International Journal of Drug Delivery Technology最新文献_第2页

A Study of Hepcidin Levels and Other Biochemical Parameters in Women with Osteoarthritis: As a Pharmaceutical Control 女性骨关节炎患者Hepcidin水平及其他生化指标的研究:作为药物控制

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.19

Shuaib Y. Ahmed, Noorhan K. Shafeeq

{"title":"A Study of Hepcidin Levels and Other Biochemical Parameters in Women with Osteoarthritis: As a Pharmaceutical Control","authors":"Shuaib Y. Ahmed, Noorhan K. Shafeeq","doi":"10.25258/ijddt.13.3.19","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.19","url":null,"abstract":"Background: Hepcidin, one of the peptide hormones generated from the liver, can be defined as an important regulator regarding systemic iron homeostasis, while its lopsided production plays a role in the pathogenesis of a variety of iron diseases. Osteoarthritis (OA) frequently coexists with a number of diseases, including hemochromatosis, ß-thalassemia, cell disease, sickle cell disease, and hemosiderosis caused by iron overload. Evidence suggests that iron deficiency and iron overload negatively impact the bone, which acts immediately on the bone’s cells. The present work aims to determine whether a direct correlation exists between female patient’s OA and levels of hepcidin, DHVD3, and other indicators. Methods: A total of 60 participants were split into two groups for this work: 30 healthy controls and 30 female OA patients. This work was carried out from Nov. 2021 to the end of June. 2021. The ages ranged from (40 to 55). In Al-Mahmudiya Hospital and in Al-Yarmok Teaching Hospital, an endocrinologist assessed each one of the patients. We measured Hb, BMI, ferritin, hepcidin, DHVD3, iron, Ca, and PO4. Results: Hepcidin levels significantly increased, whereas ferritin, BMI, iron, vitamin D, calcium, and PO4 levels significantly decreased compared with the control group. However, alterations in lipid profile and glycemic profile were not statistically significant. Conclusion: By connecting low levels of iron, ferritin, calcium, vitamin D3, and PO4 with high levels of hepcidin in women with OA, it may be concluded that vitamin D3 insufficiency is associated with hepcidin malfunction as a factor affecting women with OA.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iraqi Hyacinthus orientalis L. Flowers as the Source of Bioactive Compounds Especially Stigmasterol: Identification, Isolation and Characterization 伊拉克风信子花中生物活性物质尤其是豆甾醇的鉴定、分离与表征

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.02

Noor M. Shareef, Thukaa Z. Abdul-Jalil

引用次数: 0

Depression and Associated Factors among Type 2 Diabetics in Karbala City, Iraq: As a Model of Anti-depressant Drugs 伊拉克卡尔巴拉市2型糖尿病患者的抑郁及其相关因素:作为抗抑郁药物的典范

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.55

TiSammar J Mahanrth, Mohammed M Mahammad

{"title":"Depression and Associated Factors among Type 2 Diabetics in Karbala City, Iraq: As a Model of Anti-depressant Drugs","authors":"TiSammar J Mahanrth, Mohammed M Mahammad","doi":"10.25258/ijddt.13.3.55","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.55","url":null,"abstract":"depression symptoms are well-known co-occurring diseases. A person’s ability to do everyday things can be affected by depressed symptoms and DM. Objectives: To find the level of depression symptoms among type 2 diabetics, observe the socio-demographic & disease-related agents that cause depression. Methods: A cross-sectional study design was used to assess depression in 200 people suffering from type 2 diabetes and 120 healthy participants as a control group. Patients scoring 5 or more were termed depressed. Each participant’s verbal informed consent was obtained before the interview. On the questionnaires, no names were written. Depression was correlated with demographic and patient-related disease characteristics using Spearman’s rho correlation. Results: The severe, moderate, and mild depression rates were 7.5, 56, and 29%, respectively and 92.5% of diabetics had depressed symptoms. Among the control group, absences of depressed symptoms and mild depressed symptoms were more common. Diabetics had moderate, moderately severe, and severe depression are all more common than mild depression symptoms. Diabetic patients’ median PHQ-9 score (10) was significantly higher than the control group’s 8. Conclusion: Depression is common among diabetes mellitus type 2 patients. Glycemic control is poor & obesity have an impact on it. Endocrinologists should be aware of the elevated risk of depression in this patient population","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Bentonite Clay/TiO2 Nanocomposites Surface as Drug Carrier: In-vitro Release Study of Chloramphenicol Drug 膨润土/TiO2纳米复合材料表面药物载体制备&氯霉素药物体外释放研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.36

Mohammed K Al-Hussainawy, Aseel M Aljeboree, Mohammed A Jawad, Fatime S Sheri, Ayad F Alkaim

{"title":"Preparation of Bentonite Clay/TiO2 Nanocomposites Surface as Drug Carrier: In-vitro Release Study of Chloramphenicol Drug","authors":"Mohammed K Al-Hussainawy, Aseel M Aljeboree, Mohammed A Jawad, Fatime S Sheri, Ayad F Alkaim","doi":"10.25258/ijddt.13.3.36","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.36","url":null,"abstract":"The delivery of pharmaceuticals via nanocomposites has become a fascinating area of study in recent years, with applications in the development of tools and the treatment of infections and cancer. The porous properties of titanium dioxide and clay nanocomposites play a key role in the targeted delivery system. So, the large surface area and porous volume have more interest in the delivery of drugs and their loading. In this study, bentonite clay and titanium dioxide (TiO2) nanocomposites were synthesized by a hydrothermal method to guide infections and drugs. The composites of nanocomposites were used by the adsorption technique as loading drugs and studied for their ability to deliver drugs. It was confirmed that titanium oxide was added to the bentonite clay through the EDX and XRD. Sharp diffraction values were observed by the X-ray spectrum for clay and titanium oxide and less intensity for the superimposed (TiO2/bentonite), While it was found that EDX spreads the titanium and other ions. The thermal stability of the composite (TiO2/bentonite) was increased after adding titanium dioxide nanoparticles. The removal rate of chloramphenicol was higher in the base media, reaching 98% for both bentonite and TiO2/bentonite. An examination of the release rate of the drug was carried out by bentonite clay and TiO2/bentonite in the stomach and blood media, and the percentage of release was 26.6 and 5% in pH 1.2 and 7.5 for bentonite and 54.6 and 23.6% in pH 1.2 and 7.5, respectively, for TiO2/bentonite.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases 治疗心血管疾病的新型微型片头技术的设计与开发

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.04

Anil K. Adimulapu, Lalchand D. Devhare, Anasuya Patil, Nilesh O. Chachda, G. Dharmamoorthy

{"title":"Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases","authors":"Anil K. Adimulapu, Lalchand D. Devhare, Anasuya Patil, Nilesh O. Chachda, G. Dharmamoorthy","doi":"10.25258/ijddt.13.3.04","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.04","url":null,"abstract":"Objectives: The purpose of the investigation was to extend and evaluate the novel mini tablet cap for treating cardiovascular disease at a desired combinational therapeutic activity and to improve patient compliance. A cheap four-in-one pill can guard against heart attacks and stroke. Methods and Materials: The drug product was manufactured by mini tablet cap technology. The technology was designed to initially use hydrochlorothiazide, simvastatin immediate release, metoprolol succinate, and asprin sustained release to reach the therapeutic levels at prolonged therapy. The two mini-bilayer tablets were prepared by wet granulation method and compression coated with a hydrophobic and hydrophilic polymer like ethyl cellulose and super disintegrating agents to release simvastatin and hydrochlorothiazide immediately. Results: Fourier transformer infrared spectroscopy (FTIR) studied the interaction studies of four chosen drugs. The mini tablet cap technology was designed as two mini bi-layer tablets in a capsule. The quantitative detection of four individual drugs was determined by using the RP-HPLC method. It was found that RP-HPLC is sensitive, reproducible, and valid for determining the mini tablet cap. The in-vitro drug release studies found that simvastatin and hydrochlorothiazide release 90% immediately within 20 minutes. Metoprolol and aspirin controlled the release for up to 24 hours, and drug release kinetics found that the drug release behavior of the optimized formulation followed first-order kinetics. Conclusion: The mini tablet cap is one of the best dosage forms to treat cardiovascular diseases. Because it was reported, the combination of these four drugs reduces mortality by 83% in high-risk patients with heart diseases, hypertension, diabetes, and obesity. The novel mini tablet cap approach data revealed a promising formula for improved relief of patient complaints during treatment or prevention of cardiovascular diseases","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effect of L-cycloserine and Capecitabine on Human Colon Cancer Cell Line l -环丝氨酸和卡培他滨对人结肠癌细胞系的协同作用

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.34

Zena H Sahib, Seher A. R Almedeny

{"title":"Synergistic Effect of L-cycloserine and Capecitabine on Human Colon Cancer Cell Line","authors":"Zena H Sahib, Seher A. R Almedeny","doi":"10.25258/ijddt.13.3.34","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.34","url":null,"abstract":"Introduction: Colon cancer comes in second place in the list of cancers in developed countries. Drug resistance is one of the causes of colorectal cancer therapeutic failure that usually occurs in most patients in advanced stage of colon cancer. This study investigates the effect of adding L-cycloserine to capecitabine in the HCT-116 colon cancer cell line. Materials and methods: We compared the combined L-cycloserine-capecitabine effect with each of the two drugs alone on the HCT-116 colon cancer cell line as a positive control group. The growth rate inhibition was examined by crystal violet assay. Results: The growth inhibition effect of L-cycloserine-capecitabine, L-cycloserine and capecitabine on HCT-116 cells was assessed with crystal violet assay, different concentrations including 3.12, 6.25, 12.5, 25, 50, and 100 μg/mL were used for L-cycloserine-capecitabine combination, and for both L-cycloserine and capecitabine. After incubation for 24 hours, results appeared that the combination of L-cycloserine and capecitabine increased the effect of both drugs alone as seen by a significant increase (p <0.05) of the growth inhibition percentages in the L-cycloserine-capecitabine combination as compared with the positive control groups. Conclusion: From the result, we can conclude that the L-cycloserine combination with capecitabine has a synergistic effect for colon cancer treatment that could be a more effective regimen.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric Fluoroquinolone Microparticles for Pulmonary Drug Delivery: A Review on Characteristics, Drug Release Profile, and Antibacterial Study 用于肺部给药的聚合氟喹诺酮微颗粒:特性、药物释放特征和抗菌研究综述

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.44

Deliaz M.F, Hendradi E, Hariyadi D.M

{"title":"Polymeric Fluoroquinolone Microparticles for Pulmonary Drug Delivery: A Review on Characteristics, Drug Release Profile, and Antibacterial Study","authors":"Deliaz M.F, Hendradi E, Hariyadi D.M","doi":"10.25258/ijddt.13.3.44","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.44","url":null,"abstract":"Polymeric microparticles have recently gained significant attention as promising carriers for antibiotic administration to the pulmonary route, especially the antibiotics from the fluoroquinolone class. The versatility and efficiency of fluoroquinolones, combined with the stability, biocompatibility, and tunable protection provided by polymeric encapsulation in microparticles, contribute to the effectiveness of fluoroquinolone microparticles in achieving desirable characteristics, particularly precise and controlled drug release in the lungs. Such characteristics, drug release profile, and antibacterial activities are mainly influenced by the physics and chemistry of the fluoroquinolones-polymer system as a whole, formulation parameters, and solvent usage. Therefore, this review provides a comprehensive summary of studies and research conducted between 2012 and the present, focusing on the characteristics, drug release profile, and antibacterial investigation of fluoroquinolone microparticles that utilize polymeric formulations for the purpose of delivering drugs to the lungs.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin-E TPGS Based Microemulsion: An Approach for Solubility Enhancement of Poorly Water-Soluble Drugs 基于维生素e TPGS的微乳:一种提高难水溶性药物溶解度的方法

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.47

Vallabh Deulkar, Sunitha Panchani

引用次数: 0

A Relationship of Dickkopf-1 with Glutathione in Iraqi Patients with Unstable Angina as a Model of Pharmaceutical Compounds 伊拉克不稳定型心绞痛患者中Dickkopf-1与谷胱甘肽的关系

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.08

Mohanad S.B Musleh, Khalid F.A Alrawi, Hazim I Ghazzay

{"title":"A Relationship of Dickkopf-1 with Glutathione in Iraqi Patients with Unstable Angina as a Model of Pharmaceutical Compounds","authors":"Mohanad S.B Musleh, Khalid F.A Alrawi, Hazim I Ghazzay","doi":"10.25258/ijddt.13.3.08","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.08","url":null,"abstract":"Background: The importance of inflammation in coronary artery disease and the inflammatory biomarkers linked to adverse outcomes have recently been the subject of numerous investigations. In addition to examining the relationship between dickkopf-1 and high mobility group box-1 with other biochemical markers, this study seeks to ascertain the relationship between dickkopf-1 and high mobility group box-1 in patients whose angina pectoris is not stable. Methods: The work includes 50 patients (20 female and 30 male) and 40, 20 female and 20 males as controls who attended Al Ramadi Teaching Hospital between November 2021 and April. The sample age ranged between 52.16 ± 8.423 years in comparison to 49.58 ± 8.098 for the controls. Results: The serum DKK-1 levels (ng/mL) rose in unstable angina (UA) patients (135.527.13 for UA patients vs. 36.614.07 for the control group), so UA patients had higher DKK-1 release during platelet aggregation because DKK1 is involved in platelet-induced endothelial cell activation, so DKK1 causes inflammation. Additionally, the GSH was significantly lower in those having UA than in controls. Conclusion: Serum DKK-1 levels was significantly higher for those with UA compared to the healthy and there is a significant drop in GSH levels in people with UA than in controls.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational Exploration of Anti-Alzheimer Potential of Flavonoids against Inducible Nitric Oxide Synthetase: An In-silico Molecular Docking and ADMET Analysis Approach 黄酮类化合物抗诱导型一氧化氮合成酶抗阿尔茨海默病潜能的计算探索:一种硅分子对接和ADMET分析方法

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.20

Mahesh Nemade, Khushabu Patil, Anjali Bedse, Piyush Chandra, Rakesh Ranjan, Harshal Tare, Samir Patil

{"title":"Computational Exploration of Anti-Alzheimer Potential of Flavonoids against Inducible Nitric Oxide Synthetase: An In-silico Molecular Docking and ADMET Analysis Approach","authors":"Mahesh Nemade, Khushabu Patil, Anjali Bedse, Piyush Chandra, Rakesh Ranjan, Harshal Tare, Samir Patil","doi":"10.25258/ijddt.13.3.20","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.20","url":null,"abstract":"Alzheimer’s disease (AD) is a formidable challenge in neurodegenerative disorders, marked by relentless cognitive decline, memory impairment, and a pervasive neuroinflammatory milieu. Recent scientific inquiries have unveiled a compelling link between the rampant overexpression of inducible nitric oxide synthetase (iNOS) and the intricate pathogenesis of AD. Within this context, flavonoids, a diverse class of polyphenolic compounds widely distributed in fruits & vegetables, have garnered substantial interest due to their recognized antioxidant and anti-inflammatory attributes. This research endeavor harnessed the power of cutting edge in-silico molecular docking techniques to embark on a compelling exploration. Specifically, we aimed to unravel the therapeutic potential of various flavonoids as putative inhibitors of iNOS, with the ultimate objective of combatting the insidious progression of AD. Our investigative odyssey unveiled promising outcomes. Molecular docking simulations illuminated the binding interactions between diverse flavonoids and the iNOS enzyme, offering insights into their potential inhibitory prowess. Among these flavonoids, a notable contender emerged, denoted as CHEMBL490697, which exhibited a remarkable negative binding affinity of -8.3 kcal/mol, demonstrating its strong attraction to the targeted protein. Furthermore, CHEMBL490697, admirably traversed the rigorous terrain of drug likeness parameters, underscoring its potential as a viable therapeutic candidate. In summation, this comprehensive investigation has illuminated the potential of CHEMBL490697 as a promising therapeutic agent with drug like properties, exemplified by its robust, stable, and tight binding to the iNOS enzyme. These findings present a compelling avenue for further research and development in the pursuit of best managements for AD.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0