International Journal of Pharmaceutical Chemistry and Analysis最新文献_第9页

Immunomodulatory phytochemicals for chemoprevention 用于化学预防的免疫调节植物化学物质

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.011

S. Agrawal, P. Patil

引用次数: 0

Determination of potential sources of drug development for menstrual disorders: A qualitative analysis of published literature of in-vitro rat uterus experimental studies 确定月经紊乱药物开发的潜在来源:大鼠体外子宫实验研究的已发表文献的定性分析

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.010

Paroma Arefin, Md. Shehan Habib, A. Arefin, Md. Saidul Arefin

引用次数: 1

Medicinal plants used in cosmetics for skin and hair care 用于皮肤和头发护理化妆品的药用植物

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.008

Yogesh S Kolekar, F. Tamboli, H. More, Sajid A. Mulani, N. Mali

引用次数: 3

Chemical classification of MDM2 inhibitors MDM2抑制剂的化学分类

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.009

Chiragkumar J. Gohil, M. Noolvi, C. Patel, D. Sen

引用次数: 2

Doxycycline- A new tool in the armamentarium against the oldest known infection to mankind 强力霉素——对抗人类已知最古老感染的新工具

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.017

S. Yadav, G. Rawal

{"title":"Doxycycline- A new tool in the armamentarium against the oldest known infection to mankind","authors":"S. Yadav, G. Rawal","doi":"10.18231/J.IJPCA.2021.017","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.017","url":null,"abstract":"The developing world is having a number of issues related to healthcare.1 The situation in some of these countries is so grave that the population at large is lacking access to basic healthcare facilities.2 The diseases that have been commonly responsible for such situations are tuberculosis (TB), HIV, malaria, etc.3 TB is a public health problem.4 The disease is known to mankind for a long time and the first reports of this bacterial infection date to three million years ago.5 Globally the disease causes largescale morbidity and mortality.4 The WHO global report of the year 2020 estimated that ten million people developed active TB disease in 2019, with 1.4 million mortalities.6 The highest burden lying in WHO regions of South-East Asia, Africa, and the Western Pacific.6 The disease as detailed in the medical literature is a contagious, infectious disease, due to the bacterium Mycobacterium tuberculosis and has always been a major challenge over the course of human history, due to its severe social implications.5 The management of TB involves the use of drugs that are associated with multiple adverse effects and the treatment regimen is usually six months.7 The high pill burden, adverse drug reaction, social stigma, etc. are some of the common issues associated with TB management.8 The development and inclusion of newer drugs like Bedaquiline, Pretomanid, and Delamanid have","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90992363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of novel HPTLC method for determination of imidazole antifungal drug fenticonazole: Exploring hydrotropy 高效液相色谱法测定咪唑类抗真菌药物非替康唑含量的研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.016

Minakshi D. Pawara, Snehal S Pardeshi, Amol R. Gaware, A. Patil, M. V. Girase

{"title":"Development of novel HPTLC method for determination of imidazole antifungal drug fenticonazole: Exploring hydrotropy","authors":"Minakshi D. Pawara, Snehal S Pardeshi, Amol R. Gaware, A. Patil, M. V. Girase","doi":"10.18231/J.IJPCA.2021.016","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.016","url":null,"abstract":"A novel High-Performance Thin-Layer Chromatography (HPTLC) method was portrayed for the determination of Fenticonazole Nitrate (FTZ) in Bulk and Vaginal Capsules. The estimation of Fenticonazole Nitrate was achieved on aluminium pre-coated sheets of silica gel 60 F(10 cm × 10 cm) using mobile phase Toluene: Methanol: Triethylamine (4:1:0.5 v/v/v). Densitometry detection of Fenticonazole Nitrate was performed at 254nm. Fenticonazole nitrate demonstrated a strong correlation with a coefficient of correlation of 0.999 over the concentration range of 500 – 3000 ng/band. The Rvalue for Fenticonazole Nitrate was found to be 0.65. As per International Conference on Harmonization the established method was successfully validated to various parameters like accuracy, precision, sensitivity, specificity, robustness and shows the satisfactory results for all parameters. The recognized method is simple, accurate, precise, robust, sensitive and economical in nature. This method can be used for quality control analysis of Fenticonazole Nitrate in bulk and vaginal capsules.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91430685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of pimavanserin tartrate by normal phase- HPTLC method 正相高效液相色谱法制备酒石酸匹马万色林并对其进行验证

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-07-15 DOI: 10.18231/J.IJPCA.2021.015

Mohammad Mojeeb Gulzar Khan, Pawar Vivek Laxman, A. Talib, S. Firke, Mohan Ganpat Kalaskar, A. Shirkhedkar

引用次数: 0

A review: Pathophysiology, diagnosis and management of multiple sclerosis 综述:多发性硬化症的病理生理学、诊断和治疗

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-05-15 DOI: 10.18231/J.IJPCA.2021.003

Sourabh Jain, P. Shukla, A. Agrawal, Shikha Sharma

{"title":"A review: Pathophysiology, diagnosis and management of multiple sclerosis","authors":"Sourabh Jain, P. Shukla, A. Agrawal, Shikha Sharma","doi":"10.18231/J.IJPCA.2021.003","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.003","url":null,"abstract":"Multiple Sclerosis (MS) is common, non-traumatic disability disease which affects young peoples. The incidence of multiple sclerosis is increasing worldwide with socioeconomic impact of the disease. Multiple sclerosis affect about more than 2 million people and currently it is incurable. The ratio of effect of MS in women and men is 2:1 respectively. Approx 250, 000- to 350,000 people are diagnosed with MS in the USA and about 10,000 new cases diagnosed each year. The epidemiology of Multiple sclerosis indicates that low serum levels of vitamin D, smoking, obesity and infection etc. are likely to play a role in disease development. In case of treatment of MS, it is divided three phases include: symptomatic, acute attack and\u0000disease modifying methods. In case of symptomatic around helping to maintain a patient’s quality of life. Treatment of acute attack is centered on the treatment of exacerbations that affects a patient’s functional ability. In disease modifying treatment focuses on the long term management of the disease with the goal to reduce relapse rates, lessen severity and to slow the progression of disability.\u0000\u0000Keywords: Multiple Sclerosis (MS), Symptomatic, Acute attack and Disease modifying.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76534630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solubility: An overview 溶解度:概述

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-01-15 DOI: 10.18231/J.IJPCA.2020.027

A. Singh, N. Singh, A. Singh

引用次数: 1

Development and validation of dissolution test method for determination of cyclobenzaprine hydrochloride from its formulation using HPLC 高效液相色谱法测定盐酸环苯扎林的溶出度方法的建立与验证

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2021-01-15 DOI: 10.18231/J.IJPCA.2020.029

Yasmini T Parshuramkar, M. Umekar, K. R. Gupta

{"title":"Development and validation of dissolution test method for determination of cyclobenzaprine hydrochloride from its formulation using HPLC","authors":"Yasmini T Parshuramkar, M. Umekar, K. R. Gupta","doi":"10.18231/J.IJPCA.2020.029","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.029","url":null,"abstract":"Aim: The aim of present study was to develop and validate a dissolution test method for Cyclobenzaprine HCL in its formulation using RP-HPLC method.\u0000Design: Optimization of chromatographic parameters, development of the dissolution test method using RP-HPLC and to validate the developed methods as per ICH guidelines.\u0000Materials and Methods: The optimized dissolution parameters includes USP apparatus II at a paddle rotation rate of 50 rpm and 900 ml of 1.2 pH 0.1N HCL buffer at 37?C0.5?C. Under these conditions, the in vitro release profiles of cyclobenzaprine HCL showed good results. The drug release was estimated by RP-HPLC using column Shodex C18-4E (250×4.6mm×5mm), detection wavelength 289.4 nm having the flow rate 1.0 mL/min using Acetonitrile : phosphate buffer (3.0 pH) in the proportion of 65:35%v/v.\u0000Results: The percent drug amount released estimated by proposed method was found to be 99.04%, The method was found to be linear with correlation coefficient was found to be 0.9991 in the concentration range was 2-10 mg/mL. The mean % recovery of Cyclobenzaprine was found to be 100.04.Precision values observed less than 2.All the validation parameters were within the acceptance range.\u0000Conclusion: The results obtained by proposed dissolution method for tablet formulation containing Cyclobenzaprine HCL are reliable, precise and accurate. Hence it was routinely adopted for dissolution analysis of the said drugs in the formulation.\u0000\u0000Keywords: Cyclobenzaprine HCL, Dissolution test, RPHPLC, Validation.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72652167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0