{"title":"Early administration of Ivermectin, Azithromycin & Doxycycline along with I.V. Prednisolone in a case of COVID -19 disease may lead to early recovery?","authors":"A. Prasad","doi":"10.18231/j.ijpca.2020.023","DOIUrl":null,"url":null,"abstract":"A case of high-grade fever with chills for 5 days with shortness of breath since 12 an hour and mild abdominal discomfort is being presented in this report. A 62-year-old female doctor who was a known asthmatic for the last 20 years (on Seretide accuhaler S.O.S) presented with a history of heat exhaustion 7 days back, no history of nausea/vomiting/diarrhoea/sore throat or cough. Clinical examination revealed a fever of 101.8®F, SpO2- 94%, blood pressure of 100/70, and pulse rate of 100/min. Breath sounds were normal vesicular, heart sounds normal and no murmur present. In investigations, Real-time PCR for COVID-19 was done on 02/06/20 and came out to be positive. HRCT chest revealed few multifocal\npatchy areas of subpleural ground-glass haze in both the lungs with associated patchy fibrosis. She was treated with Azithromycin (500 mg OD x 5 days) and Ivermectin (6mg BD x 3 days /orally) along with Doxycycline 100 mg BD x 5 days and high flow oxygen. Prednisolone 50 mg/I.V. OD for 5 days followed by Dexamethasone (6mg P.O. and Monocef 1.5 gm x I.V. x BD x 5 days were added when SpO2 of less than 90% was recorded and the patient complained of breathlessness and chest discomfort. A repeat test for COVID -19 was done on 20.06.20 which came out to be positive followed by a third test on 22.06.20 which came out negative. The patient recovered after 15 days of admission and was requested to get a repeat CT\nchest / Xray done after a month.\n\nKeywords: Dexamethasone, Azithromycin, Doxycycline, COVID 19.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"70 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Chemistry and Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/j.ijpca.2020.023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
A case of high-grade fever with chills for 5 days with shortness of breath since 12 an hour and mild abdominal discomfort is being presented in this report. A 62-year-old female doctor who was a known asthmatic for the last 20 years (on Seretide accuhaler S.O.S) presented with a history of heat exhaustion 7 days back, no history of nausea/vomiting/diarrhoea/sore throat or cough. Clinical examination revealed a fever of 101.8®F, SpO2- 94%, blood pressure of 100/70, and pulse rate of 100/min. Breath sounds were normal vesicular, heart sounds normal and no murmur present. In investigations, Real-time PCR for COVID-19 was done on 02/06/20 and came out to be positive. HRCT chest revealed few multifocal
patchy areas of subpleural ground-glass haze in both the lungs with associated patchy fibrosis. She was treated with Azithromycin (500 mg OD x 5 days) and Ivermectin (6mg BD x 3 days /orally) along with Doxycycline 100 mg BD x 5 days and high flow oxygen. Prednisolone 50 mg/I.V. OD for 5 days followed by Dexamethasone (6mg P.O. and Monocef 1.5 gm x I.V. x BD x 5 days were added when SpO2 of less than 90% was recorded and the patient complained of breathlessness and chest discomfort. A repeat test for COVID -19 was done on 20.06.20 which came out to be positive followed by a third test on 22.06.20 which came out negative. The patient recovered after 15 days of admission and was requested to get a repeat CT
chest / Xray done after a month.
Keywords: Dexamethasone, Azithromycin, Doxycycline, COVID 19.