International Journal of Drug Delivery Technology最新文献_第10页

Knowledge of The HILIC Retention Behaviors of Two Quinolone Antibiotics on Sulfobetaine-Type Zwitterionic Stationary Phases 两种喹诺酮类抗生素在磺胺甜菜碱型两性离子固定相上的HILIC保留行为研究

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.60

Bashaer A. Al-Aphalahy, A. W. Qassim, R. R. Karabat

{"title":"Knowledge of The HILIC Retention Behaviors of Two Quinolone Antibiotics on Sulfobetaine-Type Zwitterionic Stationary Phases","authors":"Bashaer A. Al-Aphalahy, A. W. Qassim, R. R. Karabat","doi":"10.25258/ijddt.13.1.60","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.60","url":null,"abstract":"Fluoroquinolones treat infections of the urinary, respiratory, gastrointestinal, skin, bone, and joint systems. This article describes the development of the hydrophilic interaction liquid chromatography (ZIC-HILIC) method to determine norfl oxacin and ofl oxacin retention characteristics. Separation of all analytes was accomplished using ZIC-HILIC1 and ZIC-HILIC4 columns. The mobile phase was 40 mM sodium acetate water solution in acetonitrile pumped at a 0.7 mL/min fl ow rate. The infl uence of acetonitrile concentration, the presence of salt in the mobile phase, and pH on the retention of norfl oxacin and ofl oxacin in the HILIC mode were investigated in this study. When using ZIC-HILIC columns, it was discovered that the retention factors of the analytes were inversely proportional to the amount of water present in the mobile phase, which is representative of a conventional hydrophilic partitioning mechanism. The ZIC-HILIC based strategies described in this article represent a signifi cant step toward more sensitive drug analysis. We observed that zwitterionic materials could govern the separation of materials, as shown by the infl uence of the chain length between the zwitterion groups, which contributed to the explanation of the variation in the retention period of the materials to be separated.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43576676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Study Around Effects Cell Wall of Streptococcus pyogenes on the Immune System Response 化脓性链球菌细胞壁对免疫系统反应影响的研究

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.48

Mytham J A Hussain, Fadaa A Mahmoud, Mervet A. Mshachal

引用次数: 0

The Effect of Metformin and Biological Therapy on Insulin Resistance in Iraqi Psoriatic Patients 二甲双胍和生物治疗对伊拉克银屑病患者胰岛素抵抗的影响

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.35

Ghadah Ali Al-Oudah, Mohammed K. Al-hattab, A. Sahib, Shaimaa M. Mohammed

{"title":"The Effect of Metformin and Biological Therapy on Insulin Resistance in Iraqi Psoriatic Patients","authors":"Ghadah Ali Al-Oudah, Mohammed K. Al-hattab, A. Sahib, Shaimaa M. Mohammed","doi":"10.25258/ijddt.13.1.35","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.35","url":null,"abstract":"Psoriasis refers to a medical condition involving long-term infl ammation, high insulin resistance, obesity and a likelihood of cardiovascular disease. Objective: This paper attempts to fi nd out if the addition of metformin to biological therapy has the benefi cial eff ect of increasing insulin sensitivity in moderate to severe Iraqi psoriatic patients. Subjects and Methods: The experimental group comprises 24 patients suff ering from moderate to severe psoriasis. They were randomly selected into two groups: group A comprises 13 psoriatic patients treated with 40 mg of adalimumab twice monthly for 12 weeks. While group B contains 11 psoriatic patients treated with 40 mg of adalimumab twice monthly and a single daily dose of 850 mg of metformin for 12 weeks. The psoriasis area and severity index (PASI), glycosylated hemoglobin (HbA1c), body mass index (BMI), as well as insulin-resistance parameters, which include fasting blood glucose (FBG) and fasting serum insulin (FSI) are estimated for each patient before and after completion of therapy. Results: The two groups showed a signifi cant reduction in insulin resistance. Nonetheless, group B showed greater reduction. Furthermore, the PASI score of the two groups exhibited improvement, but group B exhibited a higher percentage improvement than group A, and the diff erence was signifi cant (p <0.05). Conclusion: This study demonstrates that adding a single daily dose of 850 mg of metformin has a more benefi cial eff ect on insulin resistance (IR) in psoriasis patients than using only biological therapy.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42640668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Eff ectiveness of the Copper (II) Complex with a New Ligand derived from Benzothiazole and Anthranilic Acid as Anticancer and Antioxidant 苯并噻唑和邻苯甲酸新配体铜（II）配合物抗癌和抗氧化作用的评价

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.41

Maysson H . Ali, H. O. Jamel

{"title":"Evaluation of the Eff ectiveness of the Copper (II) Complex with a New Ligand derived from Benzothiazole and Anthranilic Acid as Anticancer and Antioxidant","authors":"Maysson H . Ali, H. O. Jamel","doi":"10.25258/ijddt.13.1.41","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.41","url":null,"abstract":"Four steps were used to convert 2-mercaptobenzothiazole into the new ligand (2-((2-((4-(1-((4’-(benzothiazol-2-ylamino)- [1,1’-biphenyl]-4-yl)imino) ethyl) phenyl)imino)-1,2diphenylethylidene) amino)benzoic acid (LH) type of schiff bases: The fi rst step included preparing compound (A) N-(benzothiazol-2-yl)-[1, 1’-biphenyl]-4, 4’-diamine by the reaction 2-mercaptobenzothiazole with benzidine. The second step was prepared the compound(B) 2 OXO-1, 2-diphenylethylidene) amino) benzoic -(( 2- acid by the reacting anthranilic acid with benzil As for the third step, it included the reaction of the product of the fi rest step with 4-aminoacitophenon and the formation compound (C). The fourth step was the preparation ligand (LH) by reacting compound(B) with compound (C). Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR), UV-vis, melting points, molar conductivity, CHN, atomic absorption, magnetic sensitivity, and other measurements were used to determine the structure of the ligand (LH) and its complex with copper (II). The MTT method was used to evaluate the activity of the ligand (LH) and its complex with copper (II) in-vitro as an anticancer (human breast cancer (MCF7). Nd (MTT) assay was used to evaluate the ligand schiff base in-vitro anticancer activity of a Cu(II) complex against human breast cancer MCF7","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47922832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, Characterization, Antioxidant and Antibacterial Studies of New Metal (II) Complexes with Schiff Base for 3-amino-1-phenyl-2- pyrazoline-5-one 新型3-氨基-1-苯基-2-吡唑啉-5-酮Schiff碱金属配合物的制备、表征、抗氧化及抗菌性能研究

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.47

N. M. Abdalsahib, L. K. A. Karem

引用次数: 1

Fabrication of Transdermal Gel Embedded with Solid Lipid Nanoparticles of Indomethacin 吲哚美辛固体脂质纳米颗粒包埋透皮凝胶的制备

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.66

Amina Hajwani, Afreen Khan, Numan Ansari, Nazir Zerdi, Mohd Hassan Baig

引用次数: 0

Eff ect of Tea Extract on Few Bacterial Species Isolated from Tonsillitis by Adding Some Concentrations of NaCl 不同浓度NaCl对茶提取物对扁桃体炎病原菌的影响

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.49

A. A. Jasim, N. S. Ahmed, Marwan A Hussein

{"title":"Eff ect of Tea Extract on Few Bacterial Species Isolated from Tonsillitis by Adding Some Concentrations of NaCl","authors":"A. A. Jasim, N. S. Ahmed, Marwan A Hussein","doi":"10.25258/ijddt.13.1.49","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.49","url":null,"abstract":"Several bacterial species associated with tonsillitis were isolated from the samarra general hospital, including Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. The extract of alcohol and water tea was used to observe its eff ect in inhibiting the growth of bacteria with the addition of 3 concentrations of NaCl (5, 7.5, 10 g/L ) to the medium used (Muller hinton agar, Nutrient agar), the results showed that the eff ect of S. aureus on the alcohol and water extracts and all the concentrations used in addition to the use of the muller hinton agar and the use of nutrient agar the result showed that the bacteria were aff ected by alcohol extract and all the concentrations used however when adding the water extract the eff ect of bacteria was observed when adding the third concentration of NaCl , The eff ect of E. coli was observed by alcoholic and water extract of tea with the addition of the third concentration of NaCl using the muller hinton agar and the use of the nutrient agar the growth of E. coli was observed by alcoholic extract only and by the addition of the third concentration of NaCl, The eff ect of the bacteria was observed with alcohol extract only for the tea and all the concentrations using the muller hinton agar and using the nutrient agar the eff ect of bacterial growth was observed by the extract when adding the third concentration of NaCl to the medium, we conclude are diff erences in the eff ect of extract on isolated bacterial species","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45787584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential Protective Eff ects of Pirfenidone on Diclofenac Sodium Induced Gastric Ulcer in a Rat Model 吡非尼酮对双氯芬酸钠诱导大鼠胃溃疡的潜在保护作用

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.52

Russul Abdelfatah, Huda I Al-Qadh

{"title":"The Potential Protective Eff ects of Pirfenidone on Diclofenac Sodium Induced Gastric Ulcer in a Rat Model","authors":"Russul Abdelfatah, Huda I Al-Qadh","doi":"10.25258/ijddt.13.1.52","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.52","url":null,"abstract":"Introduction: Non-steroidal anti-infl ammatory drugs (NSAIDs), are widely prescribed in clinical practice because of their ability to reduce pain, fever, and infl ammation. However, NSAID-induced gastric mucosal damage is the major side eff ect of these medications. This study aims to reduce gastric mucosal lesions caused by NSAIDs by using pirfenidone by investigating their eff ect on histological, gastric gross mucosal damage. Method: 30 healthy male albino rats were divided into 3 groups each of ten (N=10). A single oral dose of diclofenac sodium (150 mg/kg body weight) was used to induce ulceration for all groups except fi rst. The vehicle (tween 80+NS) was given to the fi rst group, while diclofenac sodium was given to the second group and to all pre-treated groups. The third group were pre-treated with pirfenidone (300 mg/kg). At the end of the experiment, histological examination, and antioxidant and antiinfl ammatory parameters by immunohistochemistry method were evaluated. Results: Diclofenac sodium at a dose (150 mg/kg) produces a signifi cant increment (p > 0.01) in gastric damage score, the expression of tumor necrosis factor-alpha (TNF-α), myeloperoxidase, malonaldehyde, and the ulcer formation percent, compared to the healthy rat’s group. Pirfenidone at a dose of (300 mg/kg) pretreatment in diclofenac induced-ulcer in rats produces a signifi cant reduction (p > 0.01) in gastric damage score, the expression of TNF-alpha, myeloperoxidase, the expression of TNF-alpha, myeloperoxidase, malonaldehyde, and in the ulcer formation percent, yet, less eff ectively than omeprazole and pirfenidone. Conclusion: Diclofenac can be reduced or prevented by the pretreatment of pirfenidone. Pirfenidone showed similar results to the standard treatment (Omeprazole), the protective eff ect of pirfenidone was mainly through their antioxidant and anti-infl ammatory activity by reducing oxidation markers like MPO and MDA, and also reducing infl ammatory cytokines like TNF-alpha","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46531031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems 不同表面活性剂/助表面活性剂体系制备苯甲酸利扎曲坦纳米结构脂质载体及评价

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.18

N. Rajab, M. Jawad

{"title":"Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems","authors":"N. Rajab, M. Jawad","doi":"10.25258/ijddt.13.1.18","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.18","url":null,"abstract":"Migraine is the second most common neurological illness, aff ecting around one billion people each year; triptans are commonly used in the treatment; rizatriptan benzoate is a member of the triptan class, it’s available as a tablet dosage form. Unfortunately, it undergoes fi rst-pass eff ect after oral intake. The intranasal route of administration represents a solve to such a problem. Because it has a limited permeability, an eff ort has been made to circumvent this hurdle. Nanotechnology’s innovation has off ered a useful answer to several issues in the pharmaceutical fi eld in which it could improve drug permeability. The aim of the present work involved loading rizatriptan benzoate on a nanostructured lipid carrier as an attempt to resolve adversity affi liated with the intended drug. The high-speed homogenization technique prepares six formulas. The formulations’ particle size, polydispersity index, zeta potential, entrapment effi ciency, loading capacity, and in-vitro drug release were studied. Diff erential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), and powder X-ray diff raction (PXRD) was investigated to exclude drug excipient incompatibility and to evaluate the crystallinity state of rizatriptan benzoate before and after formulation. Successful formulations were obtained with an acceptable nanostructured parameter In-vitro drug release profi le illustrates a biphasic pattern in which an immediate followed by a persistent phase over a 6 hours. release period, with an estimated percent of the medication being released with an anomalous release mechanism. The compatibility and crystallinity investigation revealed that rizatriptan benzoate was compatible with the other excipients used in the research, and the drug molecule was found to be in an amorphous state within the lipid matrix. In conclusion, nanostructured lipid carriers might be a potential delivery approach for improving intranasal administration of rizatriptan benzoate.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42349400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Development and Optimization of Solid Lipid Nanoparticles for Ocular Delivery of an Antifungal Agent 用于眼部给药的固体脂质纳米颗粒的设计、开发和优化

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI: 10.25258/ijddt.13.1.53

Raff ah K Mahal, F. Al-Gawhari

{"title":"Design, Development and Optimization of Solid Lipid Nanoparticles for Ocular Delivery of an Antifungal Agent","authors":"Raff ah K Mahal, F. Al-Gawhari","doi":"10.25258/ijddt.13.1.53","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.53","url":null,"abstract":"Oral and intravenous dosing of the second-generation antifungal drug voriconazole (VCZ), with its wide range of antifungal action, is commercially accessible. Visual and hepatic problems might occur when VCZ is used in large doses. Voriconazole SLNs were prepared in this study with the goal of increasing corneal penetration and drug release. The thin fi lm hydration approach was used to make VCZ SLNs. The central composite experimental design was used to maximize the impacts of independent processing factors on vesicle size (R1), drug entrapment effi ciency (%EE) and zeta potential (ZP; R3) responses on lipid concentration (X1), surfactant concentration (X2), and sonication duration (X3). An evaluation of the drug release profi le, corneal penetration, antifungal susceptibility, and cytotoxicity of the improved formula was conducted. The improved recipe achieved the best results with a ZP of -39.6 ± 0.28 mV, an average particle size of 156 ± 3.84 nm, and an EE% of 89.2 ± 2.01. When compared to the unformulated drug solution, the VCZ-SLNs had a prolonged 10 hours drug release profi le with improved corneal penetration, with Papp and Jss measuring 14.35×10-2 cm h-1 and 4.61 mol h-1, respectively, instead of 7.28×10-2 cm h-1 and 2.48 mol h-1. Non-irritating VCZ-SLNs were determined to be corneal tissue, according to the study. Improved corneal penetration and higher antifungal activity without harmful eff ects on ocular tissues were achieved by VCZ-SLNs","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41973780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0