International Journal of Drug Delivery Technology最新文献_第4页

Synthesis and Characterization of Co3O4 Spinel Nanoparticles with Antibacterial Activity 具有抗菌活性的Co3O4尖晶石纳米颗粒的合成与表征

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.37

Mustafa Hammadi, Rulla Sabah, Esam H Hummadi

{"title":"Synthesis and Characterization of Co3O4 Spinel Nanoparticles with Antibacterial Activity","authors":"Mustafa Hammadi, Rulla Sabah, Esam H Hummadi","doi":"10.25258/ijddt.13.3.37","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.37","url":null,"abstract":"Nanoparticles are abundant and usable in the medical field as an antibiotic. It has been found that metal oxide nanoparticles, such as Co3O4, are efficient against bacteria that are resistant to antibiotics. Escherichia and Staphylococcus bring on enteric sickness and other illnesses. This study used co-precipitation to create Co3O4 nanoparticles. SEM, X-ray diffraction (XRD), and Fourier-transform infrared (FTIR) spectroscopy were used to analyze these oxide nanoparticles. The XRD pattern validated the Co3O4 crystalline match. SEM also showed the morphology of Co3O4 nanoparticles. As determined by X-rays, Co3O4 has an average diameter of around 37.08 nm. The Co3O4 nanoparticles were highly pure, showed by an energy-dispersive EDX pattern. Both on their own and in conjunction with cephalexin, these metal oxide nanoparticles demonstrated antibacterial efficacy against S. aureus and E. coli. These Co3O4 nanoparticles showed high growth inhibition compared with using cephalexin individually. These conclusions found that the presence of cephalexin with Co3O4 showed high growth inhibition. The antibacterial activity of Co3O4 nanoparticles should be subjected for further studies.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Screening, Molecular Docking, and ADMET Analysis of Flavonoids as a Potential Pi3k Inhibitor for Cancer Treatment 类黄酮作为Pi3k抑制剂的虚拟筛选、分子对接和ADMET分析

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.31

Khushabu Patil, Mahesh Nemade, Anjali Bedse, Piyush Bedse, Rakesh Ranjan, Harshal Tare, Manish Bedse

引用次数: 0

Synthesis, Characterization, Biological Activity and Thermal Study of New Complexes [Ni II, Hg II and La III] from Mixed Ligands (Curcumin and Azo compounds type N2O2) 混合配体(姜黄素和N2O2型偶氮化合物)新配合物[Ni II, Hg II和La III]的合成、表征、生物活性和热研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.42

Muna A Shakir, Wurood A Jaafar, Malath K Rasheed

引用次数: 0

Assessment of Blood Lipids in People with Chronic Hypertensive 慢性高血压患者血脂的评估

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.50

Methaq N Mahmood, Noor S Hasan, Sabreen H Majeed

{"title":"Assessment of Blood Lipids in People with Chronic Hypertensive","authors":"Methaq N Mahmood, Noor S Hasan, Sabreen H Majeed","doi":"10.25258/ijddt.13.3.50","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.50","url":null,"abstract":"High blood pressure remains one of the world’s leading health problems. High blood pressure is already manageable, and early detection can prevent complications by using therapy or changing lifestyle to healthy habits. High blood pressure and dyslipidemia are two of the main hazard factors for cardiovascular disease. The current study was conducted on 60 male and female samples aged 35 to 70 years, which divided the samples into three groups each group including 20 samples. The first group are healthy people who don’t have high blood pressure or chronic diseases (control group), the second group of patients with chronic hypertension without treatment but follow lifestyle modification, and the third group of patients with chronic hypertension with treatment the active substance hydrochlorothiazide and Losartan potassium, The regulated questionnaire information was recorded for all members of the sample and was measured the lipid profile test of triglycerides, cholesterol, lipoprotein (HDL, VLDL, LDL) in serum, atherogenic index plasma, body mass index (BMI), waistline. Levels of triglycerides and cholesterol were a non-significant increase in group of patients hypertensive without treatment and a significant increase in group of patients hypertensive with treatment than the control group. The results of lipoproteins showed non-significant differences than the control group while there was a significant increase in the VLDL level of group patients hypertensive with treatment than the control group. The results also indicated non-significant differences in the groups of atherogenic index plasma, body mass index and waistline measurement except for group of patients hypertensive without treatment that showed a significant increase in BMI than control group.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Film Forming Ability of Newly Synthesized Rosin Esters 新合成松香酯的成膜性能研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.22

Pramod Burakale, Suresh Sudke, Manish Bhise, Harshal Tare, Ramanlal Kachave

{"title":"Exploring Film Forming Ability of Newly Synthesized Rosin Esters","authors":"Pramod Burakale, Suresh Sudke, Manish Bhise, Harshal Tare, Ramanlal Kachave","doi":"10.25258/ijddt.13.3.22","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.22","url":null,"abstract":"The present investigation was planned to confirm the film-forming potential of synthesized rosin esters. The free films of rosin esters were prepared by solvent evaporation and characterized for the physicochemical and mechanical attributes. Suitable concentrations of rosin esters were used for coating tablets, and coated tablets were evaluated for official and unofficial quality control tests. The free films had low tensile strength, higher percent elongation value, and smooth surfaces. Therefore, the plasticizer was used to provide tensile strength to the films. The tablets were coated rapidly without agglomeration, confirming the suitability of rosin esters as a coating agent. The drug release from tablets was delayed up to 6 to 8 hours because of 10% w/w coating of rosin ester, and regioselectivity was achieved by coating with hydroxypropyl methylcellulose with sodium bicarbonate. The pH-dependent solubility of rosin esters produces chrono-triggered drug release from coated tablets. The present investigation confirms the suitability of newly synthesized rosin esters in in designing a region selective chrono- triggered drug delivery system.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Adding Taurine to Gabapentin on Toronto Clinical Neuropathy Score in Patient with Diabetic Neuropathy 加巴喷丁加牛磺酸对糖尿病神经病变多伦多临床神经病变评分的影响

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.54

Haider R Mohammad, Mohammed M Mohammed, Ahmed A Hlail

{"title":"Effect of Adding Taurine to Gabapentin on Toronto Clinical Neuropathy Score in Patient with Diabetic Neuropathy","authors":"Haider R Mohammad, Mohammed M Mohammed, Ahmed A Hlail","doi":"10.25258/ijddt.13.3.54","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.54","url":null,"abstract":"Diabetic neuropathy is a type of nerve damage that can occur in patients with diabetes mellitus. High blood glucose can injure nerves throughout the body. Diabetic neuropathy most often damages nerves in the legs and feet causing symptoms like pain and numbness. Taurine has been widely investigated regarding to its properties as a neuroprotective agent, antioxidant, anti-inflammatory in several neurodegenerative diseases. A sample consist of 40 participants enrolled randomly into two groups; group A, 20 patients treated with gabapentin capsules 300 mg once daily at night for 3 consecutive months, and group B, 20 patients treated with gabapentin capsules 300 mg once daily at night plus taurine 1 g thrice daily for 3 consecutive months. Adding taurine in combination with gabapentin significantly improves numbness, tingling, and temperature when compared with gabapentin alone. As well as, has a highly significant improving on ataxia. Taurine is better in improving insulin sensitivity due to lowering HbA1c level significantly, beside a medium degree in increasing insulin secretion; as evidenced by decreased fasting serum glucose, decreased HbA1c significantly, increased insulin level significantly, and increased C-peptide level. The conclusion of this study, adding taurine to patients with diabetic neuropathy has a significant improving effect on Toronto clinical neuropathy score by alleviating signs and symptoms, and improving insulin sensitivity.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Pot Synthesis of 1-(phenyl)-1H Indoles, their Biological Screening and ADME Studies 1-(苯基)- 1h吲哚的一锅合成及其生物学筛选和ADME研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.30

Tirth Thaker, Dipen Panchani, Vaishal Bhuva

引用次数: 0

Development and Validation of a Stability-Indicating RP-HPLC Method for Estimation of Glibenclamidei Bulk and Pharmaceutical Formulation 稳定性指示反相高效液相色谱法测定格列本脲原料药及制剂的含量

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.17

Jirvankar Pranita, Rishabh Agrawal, Nikhita Chambhare, Sahare A.Y

{"title":"Development and Validation of a Stability-Indicating RP-HPLC Method for Estimation of Glibenclamidei Bulk and Pharmaceutical Formulation","authors":"Jirvankar Pranita, Rishabh Agrawal, Nikhita Chambhare, Sahare A.Y","doi":"10.25258/ijddt.13.3.17","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.17","url":null,"abstract":"Glibenclamide is the choice of medicine for diabetes type II. There are numerous methods for estimation; however the methods are either not suitable or expensive. A simple, cheap, precise, and accurate stability-indicating HPLC method was developed and further validated. The wavelength of 229 nm with a constant flow rate of (Methanol: Mixed Phosphate Buffer, 70:30% v/v (pH 7.3)) 1 mL/min was used during the experimentation. The run time was (run time). The internal standard used was (Internal standard). The sample eluted and showed a sharp peak at 2.1 minutes. It was discovered that calibration curve experiments had a 5–50 ppm linearity. The precision of the developed method was lower than 2% RSD. Recovery studies showed that the method’s accuracy and precision ranged from 99.25 to 101.81%. Stress testing was used to determine specificity. The developed method was capable of separating the drug peak from any probable degradation products. There was no evidence of recipient or impurity interference. The method can be used to anticipate how long glibenclamide will be stable. The method was feasible and appropriate for analyzing the presence of glibenclamide in a drug substance as well as a drug product.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Evaluation of Herbal Shampoo as an Antifungal Formulation 草药香波抗真菌制剂的研制与评价

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.23

Milind Dyagatwar, Bhushan Pimple, Mohini Kuchekar, Suvarna Vadje, Siddhant Gaikwad, Vanita Bhurkunde, Harshal Tare, Deshraj Chumbhale

引用次数: 0

Design of Mouth Dissolving Polyherbal Films for Dental Caries 口腔溶解型多草药龋膜的设计

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.35

Sushma M, Ashoka Babu VL, Sharon C Furtado, Aishwarya R, Jyothi Lakshmi N

引用次数: 0