A. Shetti, Bhaskaran Ashokan, Mangesh Hivre, Jayanthi D., Rachita G Mustilwar, Krishan Kant
{"title":"From scalpels to algorithms: The next step in surgical advancement","authors":"A. Shetti, Bhaskaran Ashokan, Mangesh Hivre, Jayanthi D., Rachita G Mustilwar, Krishan Kant","doi":"10.18231/j.ijpca.2023.012","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.012","url":null,"abstract":"The field of surgery has come a long way since the days of sharpened stones and crude instruments. Today, medical professionals rely on a range of high-tech tools and technologies to perform a wide variety of procedures, from routine operations to life-saving treatments. As surgical technology continues to advance, many experts believe that algorithms will play an increasingly important role in the operating room of the future. Algorithms, which are sets of mathematical instructions that help computers solve complex problems, can be used in a number of ways to enhance the surgical process. For example, they can be used to create virtual simulations of surgical procedures, allowing medical professionals to practice and perfect their techniques in a safe and controlled environment. Algorithms can also be used to analyze patient data, providing doctors with valuable insights into the best ways to approach a particular case. Another area where algorithms are expected to make a big impact is in the field of robotics. Robotic systems can be programmed to perform complex surgical procedures with greater precision and accuracy than is possible with human hands alone. In addition, robots can be equipped with algorithms that help them make real-time decisions during a procedure, ensuring that the patient receives the best possible care. Overall, the integration of algorithms into the surgical process represents a major step forward in the field of medicine.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78929113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An extensive review on tier 2 safety pharmacology","authors":"Keval Y. Raval, P. Tirgar","doi":"10.18231/j.ijpca.2023.015","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.015","url":null,"abstract":"This study provides a comprehensive overview of safety pharmacology practises, technologies, and emerging concepts in drug discovery and development. The field of safety pharmacology serves a crucial role in anticipating and minimising the hazards and adverse effects of new medications. Evaluation of important organ systems, such as the cardiovascular, central nervous, respiratory, gastrointestinal, and renal systems, is involved. While the main battery of safety pharmacology research focuses on major organ systems, additional studies may be done depending on the unique properties of prospective medications. The research emphasises the significance of evaluating the gastrointestinal and renal systems and addresses the many approaches, biomarkers, and technologies used to enhance safety evaluations. In addition, new ideas like as frontloading, alternative models, and the incorporation of safety pharmacology endpoints into regulatory toxicology studies are investigated. These developments help to better informed decision-making and lead candidate selection, eventually improving the safety and effectiveness of novel treatments.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80070857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shetti, Shailesh Shenoy, Z. Pasha, Suresh Rajendiran, S. Ahmed, Krishan Kant
{"title":"The intersection of pharmacology and dentistry: A comprehensive overview of pharmacotherapeutics","authors":"A. Shetti, Shailesh Shenoy, Z. Pasha, Suresh Rajendiran, S. Ahmed, Krishan Kant","doi":"10.18231/j.ijpca.2023.013","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.013","url":null,"abstract":"Pharmacotherapy is an essential component of dental practice to manage pain, prevent infections, and maintain oral health. Analgesics such as non steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly used to manage pain during and after dental procedures. Antibiotics are prescribed to treat and prevent infections, but their use should be limited to reduce the risk of antibiotic resistance. Local anesthetics provide safe and effective pain relief during dental procedures. Fluorides are used to prevent tooth decay and strengthen tooth enamel. Dental healthcare providers should evaluate each patient's individual needs and medical history to determine the most appropriate pharmacotherapy. Patient education on the proper use of medications and potential side effects is also important. By incorporating pharmacotherapy as part of a comprehensive dental care plan, patients can experience a more comfortable and successful dental experience.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81939979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. A. Hajam, Neelam Bhatti, Rajesh Kumar, Shweta Singh, I. Kumari
{"title":"Comparative antibacterial and antifungal activities of Cinnamomum Tamala Nees & Eberm. and Taraxicum officinale leaf extract","authors":"Y. A. Hajam, Neelam Bhatti, Rajesh Kumar, Shweta Singh, I. Kumari","doi":"10.18231/j.ijpca.2023.007","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.007","url":null,"abstract":"Present study proposed to analyse the antibacterial and antifungal activities of Nees & Eberm. And leaf extract against well-known pathogenic bacteria and andand Extract was prepared in 70% ethanol using soxhelt extraction unit. Paper disc diffusion method was used for antibacterial and antifungal activities of extract. The culture was maintained in nutrient agar medium during the whole experiment. Penicillin and tetracycline were used as standard antibiotics for comparative antibacterial assessment of extracts and sabaround’s browth medium was for assessment of antifungal activities of extract. taken as standard to compare the antifungal activities. Results of the current study revealed that leaf extract can be used in the formulation of antibacterial and antifungal drugs.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86149089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. A. Shaikh, J. Pawar, Sachin J. Anbhule, V. Kakade
{"title":"Review on nanoparticles for topical drug delivery","authors":"A. A. Shaikh, J. Pawar, Sachin J. Anbhule, V. Kakade","doi":"10.18231/j.ijpca.2023.003","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.003","url":null,"abstract":"An overview of the use of nanoparticles for topical drug delivery will be given in this review paper. Several experiments have been conducted in the past 25 years to remove some of the obstacles to skin delivery. These investigations have led to a rather modest progress in technology. A more recent method involved increasing the medication's concentration in the carrier to increase drug flow into and through the skin. Hydrophobic and hydrophilic medications can be delivered using nanoparticles, which have the ability to release drugs under regulated conditions over an extended period of time. It also increases patient compliance. Liposomes and solid lipid nanoparticles have the potential to be useful as topical medication delivery methods.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76900861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shetti, A. R. Kumar, A. Nagaraj, Shramana M. Banerjee, Ashwin A.B., Nidhal S Mohamed
{"title":"Anesthesiology's next frontier: Exploring the boundless potential of artificial intelligence","authors":"A. Shetti, A. R. Kumar, A. Nagaraj, Shramana M. Banerjee, Ashwin A.B., Nidhal S Mohamed","doi":"10.18231/j.ijpca.2023.002","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.002","url":null,"abstract":"Artificial Intelligence (AI) is a rapidly growing field that has the potential to revolutionize various industries, including healthcare. In the field of anesthesia, AI has shown great promise in improving patient outcomes and enhancing the overall efficiency and safety of anesthesia practices. One of the main ways AI is being used in anesthesia is through predictive modeling, where machine learning algorithms are trained on large datasets to identify patterns and make predictions about patient outcomes. For example, AI can be used to predict patient response to anesthesia, predict the likelihood of postoperative complications, or optimize drug dosing. This allows anesthesiologists to make more informed decisions and reduce the risk of adverse events. Another area where AI is being used in anesthesia is in computer-assisted drug dosing. With the help of AI, anesthesiologists can determine the optimal dose of anesthesia for each patient, taking into account factors such as age, weight, medical history, and the type of surgery being performed. This helps to improve patient safety and reduce the risk of adverse events. As AI technology continues to advance, it is likely that the use of AI in anesthesia will become more widespread, and it will play an increasingly important role in improving patient outcomes and enhancing the overall quality of care in the field of anesthesia. Overall, the integration of AI in anesthesia is a promising development that has the potential to transform the field and improve patient outcomes. Telemedicine is one of the area where AI is utilized which will drastically contribute the healthcare system especially for underdeveloped and developing countries.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81901933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A stability indicating RP-HPLC method development and validation for simultaneous quantification for assay of rifampicin in pharmaceutical solid dosage form","authors":"MD Nazmus Sakib Chowdhury","doi":"10.18231/j.ijpca.2023.010","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.010","url":null,"abstract":"A cost effective stability indicating reverse phase high performance liquid chromatography (RP-HPLC) for simultaneous quantification for assay of Rifampicin in pharmaceutical solid dosage form (tablets) was developed and validated. Chromatographic procedure was conducted using stationary phase packing c18 column (Luna), having 5 µm particle size with inner diameter (250 x 4.6) mm, mobile phase consists of 60% acetate buffer (pH 4.5) and 40% acetonitrile (HPLC grade of sharlau manufacturer). The detection wavelength was uv 254 nm with flow rate of 1.0 ml/min and injection volume was 10 µL with run time 10 min. Based on proposed method validation was conducted following system precision, specificity or selectivity, method precision, accuracy, linearity, robustness, solution stability, limit of quantitation (LOQ), limit of detection. It was observed the system (Waters, HPLC) was precise enough to quantify Rifampicin, no interference of blank, placebo or other known impurity at the elution zone of Rifampicin; % RSD for six sample solutions of Rifampicin was 0.9% (% average assay: 98.7%); accuracy observed 101.1% for 80% recovery, 100.4% for 100% recovery and 100.5% for 120% recovery; co-relation coefficient of linearity (r =1.000); limit of quantification (LOQ) found 0.18 ppm.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73532546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and validation of stability indicating RP-HPLC method for determination of aspirin and pantoprazole sodium in synthetic mixture stability indicating HPLC method","authors":"Preetiben N. Yadav, Pinak Patel, Rashmi Shukla, Krunal Detholia, Anamika Singh","doi":"10.18231/j.ijpca.2023.006","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.006","url":null,"abstract":"The present study describes a new accurate and precise stability indicating reverse phase HPLC method for quantitative computation of pantoprazole sodium and Aspirin from physical simulated mixture. The proposed chromatographic method employs Hypersil ODS C18 column (250 x 4.6 mm, 5μ) as the stationary phase and combination of methyl alcohol and water in ratio of 70: 30 v/v as the elution medium. Overall separation was carried out at 0.8 ml/minute flow rate and elution was monitored at 254 nm. The proposed system gave well resolved peak of Aspirin and Pantoprazole sodium with elution time of 2.32 and 5.85 minute respectively. Same system was effective in separation of active components and degradation products when the components were subjected to forced degradation as per regulatory guidelines (ICHQ1). Finally, the optimized method was successfully validated as per ICH Q2R1 guidelines and applied for quantitative analysis of both active components in synthetic mixture.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88604331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Higher prevalence of Listeriosis in Indian subcontinent, a food related menace","authors":"S. Chaudhry","doi":"10.18231/j.ijpca.2023.001","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.001","url":null,"abstract":"The recent emergence of zoonotic disease from L. monocytogenes transmitted directly from infected animals and contaminated food products to humans is on rise in many developing countries. The calculated prevalence in south-east Asia is about 22.2 %. Orations on update are regularly conducted in some countries like Sri Lanka.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82806674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review on specific and sensitive analytical method development and validation","authors":"MD Nazmus Sakib Chowdhury","doi":"10.18231/j.ijpca.2023.005","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.005","url":null,"abstract":"A specific and sensitive analytical method development and validation plays an important role for building drug discovery, product development and manufacturing of pharmaceuticals. The main purpose of this review article is to check the report of specific and sensitive analytical method development and validation parameters involved in different pharmaceuticals manufacturing. Development of sensitive analytical method is extremely much significant because it ensures product efficacy and product quality. The sensitive analytical method development and validation is the process of proving that the analytical method meets the analytical acceptance criteria and it can use to measure the concentration of target molecule at its specification limit. The aim of method development is to produce a reproducible specific and sensitive analytical method in a cost effective manner. The parameters of validation involved are introduced as specificity, method precision, accuracy, linearity, limit of detection (LOD), limit of quantitation (LOQ), ruggedness, robustness and system precision of the target molecule.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90872248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}