Early administration of Ivermectin, Azithromycin & Doxycycline along with I.V. Prednisolone in a case of COVID -19 disease may lead to early recovery?

A. Prasad
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引用次数: 5

Abstract

A case of high-grade fever with chills for 5 days with shortness of breath since 12 an hour and mild abdominal discomfort is being presented in this report. A 62-year-old female doctor who was a known asthmatic for the last 20 years (on Seretide accuhaler S.O.S) presented with a history of heat exhaustion 7 days back, no history of nausea/vomiting/diarrhoea/sore throat or cough. Clinical examination revealed a fever of 101.8®F, SpO2- 94%, blood pressure of 100/70, and pulse rate of 100/min. Breath sounds were normal vesicular, heart sounds normal and no murmur present. In investigations, Real-time PCR for COVID-19 was done on 02/06/20 and came out to be positive. HRCT chest revealed few multifocal patchy areas of subpleural ground-glass haze in both the lungs with associated patchy fibrosis. She was treated with Azithromycin (500 mg OD x 5 days) and Ivermectin (6mg BD x 3 days /orally) along with Doxycycline 100 mg BD x 5 days and high flow oxygen. Prednisolone 50 mg/I.V. OD for 5 days followed by Dexamethasone (6mg P.O. and Monocef 1.5 gm x I.V. x BD x 5 days were added when SpO2 of less than 90% was recorded and the patient complained of breathlessness and chest discomfort. A repeat test for COVID -19 was done on 20.06.20 which came out to be positive followed by a third test on 22.06.20 which came out negative. The patient recovered after 15 days of admission and was requested to get a repeat CT chest / Xray done after a month. Keywords: Dexamethasone, Azithromycin, Doxycycline, COVID 19.
在COVID -19病例中,早期给予伊维菌素、阿奇霉素和强力霉素以及静脉注射强的松龙可能导致早期康复?
本报告报告一例高热伴发冷5天,每小时12分起呼吸急促,腹部轻度不适。一名62岁女医生,已知有20年的哮喘病史(使用舒雷替纳药S.O.S), 7天前出现中暑史,无恶心/呕吐/腹泻/喉咙痛或咳嗽史。临床检查:发热101.8°F, SpO2- 94%,血压100/70,脉搏100次/min。呼吸音正常,心音正常,无杂音。在调查中,于20年6月2日进行了COVID-19实时荧光定量PCR,结果为阳性。胸部HRCT显示双肺胸膜下少量多灶斑片状磨玻璃雾,伴斑片状纤维化。患者给予阿奇霉素(500mg OD × 5天)、伊维菌素(6mg BD × 3天/口服)、强力霉素100mg BD × 5天及高流量氧治疗。强的松龙50mg /静脉注射当SpO2低于90%且患者出现呼吸困难、胸部不适时,给予用药过量(OD) 5 d,随后给予地塞米松(6mg P.O.)和莫诺塞夫1.5 gm x静脉滴注x BD x 5 d。20年6月20日再次检测呈阳性,6月22日第三次检测呈阴性。患者入院15天后恢复,并要求在一个月后再次进行ct胸部/ x光检查。关键词:地塞米松,阿奇霉素,强力霉素,COVID - 19
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