Determining the Influence of Breadfruit Mucilage on the Disintegration and Dissolution of Losartan Fast-Dissolving Tablets

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI:10.25258/ijddt.13.3.01

Nina Varghese, M. Komala

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Abstract

organoleptic characteristics, hydration, swelling capacity, and pasting temperature of breadfruit starch were determined. It was found that breadfruit starch exhibited partial solubility in warm water, a pH of 5.8, and good hydration and swelling capacities. Furthermore, a compatibility test using differential scanning calorimetry confirmed the compatibility of losartan and breadfruit starch. It was determined that the formulated losartan tablets were satisfactory in terms of flow properties as well as consistent drug content both before and after compression. Dissolution studies in-vitro showed improved drug release profiles than those of losartan tablets marketed on the market. According to stability studies, the physical appearance and color of the drug did not change over 3 months, but there was a slight decrease in the amount of the drug and the rate of drug release during that period. Overall, breadfruit starch showed promise as an excipient for losartan tablets, offering potential benefits in terms of enhanced drug release characteristics. Further investigations are necessary to optimize the formulation and evaluate its clinical efficacy and safety.

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面包果黏液对氯沙坦速溶片崩解度影响的测定

测定了面包果淀粉的感官特性、水化、膨胀能力和糊化温度。结果表明，面包果淀粉在pH值为5.8的温水中具有部分溶解度，具有良好的水化和溶胀能力。并用差示扫描量热法进行配色试验，证实了氯沙坦与面包果淀粉的配色。实验结果表明，所制氯沙坦片的流动性能令人满意，且压缩前后药物含量一致。体外溶出度研究显示，与市场上销售的氯沙坦片相比，其药物释放谱有所改善。根据稳定性研究，在3个月内，药物的物理外观和颜色没有变化，但在此期间药物的量和药物释放速度略有下降。总的来说，面包果淀粉作为氯沙坦片剂的赋形剂，在增强药物释放特性方面提供了潜在的好处。需要进一步的研究来优化配方，评价其临床疗效和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.