International Journal of Pharmaceutical Chemistry and Analysis最新文献_第10页

Role of zinc-aspirin metal coordination complex in diabetic cataract induced in vitro in goat eye lens 锌-阿司匹林金属配合物在羊眼离体糖尿病性白内障中的作用

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0022

Dimak Chand Sahu, Girendra Kumar Gautam, Durga Prasad Panda, Mohd. Akhtar Rasool

引用次数: 0

Synthesis and antimicrobial activities of some novel thieno [2,3-d]- Pyrimidin-4(3H)-One derivatives 新型噻吩[2,3-d]-嘧啶-4(3H)- 1衍生物的合成及抗菌活性研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0010

D. Kawade, A. Hadke

{"title":"Synthesis and antimicrobial activities of some novel thieno [2,3-d]- Pyrimidin-4(3H)-One derivatives","authors":"D. Kawade, A. Hadke","doi":"10.18231/2394-2797.2018.0010","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0010","url":null,"abstract":"Pain and inflammation are simultaneous responses in bacterial infections. In current clinical practice, the agents like antimicrobial drug are prescribed concurrently. A POCl3 catalyzed, efficient, one-step and solvent-free synthesis of novel thieno [2, 3-d] pyrimidin-4(3H)-one derivatives from 2-amino-4,5-substitutedthiophene-3-carbonitrile has been developed using various aliphatic acid under conventional heating and microwave irradiation. The formation of compounds was confirmed using elemental analysis and spectroscopic techniques like FTIR, 1H NMR and Mass spectroscopy. All synthesized compounds have been screened for their antimicrobial activity against Escherichia coli (Gram –ve strain), Bacillus subtilis (Gram +ve strain) for antibacterial activity and antifungal activities against Aspergillus niger and Candida albicans. The result showed that synthesized compounds exhibit weak, moderate and good antimicrobial activity. It was observed that the compounds 2a, 2c, 2d, 2e, 2f, 2g, 2j and 2k showed good antimicrobial activity whereas compounds 2b, 2i, 2j showed significant antimicrobial activity compared with standard drug Streptomycin and Amphotericin B respectively.\u0000\u0000Keyword:POCl3, Thieno[2, 3-d]pyrimidin-4 (3H)-one, Antimicrobial activity, Streptomycin and Amphotericin B","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88761416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous estimation of canagliflozin and metformin hydrochloride in tablet dosage form by UV spectrophotometry 紫外分光光度法测定片剂剂型中卡格列净和盐酸二甲双胍的含量

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0015

D. Sharmila, J. Chandini, K. Lakshmi, C. Balaji, A. Rao

{"title":"Simultaneous estimation of canagliflozin and metformin hydrochloride in tablet dosage form by UV spectrophotometry","authors":"D. Sharmila, J. Chandini, K. Lakshmi, C. Balaji, A. Rao","doi":"10.18231/2394-2797.2018.0015","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0015","url":null,"abstract":"The combination of Canagliflozin and Metformin was available as fixed dose tablets for the treatment of type 2 diabetes. The present method aims to develop a simple, precise and accurate spectrophotometric method for simultaneous determination of Canagliflozin and Metformin in commercial formulation. The method utilizes Vierordt’s equation based on the measurement at two wavelengths 290nm (?max of Canagliflozin) and 236nm (?max of Metformin). The method exhibited linear range of 2.5 to 15µg/ml and 5 to 17.5µg/ml for Canagliflozin and Metformin, respectively, with a correlation coefficient of 0.999. The LOD and LOQ for Canagliflozin were found to be 0.43 and 1.31 respectively. For Metformin the LOD and LOQ were found to be 0.49 and 1.49 respectively. The recovery of Canagliflozin and Metformin were found to be 99.43 and 98.82 respectively. The results were validated statistically as per ICH guidelines and were found to be satisfactory. To conclude, the developed UV spectrophotometric method is more economical for analysis of Canagliflozin and Metformin in both bulk and pharmaceutical dosage form for routine analysis.\u0000\u0000Keywords: Canagliflozin, Metformin, Vierordt’s equation, UV-Spectrophotometry, ICH guidelines","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78718329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and screening for biological potential of some substituted chalcones 一些取代查尔酮的合成及生物潜能的筛选

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0013

K. Gupta, S. Badole, J. Gupta, S. Singh

引用次数: 0

Estimation of four drugs: Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol by RP-HPLC in tablet dosage form 盐酸氨溴索、盐酸左西替利嗪、盐酸苯肾上腺素、扑热息痛4种药物片剂剂型的RP-HPLC评价

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0006

Devangi Patel, A. Vyas, M. Noolvi, A. Patel, Nilesh Patel

{"title":"Estimation of four drugs: Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol by RP-HPLC in tablet dosage form","authors":"Devangi Patel, A. Vyas, M. Noolvi, A. Patel, Nilesh Patel","doi":"10.18231/2394-2797.2018.0006","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0006","url":null,"abstract":"A simple, specific, precise, accurate and economic isocratic RP-HPLC method was developed for the simultaneous determination of Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol in bulk and tablet dosage form. A reverse phase Nucleosil C18 column (250 mm x 4.6 mm x 5 µm) with mobile phase consisting of Methanol: Sodium Phosphate dibasic anhydrous Buffer (65:35 V/V) having (pH of buffer 7.0 ± 0.02 adjusted with ortho phosphoric acid) was used. The flow rate was 1.0 mL/min and the effluents were monitored at 230 nm. The retention times of Paracetamol, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Ambroxol hydrochloride were found to be 3.117, 4.925, 6.217 and 12.308 min. respectively. The method was validated in terms of linearity, range, specificity, accuracy, precision and robustness. The proposed method was successfully applied for the estimation of paracetamol, levocetirizine hydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride in combined tablet dosage form.\u0000\u0000Keywords: Paracetamol (PCM), Levocetirizine hydrochloride (LEVO), Phenylephrine hydrochloride (PHEN), Ambroxol hydrochloride (AMB), Isocratic; RP-HPLC.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85640244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The magic particle silica: Past to present 神奇粒子二氧化硅:从过去到现在

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0019

A. V. Ganokar, S. U. Bhoyar, N. S. Raut, K. R Gupta

引用次数: 0

Method development and validation of aliskiren in tablet formulation by UV spectrophotometric methods 紫外分光光度法测定阿利克连片剂的含量

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0014

Nita Yadav, A. Goyal

{"title":"Method development and validation of aliskiren in tablet formulation by UV spectrophotometric methods","authors":"Nita Yadav, A. Goyal","doi":"10.18231/2394-2797.2018.0014","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0014","url":null,"abstract":"Optical methods through ultraviolet-spectrophotometer were developed and justification was done to validate the method for quantitative determination of aliskiren in its tablet formulation. Wavelengths for different methods were chosen by running selected sample in spectrum mode of the instrument, it was 279 nm; absorbance maxima for zero order technique, 289 nm; peak minima for first order derivative technique and between 269 nm and 289 nm for AUC technique using distilled water as reference. After studying linearity graph, working concentration range selected for method I, method II and method III was in between 25 to 150 µg mL-1. R2 value equal to 0.999 confirmed a better correlation between concentration and absorbance. Percentage purity of aliskiren in tablet formulation was found in between 98.54-100.36 which was very close to label claim. Validation following ICH guidelines was done to justify the results obtained through method I, method II and method III. The percentage of the standard drug recovered in recovery study for all the three techniques were within the limit and were in between 98.61-101.66. The percentage relative standard deviation in precision study was less than 2 for all the techniques. From the observed data it can be said that the developed methods can be utilized for quantitative estimation of aliskiren in tablet formulation.\u0000\u0000Keywords: Ultraviolet-Spectrophotometer, Optical methods, Aliskiren, Validation, First order derivative, AUC","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82008756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedaquiline –A new drug against multidrug-resistant tuberculosis 贝达喹啉——一种治疗耐多药结核病的新药

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0017

S. Yadav, G. Rawal

引用次数: 0

Method development, degradation pathway and kinetic of capecitabine 卡培他滨的方法建立、降解途径及动力学

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0021

Dhara R. Patel

{"title":"Method development, degradation pathway and kinetic of capecitabine","authors":"Dhara R. Patel","doi":"10.18231/2394-2797.2018.0021","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0021","url":null,"abstract":"The present work describes a simple, accurate and precise Stability indicating RP-HPLC method for the estimation of Capecitabine (CPT) in bulk and pharmaceutical formulation. The Mobile phase used was Acetonitrile: Water (60: 40v/v) with 1ml/min. flow rate and 240nm was used as a wavelength maximum. The C18 HS (250 X 4.6) mm, 5 μm column was used as a stationary phase. The method was validated as per the ICHQ2 Guidelines. The retention time of CPT was found to be 3.3 min. A linear response was observed in the range of 10-50 μg/mL with a regression coefficient of 0.999. The LOD and LOQ were found to be 1.43μg/mL and 4.34μg/mL respectively. This method can be used for the determination of CPT in quality control of API and dosage form without interference of the excipients, impurities and degradation products and hence can be used as stability indicating assay method. CPT was subjected to degradation under different stress conditions recommended by ICH viz acid, alkali, photolytic, dry heat and oxidative condition. The samples so generated were used for degradation studies including degradation kinetic study using the developed method. The degradation pathway of CPT was found to be acid hydrolysis and temperature exceeding 100°c. The degradation kinetic study shows that the acid hydrolysis, alkaline hydrolysis and oxidative degradation of the CPT follow first order kinetic.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79502585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis and characterization of cefixime by using IR, HPLC and gas chromatography 头孢克肟的红外光谱、高效液相色谱和气相色谱分析与表征

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0012

M. P. Rao, B. R. Rao, M. Srikanth

引用次数: 1