International Journal of Drug Delivery Technology最新文献

Some Immunological and Physiological Parameters Levels in Iraq Children with Autism Spectrum Disorders 伊拉克自闭症谱系障碍儿童的一些免疫和生理参数水平

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.29

Rusul A.A Alshammary, Jamela Jouda, Adil A. S Al-Salihy

{"title":"Some Immunological and Physiological Parameters Levels in Iraq Children with Autism Spectrum Disorders","authors":"Rusul A.A Alshammary, Jamela Jouda, Adil A. S Al-Salihy","doi":"10.25258/ijddt.13.3.29","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.29","url":null,"abstract":"Some studies suggested that dysfunction of immune and endocrine systems could link with neurodevelopment disorder and immunopathogenesis of ASD. Therefore, the goal of this research is to examine the level of some immunological and physiological indicators in an effort to identify a new biomarker for ASD. In the current study, there were 72 Iraqi kids (both boys and girls), 50 kids with ASD who attended different autism centers in Iraq, and 22 kids without ASD. They were between the ages of 6 and 12. These children’s peripheral venous blood was drawn in order to measure the concentrations of several cytokines, such as (TNF-α and IL-6), cortisol, and WBCs indices and platelets/lymphocytes ratio. The study’s findings revealed: 1) a significantly higher level of TNF- α but not IL-6 in ASD patients when compared to control; 2) a significantly higher level of cortisol in ASD patients compared to controls; and 3) a significantly higher level of lymphocytes and total WBCs but not neutrophils and monocytes. 4) A significant increase in the platelets/lymphocytes ratio. Furthermore, there were no differences in these parameters based on the gender and severity of the autism. As a result, our findings revealed that cytokine level alterations may be crucial in the development of neurological diseases like autism since microglia release large amounts of TNF-α, which plays a significant role in the so-called neuroinflammatory response. An abnormal HPA axis with high or low concentration of cortisol in more than 22% of the ASD was found in our results, which could explain the different reactions of autistic children when exposed to the same situation. So we thought that cytokines, especially TNF-α, and cortisol, may represent a serological marker for autism.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Some Psychotic Drug Quetiapine on Reproductive System Activity in Male Rats 一些精神药物喹硫平对雄性大鼠生殖系统活性的影响

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.11

Mohammed A. Assi, Makarim H. Mohammed

{"title":"Effect of Some Psychotic Drug Quetiapine on Reproductive System Activity in Male Rats","authors":"Mohammed A. Assi, Makarim H. Mohammed","doi":"10.25258/ijddt.13.3.11","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.11","url":null,"abstract":"Aim of study: To investigate the effects of antipsychotic medications utilized to treat schizophrenic patients and its effects on the reproductive system. Introduction: Antipsychotics, anticonvulsants, and other all psychotropic drugs have negative effects on the quality of sperm and sexual activity. These negative side effects differ amongst males and its less severe for some drugs, enabling some degree of control over their effects. Sperm can suffer oxidative damage from spending too much time in the male reproductive system. One of the antipsychotics most frequently administered to treat schizophrenia in adults is quetiapine. In this work, the effects of repeated rats’ healthy production of sperm in response to therapeutic doses of quetiapine was studied. Rats were also used to assess quetiapine’s effects on hormonal balance and oxidative state. Methodology: The experiment employed male wistar rats weighing 300 to 350 g at 10 to 12 weeks of age. The experiment employed male wistar rats weighing 300 to 350 g at 10 to 12 weeks of age. Rats received oral dosages of quetiapine for 30 days. At this time’s conclusion, the body’s weights and the organs were analyzed, additionally to sperm concentration, motility, shape, and degree of sperm damage. The levels of testosterone, LH, and other male hormones related to reproduction were measured in the serum. Malondialdehyde and glutathione levels were measured to assess the oxidative state of testicular tissues. Results: The results of this investigation demonstrated that in rats receiving quetiapine, aberrant sperm morphology increased while relative epididymis weights and sperm concentration dropped. Rats receiving quetiapine experienced a drop in serum LH and testosterone levels. Rats receiving quetiapine also had lower amounts of malondialdehyde, which was assessed. Conclusion: Quetiapine therapy this negative effect may be attributed to lower sperm quality, changed hormone levels, and enhanced oxidative stress.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Arachidonic Acid Metabolic Pathway and Recent Updates on a Few Heterocyclic Derivatives showing COX-2 Inhibition 花生四烯酸代谢途径综述及几种具有COX-2抑制作用的杂环衍生物的最新进展

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.49

Swagatam Sahoo, Ragghee Bhattacharya, Manish Yadav, Debasis Sai Panda, Tunul Guria, Kirtimaya Mishra

{"title":"An Overview of Arachidonic Acid Metabolic Pathway and Recent Updates on a Few Heterocyclic Derivatives showing COX-2 Inhibition","authors":"Swagatam Sahoo, Ragghee Bhattacharya, Manish Yadav, Debasis Sai Panda, Tunul Guria, Kirtimaya Mishra","doi":"10.25258/ijddt.13.3.49","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.49","url":null,"abstract":"Inflammation crucial part of the immune response associated with a broad range of immunological diseases. The arachidonic acid (AA) pathway, which is an essential inflammatory mediator present at the internal surface of the cellular matrix, is hydrolyzed by phospholipase A2, which leads to the development of metabolites such as cytochrome P450 (CYP), lipoxygenases (LOXs), cyclooxygenases (Coxs) and enzymes which further develops into bioactive mediators such as prostanoids, leukotrienes (LTs) and more. Cyclooxygenases produce prostaglandins, available as 2 isomorphs, COX-1(constitutive) & COX-2(inducible), targeted by NSAIDs used to treat inflammation. Yet, they have a number of negative effects that lead to market withdrawal. Research has been done to look at novel COX-2 inhibitors and safety precautions. By structural alteration at COX-2 strong receiving site, structural along with functional research on a number of selective COX-2 blockers results in the creation of novel structures that are more potent and selective against inflammation while having a very low risk of side effects. This is made possible by computer-assisted medication design. This review gives an explanation regarding the biological functionalization of several COX-2 derivatives obtained by the help of in vitro, in vivo & molecular docking for better understanding of the structures and bonding accountable for an action","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Isomalt and Co-processed Isomalt 异麦芽糖与同加工异麦芽糖的比较研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.13

Sandhan S B, Wagh M P

引用次数: 0

Phytochemical Screening, GC-MS Analysis and Total Phenolic Content Determination of Bioactive Compound of Propolis 蜂胶的植物化学筛选、GC-MS分析及总酚含量测定

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.18

Meenu ., Tarun Virmani, Lubhan Singh, Rahul Kaushik

{"title":"Phytochemical Screening, GC-MS Analysis and Total Phenolic Content Determination of Bioactive Compound of Propolis","authors":"Meenu ., Tarun Virmani, Lubhan Singh, Rahul Kaushik","doi":"10.25258/ijddt.13.3.18","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.18","url":null,"abstract":"India is a hub for a large variety of natural products that have proven their therapeutic efficacy in various ailments and disorders. Despite it, a lot of natural products are yet to be explored, and Indian propolis is one of them. Indian propolis is a waxy natural product obtained from beehives. In this research, phytochemical constituents present in Indian propolis were qualitatively analyzed using phytochemical screening, gas chromatography-mass spectroscopy (GC-MS), and quantitatively using total phenolic content. Phytochemical screening results revealed the presence of total phenolic content, saponins, glycosides, alkaloids, terpenoids, proteins, steroids, flavonoids, oils & resins supported by GC-MS results. The GC-MS analysis revealed the presence of 17 different constituents having higher peak areas. Amongst these 17 bioactive compounds, oxirane, phenyl ethyl alcohol, caffeine, chrysene, riboflavin and 2-aminophenol were found to have higher peak areas of 5.78, 4.58, 4.46, 3.11, 2.65 and 2.56%, respectively. The results of total phenolic contents revealed the presence of 23 different constituents in different concentrations amongst ellagic acid, kaempferol, epicatechin, galangin, and quercetin were present in rich amounts 538.73, 402.34, 234.85, 121.95 and 95.3 μg/kg, respectively. These constituents are well known for their therapeutic efficacy, which is an indication for the exploration of the therapeutic efficacy of Indian propolis in the future.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Syringes and Pills: Advances in Drug Delivery Systems for Diabetes 超越注射器和药片:糖尿病药物输送系统的进展

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.48

Muggu S. Bhavani, Ravindran Sarvanana

{"title":"Beyond Syringes and Pills: Advances in Drug Delivery Systems for Diabetes","authors":"Muggu S. Bhavani, Ravindran Sarvanana","doi":"10.25258/ijddt.13.3.48","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.48","url":null,"abstract":"Diabetes is a chronic disease that affects millions of people worldwide, and its prevalence is increasing. The two primary subtypes, type 1 and 2, have different causes and mechanisms, but both result in abnormal glucose metabolism. The standard of care for diabetes includes insulin therapy, oral anti-diabetic medications, diet, exercise, weight loss, and frequent self-monitoring of blood glucose levels. However, these treatments have limitations that can lead to poor patient compliance and suboptimal outcomes. Alternative insulin delivery systems such as inhalers, patches, and oral sprays offer potential benefits such as increased convenience, reduced pain, and improved adherence. Non-insulin injectables, long-acting basal insulins, and GLP-1 agonists have also shown promise in improving glycemic control and reducing the risk of complications. Nanoparticle-based systems like SLNs are a novel approach that offers several advantages for diabetic management. They allow for targeted drug delivery, controlled release, and improved biocompatibility, enhancing drug efficacy and reducing side effects. SLNs have shown potential in animal models for reducing extracellular matrix degradation, inhibiting carbohydrate digestive enzymes, and enhancing the regeneration of insulin-producing beta cells. More studies are needed to validate their safety and efficacy in humans, but the potential benefits of SLNs make them a promising option for diabetes management.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fexofenadine Hydrochloride Dispersible Tablets: A Taste Masking Strategy using Ion Exchange Resin 盐酸非索非那定分散片:离子交换树脂掩味策略

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.12

Kajal Barge, Shivali Tank, Bhagyashri Parab, Mangal Nagarsenkar, Supriya Shidhaye

{"title":"Fexofenadine Hydrochloride Dispersible Tablets: A Taste Masking Strategy using Ion Exchange Resin","authors":"Kajal Barge, Shivali Tank, Bhagyashri Parab, Mangal Nagarsenkar, Supriya Shidhaye","doi":"10.25258/ijddt.13.3.12","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.12","url":null,"abstract":"The pediatric population is more sensitive to allergies. Fexofenadine hydrochloride (FXD-HCL), a non-sedative antihistaminic drug, was chosen to create taste-masked patient-compliant pediatric dispersible tablets. Due to its bitter taste, fexofenadine hydrochloride is unsuitable for the formulation of dispersible tablets; therefore, Kyron T-134®, cation exchange resin was used to form a taste-masked complex with the drug to overcome its bitterness. The FXD HCL-resin complex was prepared using a kneading method and the complexation was confirmed by differential scanning calorimetry and FTIR studies. The FXD HCL-resin complex was evaluated for flow properties, degree of bitterness, assay and release study. Dispersible tablets were formulated by using a co-processed excipient, Granfiller-D211® containing croscarmellose sodium and crosspovidone, microcrystalline cellulose and mannitol. 22 factorial designs with two replicates optimized the dispersible tablets. The tablets, prepared using the direct compression technique on a single-stroke tablet compression machine, were elegant in appearance. Various pre and post-compression tests were conducted on all formulations. The tablets of hardness 3.5 kg/cm2 showed friability, disintegration time, assay within the compendial limit and showed immediate release of a drug (NLT 60% in 10 min and NLT 80% in 30 minutes) in 0.001 N HCl (pH 3). The DSC thermogram indicated partial amorphization of the FXD HCL. Dispersible tablets of fexofenadine hydrochloride and Granfiller-D®211 at 1:4 proportion was stable for one month at ambient and accelerated storage conditions.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clopidogrel Responsiveness in Patients Undergoing Percutaneous Coronary Intervention using Multiplate Analyzer: Frequency and Outcomes 使用多板分析仪进行经皮冠状动脉介入治疗的患者的氯吡格雷反应性:频率和结果

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.53

Murad A. Khadim, Hasan A. Farhan, Muthanna ., Muthanna H Al-Quraishi

{"title":"Clopidogrel Responsiveness in Patients Undergoing Percutaneous Coronary Intervention using Multiplate Analyzer: Frequency and Outcomes","authors":"Murad A. Khadim, Hasan A. Farhan, Muthanna ., Muthanna H Al-Quraishi","doi":"10.25258/ijddt.13.3.53","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.53","url":null,"abstract":"Objectives: Over and under response to dual antiplatelet therapy (DAPT) can lead to bleeding and thrombotic events in patients undergoing coronary stent placement. The present study aimed to assess the platelet response to clopidogrel in patient undergoing percutaneous coronary intervention (PCI) using Multiplate Analyzer. The primary outcome in the present study was the short-term incidence of stent thrombosis and bleeding events. Background: Multiple electrode aggregometry is a rapid and standardized tool to for diagnosis of platelet defects and monitoring response to DAPT. Methods: A hospital-based, prospective study was conducted on 431 patients who underwent PCI from September 2016 to November 2017 and received clopidogrel therapy. The platelet aggregometry was done using a Multiplate analyzer (Dynabyte, Munich, Germany). Patients were followed for 30 days to assess the incidence of stent thrombosis and bleeding. Results: The patients’ mean age was 58 ± 6.7 years. A total of 40% of the patients were diabetic and 7.7% had chronic renal failure. The rate of clopidogrel non-responders was 10.7%, while clopidogrel over-responders were 18.3%. Patients with diabetes and chronic renal failure had significantly lower platelet responsiveness (40.1% with p < 0.05 and 7.7% with p <0.005, respectively). Smoking was significantly associated with platelet over-responsiveness (39.4%, p < 0.001). Patients with low platelet responsiveness to clopidogrel were associated with an increased risk of definite stent thrombosis (p < 0.005), while increasing bleeding risk was significantly associated with over-responsiveness to patients to clopidogrel (p <0.001). Conclusions: Antiplatelet responsiveness showing individual variability with increased risk of stent thrombosis among the cases with no response to the effect of clopidogrel and high risk of bleeding with the over-responsiveness group.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study of Hepcidin Levels and Other Biochemical Parameters in Women with Osteoarthritis: As a Pharmaceutical Control 女性骨关节炎患者Hepcidin水平及其他生化指标的研究:作为药物控制

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.19

Shuaib Y. Ahmed, Noorhan K. Shafeeq

{"title":"A Study of Hepcidin Levels and Other Biochemical Parameters in Women with Osteoarthritis: As a Pharmaceutical Control","authors":"Shuaib Y. Ahmed, Noorhan K. Shafeeq","doi":"10.25258/ijddt.13.3.19","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.19","url":null,"abstract":"Background: Hepcidin, one of the peptide hormones generated from the liver, can be defined as an important regulator regarding systemic iron homeostasis, while its lopsided production plays a role in the pathogenesis of a variety of iron diseases. Osteoarthritis (OA) frequently coexists with a number of diseases, including hemochromatosis, ß-thalassemia, cell disease, sickle cell disease, and hemosiderosis caused by iron overload. Evidence suggests that iron deficiency and iron overload negatively impact the bone, which acts immediately on the bone’s cells. The present work aims to determine whether a direct correlation exists between female patient’s OA and levels of hepcidin, DHVD3, and other indicators. Methods: A total of 60 participants were split into two groups for this work: 30 healthy controls and 30 female OA patients. This work was carried out from Nov. 2021 to the end of June. 2021. The ages ranged from (40 to 55). In Al-Mahmudiya Hospital and in Al-Yarmok Teaching Hospital, an endocrinologist assessed each one of the patients. We measured Hb, BMI, ferritin, hepcidin, DHVD3, iron, Ca, and PO4. Results: Hepcidin levels significantly increased, whereas ferritin, BMI, iron, vitamin D, calcium, and PO4 levels significantly decreased compared with the control group. However, alterations in lipid profile and glycemic profile were not statistically significant. Conclusion: By connecting low levels of iron, ferritin, calcium, vitamin D3, and PO4 with high levels of hepcidin in women with OA, it may be concluded that vitamin D3 insufficiency is associated with hepcidin malfunction as a factor affecting women with OA.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iraqi Hyacinthus orientalis L. Flowers as the Source of Bioactive Compounds Especially Stigmasterol: Identification, Isolation and Characterization 伊拉克风信子花中生物活性物质尤其是豆甾醇的鉴定、分离与表征

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.02

Noor M. Shareef, Thukaa Z. Abdul-Jalil

引用次数: 0