化脓性链球菌细胞壁对免疫系统反应影响的研究

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI:10.25258/ijddt.13.1.48

Mytham J A Hussain, Fadaa A Mahmoud, Mervet A. Mshachal

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引用次数: 0

摘要

许多影响人类的最常见疾病都是由链球菌引起的。对这些细菌细胞壁的研究直接关系到免疫应答。在我们的研究中，根据世界卫生组织(WHO)的程序和方案，收集了约20例5至15岁儿童的咽拭子，以寻找化脓性链球菌。我们在血琼脂培养基上培养细菌，然后用HA和HAI获得菌壁的主要成分肽聚糖，以测定其免疫反应。然而，我们的研究证明，1个月后注射Ags S/C并从这些实验室收集血清，其滴度为1∶1280组和2∶640组，表明抗原是由多肽和碳水化合物组成的高毒力(复合抗原)。我们测试的所有样本都呈阳性结果，并对细菌的细胞壁肽聚糖物质产生免疫反应

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The Study Around Effects Cell Wall of Streptococcus pyogenes on the Immune System Response

Many of the most common diseases aff ecting humans are caused by Streptococcus. The study of the cell wall of these bacteria is directly related to the immune response. In our study, about 20 throat swabs were collected for children aged 5 to 15 years, according to the procedures and protocol of the World Health Organization (WHO), to search for Streptococcus pyogenes. We cultured bacteria on blood agar media and then used HA and HAI to obtain the main component of the bacteria wall, peptidoglycan, to determine its immune response. Whereas the study we carried out proved that the injection of Ags S/C after one month and collecting serum from these labs gives titers in group 1 1:1280 and in group 2 1:640, indicating that antigens are highly virulence (complex antigens), composed of peptides and carbohydrates. All samples we tested gave positive results and generated an immune response to the bacteria’s cell wall peptidoglycan material

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.