International Journal of Pharmaceutical Chemistry and Analysis最新文献

{"title":"Silver nanoparticles used in the antibacterial preparations","authors":"C. Yadav, Vaishnav Rajat, A. Goyal","doi":"10.18231/j.ijpca.2019.011","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.011","url":null,"abstract":"Nanotechnology is the emerging field in medicine that is expected to induce exceptional therapeutic benefits. Nanoparticles have been improving the therapeutic effect of drugs and are prepared by using varioustechniques. Silver Nanoparticles are attracting interest for the clinical application because of its potential biological properties such as antibacterial properties; antifungal properties etc. Due to its highly efficient properties Silver Nanoparticles are invasively used in the field of medical and health care. Against a large number of micro-organisms, Silver Nanoparticles are proven to be exceptionally productive for their antibacterial effects. Its mechanism of action is still unknown but the method of synthesis is highly economical, affordable and reliable. Desired properties can be achieved by changing the shapes and Sizes of Silver Nanoparticles. The main aim of this work is to provide an outline and general review on Silver Nanoparticles, with special reference to their mechanism of action and antimicrobial activity.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76100023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medications mostly used in dentistry","authors":"S. Hassan, Sumit Bheteja, Geetika Arora","doi":"10.18231/j.ijpca.2019.012","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.012","url":null,"abstract":"","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83519070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid acid catalyst for isobutyl propionate production from solid waste","authors":"A. Bhatia, Sarishti Sharma","doi":"10.18231/j.ijpca.2019.013","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.013","url":null,"abstract":"This paper presents a study of the isobutanol based esterification of propionic acid with the synthesized solid acid catalyst (NAFA) at different temperature and reaction time. An efficient nano crystalline solid acid catalyst (NAFA) with crystallite size of 14 nm has been synthesized by F-type fly ash (SiO2 and Al2O3>70%) by chemical activation using concentrated HNO3 at 110oC. The Catalyst was characterized by XRD, FT-IR, and SEM techniques. Fly ash generated catalytic material has shown sufficient catalytic activity for esterification of propionic acid and isobutyl alcohol to give isobutyl propionate, which is widely used in food and beverage industries as a rum flavor. The catalyst was completely recyclable without significant loss in activity up to four reaction cycles, which confers its stability during reaction. The work reports an innovative use of solid waste fly ash as an effective solid acid catalyst.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80511598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives","authors":"D. Rishipathak, Poonam S.Wajpeyi, Sonal P. Tathe, P. Udavant","doi":"10.18231/J.IJPCA.2019.008","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.008","url":null,"abstract":"In present investigation the synthesis of few 2-(substituted phenyl-3-(5-substituted phenyl-4H-1, 2, 4-triazole-3-yl)-thiazolidine-4-ones and 3-(5-(4-substituted phenyl)-1, 3, 4-thiadiazole-2-yl)-2-phenylthiazolidine-4-ones is reported with the aim of achieving enhanced anticonvulsant effect. Two schemes were designed viz. first scheme for clubbed triazole-thiazolidinone derivatives and second scheme for clubbed thiadiazole-thiazolidinone derivatives. The compounds were characterized on the basis of IR, H-NMR and Mass analyses. Acute toxicity study was done to determine the LD50 of the compounds. Some of the compounds were evaluated for their anticonvulsant activity using PTZ induced convulsions method. The compounds DCThizd-N and NMThizd-N showed highest percentage of protection (80%) at the dose of 30mg/kg among the evaluated compounds compared to control.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85464373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of HPLC technique covering its pharmaceutical, environmental, forensic, clinical and other applications","authors":"G. Chawla, K. Chaudhary","doi":"10.18231/J.IJPCA.2019.006","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.006","url":null,"abstract":"HPLC is an analytical technique widely used for identification, separation, detection and quantification of various drugs and its related degradants. Appropriate mobile phase, stationary phase, column, column size, temperature, wavelength and gradient selection is important for the suitable compatibility and stability of drug as well as impurities and degradants. Most of the drugs as well as other compounds can be analyzed by HPLC method because of the several advantages like rapidity, specificity, accuracy, precision and ease of automation in this method. This article has been prepared with an aim to review different aspects of HPLC, such as principle, types, mode of separation, characteristics, instrumentation, important parameters and various applications of HPLC in different fields. Keyword: HPLC, Analysis, Method development and Validation, Detection, Identification, Quantitation. Introduction High-performance liquid chromatography or High pressure liquid chromatography (HPLC) is a specific form of column chromatography generally used in biochemistry and analysis to separate, identify, and quantify the active compounds. 1 HPLC is the method of choice for checking peak purity of new chemical entities, monitoring reaction changes in synthetic procedures or scale up, evaluating new formulations and carrying out quality control / assurance of the final drug products. 2,3 HPLC is now one of the most powerful tools in analytical chemistry. It has the ability to separate, identify, and quantify the compounds that are present in any sample that can be dissolved in a liquid. HPLC is the most accurate analytical methods widely used for the quantitative as well as qualitative analysis of drug product and used for determining drug product stability. 4,5 High pressure liquid chromatography is the full form for HPLC and as given in the name, there is use of high pressure in the principle of its operation. Also due to its efficiency in analysis of compounds it is regarded as High performance liquid chromatography. Some have even gone to the extent of calling it as High patience liquid chromatography based on the long human time requirement and patience needed in its operation. HPLC is basically a highly improved form of column chromatography. Instead of allowing the solvent to drip through a column under just the force of gravity, it is externally forced through the column under high pressures of up to 400 atm. This makes the chromatographic process a lot faster. It also allows the use of very small particle size for the column packing material which gives a much greater surface area for interactions between the stationary phase and the molecules flowing through it. Thus, it allows a much better separation of the components of the mixture. 6,7 Now a days, highperformance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) is one of the most versatile analytical tools available due to its rapid and diverse growth in applications in the ","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81653035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevens-Johnson syndrome and toxic epidermal necrolysis overlap associated with alternative medicine: A case report","authors":"K. Sharma, Joseph M. Saji","doi":"10.18231/J.IJPCA.2019.010","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.010","url":null,"abstract":"Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is rare, acute and life-threatening conditions usually associated with mucosal loss and can be caused by various medicines. Even it also may cause by took alternative medications from unregistered medical practitioner (Hakeem). It includes the severe form of mucosal dermatitis, and characterized by extensive epidermal blistering, it leads to epidermal necrosis and loss of the epidermis. They can also cause oral mucosa lesions. A 11 year old female patient admitted with the complain of headache, loose stool, haematuria, rashes with itching followed by mucosa loss throughout the body, including both face and hands, multiple ulcers present in the oral cavity. On laboratory investigation, abnormal values are:- White blood cell (11500/microliter) and SGOT (60 U/L), SGPT (86 U/L) levels are abnormally identified. Patient was treated with Injection Vancomycin 4ml in 60ml in Normal saline q.i.d. (4 times a day) for 10 days. Further changed to tablet Azithromycin 250 mg once daily for next 5 days. Injection Meropenum (8mL+12mL), Injection Lipomadol. Lidocaine and fusidic acid jelly application 3 times daily for lips and skin lesions was prescribed. \u0000 \u0000Keywords: Stevens - Johnson syndrome, Toxic Epidermal Necrolysis, Erythema dermatitis.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74349298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between V?O2max and systolic time interval in athletes","authors":"M. Kanvinde, V. Nalgirkar","doi":"10.18231/J.IJPCA.2019.009","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.009","url":null,"abstract":"The goal of my study was to correlate V?O2max and systolic time interval as a evaluator of cardiovascular fitness in athletes. Depending on the need of oxygen to tissues V?O2max increases with a increase in cardiac output, stroke volume, left ventricular ejection fraction and myocardial activity as a athlete does treadmill from moderate to maximal, Data collection was done at Stress test lab. at Nerul, Navi Mumbai after taking permission from medical ethic committee. Athletes were asked to do treadmill and their V?O2max and systolic time interval were assessed with their duration of exercise by taking their BMI into consideration. For proper results, athletes were asked to do treadmill for 2 weeks In athletes, after doing unpaired T - test a gradual increase in systolic time interval as left ventricular ejection phase and duration of systole (P","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77355377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of floating beads of esomeprazole magnesium USP","authors":"Daisy P.A, Tania Maria Stanley, Praveen Raj R","doi":"10.18231/J.IJPCA.2019.007","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.007","url":null,"abstract":"The aim of this study was to develop and evaluate floating beads of Esomrazole Magnesium USP. Floating beads of Esomeprazole was prepared by ionotropic Gelation method using sodium alginate as the polymer. Five different formulations were developed. The developed floating beads were evaluated for percentage yield, particle size, in vitro buoyancy, scanning electron microscopy and drug release. Stability studies were carried for 45 days. There are no significant change in the drug entrapment, buoyancy, and drug release of floating beads Esomeprazole Magnesium after 45 days. The polymer used was Sodium alginate. FTIR study results showed that there were no incompatibility between drug and polymer. Solubility study was performed and recorded the results. Results of our present study suggest that floating beads of Esomeprazole Magnesium can be successfully designed for controlled drug delivery which can reduce dosing frequency making the formulation an effective alternative to conventional dosage forms.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79691200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case report on guillain barre syndrome and rheumatoid arthritis","authors":"B. Praveena, Shaik Bobby Parveen, B. Gayatri, Chandolu Suvarna Rani, K. R. Kumar","doi":"10.18231/J.IJPCA.2019.005","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.005","url":null,"abstract":"Guillain Barre syndrome (GBS) is an acute or subacute inflammatory demyelinating poly radiculoneuropathy. It is an acquired condition that is characterized by progressive, symmetrical, proximal, and distal tingling and weakness. We report a case of a 68 years old female who presented with complaints of quadraperisis, severe sensory motor axonal neuropathy, parasthesia, severe myalgiapoly arthralgia and mononeuritis multiplex and later diagnosed as a case of guillainbarre syndrome and rheumatoid arthritis.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89980354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetic enhancement of poorly aqueous soluble rosuvastatin using natural gum as carriers: pharmaceutical modeling of release kinetics and bio-stastistical evaluation","authors":"Manoj Kumar Katual, Gurfateh Singh, S. Harikumar","doi":"10.18231/J.IJPCA.2019.004","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2019.004","url":null,"abstract":"The major focus of the present investigation is to enhance the solubility and dissolution rate of Rosuvastatin Calcium. Preaparation of Solid dispersions of Rosuvastatin Calcium by using Vitamin E TPGS, A.Marmelos, and Gum Karaya as carriers in different ratios through solvent evaporation method. As Solid dispersions have been traditionally used effective techniques to improve the dissolution properties and bioavailability of poorly-soluble drugs. The model drug selected Rosuvastatin Calcium, which is BCS class-II drug with antihyperlipidemic potential. The reported bioavailability from oral route of drug is only 20%. So aim of current study is to improve the solubility and dissolution rate of a poorly water-soluble drug Rosuvastatin Calcium, by solid dispersion technique. Physical mixtures and solid dispersions were prepared using Vitamin E TPGS, MGK & natural polymers A.Marmelos in different to drug to carrier ratios, dispersions were prepared by solvent evaporation technique. Prepared formulations were characterized in solid state by FTIR analysis, powder X-ray diffraction, Scanning electron microscopy and in-vitro dissolution study. The aqueous solubility of Rosuvastatin Calcium was favored by presence of both the polymers. Solid state characterizations indicated the Rosuvastatin Calcium was present in amorphous form and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure Rosuvastatin Calcium, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Solid dispersion prepared with TPGS showed maximum 91.19% Drug release. The best formulation of solid dispersion selected and subjected to fast dissolving tablets. The mixtures of solid dispersion and excipients were evaluated for pre-compression parameters. After then fast dissolving tablets were prepared by direct compression technique. The formulated tablets were evaluated by post compression parameters. In-vitro drug release performance of the developed formulations was investigated. Followed by that, the release mechanism of the formulations was also studied by applying various kinetic models. The overall results revealed that the formulated fast dissolving tablets complied with the standards and exhibited satisfactory performance in terms of drug release and other related parameters.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80282305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}