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International Journal of Pharmaceutical Chemistry and Analysis最新文献

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Navigating pharmaceutical product decisions: A comprehensive review 引导药品决策:全面回顾
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.014
Naseef Pp, Mohammed Ridhan Bazil, Irshad Ibrahim N, Muhsinu Rahman, Munavar Ali, Mohammed Nihal Kottangodan, Praseen G P
{"title":"Navigating pharmaceutical product decisions: A comprehensive review","authors":"Naseef Pp, Mohammed Ridhan Bazil, Irshad Ibrahim N, Muhsinu Rahman, Munavar Ali, Mohammed Nihal Kottangodan, Praseen G P","doi":"10.18231/j.ijpca.2023.014","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.014","url":null,"abstract":"Product management in the pharmaceutical industry is a complex and challenging role that involves overseeing the entire life cycle of a drug product, from development through commercialization and beyond. It requires a deep understanding of the regulatory environment, market dynamics, and patient needs, as well as strong leadership and management skills By classifying product decisions into these categories, businesses can prioritize their efforts and allocate resources effectively. Strategic decisions, for example, may require more resources and involve more stakeholders than operational decisions, but they can also have a greater impact on the success of the product. By making informed product line and product mix decisions, businesses can effectively meet customer needs and grow their market share. By using product portfolio analysis, businesses can make informed decisions about which products to invest in, which to divest or improve, and which new products or markets to pursue. This analysis helps businesses align their product offerings with their overall business strategy and maximize their profitability and growth potential.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77453795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on anti-cancer herbal drugs 抗癌中草药研究进展
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.018
S. Tiware, Komal Khond Warghane, Prasad Makde, Harshal Yeskar
{"title":"Review on anti-cancer herbal drugs","authors":"S. Tiware, Komal Khond Warghane, Prasad Makde, Harshal Yeskar","doi":"10.18231/j.ijpca.2023.018","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.018","url":null,"abstract":"One of the most important health issues facing humanity, cancer is a scary disease that demands a proactive approach to treatment. Plants, a source of novel chemical entities and a promising topic for cancer research. Despite its success, chemotherapy has so far had some unfavourable side effects. However, the use of plants and products generated from them is revolutionising the field as a simple, secure, cost-effective, time-saving, environmentally friendly, and less hazardous alternative to traditional treatment procedures. Phytochemicals have selective activities that are targeted towards tumour cells. The complex process known as carcinogenesis involves a number of signalling cascades. Phytochemicals are thought to be attractive prospects for the development of new therapeutics because of their pleiotropic effects on the target event in a number of ways.\"Researchers are looking at which of these phytochemicals might be possibilities for inhibiting or reducing the growth of cancer cells without causing any unfavourable side effects. There are a lot of phytochemicals and the analogues they were made from that have been identified as potential anticancer therapeutic possibilities. An effort has been made to highlight the most recent developments and noteworthy accomplishments in phytomolecule-based cancer therapies that target nuclear and cellular components through this succinct overview.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85243004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary phytochemicals and cancer chemoprevention 饮食中的植物化学物质和癌症化学预防
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.020
A. Sheikh, A. Arora, N. Chauhan
{"title":"Dietary phytochemicals and cancer chemoprevention","authors":"A. Sheikh, A. Arora, N. Chauhan","doi":"10.18231/j.ijpca.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.020","url":null,"abstract":"The goal of cancer chemotherapy is to prevent or slow the growth of tumors by using various Biological or natural agents. Epidemiological and pre-clinical data indicate that phytochemicals can influence cell proliferation and cell cycle regulation, are typically involved in multiple signaling pathways that are frequently disrupted during tumour initiation, proliferation, and propagation, strengthen the host immune system, and make cancer cells more susceptible to cell-damaging agents. Only a small subset of these medicines have undergone clinical testing, and the results of those trials have been inconsistent, despite favorable outcomes from Experimental investigation. Recognizing the impact of these dietary changes may inspire easy and affordable solutions to improve health globally as the global rate of cancer continues to rise. In this article, we provide a summary of the information on a few phytochemicals with a particular focus on the clinical data demonstrating these compounds' effectiveness in populations at significant risk.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90240721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary phytochemical analysis, formulation and evaluation of anti-inflammatory potential of the formulated gel obtained from an Ethanolic leaves extract of Lour 初步的植物化学分析，配方和抗炎潜力的评价，从鸢尾叶乙醇提取物中获得的配方凝胶
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.022
Praveen Sekar, Vignesh Natarajan, Nivetha Shanmugam, Thilagasundari Kandasamy
{"title":"Preliminary phytochemical analysis, formulation and evaluation of anti-inflammatory potential of the formulated gel obtained from an Ethanolic leaves extract of Lour","authors":"Praveen Sekar, Vignesh Natarajan, Nivetha Shanmugam, Thilagasundari Kandasamy","doi":"10.18231/j.ijpca.2023.022","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.022","url":null,"abstract":"Infectious microbes like bacteria, viruses, or fungi commonly cause inflammation when they enter the body, live in certain tissues or circulate in the circulation. For long years ago, natural sources have been used for the treatment of various diseases. In this way, belonging to the family Lamiaceae was found to be having various pharmacological activities like anticancer, antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, larvicidal and cardiovascular activities. The objective of the study is to formulate and evaluate the anti-inflammatory potential of the topical gel using an Ethanolic leaves extract of The formulated gel F3 showed better spreadability with a net content of 99 % and a drug release of 94.84 %. The anti-inflammatory potential of the formulation F3 was evaluated using the inhibition of albumin denaturation assay and Human red blood cells (HRBC) membrane stabilization assay. The formulated gel and standard exhibited 45.86-82.32 % and 55.25-88.07 % of inhibition at the concentration of 50-250 µg/ml, respectively at albumin denaturation assay and 25.35-75.49 % and 30.70-87.18 % of inhibition at 50-250 µg/ml concentration, respectively. Thus, the formulated topical gel using an Ethanolic leaves extract of was found to be possessing potent anti-inflammatory activity.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91414249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and evaluation of herbal sunscreen creams 草本防晒乳的制备与评价
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.021
Rajvee Mewada, Y. Shah
{"title":"Preparation and evaluation of herbal sunscreen creams","authors":"Rajvee Mewada, Y. Shah","doi":"10.18231/j.ijpca.2023.021","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.021","url":null,"abstract":"Presently herbal sunscreens are widely used by almost everyone on this planet to prevent from harmful effects of UV radiation from sunlight. Herbals are preferable because of fewer side effects and a better safety profile. This study is about the preparation and evaluation of herbal sunscreen creams possessing anti-UV radiation effectiveness and anti-inflammatory properties. Creams were prepared from the extract of plant materials, such as respectively. Glycyrrhiza glabra, Tinospora cordifolia and Terminalia arjuna, total polyphenol and flavonoid content. Evaluation of prepared herbal sunscreen creams was performed on parameters such as organoleptic properties, pH, rancidity, spreadability and drug content. The effectiveness of the products was evaluated by measuring Sun Protection Factor (SPF). These products showed good spreadability, consistency, homogeneity, appearance, desired pH, ease of removal and no evidence of phase separation. Our formulation of sunscreen creams is considered to be effective sunscreen in healing, softening and rejuvenating the skin.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77686887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biophenols for cancer treatment: Current perspective and future potential 生物酚治疗癌症:目前的观点和未来的潜力
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.019
B. Prajapati, D. Kapoor, S. Yele
{"title":"Biophenols for cancer treatment: Current perspective and future potential","authors":"B. Prajapati, D. Kapoor, S. Yele","doi":"10.18231/j.ijpca.2023.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.019","url":null,"abstract":"Vegetable and natural product utilization are conversely connected with diminished malignant growth rate and mortality. Fruit antioxidants have been extensively studied for their ability to scavenge free radicals, preventing to develop the chronic degenerative diseases. As antiproliferative agents, mixtures of biophenols were more effective than individual biophenols. The tyrosol and hydroxytyrosol are major biophenol exist in olive samples. The other biophenol present in olive samples include lignans, verbascoside and flavonoids possessing anticancer properties. The Hydroxychavicol extracted from leaf of also have chemotherapeutic and chemo preventive properties. Additionally, Curcumin also exhibited strong antit-tumor characteristics against a different type of cancers, including blood, breast, skin, colon, blood and prostrate.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84153271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical method development and validation of UV-visible spectrophotometric method for the estimation of CNS stimulant drug in bulk 紫外可见分光光度法测定散装中枢神经系统兴奋剂含量的分析方法的建立与验证
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.023
Saba Khan, Mohd Anas Shaikh, Nehal Shaikh, J. Agnihotri
{"title":"Analytical method development and validation of UV-visible spectrophotometric method for the estimation of CNS stimulant drug in bulk","authors":"Saba Khan, Mohd Anas Shaikh, Nehal Shaikh, J. Agnihotri","doi":"10.18231/j.ijpca.2023.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.023","url":null,"abstract":"A simple, rapid, accurate, economical and precise UV/VIS method has been developed and validated. Choices of a common solvent were essential so various solvent ranges including methanol, ethanol, acetonitrile, and 0.1 N HCL, and various concentrations ranges of various buffers were analyzed. Hence 0.1 N HCL was selected as a solvent for the proposed method. Caffeine showed maximum absorbance at 273nm.Drug obey Beer Lambert’s law in the concentration range of 3-18 μg/mL for Caffeine. The LOD and LOQ were found to be 0.5476 μg/mL and 1.6594 μg/mL for Caffeine. The method was quantitatively evaluated in terms of linearity, precision, precision, LOD, LOQ and recovery. The method is simple, convenient and suitable for the analysis of Caffeine in bulk drugs.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76246208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging paradigms in pre-clinical screening models for drugs acting against diabetes: Delving into complex approaches and advancements 抗糖尿病药物临床前筛选模型的新范例:探究复杂的方法和进展
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.016
Keval Y. Raval, Yash Dhamsaniya
{"title":"Emerging paradigms in pre-clinical screening models for drugs acting against diabetes: Delving into complex approaches and advancements","authors":"Keval Y. Raval, Yash Dhamsaniya","doi":"10.18231/j.ijpca.2023.016","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.016","url":null,"abstract":"Animal models play a critical role in diabetes research, aiding in the comprehension of both type 1 and type 2 diabetes pathogenesis and the assessment of potential therapeutic interventions. These models offer numerous advantages, including the ability to induce stable hyperglycemia and hyperlipidemia, minimal variability, and the opportunity to study genetic mutations and single gene effects. However, they also present limitations such as lengthy induction periods, fluctuating glucose parameters, potential toxicity to other organs, and high costs. Various screening models, encompassing in vitro assays and models like Alloxan-induced and Streptozotocin-induced diabetes, serve as valuable tools for investigating diabetes and testing drug efficacy. The selection of an appropriate model requires careful consideration of specific research objectives. Despite their limitations, animal models continue to be indispensable for advancing our understanding of diabetes and developing effective treatments.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87072888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview: Herbal cosmetics and cosmeceuticals 概述:草药化妆品和药妆品
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.017
Phatangre Piyal, L. Phalke Pallavi, T. Phatangare, Sharmale Mani
{"title":"An overview: Herbal cosmetics and cosmeceuticals","authors":"Phatangre Piyal, L. Phalke Pallavi, T. Phatangare, Sharmale Mani","doi":"10.18231/j.ijpca.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.017","url":null,"abstract":"The Greek term “kosm tikos,” which meaning having the capacity to arrange and adorn in a dazzling style, is where the word “cosmetic” originates. Here, a number of legal cosmetic chemicals are used to create the products as a base, and one or more herbal substances are then added to provide certain cosmetic benefits. “Herbal cosmetics” is the term used to describe these goods. Everyday items including herbal face wash, herbal conditioner, herbal soap, herbal shampoo, herbal face mask, and others are produced. Numerous herbal plants can be found in nature, and they include a wide range of chemical ingredients that are employed in the creation of cosmetics. Demand has increased as a direct result of the contemporary desire to look younger than one’s true age and to be attractive, youthful, lovable, and fair.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77989659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The regulatory quest for specific drugs marketed in India and western world-perception difference 在印度上市的特定药物的监管要求与西方世界的认知差异
International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI: 10.18231/j.ijpca.2023.011
S. Chaudhry
{"title":"The regulatory quest for specific drugs marketed in India and western world-perception difference","authors":"S. Chaudhry","doi":"10.18231/j.ijpca.2023.011","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.011","url":null,"abstract":"","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77690967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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