{"title":"一些取代查尔酮的合成及生物潜能的筛选","authors":"K. Gupta, S. Badole, J. Gupta, S. Singh","doi":"10.18231/2394-2797.2018.0013","DOIUrl":null,"url":null,"abstract":"The present paper describes the synthesis and antibacterial as well as antioxidant activity of new chalcone derivatives derived from p-chloroacetopheneone. In the present work the reaction of p-chloroacetophenone with different substituted aromatic aldehyde. The newly synthesized chalcones (A-D) were analysed by their spectral data TLC, IR, UV and melting point. These newly synthesized compounds were evaluated for in-vitro antioxidant activity by Diphenyl Picryl Hydrazine (DPPH) model using ascorbic acid as standard and for antimicrobial activity by Cup Plate method on gram positive and gram negative bacterial strain using amoxicillin as standard. \n\nKeywords: Chalcone, Antimicrobial, Antioxidant, P-chloroacetophenone, Aromatic aldehyde","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and screening for biological potential of some substituted chalcones\",\"authors\":\"K. Gupta, S. Badole, J. Gupta, S. Singh\",\"doi\":\"10.18231/2394-2797.2018.0013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present paper describes the synthesis and antibacterial as well as antioxidant activity of new chalcone derivatives derived from p-chloroacetopheneone. In the present work the reaction of p-chloroacetophenone with different substituted aromatic aldehyde. The newly synthesized chalcones (A-D) were analysed by their spectral data TLC, IR, UV and melting point. These newly synthesized compounds were evaluated for in-vitro antioxidant activity by Diphenyl Picryl Hydrazine (DPPH) model using ascorbic acid as standard and for antimicrobial activity by Cup Plate method on gram positive and gram negative bacterial strain using amoxicillin as standard. \\n\\nKeywords: Chalcone, Antimicrobial, Antioxidant, P-chloroacetophenone, Aromatic aldehyde\",\"PeriodicalId\":13889,\"journal\":{\"name\":\"International Journal of Pharmaceutical Chemistry and Analysis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharmaceutical Chemistry and Analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18231/2394-2797.2018.0013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Chemistry and Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/2394-2797.2018.0013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and screening for biological potential of some substituted chalcones
The present paper describes the synthesis and antibacterial as well as antioxidant activity of new chalcone derivatives derived from p-chloroacetopheneone. In the present work the reaction of p-chloroacetophenone with different substituted aromatic aldehyde. The newly synthesized chalcones (A-D) were analysed by their spectral data TLC, IR, UV and melting point. These newly synthesized compounds were evaluated for in-vitro antioxidant activity by Diphenyl Picryl Hydrazine (DPPH) model using ascorbic acid as standard and for antimicrobial activity by Cup Plate method on gram positive and gram negative bacterial strain using amoxicillin as standard.
Keywords: Chalcone, Antimicrobial, Antioxidant, P-chloroacetophenone, Aromatic aldehyde
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
