An extensive review on tier 2 safety pharmacology

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2023-07-15 DOI:10.18231/j.ijpca.2023.015

Keval Y. Raval, P. Tirgar

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Abstract

This study provides a comprehensive overview of safety pharmacology practises, technologies, and emerging concepts in drug discovery and development. The field of safety pharmacology serves a crucial role in anticipating and minimising the hazards and adverse effects of new medications. Evaluation of important organ systems, such as the cardiovascular, central nervous, respiratory, gastrointestinal, and renal systems, is involved. While the main battery of safety pharmacology research focuses on major organ systems, additional studies may be done depending on the unique properties of prospective medications. The research emphasises the significance of evaluating the gastrointestinal and renal systems and addresses the many approaches, biomarkers, and technologies used to enhance safety evaluations. In addition, new ideas like as frontloading, alternative models, and the incorporation of safety pharmacology endpoints into regulatory toxicology studies are investigated. These developments help to better informed decision-making and lead candidate selection, eventually improving the safety and effectiveness of novel treatments.

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对二级安全药理学的广泛回顾

本研究提供了安全药理学实践，技术和药物发现和开发的新兴概念的全面概述。安全药理学领域在预测和减少新药物的危害和不良反应方面起着至关重要的作用。评估重要的器官系统，如心血管系统、中枢神经系统、呼吸系统、胃肠系统和肾脏系统。虽然主要的安全药理学研究集中在主要的器官系统上，但根据未来药物的独特特性，可能会进行额外的研究。该研究强调了评估胃肠道和肾脏系统的重要性，并讨论了用于加强安全性评估的许多方法、生物标志物和技术。此外，新的想法，如前负荷，替代模型，并纳入安全药理学终点纳入监管毒理学研究进行了调查。这些发展有助于更好地做出明智的决策和选择主要候选药物，最终提高新疗法的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Pharmaceutical Chemistry and Analysis

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