International Journal of Drug Delivery Technology最新文献_第3页

Pharmaceutical Interventions in the Management of Oral Mucositis in Cancer Patients Undergoing Dental Treatments: A Randomized Controlled Trial 一项随机对照试验:药物干预对接受牙科治疗的癌症患者口腔黏膜炎的管理

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.32

Dushyantsinh Vala, Neha Gupta, Prajna P Nayak, Dhaval Niranjan Mehta, Md Waquar Alam, Santosh Kumar

{"title":"Pharmaceutical Interventions in the Management of Oral Mucositis in Cancer Patients Undergoing Dental Treatments: A Randomized Controlled Trial","authors":"Dushyantsinh Vala, Neha Gupta, Prajna P Nayak, Dhaval Niranjan Mehta, Md Waquar Alam, Santosh Kumar","doi":"10.25258/ijddt.13.3.32","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.32","url":null,"abstract":"Benzydamine hydrochloride, chlorhexidine as mouthwash, amifostine, palifermin, and a placebo were the five treatments that were investigated in this study. Oral mucositis is a common adverse effect of cancer treatment, and this study aimed to analyse and compare the effectiveness of these treatments. For the purpose of evaluating the treatments, we used descriptive statistics, analysis of variance (ANOVA), and rigorous tests to determine whether or not the means were equal. We took into account standard scores, deviations from the mean, and statistically significant differences. The data showed significant differences in the mean scores of each treatment group (p 0.001), indicating that different treatments had different levels of effectiveness in treating oral mucositis. Benzydamine hydrochloride consistently had superior mean scores and lower standard deviations compared to chlorine dioxide mouthwash, amifostine, palifermin, and the placebo. Oral mucositis may be treated with a variety of different medications, however the research suggests that benzydamine hydrochloride in is the most successful option. These results have significant ramifications for the decisions that should be made for therapy based on evidence, and they highlight the need to compare the relative efficacy of the many drugs used to treat oral mucositis. Additional research is required to examine the underlying mechanisms and unique treatment responses, which will pave the way for more individualised and effective treatment approaches.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the Influence of Breadfruit Mucilage on the Disintegration and Dissolution of Losartan Fast-Dissolving Tablets 面包果黏液对氯沙坦速溶片崩解度影响的测定

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.01

Nina Varghese, M. Komala

{"title":"Determining the Influence of Breadfruit Mucilage on the Disintegration and Dissolution of Losartan Fast-Dissolving Tablets","authors":"Nina Varghese, M. Komala","doi":"10.25258/ijddt.13.3.01","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.01","url":null,"abstract":"organoleptic characteristics, hydration, swelling capacity, and pasting temperature of breadfruit starch were determined. It was found that breadfruit starch exhibited partial solubility in warm water, a pH of 5.8, and good hydration and swelling capacities. Furthermore, a compatibility test using differential scanning calorimetry confirmed the compatibility of losartan and breadfruit starch. It was determined that the formulated losartan tablets were satisfactory in terms of flow properties as well as consistent drug content both before and after compression. Dissolution studies in-vitro showed improved drug release profiles than those of losartan tablets marketed on the market. According to stability studies, the physical appearance and color of the drug did not change over 3 months, but there was a slight decrease in the amount of the drug and the rate of drug release during that period. Overall, breadfruit starch showed promise as an excipient for losartan tablets, offering potential benefits in terms of enhanced drug release characteristics. Further investigations are necessary to optimize the formulation and evaluate its clinical efficacy and safety.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric Assisted UV-Spectrophotometric Quantification of Tigecycline in Parenteral Dosage Form 化学计量辅助紫外分光光度法测定替加环素非肠外剂型的含量

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.33

Kirtimaya Mishra, A Dash, A Jabeen, S Vegesna, SK Sahoo, V Gupta, D Jena

{"title":"Chemometric Assisted UV-Spectrophotometric Quantification of Tigecycline in Parenteral Dosage Form","authors":"Kirtimaya Mishra, A Dash, A Jabeen, S Vegesna, SK Sahoo, V Gupta, D Jena","doi":"10.25258/ijddt.13.3.33","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.33","url":null,"abstract":"Relating to the current study, the quality by design (QbD) concept is used for creating and validating an unique, resilient, accurate, and reliable spectrophotometric approach to quantify Tigecycline (TIG) in injections. Fractional factorial design (FFD) was a design implemented to screen the initial parameters. Moreover, the variables went through the central composite design (CCD) to assess the dependency and optimize the design. Several measures were analyzed statistically to determine the appropriateness of the data obtained from the experiments. At 250 nm, by the use of ethanol, TIG displays an absorption maximum. Variables like screening, slit-width, and sampling interval were recognized as critical method and again, evaluation was done by a CCD. A good linearity was produced for TIG within a range of 2 to 12 μg/mL, with R2 less than 0.999. The process was determined to be perfect, having a good average percent recovery (greater than 100%). According to ICH guidelines, validation of the developed method was performed. By the implementation of QbD principles, spectrophotometric techniques were created and planned to, integrate the qualities into the methods. These processes were manifested for being flexible and pertinent for identifying TIG in pharmaceutical dose regimens.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Role of Methionine: As an Essential Sulfur-containing Amino Acids 蛋氨酸的抗氧化作用:作为必需的含硫氨基酸

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.38

Samera M Alkatib, Ahmed M Zaki, May Kh Ismail, Raghad Kh Alsarraf

{"title":"Antioxidant Role of Methionine: As an Essential Sulfur-containing Amino Acids","authors":"Samera M Alkatib, Ahmed M Zaki, May Kh Ismail, Raghad Kh Alsarraf","doi":"10.25258/ijddt.13.3.38","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.38","url":null,"abstract":"Methionine is one of the essential sulfur-containing amino acids that are used in building proteins. In the body, methionine condenses with ATP to form S-adenosylmethionine (SAM), which acts as a methylation donor in various biological pathways. Methionine is characterized by its antioxidant activity and its ability to modify tissue sensitivity against oxidizing agents. Therefore, this study’s aim included using hydrogen peroxide 0.5% in drinking water to induce oxidative stress in the male rats and testing the ability of different concentrations of methionine for protection or prevention the oxidative stress during 10, 20 and 30 days. Forty male rats with the age of 3-4 months and of weights ranging between 300 to 400 gm were divided into 4 groups: Group (1): control group received drinking tap water, group (2): treated with H2O2 0.5% in drinking water, group (3): treated with H2O2 and methionine 0.3%, group (4): treated with H2O2 and methionine 0.6%. The following parameters in the serum were measured: Vit. C, Vit. E, peroxynitrite, albumin, selenium, zinc, and copper. Treatment with 0.3% methionine produced clear effects on the vit C, peroxynitrite, Zn and Cu levels in the serum, while the treatment with 0.6% methionine produced clear effects on the serum vit E, albumin, and Se levels","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Extraction, Purification and Evaluation of Long Chain Fatty Alcohol from Saccharum officinarum of Sugar Refinery Waste for Human Wellness 制糖厂废糖中长链脂肪醇的有机提取、纯化及对人体健康的评价

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.14

Singh A.K, Kharb R, Kandpal J.B

{"title":"Organic Extraction, Purification and Evaluation of Long Chain Fatty Alcohol from Saccharum officinarum of Sugar Refinery Waste for Human Wellness","authors":"Singh A.K, Kharb R, Kandpal J.B","doi":"10.25258/ijddt.13.3.14","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.14","url":null,"abstract":"The current study has explored an extraction and purification method for 1-octacosanol from sugarcane waste, commonly known as press mud, through the application of SCFE by the unique concept of solid-solid and liquid-liquid extraction which increases content and decreases impurity which is an extra advantage at purification stage by help of green solvent instead any carcinogenic solvent, which reduce process time, increase content and environment friendly. The isolated compounds were characterized by gas chromatography-flame ionization detection, which shows 50% content of octacosanol in the final product. Novel refinement technique through hot ethanolic reflux method has substantially increased the octacosanol assay to ≥ 50% with more than 67% purity from the crude wax assay of 26% obtained by the current method of extraction. The identity of said compound was further authenticated by X-ray diffraction (XRD), Diffraction scanning calorimetry (DSC) and FTIR studies. The purity of the octacosanol obtained was ≤70% and the conversion recovery of octacosanol was 80.04% by the reflux method, thereby representing the simplicity of the above process for industrial feasibility. The current process represents a value addition liquid-liquid supercritical extraction with a time-saving, cost-effective, reproducible, newer, green, safe, and sustainable technology valorizing sugarcane waste for a high-end nutraceutical","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Synthesis, Physicochemical Characterization of 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity 以抗抑郁活性为目的的1,3,4-恶二嗪吲哚衍生物的新合成及理化表征

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.26

Mahadev Agarwal, Neelam Singla, S.K Singh

引用次数: 0

Synthesis and Molecular Docking Studies of New Pyrimidinone ring Containing 1,2,3-Triazole Derivatives 含1,2,3-三唑类新型嘧啶环的合成及分子对接研究

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.39

Ahmed A Kozan, Riyadh J Nahi

引用次数: 0

In-silico Assessment of Potent Immunomodulators from Pimpinella anisum and its Antioxidant Potential 茴香草有效免疫调节剂及其抗氧化潜力的计算机评价

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.15

Snehal Kashid, Ashish Suttee, Prasad Kadam, Ramesh Kasarla

{"title":"In-silico Assessment of Potent Immunomodulators from Pimpinella anisum and its Antioxidant Potential","authors":"Snehal Kashid, Ashish Suttee, Prasad Kadam, Ramesh Kasarla","doi":"10.25258/ijddt.13.3.15","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.15","url":null,"abstract":"New targets, effective substances, and safety in pharmacological models are highlighted by recent drug development. The study’s primary goal is to use an in-silico technique to determine the immunomodulatory potential of phytoconstituents from Pimpinella anisum. Several computer aided tool were utilized for in-silico. autodock vina is major free tool utilized to examine a drug discovery strategy based on the atomic-level screening of small compounds and proteins and protein-ligand interactions. Basic docking phases include ligand position, orientation, and binding affinities. The current methodology includes ligand choice, protein prep, target, ligand optimisation, target active binding site analysis, and binding affinity. SwissADME was used to assess the pharmacokinetic parameters, and Lipinski’s “rules” were used to assess drug similarity. In the current research paper six ligands such as P-anisaldehyde, trans-anethole, cis-anethole, estragole, and linalool were dock against two proteins 1M48 and 1P9M. Molecular docking studies suggest strong binding affinity between -6.9 to -4.2 in case on 1M48 and -6.2 to -4.7 in case of 1P9M. Further antioxidant potential of P. anisum using several solvents was determined. In-vitro antioxidant study and in-silico screening suggested that P. anisum ethanolic extract can be contributed in immunomodulation","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Colloidally Stable Self-crosslinking Water-based Anticorrosive Polymer at Room Temperature 室温稳定自交联水性防腐聚合物的合成与表征

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.25

Khalida A Omran

{"title":"Synthesis and Characterization of Colloidally Stable Self-crosslinking Water-based Anticorrosive Polymer at Room Temperature","authors":"Khalida A Omran","doi":"10.25258/ijddt.13.3.25","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.25","url":null,"abstract":"The emulsion polymerization of butyl acrylate (BuA), styrene (St), and 3-isopropenyl-α,α-dimethylbenzyl isocyanate (IPMBI) is presented in this work. Obtain colloidally stable latexes for the poly (BuA/St/IPMBI) system during polymerization and storage for use in a water-based coating formulation. A series of semicontinuous polymerizations were also performed to investigate the effect of comonomer composition (w/w) in the feed (BuA/St) on conversion. The particle diameter (Dp), particle number (Np), hydrolysis of the IPMBI’s isocyanate groups, stability and storage properties. Films were created in which the effect of comonomer composition was also investigated, the glass transition temperature (Tg) was determined, the gel content was selected, and the mechanical properties and capacity as a barrier to water vapour and oxygen were assessed. Another series of reactions, on the other hand, was carried out in which the effect of the IPMBI content (1.5, 3.5, and 5.5%) was studied using a constant composition BuA/St=60/40. The studies conducted are the same as those mentioned for the effect of comonomer composition in feed. With increasing IPMBI percentage, slight differences in conversion, Dp, and Np were observed; the latices undergo hydrolysis during polymerization and storage. Colloidal stability, on the other hand, was preserved. The mechanical properties of the films improved as the percentage of IPMBI increased, while the boundary characteristics to moisture and oxygen improved when compared to the white film (0% of IPMBI). Finally, the formulation of a self-crosslinking water-based coating at room temperature using the previously obtained latex as a binder is reported; the coating demonstrated excellent adhesion, scratch hardness, and gloss regardless of the type of latex used.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Moxifloxacin Dry Powder Inhaler Combined with Mucolytic Agent for Pulmonary Diseases 莫西沙星干粉吸入剂联合黏液剂治疗肺部疾病的处方及疗效评价

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI: 10.25258/ijddt.13.3.07

Ratnaparkhi M.P, Kamble O.V, Salvankar S.S, Shinde S.R, Kulkarni G.M, Shewale A.B, Kadam D.D, Shaikh A.J

{"title":"Formulation and Evaluation of Moxifloxacin Dry Powder Inhaler Combined with Mucolytic Agent for Pulmonary Diseases","authors":"Ratnaparkhi M.P, Kamble O.V, Salvankar S.S, Shinde S.R, Kulkarni G.M, Shewale A.B, Kadam D.D, Shaikh A.J","doi":"10.25258/ijddt.13.3.07","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.07","url":null,"abstract":"The DPI is the device that administers the drug through the dry powder to the lungs. People with Multi-drug resistant tuberculosis or other lung diseases frequently use such devices to take their prescribed medicines. Numerous approaches have been used to formulate dry powder inhalation formulation and enhance the delivery performance of dry powder inhaler preparation. In the case of multi-drug resistance tuberculosis, a high dose of combination therapy was delivered, resulting in resistance to the anti-TB medications in the majority of patients. Moxifloxacin and levofloxacin are being used to minimize the need for a high-dose treatment regimen. This study aimed to achieve local lung administration of tumor-targeting Moxifloxacin, by administering microspheres that can be inhaled as a dry powder inhaler for targeting Phagocytes of alveoli via pulmonary passage. Spray drying had been used to formulate MXN-DPI formulations, afterward optimized with the 23-factorial design model. Two different amounts of lactose, leucine, and medication were used to make the eight batches. The developed formulation was studied for physicochemical properties like morphology and particle size. The particle dimensions of the MXN-DPI compositions have been confirmed to be in the range of 1.4 to 4.1 μm. The prepared formulations effectively showed drug release up to 93% in 5 hours, which was observed through in-vitro diffusion studies.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0