International Journal of Pharmaceutical Chemistry and Analysis最新文献_第8页

Synthesis and screening for biological potential of some substituted chalcones 一些取代查尔酮的合成及生物潜能的筛选

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0013

K. Gupta, S. Badole, J. Gupta, S. Singh

引用次数: 0

Method development and validation of aliskiren in tablet formulation by UV spectrophotometric methods 紫外分光光度法测定阿利克连片剂的含量

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0014

Nita Yadav, A. Goyal

{"title":"Method development and validation of aliskiren in tablet formulation by UV spectrophotometric methods","authors":"Nita Yadav, A. Goyal","doi":"10.18231/2394-2797.2018.0014","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0014","url":null,"abstract":"Optical methods through ultraviolet-spectrophotometer were developed and justification was done to validate the method for quantitative determination of aliskiren in its tablet formulation. Wavelengths for different methods were chosen by running selected sample in spectrum mode of the instrument, it was 279 nm; absorbance maxima for zero order technique, 289 nm; peak minima for first order derivative technique and between 269 nm and 289 nm for AUC technique using distilled water as reference. After studying linearity graph, working concentration range selected for method I, method II and method III was in between 25 to 150 µg mL-1. R2 value equal to 0.999 confirmed a better correlation between concentration and absorbance. Percentage purity of aliskiren in tablet formulation was found in between 98.54-100.36 which was very close to label claim. Validation following ICH guidelines was done to justify the results obtained through method I, method II and method III. The percentage of the standard drug recovered in recovery study for all the three techniques were within the limit and were in between 98.61-101.66. The percentage relative standard deviation in precision study was less than 2 for all the techniques. From the observed data it can be said that the developed methods can be utilized for quantitative estimation of aliskiren in tablet formulation.\u0000\u0000Keywords: Ultraviolet-Spectrophotometer, Optical methods, Aliskiren, Validation, First order derivative, AUC","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82008756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedaquiline –A new drug against multidrug-resistant tuberculosis 贝达喹啉——一种治疗耐多药结核病的新药

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0017

S. Yadav, G. Rawal

引用次数: 0

Method development, degradation pathway and kinetic of capecitabine 卡培他滨的方法建立、降解途径及动力学

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0021

Dhara R. Patel

{"title":"Method development, degradation pathway and kinetic of capecitabine","authors":"Dhara R. Patel","doi":"10.18231/2394-2797.2018.0021","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0021","url":null,"abstract":"The present work describes a simple, accurate and precise Stability indicating RP-HPLC method for the estimation of Capecitabine (CPT) in bulk and pharmaceutical formulation. The Mobile phase used was Acetonitrile: Water (60: 40v/v) with 1ml/min. flow rate and 240nm was used as a wavelength maximum. The C18 HS (250 X 4.6) mm, 5 μm column was used as a stationary phase. The method was validated as per the ICHQ2 Guidelines. The retention time of CPT was found to be 3.3 min. A linear response was observed in the range of 10-50 μg/mL with a regression coefficient of 0.999. The LOD and LOQ were found to be 1.43μg/mL and 4.34μg/mL respectively. This method can be used for the determination of CPT in quality control of API and dosage form without interference of the excipients, impurities and degradation products and hence can be used as stability indicating assay method. CPT was subjected to degradation under different stress conditions recommended by ICH viz acid, alkali, photolytic, dry heat and oxidative condition. The samples so generated were used for degradation studies including degradation kinetic study using the developed method. The degradation pathway of CPT was found to be acid hydrolysis and temperature exceeding 100°c. The degradation kinetic study shows that the acid hydrolysis, alkaline hydrolysis and oxidative degradation of the CPT follow first order kinetic.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79502585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis and characterization of cefixime by using IR, HPLC and gas chromatography 头孢克肟的红外光谱、高效液相色谱和气相色谱分析与表征

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0012

M. P. Rao, B. R. Rao, M. Srikanth

引用次数: 1

Formulation and evaluation of sustained release mucoadhesive microspheres of lornoxicam by using novel isolated polymer of fruit artocarpus heterophyllus 新型分离聚合物制备氯诺昔康缓释黏附微球及评价

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0008

Bebee Pathare, V. Tambe, D. Waichal, R. Chanshetti, R. Pujari

{"title":"Formulation and evaluation of sustained release mucoadhesive microspheres of lornoxicam by using novel isolated polymer of fruit artocarpus heterophyllus","authors":"Bebee Pathare, V. Tambe, D. Waichal, R. Chanshetti, R. Pujari","doi":"10.18231/2394-2797.2018.0008","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0008","url":null,"abstract":"Objective: To investigate the potential of novel polymer isolated from fruit Artocarpus heterophyllus for mucoadhesion and sustained release action. Microspheres containing Lornoxicam formulated using isolated polymer offered a suitable, practical approach to achieve a prolonged therapeutic anti-inflammatory effect by continuously releasing the medication over extended period of time.\u0000Materials and Methods: D-Optimal design was applied to optimize the fruit polymer and sodium tripolyphosphate concentration which was used as a cross-linking agent.\u0000Result: Fruit polymer and sodium tripolyphosphate concentration has significant impact on % entrapment efficiency, mucoadhesivity, and in vitro release. Differential scanning calorimetry and infrared spectroscopy results indicates that no interaction between drug and excipients. Polynomial models were validated using one way ANOVA and results indicated that isolated fruit polymer and sodium tripolyphosphate used have significant effect on selected response (p","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91526608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Early administration of Ivermectin, Azithromycin & Doxycycline along with I.V. Prednisolone in a case of COVID -19 disease may lead to early recovery? 在COVID -19病例中，早期给予伊维菌素、阿奇霉素和强力霉素以及静脉注射强的松龙可能导致早期康复?

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2020-10-15 DOI: 10.18231/j.ijpca.2020.023

A. Prasad

{"title":"Early administration of Ivermectin, Azithromycin & Doxycycline along with I.V. Prednisolone in a case of COVID -19 disease may lead to early recovery?","authors":"A. Prasad","doi":"10.18231/j.ijpca.2020.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.023","url":null,"abstract":"A case of high-grade fever with chills for 5 days with shortness of breath since 12 an hour and mild abdominal discomfort is being presented in this report. A 62-year-old female doctor who was a known asthmatic for the last 20 years (on Seretide accuhaler S.O.S) presented with a history of heat exhaustion 7 days back, no history of nausea/vomiting/diarrhoea/sore throat or cough. Clinical examination revealed a fever of 101.8®F, SpO2- 94%, blood pressure of 100/70, and pulse rate of 100/min. Breath sounds were normal vesicular, heart sounds normal and no murmur present. In investigations, Real-time PCR for COVID-19 was done on 02/06/20 and came out to be positive. HRCT chest revealed few multifocal\u0000patchy areas of subpleural ground-glass haze in both the lungs with associated patchy fibrosis. She was treated with Azithromycin (500 mg OD x 5 days) and Ivermectin (6mg BD x 3 days /orally) along with Doxycycline 100 mg BD x 5 days and high flow oxygen. Prednisolone 50 mg/I.V. OD for 5 days followed by Dexamethasone (6mg P.O. and Monocef 1.5 gm x I.V. x BD x 5 days were added when SpO2 of less than 90% was recorded and the patient complained of breathlessness and chest discomfort. A repeat test for COVID -19 was done on 20.06.20 which came out to be positive followed by a third test on 22.06.20 which came out negative. The patient recovered after 15 days of admission and was requested to get a repeat CT\u0000chest / Xray done after a month.\u0000\u0000Keywords: Dexamethasone, Azithromycin, Doxycycline, COVID 19.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Formulation and characterization of cyclophosphamide injections using lyophilization technique 冻干技术制备环磷酰胺注射剂的配方及性能研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2019-10-28 DOI: 10.18231/j.ijpca.2019.014

G. Srikar, D. Chakradhar, A. Sunitha, B. Sofía, Pharmaceutical Analysis

{"title":"Formulation and characterization of cyclophosphamide injections using lyophilization technique","authors":"G. Srikar, D. Chakradhar, A. Sunitha, B. Sofía, Pharmaceutical Analysis","doi":"10.18231/j.ijpca.2019.014","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.014","url":null,"abstract":"Introduction: The parenteral route of administration is generally adopted for rapid onset of action and 100% bioavailability especially for the drugs which have poor bioavailability through peroral route. Newly developed drugs often show poor solubility and require novel dosage forms such as liposomes, nanoparticles to minimize solubility problems and side effects due to toxicity. These dosage forms are often inherently labile due to agglomeration, sedimentation etc., and can be stabilized and manufactured by freeze drying. Lyophilization is the most common method for manufacturing solid pharmaceuticals products and is central to the preservation of materials which must be dried thoroughly in order to ensure stability and require a gentle, easily sterilizable process. Materials and Methods: The current research work involves the formulation of cyclophosphamide injections using lyophilization technique by using different concentrations of cyclophosphamide. The formulated cyclophosphamide injections are further subjected to different evaluation tests such as melting point, differential scanning calorimetry, dissolution rate study, solution stability, pH stability, rubber stopper compatibility and photostability. Results: The moisture content of the formulation is greatly reduced to as low as 0.9% (w/w) thus enhancing the stability of the product. Conclusion: The lyophilized technique proved to be an advantage for the development of stable injectable dosage form of Cyclophosphamide.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80735041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver nanoparticles used in the antibacterial preparations 纳米银在抗菌制剂中的应用

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2019-10-28 DOI: 10.18231/j.ijpca.2019.011

C. Yadav, Vaishnav Rajat, A. Goyal

引用次数: 0

Medications mostly used in dentistry 主要用于牙科的药物

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2019-10-28 DOI: 10.18231/j.ijpca.2019.012

S. Hassan, Sumit Bheteja, Geetika Arora

引用次数: 0