初步的植物化学分析,配方和抗炎潜力的评价,从鸢尾叶乙醇提取物中获得的配方凝胶

Praveen Sekar, Vignesh Natarajan, Nivetha Shanmugam, Thilagasundari Kandasamy
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引用次数: 0

摘要

感染性微生物,如细菌、病毒或真菌,在进入人体、生活在某些组织中或在循环中循环时,通常会引起炎症。很久以前,自然资源就被用来治疗各种疾病。结果表明,兰科植物具有抗癌、抗菌、抗氧化、抗炎、抗糖尿病、杀虫和心血管等多种药理活性。本研究的目的是制备并评价其抗炎作用。制备的凝胶F3具有较好的涂抹性,净含量为99%,释药率为94.84%。通过抑制白蛋白变性试验和人红细胞(HRBC)膜稳定试验来评估配方F3的抗炎潜力。配制的凝胶和标准品在50 ~ 250µg/ml浓度下对白蛋白变性试验的抑制率分别为45.86 ~ 82.32%和55.25 ~ 88.07%,在50 ~ 250µg/ml浓度下对白蛋白变性试验的抑制率分别为25.35 ~ 75.49%和30.70 ~ 87.18%。因此,使用乙醇叶提取物的配方局部凝胶被发现具有有效的抗炎活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preliminary phytochemical analysis, formulation and evaluation of anti-inflammatory potential of the formulated gel obtained from an Ethanolic leaves extract of Lour
Infectious microbes like bacteria, viruses, or fungi commonly cause inflammation when they enter the body, live in certain tissues or circulate in the circulation. For long years ago, natural sources have been used for the treatment of various diseases. In this way, belonging to the family Lamiaceae was found to be having various pharmacological activities like anticancer, antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, larvicidal and cardiovascular activities. The objective of the study is to formulate and evaluate the anti-inflammatory potential of the topical gel using an Ethanolic leaves extract of The formulated gel F3 showed better spreadability with a net content of 99 % and a drug release of 94.84 %. The anti-inflammatory potential of the formulation F3 was evaluated using the inhibition of albumin denaturation assay and Human red blood cells (HRBC) membrane stabilization assay. The formulated gel and standard exhibited 45.86-82.32 % and 55.25-88.07 % of inhibition at the concentration of 50-250 µg/ml, respectively at albumin denaturation assay and 25.35-75.49 % and 30.70-87.18 % of inhibition at 50-250 µg/ml concentration, respectively. Thus, the formulated topical gel using an Ethanolic leaves extract of was found to be possessing potent anti-inflammatory activity.
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