with AUCs of ≥0.8, indicating that they have high diagnostic significance. CIBERSORT analysis revealed an increase in resting NK cells, M1 macrophages and a decrease in dendritic cells in the immune microenvironment of BCC patients. In addition, versican (VCAN) may be involved in the polarization of M1 macrophages in skin cancer. When VCAN was knocked down, the skin cancer cell line A431 was weakened in terms of proliferation, migration and invasion. Meanwhile, the expression of the key oncogenic factors DDX5 was also reduced and apoptosis was promoted through the BAX/BCL-2/c-Caspase3 pathway. The cell-derived xenograft model study in nude mice showed that knockdown of VCAN in tumour cells significantly suppressed tumour size compared to control tumour cells, suggesting that VCAN is one of the important genes for tumourigenesis. Meanwhile, we examined the level of macrophage M1 polarization in tumour samples from a cell-derived xenograft mouse model, and VCAN knockdown significantly reduced macrophage M1 polarization compared to controls. We also detected the expression of VCAN in tumour samples from BCC patients and verified that VCAN expression was significantly higher in BCC than in normal skin tissue. Thus, VCAN could be a potential clinical target for the diagnosis and treatment of BCC.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2488-2501"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old.","authors":"Dizhi Liu, Sihang Fang, Danni Gao, Zhaoping Wang, Tenger Wang, Lei Tang, Mingjun Jiang, Juan Jiao, Hongye Zhao, Huabin Su, Rongqiao Li, Bin Huang, Yuan Lv, Guofang Pang, Caiyou Hu, Ze Yang, Huiping Yuan","doi":"10.7150/ijms.109606","DOIUrl":"10.7150/ijms.109606","url":null,"abstract":"<p><p><b>Background:</b> Thyroid function differs between the oldest-old and younger adults, however, there is a lack of appropriate RIs for the serum FT4, T4, FT3, T3, and TSH concentrations for the oldest-old. <b>Methods:</b> A total of 349 people was selected from the natural longevity cohort of Guangxi residents over 90 years old. The distributions of serum FT4, T4, FT3, T3, and TSH concentrations and the FT3/FT4 ratio were also analyzed. Regression curves and centile curves were constructed. Correlations between body indices and blood pressure and serum thyroid-related hormone levels were analyzed. The RIs were determined using a nonparametric approach (2.5th-97.5th percentiles) following the CLSI guidelines. <b>Results:</b> The RIs for Chinese oldest-old are different from the current standard RIs for younger adults. A notable correlation was found between FT4 levels and age. BMI and WHtR were positively correlated with FT4, FT3, T3 and the FT3/FT4 ratio. The T3 level is correlated with SBP and DBP, and the FT3/FT4 ratio is correlated with SBP. The RIs established for the healthy oldest-old were as follows: T4, 81-193 nmol/L; FT4, 10.39-20.46 pmol/L; T3, 0.94-2.05 nmol/L; FT3, 3.56-6.43 pmol/L; TSH, 0.29-5.28 μIU/ml; and FT3/FT4, 0.197-0.496. <b>Conclusions:</b> In this study, we established RIs of thyroid-related hormone levels for the oldest-old in China and evaluated the associations between thyroid hormone levels and body indices. These findings may provide evidence for the diagnosis and treatment of thyroid-related diseases in the oldest-old.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2408-2418"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-thrombectomy cerebral edema affects outcomes in acute stroke patients treated with thrombectomy.","authors":"Lu Yang, Yuan Kan, Changhong Ren, Sijie Li, Chuanhui Li, Longfei Wu, Jiali Xu, Wenting Guo, Haiqing Song, Qingfeng Ma, Wenbo Zhao, Xunming Ji","doi":"10.7150/ijms.105692","DOIUrl":"10.7150/ijms.105692","url":null,"abstract":"<p><p><b>Objective</b>: Cerebral edema significantly impacts the functional outcomes in patients with acute stroke treated with thrombectomy, especially those with an extended time window (6-24 hours). This study was to investigate whether pre-thrombectomy cerebral edema predicts functional prognosis in ischemic stroke patients within an extended onset time window. <b>Methods:</b> All patients from Xuanwu Hospital of Capital Medical University underwent computed tomography (CT) examination and endovascular treatment between December 2021 and December 2023. Quantitative Net Water Uptake (NWU) was assessed according to baseline CT. The ability to predict onset time and outcomes was assessed by univariate receiver operating characteristic curves and logistic regression analyses. The primary endpoint was an unfunctional outcome at 90 days, defined as a modified Rankin Scale Score of 3-6. <b>Results:</b> We reviewed a total of 247 patients, and the last 134 were included in the study, of whom 41.8% had stroke onset within 6 hours. NWU was significantly lower in patients with stroke onset within 6 hours (6.57±3.43) compared to 6-24 hours (11.69±3.01). Of patients with onset times of 6-24h, the area under the curve (AUC) for distinguishing patient groups according to NWU% was 0.863, with a cut-off value of 9.3 (sensitivity, 80.8%; specificity, 82.1%). A multivariable predictive model including NWU% and age yielded the highest diagnostic ability, with an AUC of 0.857 (sensitivity, 66.7%; specificity, 92.9%). <b>Conclusion:</b> NWU as an imaging biomarker of brain edema predicts functional prognosis after endovascular recanalization therapy in ischemic stroke patients within an extended onset time window.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"22 10","pages":"2354-2361"},"PeriodicalIF":3.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}